CN111296500A - Disinfecting and sterilizing composition and preparation method thereof - Google Patents

Disinfecting and sterilizing composition and preparation method thereof Download PDF

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Publication number
CN111296500A
CN111296500A CN202010201515.3A CN202010201515A CN111296500A CN 111296500 A CN111296500 A CN 111296500A CN 202010201515 A CN202010201515 A CN 202010201515A CN 111296500 A CN111296500 A CN 111296500A
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composition
parts
disinfection
disinfecting
extract
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姜春鹏
李岗
张学强
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Shanghai Lvrui Biotechnology Co ltd
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Shanghai Lvrui Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/24—Lauraceae [Laurel family], e.g. laurel, avocado, sassafras, cinnamon or camphor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/09—Lichens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/51—Gentianaceae (Gentian family)
    • A61K36/515—Gentiana
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract

The application belongs to the technical field of disinfection and sterilization, and particularly relates to a disinfection and sterilization composition and a preparation method thereof. The invention provides a disinfection and sterilization composition which comprises the following components in parts by weight: 0.01-5 parts of benzalkonium chloride and 0.01-5 parts of N-alkyl propylamine glycine. The disinfection and sterilization composition has rich active ingredients; the range of killing the microorganisms is wide; the smell is comfortable without adding any essence; can be directly used without blending and diluting; meanwhile, the disinfectant has no irritation and is not mild, and can be used for disinfecting and sterilizing surfaces of hands, public places, family table tops, toilets, bathrooms, air conditioners, toys, pet places, automobiles, clothes, restaurants, fruits and vegetables and the like.

Description

Disinfecting and sterilizing composition and preparation method thereof
Technical Field
The application belongs to the technical field of disinfection and sterilization, and particularly relates to a disinfection and sterilization composition and a preparation method thereof.
Background
It is well known that microorganisms such as bacteria and viruses, e.g., norovirus, poliovirus and adenovirus present health hazards due to infection or contamination. Together with fungi, yeasts and other microorganisms, they can also cause spoilage of items such as food, clothing and produce unpleasant odors. When microorganisms are present on the surface of a substrate, such as skin, they can rapidly replicate to form colonies. The disinfectant is a chemical preparation for killing pathogenic microorganisms on a transmission medium to make the transmission medium achieve the harmless requirement.
The traditional disinfection and sterilization product has the following defects: the active ingredients are single; the range of killing microorganisms is narrow; the smell is unpleasant; the product operation is complicated; the traditional disinfection and sterilization product has stimulation and is not mild; the safety factor is low.
Disclosure of Invention
In order to solve the technical problems, the first aspect of the invention provides a disinfection and sterilization composition, which comprises the following components in parts by weight: 0.01-5 parts of benzalkonium chloride and 0.01-5 parts of N-alkyl propylamine glycine.
As a preferable technical scheme, the disinfection and sterilization composition also comprises 0.01-10 parts of plant extracts.
As a preferred technical solution, the plant extract comprises at least one of pogostemon cablin extract, cinnamon extract, usnea barbata extract and gentiana tibetana extract.
As a preferable technical scheme, the disinfection and sterilization composition also comprises 0.1-10 parts of polyhydric alcohol with 3-6 carbon atoms, 70-99 parts of water and a proper amount of alkali metal hydroxide.
In a preferred embodiment, the polyhydric alcohol having 3 to 6 carbon atoms includes at least one of 1, 2-propanediol, 1, 3-propanediol, 1, 2-butanediol, 1, 3-butanediol, 1, 4-butanediol, 1, 2-pentanediol, 1, 3-pentanediol, 1, 4-pentanediol, 1, 5-pentanediol, 1, 2-hexanediol, 1, 3-hexanediol, 1, 4-hexanediol, and 1, 5-hexanediol.
As a preferred technical solution, the alkali metal hydroxide is potassium hydroxide and/or sodium hydroxide.
As a preferable technical scheme, the coating also comprises 0.01 to 5 parts of thickening agent by weight.
As a preferable technical solution, the thickener is at least one selected from the group consisting of hydroxyethyl cellulose, xanthan gum, carbomer, carrageenan, hypromellose, hydroxypropyl cellulose, and hydroxybutyl methyl cellulose.
