CN111228329A - A composition for treating gynecological inflammation and its preparation method - Google Patents
A composition for treating gynecological inflammation and its preparation method Download PDFInfo
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Abstract
The invention discloses a composition for treating gynecological inflammation, which comprises the following components in parts by weight: 70-100 parts of an extract of the component A, 100-500 parts of an extract of the component B, 10-30 parts of glycerin, 80-100 parts of vaseline, 100-150 parts of beeswax and 2-8 parts of borneol; the component A comprises 20-30 parts of birch and 50-70 parts of oak; the component B comprises 10-18 parts of radix sophorae flavescentis, 20-30 parts of frankincense, 10-20 parts of caulis spatholobi and 5-10 parts of semen cuscutae. According to the invention, the birch extract and the oak extract are used as main raw materials, effective essences of the birch and the oak are furthest reserved by special extraction of the birch extract and the oak extract, and the composition is supplemented with the lightyellow sophora root, the frankincense, the suberect spatholobus stem and the dodder, is matched with the lanolin, the glycerol, the vaseline, the beeswax and the borneol, so that the effect of the composition is enhanced, the composition is used for treating and preventing gynecological inflammation, directly reaches a focus, has a quick effect, treats both symptoms and root causes, is not easy to relapse, and has a good curative effect.
Description
Technical Field
The invention belongs to the field of medicine health care, and particularly relates to a composition for treating gynecological inflammation and a preparation method thereof.
Background
Bacterial Vaginitis (BV) is a syndrome of vaginal secretion increase, fishy smell and vulvar pruritus burning caused by vaginal microecological balance disorder due to mixed infection of gardnerella vaginalis and some anaerobic bacteria. Can be classified into Haemophilus vaginitis, Corynebacterium vaginitis, anaerobic vaginitis, and Gardnerella vaginitis.
At present, the treatment of gynecological vaginitis in China can be divided into western medicine treatment and traditional Chinese medicine treatment, and the treatment process is combined with oral administration and external washing. Most western medicines adopt estrogen and antibacterial drugs for combined treatment, all the antibacterial drugs have good killing effect on bacteria, but the drugs can generate toxic and side effects and drug resistance in different degrees after long-term use; the traditional Chinese medicine for treating vulvitis, and other gynecological vaginitis is beneficial to symptomatic treatment, can well relieve symptoms, has a remarkable effect of killing insect pests, and does not have a pure traditional Chinese medicine washing liquid which has the same formula or equivalent effect with the medicinal material of the invention and is used for treating the vulvitis and the vaginitis in the market at present.
Disclosure of Invention
The invention provides a composition for treating gynecological inflammation and a preparation method thereof. The composition for conditioning gynecological inflammation is prepared from birch extract, oak extract, traditional Chinese medicine extract and other auxiliary materials, the content of active ingredients of the composition containing the birch extract for conditioning gynecological inflammation is high, better curative effect can be achieved through mutual combination effect of all the traditional Chinese medicines, after a patient uses the composition, drug efficacy is concentrated, toxic and side effects do not exist, the composition has a good treatment effect on gynecological inflammation, the traditional Chinese medicines are used from inside to inside, the internal environment of a female body is in a steady state and is mild, and the composition is convenient to use.
The invention is realized by the following technical scheme:
the disclosed composition for treating gynecological inflammation comprises the following components in parts by weight: 70-100 parts of an extract of the component A, 100-500 parts of an extract of the component B, 10-30 parts of glycerin, 80-100 parts of vaseline, 100-150 parts of beeswax and 2-8 parts of borneol; the component A comprises the following raw materials in parts by weight: 20-30 parts of birch and 50-70 parts of oak; the component B comprises the following raw materials in parts by weight: 10-18 parts of radix sophorae flavescentis, 20-30 parts of frankincense, 10-20 parts of caulis spatholobi and 5-10 parts of semen cuscutae.
The preparation method of the composition for treating gynecological inflammation comprises the following steps:
s1, treatment of the birch extract: heating the plant fragments of the birch to be carbonized, condensing and recovering discharged gas, standing for 3-4 months, distilling the middle layer liquid, taking distillate of fractions at 100-120 ℃, filtering by using filter paper, and taking a filtrate I;
s2, treating the oak extract: heating plant fragments of the oak tree to be carbonized, condensing and recovering discharged gas, standing for 2-3 months, distilling the middle layer liquid, taking distillate of distillate at 105-110 ℃, filtering by using filter paper, and taking filtrate II;
s3, placing the component B with the water content of 30-40% in a fermentation tank, adding a biological complex enzyme, uniformly stirring, treating by using microwave radiation under an aerobic condition, performing fermentation treatment with the microwave power of 500-800W and the microwave time of 100-200 min, and filtering after the fermentation is finished to obtain a filtrate and a filtrate III;
s4, adding 3-5 times of water into the first filtrate, the second filtrate and the third filtrate, boiling with strong fire, decocting with slow fire for 2-5 hours, decocting and extracting for 2-5 times, and taking supernate for later use;
s5, dissolving glycerol in purified water to obtain a uniform glycerol solution; adding the supernatant obtained in the step S4 into a glycerol solution, and uniformly stirring to obtain gel;
s6, heating the beeswax to melt to obtain a melt, adding vaseline and gel, uniformly stirring, cooling to room temperature, sterilizing, and packaging.
