CN115590780A - Bactericidal and anti-dandruff composition for hair and preparation method thereof - Google Patents
Bactericidal and anti-dandruff composition for hair and preparation method thereof Download PDFInfo
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- hydroxypyridine
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- bactericidal
- dandruff
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- 239000000203 mixture Substances 0.000 title claims abstract description 45
- 208000001840 Dandruff Diseases 0.000 title claims abstract description 41
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title abstract description 7
- -1 2-hydroxypyridine compound Chemical class 0.000 claims abstract description 25
- UBQKCCHYAOITMY-UHFFFAOYSA-N 2-hydroxy-pyridine Natural products OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 claims abstract description 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 18
- 239000004471 Glycine Substances 0.000 claims description 13
- OQLKNTOKMBVBKV-UHFFFAOYSA-N hexamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCCOC1=CC=C(C(N)=N)C=C1 OQLKNTOKMBVBKV-UHFFFAOYSA-N 0.000 claims description 13
- 229960001915 hexamidine Drugs 0.000 claims description 13
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 claims description 13
- SNUSZUYTMHKCPM-UHFFFAOYSA-N 1-hydroxypyridin-2-one Chemical compound ON1C=CC=CC1=O SNUSZUYTMHKCPM-UHFFFAOYSA-N 0.000 claims description 12
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 claims description 10
- 241000894006 Bacteria Species 0.000 claims description 8
- 229910019142 PO4 Inorganic materials 0.000 claims description 8
- 239000010452 phosphate Substances 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 7
- JVHZMYAXZUIZKS-UHFFFAOYSA-N OC1=CC=CC=[N+]1[O-] Chemical class OC1=CC=CC=[N+]1[O-] JVHZMYAXZUIZKS-UHFFFAOYSA-N 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 125000002091 cationic group Chemical group 0.000 claims description 4
- 230000002070 germicidal effect Effects 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- XTJKNGLLPGBHHO-HNNXBMFYSA-N (2s)-5-(diaminomethylideneamino)-2-(dodecanoylamino)pentanoic acid Chemical compound CCCCCCCCCCCC(=O)N[C@H](C(O)=O)CCCN=C(N)N XTJKNGLLPGBHHO-HNNXBMFYSA-N 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical class [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
- 229920002413 Polyhexanide Polymers 0.000 claims description 2
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 2
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 2
- 239000008367 deionised water Substances 0.000 claims description 2
- 229910021641 deionized water Inorganic materials 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000002184 metal Chemical class 0.000 claims description 2
- 229910052751 metal Chemical class 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 15
- 210000004761 scalp Anatomy 0.000 abstract description 8
- 230000001954 sterilising effect Effects 0.000 abstract description 6
- 230000007794 irritation Effects 0.000 abstract description 5
- 230000003750 conditioning effect Effects 0.000 abstract description 4
- 150000001768 cations Chemical class 0.000 abstract description 3
- 239000002994 raw material Substances 0.000 abstract description 3
- 239000012747 synergistic agent Substances 0.000 abstract description 3
- 239000003899 bactericide agent Substances 0.000 abstract description 2
- 241000555676 Malassezia Species 0.000 description 15
- 239000002453 shampoo Substances 0.000 description 13
- 238000011156 evaluation Methods 0.000 description 9
- 230000003385 bacteriostatic effect Effects 0.000 description 8
- 239000000126 substance Substances 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 229940043810 zinc pyrithione Drugs 0.000 description 5
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 5
- 229920001817 Agar Polymers 0.000 description 4
- 241000233866 Fungi Species 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 239000008272 agar Substances 0.000 description 4
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 241000555688 Malassezia furfur Species 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000000855 fungicidal effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 210000000170 cell membrane Anatomy 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
- OWEGWHBOCFMBLP-UHFFFAOYSA-N 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one Chemical compound C1=CN=CN1C(C(=O)C(C)(C)C)OC1=CC=C(Cl)C=C1 OWEGWHBOCFMBLP-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229960003344 climbazole Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
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- 238000002474 experimental method Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000034659 glycolysis Effects 0.000 description 1
- 230000003648 hair appearance Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 229960004125 ketoconazole Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005706 microflora Species 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229940081510 piroctone olamine Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- VIDTVPHHDGRGAF-UHFFFAOYSA-N selenium sulfide Chemical compound [Se]=S VIDTVPHHDGRGAF-UHFFFAOYSA-N 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
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- 239000010902 straw Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Birds (AREA)
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- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a bactericidal and anti-dandruff composition for hair, which is characterized by comprising a 2-hydroxypyridine compound and a cation synergistic agent. The invention also discloses a preparation method of the bactericidal and anti-dandruff composition for hair. The high-efficiency anti-dandruff bactericide is compounded and combined, and on one hand, the composition has excellent sterilizing, antibacterial and anti-dandruff capabilities, has good conditioning effect on hair, has smooth skin feel on skin, has low irritation on a human body, and has the effect of protecting hair and scalp; on the other hand, the price is moderate, the raw materials are easy to obtain, and the use is simple and convenient in the formula.