A second aspect of the invention provides a process for the preparation of the disinfecting composition comprising the steps of:
(1) weighing various raw materials according to the formula of the disinfection and sterilization composition;
(2) placing weighed water into a container at room temperature, then adding 3-6 carbon atoms of polyhydric alcohol, benzalkonium chloride, plant extract and N-alkyl propylamine glycine one by one, stirring at 100 revolutions per minute until the composition forms transparent and uniform liquid;
(3) adding alkali metal hydroxide, and stirring to obtain transparent uniform liquid.
As a preferable technical scheme, the formulation of the disinfection and sterilization composition is selected from one of solution, suspension, emulsion, ointment, gel, foam, cream, skin cream, powder, soap, face washing cream, oil and spray.
Has the advantages that: the disinfection and sterilization composition has rich active ingredients; the range of killing the microorganisms is wide; the smell is comfortable without adding any essence; can be directly used without blending and diluting; meanwhile, the disinfectant has no irritation and is not mild, and can be used for disinfecting and sterilizing surfaces of hands, public places, family table tops, toilets, bathrooms, air conditioners, toys, pet places, automobiles, clothes, restaurants, fruits and vegetables and the like.
Detailed Description
For purposes of the following detailed description, it is to be understood that the invention may assume various alternative variations and step sequences, except where expressly specified to the contrary. Moreover, other than in any operating examples, or where otherwise indicated, all numbers expressing, for example, quantities of ingredients used in the specification and claims are to be understood as being modified in all instances by the term "about". Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and attached claims are approximations that may vary depending upon the desired properties to be obtained by the present invention. At the very least, and not as an attempt to limit the application of the doctrine of equivalents to the scope of the claims, each numerical parameter should at least be construed in light of the number of reported significant digits and by applying ordinary rounding techniques.
Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements.
When a range of values is disclosed herein, the range is considered to be continuous and includes both the minimum and maximum values of the range, as well as each value between such minimum and maximum values. Further, when a range refers to an integer, each integer between the minimum and maximum values of the range is included. Further, when multiple range-describing features or characteristics are provided, the ranges may be combined. In other words, unless otherwise indicated, all ranges disclosed herein are to be understood to encompass any and all subranges subsumed therein. For example, a stated range from "1 to 10" should be considered to include any and all subranges between the minimum value of 1 and the maximum value of 10. Exemplary subranges of the range 1 to 10 include, but are not limited to, 1 to 6.1, 3.5 to 7.8, 5.5 to 10, and the like.
In order to solve the problems, the invention provides a disinfection and sterilization composition which comprises the following components in parts by weight: 0.01-5 parts of benzalkonium chloride and 0.01-5 parts of N-alkyl propylamine glycine.
Preferably, the disinfection and sterilization composition comprises the following components in parts by weight: 0.1-0.5 part of benzalkonium chloride and 1-3 parts of N-alkyl propylamine glycine.
The CAS number of the benzalkonium chloride is 63449-41-2, and the benzalkonium chloride is a cationic quaternary ammonium salt, can change the permeability of a bacterial cytoplasmic membrane, enables bacterial cytoplasmic substances to seep out, and blocks the metabolism of the bacterial cytoplasmic substances to play a role in killing. Has strong effect on gram-positive bacteria, and has no effect on pseudomonas aeruginosa, acid-fast bacillus and cell spore. Can be rapidly combined with protein, and has remarkably reduced effect when meeting the existence of blood, cotton, cellulose and organic matters.
The N-alkyl propylamine glycine is creative in brand, does not contain methylisothiazolinone, and can be used for efficiently sterilizing and broad-spectrum sterilizing.
As a preferred embodiment, the disinfection and sterilization composition also comprises 0.01-10 parts by weight of plant extract. Preferably, the composition also comprises 0.1-1 part of plant extract.
The plant extract comprises at least one of herba Agastaches extract, cortex Cinnamomi extract, Usnea barbata extract, and Gentiana tibetana flower extract.