Further, in the step S1, the temperature is raised to 500-580 ℃ under the protection of nitrogen atmosphere, and the carbonization is carried out for 3-5 hours under the heat preservation.
Further, in the step S2, the temperature is raised to 600-700 ℃ under the protection of nitrogen atmosphere, and the carbonization is carried out for 2-4 h under the heat preservation.
Further, the fermentation time in step S3 is 3-10 days.
Further, the mass ratio of the glycerol to the purified water in the step S5 is 1: 1-2.
Further, the melting temperature of the step S6 is 60-80 ℃.
The oak extract contains various components of amino acids, organic acids, alcohols, phenols, ketones, amines, methylamines, dimethylamines, pyridines and other nitrogen-containing alkalis and the like. Can provide skin immunity, regulate water, acid and alkali, balance oil, improve anti-allergy ability of sensitive skin, and prevent wrinkle. Activating the activity of superoxide dismutase peroxide of skin cells, removing excessive free radicals of skin cells, and effectively delaying skin aging. Enhance the functions of detoxification and detoxification of lymphatic system and effectively block the invasion of external harmful substances to skin. Improving skin antiallergic ability, and decomposing and excreting harmful substances and aged cells in vivo. Preventing excessive divalent metal ions from generating crosslinking action with collagen in the skin, maintaining enough collagen fibers and elastic fibers, and making the skin smooth, fine and elastic.
The birch extract contains active substances such as betulin, polysaccharide, saponin, protein, mineral substances and the like, has unique anti-inflammatory capability, can isolate external bacterial infection, sterilize and promote cell growth, and has good effect of resisting gynecological inflammation.
Compared with the prior art, the composition for treating gynecological inflammation and the preparation method thereof provided by the invention have the following advantages:
the composition for treating gynecological inflammation disclosed by the invention initiatively takes the birch extract and the oak extract as main raw materials, the effective essences of the birch and the oak are furthest reserved by special extraction of the birch extract and the oak extract, and the effects of the composition are enhanced by matching with the wool fat, the glycerin, the vaseline, the beewax and the borneol.
The composition for treating gynecological inflammation disclosed by the invention is extracted according to the characteristics of each raw material, and can effectively separate the effective components of each component, so that after the effective components of each component are combined, a better drug effect is exerted, and the treatment effect is optimal.
The preparation method of the composition for treating gynecological inflammation disclosed by the invention is simple in technological process, convenient to operate, low in energy consumption and less in pollution, and does not generate any harmful substance to the environment in the reaction process.
Detailed Description
The invention is further illustrated by the following specific examples. The starting materials and the methods employed in the examples of the present invention are those conventionally available in the art and those conventionally used, and the equipment used is equipment conventional in the art, unless otherwise specified.
The composition for treating gynecological inflammation provided by the invention comprises the following components in parts by weight: 70-100 parts of an extract of the component A, 100-500 parts of an extract of the component B, 10-30 parts of glycerin, 80-100 parts of vaseline, 100-150 parts of beeswax and 2-8 parts of borneol; the component A comprises the following raw materials in parts by weight: 20-30 parts of birch and 50-70 parts of oak; the component B comprises the following raw materials in parts by weight: 10-18 parts of radix sophorae flavescentis, 20-30 parts of frankincense, 10-20 parts of caulis spatholobi and 5-10 parts of semen cuscutae.