Description
Technical Field
The invention belongs to the field of daily chemical articles, and particularly relates to a sterilizing and dandruff-removing composition for hair and a preparation method thereof.
Background
The three major balances of human hair are maintained: disorders of the lipids, flora, metabolic balance, microflora, in particular an excessive colonization by fungi of the family of yeasts belonging to the genus Malassezia (genus Malassezia) naturally present on the scalp, can cause an excessive rapid proliferation of the scalp cells, promoting a massive production of dandruff when the metabolites of the fungi, the combing is inappropriate, the hair care is inappropriate, causing inflammation. It has been found that in china, 60% of adults suffer from dandruff to varying degrees, mainly due to the fact that chinese consumers do not pay attention to the health care of the skin of the head, and select uncomfortable washing and hair care products.
In many cases, the main factor of dandruff is also an imbalance in the amount of malassezia. Therefore, inhibition of the amount of malassezia to the scalp is critical to the treatment of dandruff. Many anti-dandruff treatments have been developed, the main purpose of which is to remove Malassezia yeasts (Malassezia yeast) from the scalp, the activity of modern anti-dandruff active agents such as zinc pyrithione, piroctone olamine, climbazole, ketoconazole or selenium sulphide being based mainly on their fungicidal properties.
Currently, there are some anti-dandruff combinations without zinc pyrithione, such as CN102973419B, which contains 3,3,4, -trichloro-sym-diphenylurea and 1-hydroxy-4-methyl-6- (2,4,4-trimethylpentyl) -2 (1H) -pyridone ethanolamine, 3,3,4, -trichloro-sym-diphenylurea, which can achieve bacteriostatic effect only when reaching 1% -2%, and the anti-dandruff compositions in this group are used in large amounts. For example, CN201510377981.6 uses piroctone olamine salt as an anti-dandruff component, the addition amount is 5-10%, and the problems of irritation, sensitization and the like of the piroctone olamine salt are concerned.
Disclosure of Invention
In order to solve the problems, the invention provides a bactericidal and anti-dandruff composition for hair and a preparation method thereof. The composition of the invention has better removal effect on malassezia.
The purpose of the invention and the technical problem to be solved are realized by adopting the following technical scheme.
The invention provides a sterilizing and dandruff-removing composition for hair, which is characterized by comprising a 2-hydroxypyridine compound and a cation synergistic agent, wherein the 2-hydroxypyridine compound has the following molecular structure:
wherein R is 1 、R 2 Each independently represents O, OH, OSO 3 M、OCO 2 M、OCOR 6 、OR 6 ，M、R 6 Each independently represents H, ammonium or a metal salt.
Preferably, when R is 1 When the compound is O, the formula I is 2-hydroxypyridine-N-oxide, and the 2-hydroxypyridine-N-oxide compounds are selected from one or more of 2-hydroxypyridine-N-oxide, 2-hydroxypyridine-N-oxide derivatives, 2-hydroxypyridine-N-oxide salts, 2-pyridinol-N-oxide or salts thereof.
Preferably, the cationic synergist is selected from one or more of N-alkyl propylamino glycine, amidoalkyl quaternary ammonium salt cations, hexamidine bis (isethionate), lauroyl arginine ethyl ester hydrochloride, benzalkonium chloride, and polyhexamethylene biguanide hydrochloride.
Preferably, the amido alkyl quaternary ammonium salt cation is selected from one or more of myristamidopropyl PG-dimethyl ammonium chloride, myristamidopropyl PG-dimethyl ammonium chloride phosphate, cocamidopropyl PG-dimethyl ammonium chloride phosphate, linoleamidopropyl PG-dimethyl ammonium chloride and linoleamidopropyl PG-dimethyl ammonium chloride phosphate.