Said herba Agastaches is dry aerial parts of herba Agastaches Pogostemon cablin (blanco) Benth. Physiological properties: the stem of the branch is slightly in a square column shape, and is multi-branched, the branch is slightly bent, the length is 30-1500 px, and the diameter is 0.2-0.175 px; the surface is soft and hairy, is crisp and easy to break, and the middle part of the fracture surface is provided with marrow; old stems are cylindrical, have the diameter of 1-30 px and are covered by grey brown cork. The leaves are paired and shrunk into a cluster, and the flattened leaves are oval or elliptical, 4-225 px in length and 3-175 px in width; both sides are coated with grey white fluff; the tip is short and sharp or blunt round, the base is wedge-shaped or blunt round, and the edge is provided with blunt teeth with irregular sizes; the petiole is thin and 2-125 px long, and is molted. Special smell and slightly bitter taste.
The cinnamon (Latin scientific name: Cinnamomum cassia Presl) is a medium and large tree of Lauraceae, with a taupe bark. Leaves are alternate or nearly opposite, oblong to nearly acicular, leathery, edge cartilaginous, involuted, green, glossy, hairless, and thick and strong petioles. Axicon or near apical growth. White, split, soft and flat, long and round in the shape of anther oval, and ovate in the ovary. Oval fruit, dark purple at maturity, hairless, light cupped fruit tray.
The Usnea barbata is an extract of natural Usnea barbata from lichen tree, and its main ingredient is usnic acid.
The radix Gentianae (Latin's name: Gentianascabra Bunge) is a Gentianaceae plant. Perennial herbs with a height of 30-60 cm; yellow-white root, rope-like, more than 20 cm long. The stem is upright, thick and strong, and is purple brown and coarse. Opposite leaves, oval or egg-shaped, with a needle shape, a length of 3-7 cm, a width of 1-2 cm, 3-5 veins, sharp or tapered, no stem, rough edge and underlying main vein. The blossom grows the stem tip or the leaf axilla; the bract is in the shape of a needle and is approximately equal to the length of a calyx; the calyx is in a shape of a bell, the length of the calyx is 2.5-3 cm, and the splinters are in a shape of a needle and are approximately as long as the calyx; the corolla is in a shape of a cylinder bell, bluish purple, 4-5 cm long, and is in a lobe shape, a tip, a fold triangle and a thin bicuspid cleft; stamen 5, the base of the filament has wide fins; the style is short, and the column cap is 2 cracked.
The plant extracts were purchased from american mu (beijing) technologies ltd, model: a plant bacteriostatic agent YDH.
As a preferable embodiment, the disinfection and sterilization composition also comprises 0.1 to 10 parts by weight of polyhydric alcohol with 3 to 6 carbon atoms, 70 to 99 parts by weight of water and proper amount of alkali metal hydroxide.
Preferably, the disinfection and sterilization composition also comprises 1-5 parts by weight of polyhydric alcohol with 3-6 carbon atoms, 80-90 parts by weight of water and a proper amount of alkali metal hydroxide.
The polyhydric alcohol with 3-6 carbon atoms comprises at least one of 1, 2-propylene glycol, 1, 3-propylene glycol, 1, 2-butanediol, 1, 3-butanediol, 1, 4-butanediol, 1, 2-pentanediol, 1, 3-pentanediol, 1, 4-pentanediol, 1, 5-pentanediol, 1, 2-hexanediol, 1, 3-hexanediol, 1, 4-hexanediol and 1, 5-hexanediol.
The alkali metal hydroxide is potassium hydroxide and/or sodium hydroxide.
The sterilizing composition has the best sterilizing effect by compounding benzalkonium chloride, the plant extract and the N-alkyl propylamine glycine and simultaneously adding the alkali metal hydroxide. The plant extract contains patchouli extract, cinnamon extract, usnea barbata extract and gentiana tibetana extract, has obvious effects of inhibiting bacteria and even eliminating viruses, for example, the bacteriostasis capability of usnic acid is equivalent to that of sorbic acid, the components contained in the plant extract are complex, the action mechanism covers different mechanisms, a synergistic effect is formed, and the antibacterial and bacteriostatic effects with long-term, low sensitization and higher effects are provided. N-alkyl propylamino glycine is shown as positive charge cation in the system, and the product is a composite active cation type disinfection product. Meanwhile, the N-alkyl propylamine glycine has low surface tension (gamma is less than 30mN/m), so that the product can be well infiltrated and spread on both hydrophilic and hydrophobic surfaces, and active ingredients in the system can be uniformly dispersed on various surfaces to be disinfected to the greatest extent, thereby optimizing the sterilization and bacteriostasis effects.