Example 1
The composition for treating gynecological inflammation provided by the embodiment comprises the following components in parts by weight: 100 parts of extract of the component A, 100 parts of extract of the component B, 100 parts of lanolin, 30 parts of glycerol, 100 parts of vaseline, 100 parts of beeswax and 8 parts of borneol; the component A comprises the following raw materials in parts by weight: 30 parts of birch and 70 parts of oak; the component B comprises the following raw materials in parts by weight: 10 parts of radix sophorae flavescentis, 30 parts of frankincense, 15 parts of caulis spatholobi and 8 parts of semen cuscutae. The specific operation steps are as follows:
s1, treatment of the birch extract: heating plant pieces of birch to 500 deg.C under protection of nitrogen atmosphere, keeping the temperature, carbonizing for 5 hr, condensing and recovering discharged gas, standing for 3 months, distilling middle layer liquid, collecting distillate of 100 deg.C fraction, filtering with filter paper, and collecting filtrate I;
s2, treating the oak extract: heating the plant fragments of the oak tree to 600 ℃ under the protection of nitrogen atmosphere, preserving heat and carbonizing for 4 hours, heating to be carbonized, condensing and recovering discharged gas, standing for 2 months, distilling the middle layer liquid, taking distillate of distillate at 105-110 ℃, filtering by using filter paper, and taking filtrate II;
s3, placing the component B with the water content of 30-40% in a fermentation tank, adding a biological compound enzyme, uniformly stirring, treating by using microwave radiation under an aerobic condition, wherein the microwave power is 500W, the microwave time is 200min, performing fermentation treatment, fermenting for 5-7 days at 50 ℃, and filtering after the fermentation is finished to obtain a filtrate III, wherein the biological compound enzyme is prepared from the following raw materials, by weight, 10% of medium temperature α -amylase, 24% of xylanase, 20% of laccase, and the balance of pectinase.
S4, adding 3-5 times of water into the first filtrate, the second filtrate and the third filtrate, boiling with strong fire, decocting with slow fire for 2-3 hours, decocting and extracting for 2 times, and taking supernate for later use;
s5, dissolving glycerol into purified water, wherein the mass ratio of the glycerol to the purified water is 1:1, so as to obtain a uniform glycerol solution; adding the supernatant obtained in the step S4 into a glycerol solution, and uniformly stirring to obtain gel;
s6, heating the beewax at 60-80 ℃ until the beewax is melted to obtain a melt, adding vaseline and gel, uniformly stirring, cooling to room temperature, sterilizing, and packaging.
Example 2
The composition for treating gynecological inflammation provided by the embodiment comprises the following components in parts by weight: 70 parts of extract of the component A, 400 parts of lanolin, 20 parts of glycerol, 80 parts of vaseline, 150 parts of beeswax and 4 parts of borneol; the component A comprises the following raw materials in parts by weight: 20 parts of birch and 50 parts of oak; the component B comprises the following raw materials in parts by weight: 18 parts of sophora flavescens, 20 parts of frankincense, 20 parts of caulis spatholobi and 5 parts of semen cuscutae. The specific operation steps are as follows:
s1, treatment of the birch extract: heating the plant pieces of birch to 580 deg.C under nitrogen atmosphere, keeping the temperature, carbonizing for 5 hr, condensing and recovering the discharged gas, standing for 2 months, distilling the middle layer liquid, collecting 120 deg.C distillate, filtering with filter paper, and collecting filtrate I;
s2, treating the oak extract: heating the plant fragments of the oak tree to 700 ℃ under the protection of nitrogen atmosphere, preserving heat and carbonizing for 2 hours, heating to be carbonized, condensing and recovering discharged gas, standing for 3 months, distilling the middle layer liquid, taking distillate of distillate at 105-110 ℃, filtering by using filter paper, and taking filtrate II;
s3, placing the component B with the water content of 30-40% in a fermentation tank, adding a biological compound enzyme, uniformly stirring, treating by using microwave radiation under an aerobic condition, wherein the microwave power is 800W, the microwave time is 100min, performing fermentation treatment, fermenting for 5-7 days at 50 ℃, and filtering after the fermentation is finished to obtain a filtrate III, wherein the biological compound enzyme is prepared from the following raw materials, by weight, 15% of medium temperature α -amylase, 30% of xylanase, 10% of laccase, and the balance of pectinase.
S4, adding 3-5 times of water into the first filtrate, the second filtrate and the third filtrate, boiling with strong fire, decocting with slow fire for 4-5 hours, decocting and extracting for 3 times, and taking supernate for later use;
s5, dissolving glycerol into purified water, wherein the mass ratio of the glycerol to the purified water is 1:2, so as to obtain a uniform glycerol solution; adding the supernatant obtained in the step S4 into a glycerol solution, and uniformly stirring to obtain gel;
s6, heating the beewax at 60-80 ℃ until the beewax is melted to obtain a melt, adding vaseline and gel, uniformly stirring, cooling to room temperature, sterilizing, and packaging.
Example 3
The composition for treating gynecological inflammation provided by the embodiment comprises the following components in parts by weight: 80 parts of the extract of the component A, 300 parts of lanolin, 30 parts of glycerol, 100 parts of vaseline, 120 parts of beeswax and 2 parts of borneol; the component A comprises the following raw materials in parts by weight: 25 parts of birch and 55 parts of oak; the component B comprises the following raw materials in parts by weight: 12 parts of radix sophorae flavescentis, 25 parts of frankincense, 15 parts of caulis spatholobi and 5 parts of semen cuscutae. The specific procedure was the same as in example 1.