As described herein, 2-hydroxypyridine-N-oxide, which is a colorless solid, has good water solubility, high antifungal activity, and a certain iron-chelating ability. Can kill fungus producing dandruff, and has remarkable effect of resisting malassezia and inhibiting dandruff growth. Therefore, the hair conditioner can be used as an antidandruff factor and can effectively care hair.
As described in the text, the N-alkyl propylamine glycine has the sterilization mechanism that the cell wall and the cytoplasmic membrane are distorted, deformed and fragmented by charge adsorption and penetration to the cell wall, and then react with key proteins of cell life substances and enzymes which are used for leading cell respiration and glycolysis to cause the change of the permeable and irreversible structures of the cell membrane or virus envelope, so that the effect of killing bacteria and viruses is achieved, and the good effect of killing fungi is achieved.
As described herein, the amidoalkyl quaternary ammonium salt cationic surfactant has good synergistic effect on an antidandruff agent of malassezia, can reduce the dosage of the antidandruff agent, has excellent conditioning effect on hair and skin, gives the hair soft and glossy characteristics, gives the skin smooth and soft, and has good water solubility, foam stability and foaming effect and good compatibility with the ionic surfactant.
As described herein, hexamidine bis (isethionate) has broad spectrum antibacterial and bactericidal properties, high bactericidal and bacteriostatic properties against a variety of gram-positive and gram-negative bacteria and a variety of mold yeasts, particularly as low as 12.4 μ g/mL for pityrosporum ovale which causes dandruff -1 The anti-bacterial anti-dandruff shampoo has the advantages of excellent anti-bacterial and anti-dandruff effect, good water solubility, mildness, no stimulation, no influence on hair quality after long-term use and excellent compatibility with common raw materials in daily chemical products.
Preferably, the composition comprises the following components in percentage by weight: 0.02-5% of 2-hydroxypyridine-N-oxygen compound, 0.02-6% of N-alkyl propylamino glycine and 0.01-0.1% of hexamidine di (isethionate).
Preferably, the composition comprises the following components in percentage by weight: 0.02-5% of 2-hydroxypyridine-N-oxygen compound, 0.02-6% of N-alkyl propylamine glycine and 0.01-5% of amidoalkyl quaternary ammonium salt cation.
Preferably, the composition comprises the following components in percentage by weight: 0.02-5% of 2-hydroxypyridine-N-oxygen compound, 0.01-0.1% of hexamidine di (isethionate) and 0.02-4% of amidoalkyl quaternary ammonium salt cation.
Preferably, the composition comprises the following components in percentage by weight: 0.02-4% of 2-hydroxypyridine-N-oxygen compound, 0.01-0.09% of hexamidine di (isethionate), 0.02-6% of N-alkyl propylamine glycine and 0.02-3% of amidoalkyl quaternary ammonium salt cation.
Preferably, the composition comprises the following components in percentage by weight: 0.01-10% of 2-hydroxypyridine-N-oxide, 0.01-8% of N-alkyl propylamino glycine, 0.01-8% of amidoalkyl quaternary ammonium salt cation and 0.01-0.1% of hexamidine di (isethionate).
The purpose of the invention and the technical problem to be solved are also realized by adopting the following technical scheme.
The invention also provides a preparation method of the sterilizing and dandruff removing composition for hair, which comprises the steps of adding the 2-hydroxypyridine compound and the cation synergistic agent into deionized water according to the proportion, and stirring and dissolving uniformly.
By the technical scheme, the invention at least has the following advantages:
the high-efficiency anti-dandruff bactericide is compounded and combined, and the composition has excellent sterilizing, antibacterial and anti-dandruff capabilities, good conditioning performance on hair, smooth skin feeling on skin, low irritation on human body and hair and scalp protection effects; on the other hand, the price is moderate, the raw materials are easy to obtain, and the use is simple and convenient in the formula.
The composition disclosed by the invention is applied to hair washing and caring products, does not contain zinc pyrithione with strong irritation, contains components with conditioning effect on hair, and can reduce the irritation of a chemical anti-dandruff agent on skin (scalp) while improving the anti-dandruff effect; avoids the problem of skin (scalp) injury caused by long-term use of chemical antidandruff agent.