The applicant has also found that said disinfecting composition, having a pH comprised between 6 and 8, is capable of killing gram-positive bacteria staphylococcus aureus, gram-negative bacteria escherichia coli, gram-negative bacteria pseudomonas aeruginosa, fungi candida albicans, viruses, etc.
The preparation method of the disinfection composition comprises the following steps:
(1) weighing various raw materials according to the formula of the disinfection and sterilization composition;
(2) placing weighed water into a container at room temperature, then adding 3-6 carbon atoms of polyhydric alcohol, benzalkonium chloride, plant extract and N-alkyl propylamine glycine one by one, stirring at 100 revolutions per minute until the composition forms transparent and uniform liquid;
(3) adding alkali metal hydroxide, and stirring to obtain transparent uniform liquid.
The disinfectant composition may be prepared in any form conventionally prepared in the art. Such as, but not limited to, solutions, suspensions, emulsions, creams, gels, foams, creams, moisturizers, powders, soaps, facial washes, oils, sprays, and the like.
The disinfection and sterilization composition can be used in the fields of factory production disinfection, hospital space cleaning disinfection, public health disinfection, family hygiene, personal hygiene and the like, can protect human life health, and can quickly dissipate faint traditional Chinese medicine smell carried by the product after being sprayed, and has no pungent smell. Moreover, the applicant unexpectedly finds that the benzalkonium chloride, the plant extract and the N-alkyl propylamine glycine in certain weight parts cooperate with each other to rapidly permeate into oil stains and between the oil stains and a base material, so that the disinfection and sterilization composition has a rapid sterilization effect on heavy oil stains in kitchens and the like.
When the disinfection and sterilization composition is made into a gel, the disinfection and sterilization composition also comprises 0.01 to 5 weight parts of thickening agent.
The thickener is at least one selected from hydroxyethyl cellulose, xanthan gum, carbomer, carrageenan, hydroxypropyl methylcellulose, hydroxypropyl cellulose and hydroxybutyl methyl cellulose.
The preparation of the disinfection and sterilization composition comprises the following steps:
(1) weighing various raw materials according to the formula of the disinfection and sterilization composition;
(2) placing the weighed water in a container;
(3) uniformly mixing a thickening agent with polyhydric alcohol with 3-6 carbon atoms in advance, adding the mixture into a container, and uniformly stirring at 100 revolutions per minute;
(4) then adding benzalkonium chloride, plant extract and N-alkyl propylamine glycine one by one, and stirring at 100-;
(5) adding alkali metal hydroxide, and stirring to obtain transparent uniform liquid.
The present invention will be specifically described below by way of examples. It should be noted that the following examples are only for illustrating the present invention and should not be construed as limiting the scope of the present invention, and that the insubstantial modifications and adaptations of the present invention by those skilled in the art based on the above disclosure are still within the scope of the present invention.
In addition, the starting materials used are all commercially available, unless otherwise specified.
Examples
Example 1
The disinfection and sterilization composition comprises the following components in parts by weight: 0.1 part of benzalkonium chloride, 1 part of N-alkyl propylamine glycine, 0.1 part of plant extract, 1 part of 1, 2-propylene glycol, 80 parts of water and a proper amount of sodium hydroxide.
The preparation method of the disinfection composition comprises the following steps:
(1) weighing various raw materials according to the formula of the disinfection and sterilization composition;
(2) placing weighed water into a container at room temperature, then adding 1, 2-propylene glycol, benzalkonium chloride, plant extract and N-alkyl propylamine glycine one by one, and stirring at 300 r/min while adding until the composition forms transparent uniform liquid;
(3) adding sodium hydroxide to adjust pH to 7.6, and stirring to obtain transparent uniform liquid.
Example 2
The disinfection and sterilization composition comprises the following components in parts by weight: 0.5 part of benzalkonium chloride, 3 parts of N-alkyl propylamine glycine, 1 part of plant extract, 5 parts of 1, 2-propylene glycol, 90 parts of water and a proper amount of sodium hydroxide.
The preparation method of the disinfection composition is the same as that of example 1, except that the pH is adjusted to 8.
Example 3
The disinfection and sterilization composition comprises the following components in parts by weight: 0.1 part of benzalkonium chloride, 1 part of N-alkyl propylamine glycine, 0.1 part of plant extract, 1 part of 1, 2-propylene glycol, 0.1 part of hydroxyethyl cellulose, 80 parts of water and a proper amount of sodium hydroxide.
The preparation of the disinfection and sterilization composition comprises the following steps:
(1) weighing various raw materials according to the formula of the disinfection and sterilization composition;
(2) placing the weighed water in a container;
(3) uniformly mixing hydroxyethyl cellulose and 1, 2-propylene glycol in advance, then adding the mixture into a container, and uniformly stirring at 300 revolutions per minute;
(4) then adding benzalkonium chloride, plant extract and N-alkyl propylamine glycine one by one, and stirring at 300 r/min while adding until the composition forms transparent uniform liquid;
(5) adding sodium hydroxide to adjust pH to 7.6, and stirring to obtain transparent uniform liquid.
Example 4
The specific implementation mode of the disinfection and sterilization composition is the same as that of example 3, and the difference is that the hydroxyethyl cellulose is replaced by xanthan gum.
Example 5
The specific implementation mode of the disinfection and sterilization composition is the same as that in example 3, except that the hydroxyethyl cellulose is replaced by carbomer.
Example 6
The disinfection and sterilization composition comprises the following components in parts by weight: 0.1 part of benzalkonium chloride, 1 part of N-alkyl propylamine glycine, 0.1 part of plant extract, 1 part of 1, 2-propylene glycol, 0.05 part of disodium EDTA, 80 parts of water and a proper amount of sodium hydroxide.
The preparation method of the disinfection and sterilization composition comprises the following steps:
(1) weighing various raw materials according to the formula of the disinfection and sterilization composition;
(2) placing weighed water into a container at room temperature, then adding EDTA disodium, 1, 2-propylene glycol, benzalkonium chloride, plant extract and N-alkyl propylamine glycine one by one, and stirring at 300 revolutions per minute while adding until the composition forms transparent and uniform liquid;
(3) the pH of the composition was adjusted to 7-8 with sodium hydroxide and the mixture was stirred at 300 rpm while adding the sodium hydroxide until the composition formed a clear and homogeneous liquid.
Comparative example 1
The specific embodiment of a disinfecting and sterilizing composition is the same as that in example 1, except that sodium hydroxide is added to adjust the pH to 5.
Comparative example 2
The specific embodiment of a disinfecting and sterilizing composition is the same as that in example 1, except that sodium hydroxide is added to adjust the pH to 10.
Comparative example 3
The specific embodiment of a disinfecting and sterilizing composition is the same as that in example 1, except that benzalkonium chloride is not included.
Comparative example 4
A disinfecting composition is similar to that of example 1, except that it does not contain plant extracts.
Comparative example 5
A disinfecting and sterilizing composition, which is similar to example 1 except that N-alkyl propylamino glycine is not included.
Performance testing
Refer to "Disinfection Specification".
And (3) stability test: the disinfecting and sterilizing compositions described in examples and comparative examples were stored in a constant temperature incubator at 54 ℃ for 14 days, and then the content of benzalkonium chloride was measured by volumetric analysis and compared with the content before storage.
And (3) testing the metal corrosivity: stainless steel and carbon steel are soaked in the disinfection and sterilization composition for 72 hours, and the corrosion rate of the stainless steel and the carbon steel is tested.
The sterilization performance is as follows: the killing effect on escherichia coli, pseudomonas aeruginosa and candida albicans is tested, and the action time is 1.5 min.
Test results for the disinfectant and bactericidal compositions described in examples 1-6
Figure BDA0002419554600000081
Sterilization effects of example 1 and comparative example
Figure BDA0002419554600000091
The sterilizing composition described in the embodiment 1 and the comparative examples 3-5 is used for sterilizing natural bacteria in heavy oil-polluted kitchens, the acting time is 3min, and the sterilizing rate of the sterilizing composition described in the embodiment 1 is more than 99.9 percent, and the sterilizing rate of the comparative examples 3-5 is less than 85 percent.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in other forms, and any person skilled in the art may modify or change the technical content of the above disclosure into equivalent embodiments with equivalent changes, but all those simple modifications, equivalent changes and modifications made to the above embodiments according to the technical spirit of the present invention still belong to the protection scope of the present invention.