The foregoing is a summary of the present invention, and in order to provide a clear understanding of the technical means of the present invention and to be implemented in accordance with the present specification, the following is a detailed description of the preferred embodiments of the present invention.
Detailed Description
In order to make the technical means, the creation features, the achievement purposes and the effects of the invention easy to understand, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Examples 1 to 19
The germicidal anti-dandruff compositions for hair of examples 1-19 were prepared according to the formulation and proportions of table 1. Wherein, the total amount of each substance is 100g according to the mass percentage content.
TABLE 1 Bactericidal and antidandruff composition for hair in examples 1-19, composition and content
Test example 1 evaluation of fungicidal Effect of fungicidal and antidandruff composition for Hair
The antibacterial and anti-dandruff composition for hair obtained according to the formula of examples 1 to 19 was compared with the size of the bacteriostatic zone of the compound and the monomer by the zone of inhibition (oxford cup) method, and the bacteriostatic effect was evaluated.
The experimental method is as follows:
1. pouring the sterilized malassezia agar culture medium at about 45 ℃ into sterile plates with about 15mL per dish, and turning over after solidification for later use.
2. Preparation of bacterial solution
2.1 operating in a biological safety cabinet, adding 5mL of malassezia culture broth into a malassezia slope, scraping off strains, sucking out the strains in a sterile test tube by using a disposable sterile straw, homogenizing, standing, and sucking the bacteria liquid without precipitates on the upper layer into the sterile test tube for later use.
2.2 this suspension requires aspiration of 1mL in 9mL of physiological saline, serial 10-fold gradient dilution with 10 dilutions -4 、10 -5 、10 -6 The diluted cell suspension (2) was applied to the malassezia agar medium prepared just before 0.1mL of the diluted cell suspension was pipetted and applied to the malassezia agar medium. Then placing the mixture in an incubator at 36 ℃ for culturing for 48-72h, and counting the viable bacteria.
3. Bacterial liquid coating
0.1mL of the bacterial solution prepared in 2.1 was pipetted onto a Malassezia agar plate and uniformly spread. And after the bacteria liquid is fixed, turning over the plate for marking. Each plate was labeled 2 dishes as replicates. Each composition was scored as 3 plates as parallel.
Adding an oxford cup into each bacteria plate at the center of the plate, and slightly pressing the oxford cup by using the finger belly without puncturing the culture medium. According to the marked composition and monomer, 200. Mu.l of the composition or monomer was added to the Oxford cup, respectively. Covering the dish cover, and culturing at 36 ℃ for 48-72h. And measuring the diameter of the bacteriostatic zone, and comparing the bacteriostatic effects. The results are shown in tables 2-4.
Table 2 examples 1-8 zone of inhibition diameter size
TABLE 3 diameter of inhibition zone in examples 9-14
TABLE 4 examples 15-19 zone of inhibition diameter size
From the results in tables 2 to 4, it is known that the synergistic bacteriostatic effect on malassezia furfur is achieved when the 2-hydroxypyridine-N-oxide, the N-alkyl propylamino glycine, the myristamidopropyl PG-dimethyl ammonium chloride phosphate and the hexamidine bis (isethionate) are compounded in pairs; the compound has better synergistic bacteriostatic effect on malassezia furfur when the 2-hydroxypyridine-N-oxide, the N-alkyl propylamino glycine, the myristamidopropyl PG-dimethyl ammonium chloride phosphate and the hexamidine di (isethionate) are compounded.
Test example 2 evaluation of Using effects of shampoo containing germicidal anti-dandruff composition for Hair
The germicidal anti-dandruff composition for hair of examples 15 to 19 was applied to shampoo to obtain shampoos numbered 1 to 5, and the formulations of the shampoos are shown in table 5. Comparison with commercially available shampoo containing zinc pyrithione (number 6)
TABLE 5 shampoo formulations
The evaluation is carried out comprehensively by asking the volunteers to try out the product and filling out a test table by adopting a civil survey evaluation method. The volunteers (20 persons in age range of 20-40; 20 persons in age range of 41-55) with dandruff problems in different age groups are respectively selected as a group of trial subjects, 6 groups of volunteers are totally used for respectively trying the dandruff removing effect of the 6 shampoos (number 1-6), the volunteers wash their hair once every two days for three months, and after trial, the test tables are filled for scoring. The evaluation items in the evaluation table are judged by the number of people with different evaluation in personal evaluation, and the using effect conditions of the shampoo are shown in table 6.
TABLE 6 evaluation table of volunteers of shampoo
From the test results of table 6, it can be derived: compared with a certain brand of commercially available shampoo containing an anti-dandruff agent zinc pyrithione, the shampoo added with the anti-dandruff composition is mild and non-irritant, hair is fresh and cool after use, the anti-dandruff shampoo has a very good anti-dandruff effect and is easy to clean.
Although the present invention has been described with reference to a preferred embodiment, it should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (10)
1. A bactericidal and antidandruff composition for hair, characterized in that it comprises a compound of the 2-hydroxypyridine series and a cationic synergist, said compound of the 2-hydroxypyridine series comprising the following molecular structure:
wherein R is 1 、R 2 Each independently represents O, OH, OSO 3 M、OCO 2 M、OCOR 6 、OR 6 ，M、R 6 Each independently represents H, ammonium or a metal salt.
2. According to claim 1The composition for killing bacteria and removing dandruff for hair is characterized in that when R is 1 When the compound is O, the formula I is 2-hydroxypyridine-N-oxide, and the compounds of the 2-hydroxypyridine-N-oxide are selected from one or more of 2-hydroxypyridine-N-oxide, 2-hydroxypyridine-N-oxide derivatives, 2-hydroxypyridine-N-oxide salts and 2-pyridinol-N-oxide or salts thereof.
3. The germicidal anti-dandruff composition for hair according to claim 1, characterized in that said cationic synergist is selected from one or more of N-alkyl propylamino glycine, amidoalkyl quaternary ammonium cations, hexamidine bis (isethionate), lauroyl arginine ethyl ester hydrochloride, benzalkonium chloride, polyhexamethylene biguanide hydrochloride.
4. The bactericidal and antidandruff composition for hair according to claim 3, wherein the quaternary ammonium salt cation of the amidoalkyl group is selected from one or more of myristamidopropyl PG-dimethyl ammonium chloride, myristamidopropyl PG-dimethyl ammonium chloride phosphate, cocamidopropyl PG-dimethyl ammonium chloride phosphate, linoleamidopropyl PG-dimethyl ammonium chloride and linoleamidopropyl PG-dimethyl ammonium chloride phosphate.
5. The bactericidal and antidandruff composition for hair according to any one of claims 1 to 4, characterized in that the composition comprises the following components and contents: 0.02-5% of 2-hydroxypyridine-N-oxygen compound, 0.02-6% of N-alkyl propylamino glycine and 0.01-0.1% of hexamidine di (isethionate).
6. The bactericidal and antidandruff composition for hair according to any one of claims 1 to 4, characterized in that it comprises the following components and contents: 0.02-5% of 2-hydroxypyridine-N-oxygen compound, 0.02-6% of N-alkyl propylamine glycine and 0.01-5% of amidoalkyl quaternary ammonium salt cation.
7. The bactericidal and antidandruff composition for hair according to any one of claims 1 to 4, characterized in that it comprises the following components and contents: 0.02-5% of 2-hydroxypyridine-N-oxygen compound, 0.01-0.1% of hexamidine di (isethionate) and 0.02-4% of amidoalkyl quaternary ammonium salt cation.
8. The bactericidal and antidandruff composition for hair according to any one of claims 1 to 4, characterized in that it comprises the following components and contents: 0.02-4% of 2-hydroxypyridine-N-oxygen compound, 0.01-0.09% of hexamidine di (isethionate), 0.02-6% of N-alkyl propylamine glycine and 0.02-3% of amidoalkyl quaternary ammonium salt cation.
9. The bactericidal and antidandruff composition for hair according to any one of claims 1 to 4, characterized in that the composition comprises the following components and contents: 0.01-10% of 2-hydroxypyridine-N-oxide, 0.01-8% of N-alkyl propylamino glycine, 0.01-8% of amidoalkyl quaternary ammonium salt cation and 0.01-0.1% of hexamidine di (isethionate).
10. A process for preparing the composition used to kill bacteria and remove dandruff for hair includes such steps as proportionally adding 2-hydroxypyridine compounds and cationic synergist to deionized water, stirring and dissolving.
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