Claims (10)

1. The disinfection and sterilization composition is characterized by comprising the following components in parts by weight: 0.01-5 parts of benzalkonium chloride and 0.01-5 parts of N-alkyl propylamine glycine.
2. The disinfectant composition according to claim 1, further comprising 0.01 to 10 parts of a plant extract.
3. The disinfectant/bactericidal composition according to claim 2, wherein said plant extract comprises at least one of a patchouli extract, a cinnamon extract, a usnea barbata extract, and a gentiana tibetana extract.
4. A disinfecting and sterilizing composition as claimed in any one of claims 1 to 3, characterized in that said disinfecting and sterilizing composition further comprises 0.1 to 10 parts of polyhydric alcohol having 3 to 6 carbon atoms, 70 to 99 parts of water and a proper amount of alkali metal hydroxide.
5. The disinfectant/bactericidal composition according to claim 4, wherein said polyhydric alcohol having 3 to 6 carbon atoms comprises at least one of 1, 2-propanediol, 1, 3-propanediol, 1, 2-butanediol, 1, 3-butanediol, 1, 4-butanediol, 1, 2-pentanediol, 1, 3-pentanediol, 1, 4-pentanediol, 1, 5-pentanediol, 1, 2-hexanediol, 1, 3-hexanediol, 1, 4-hexanediol, and 1, 5-hexanediol.
6. The disinfectant/bactericidal composition according to claim 4, wherein said alkali metal hydroxide is potassium hydroxide and/or sodium hydroxide.
7. The disinfectant composition according to claim 4, further comprising 0.01 to 5 parts by weight of a thickener.
8. The sanitizer composition of claim 7, wherein said thickener is at least one member selected from the group consisting of hydroxyethylcellulose, xanthan gum, carbomer, carrageenan, hypromellose, hydroxypropylcellulose, and hydroxybutylmethylcellulose.
9. A process for the preparation of a disinfecting composition as claimed in any one of claims 1 to 8 comprising the steps of:
(1) weighing various raw materials according to the formula of the disinfection and sterilization composition;
(2) placing weighed water into a container at room temperature, then adding 3-6 carbon atoms of polyhydric alcohol, benzalkonium chloride, plant extract and N-alkyl propylamine glycine one by one, stirring at 100 revolutions per minute until the composition forms transparent and uniform liquid;
(3) adding alkali metal hydroxide, and stirring to obtain transparent uniform liquid.
10. The disinfecting composition of claim 4, wherein the disinfecting composition is in a form selected from the group consisting of a solution, a suspension, an emulsion, a paste, a gel, a foam, a cream, a moisturizer, a powder, a soap, a facial cleanser, an oil, and a spray.
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111937872A (en) * 2020-07-30 2020-11-17 广州市加茜亚化妆品有限公司 Clothing disinfectant and preparation method thereof
CN115006348A (en) * 2022-07-11 2022-09-06 振德医疗用品股份有限公司 Long-acting spray for oral mucosa and nasal mucosa, preparation method and application
CN115590780A (en) * 2021-06-28 2023-01-13 南京华狮新材料有限公司（Cn） Bactericidal and anti-dandruff composition for hair and preparation method thereof
CN115843795A (en) * 2022-10-28 2023-03-28 南京华狮新材料有限公司 Supermolecule wrapped deodorizing, disinfecting and sterilizing composition

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111937872A (en) * 2020-07-30 2020-11-17 广州市加茜亚化妆品有限公司 Clothing disinfectant and preparation method thereof
CN115590780A (en) * 2021-06-28 2023-01-13 南京华狮新材料有限公司（Cn） Bactericidal and anti-dandruff composition for hair and preparation method thereof
CN115006348A (en) * 2022-07-11 2022-09-06 振德医疗用品股份有限公司 Long-acting spray for oral mucosa and nasal mucosa, preparation method and application
CN115843795A (en) * 2022-10-28 2023-03-28 南京华狮新材料有限公司 Supermolecule wrapped deodorizing, disinfecting and sterilizing composition

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