Comparative example 1
The composition for treating gynecological inflammation comprises the following components in parts by weight: 60 parts of extract of the component A, 100 parts of lanolin, 30 parts of glycerol, 100 parts of vaseline, 100 parts of beeswax and 8 parts of borneol; the component A comprises the following raw materials in parts by weight: 15 parts of birch and 45 parts of oak; the component B comprises the following raw materials in parts by weight: 10 parts of radix sophorae flavescentis, 30 parts of frankincense, 15 parts of caulis spatholobi and 8 parts of semen cuscutae. The specific procedure was the same as in example 1.
Comparative example 2
The composition for treating gynecological inflammation comprises the following components in parts by weight: 120 parts of the extract of the component A, 100 parts of lanolin, 30 parts of glycerol, 100 parts of vaseline, 100 parts of beeswax and 8 parts of borneol; the component A comprises the following raw materials in parts by weight: 30 parts of birch and 90 parts of oak; the component B comprises the following raw materials in parts by weight: 10 parts of radix sophorae flavescentis, 30 parts of frankincense, 15 parts of caulis spatholobi and 8 parts of semen cuscutae. The specific procedure was the same as in example 1.
Comparative example 3
The composition for treating gynecological inflammation comprises the following components in parts by weight: 100 parts of extract of the component A, 100 parts of extract of the component B, 100 parts of lanolin, 30 parts of glycerol, 100 parts of vaseline, 100 parts of beeswax and 8 parts of borneol; the component A comprises the following raw materials in parts by weight: 100 parts of birch; the component B comprises the following raw materials in parts by weight: 10 parts of radix sophorae flavescentis, 30 parts of frankincense, 15 parts of caulis spatholobi and 8 parts of semen cuscutae. The specific procedure was the same as in example 1.
Comparative example 4
The composition for treating gynecological inflammation comprises the following components in parts by weight: 100 parts of extract of the component A, 100 parts of extract of the component B, 100 parts of lanolin, 30 parts of glycerol, 100 parts of vaseline, 100 parts of beeswax and 8 parts of borneol; the component A comprises the following raw materials in parts by weight: 100 parts of oak; the component B comprises the following raw materials in parts by weight: 10 parts of radix sophorae flavescentis, 30 parts of frankincense, 15 parts of caulis spatholobi and 8 parts of semen cuscutae. The specific procedure was the same as in example 1.
Comparative example 5
The composition for treating gynecological inflammation comprises the following components in parts by weight: 100 parts of extract of the component A, 100 parts of lanolin, 30 parts of glycerol, 100 parts of vaseline, 100 parts of beeswax and 8 parts of borneol; the component A comprises the following raw materials in parts by weight: 30 parts of birch and 70 parts of oak; component B is absent. The specific procedure was carried out except that the procedure for the preparation of component B was the same as in example 1.
Comparative example 6
The comparative example provides a composition for the treatment of gynecological inflammation with the same raw materials and component contents as example 1. In the specific operation steps, the steps S1 and S2 are used for processing birch and oak by using the method of the step S3 to obtain a first filtrate and a second filtrate, and the rest steps are the same as the step 1.
Case selection: the patients with chronic vaginitis with the disease course of 1-4 years respectively comprise 60 cases of the test group (the composition for treating gynecological inflammation in any of the examples 1-3 is prepared into suppository) and the control group. The age is 55 years maximum and 20 years minimum. The comparison of general data such as age, disease course, complications, and basic body state of two groups of patients has no statistical significance (P >0.05), and is comparable.
Clinical symptoms: fever, chills and tremor, dull pain in the lower abdomen, soreness and pain in the lumbosacral region and profuse leucorrhea.
The medication method comprises the following steps: (1) control group: the suppository is commercially available in the form of suppository, and is administered by placing into vagina 1 granule each time, 1 time daily, and 7 days as one treatment course. (2) The medicine is put into vagina, 1 dose is taken every time, 1 time is taken every day, 7 days is a treatment course, and the administration period can be determined according to the condition of a patient.
The therapeutic effect judgment standard is as follows: (1) and (3) curing: patient positive symptoms and signs all disappeared; (2) the effect is shown: most symptoms and signs of the patient disappear, the gynecological examination result shows that the improvement is obvious, and B ultrasonic indicates that the inflammatory mass is obviously reduced; (3) the method has the following advantages: the symptoms and physical signs of the patient can be improved, the B ultrasonic wave prompts that the inflammatory mass is reduced, and the reduction range of the volume of the inflammatory mass is less than two thirds according to the time; (4) and (4) invalidation: the symptoms of the patients are not improved, and the examination results show that the disease condition is not changed or progressed.
Treatment record: the onset time, the medication time, the average treatment cost, the treatment effective rate, the occurrence of adverse reactions and the recurrence rate within 6 months of the two groups of patients are observed and recorded.
The therapeutic effects of the drugs of the invention and the drugs of the control group against chronic vaginitis are shown in table 1.
TABLE 1
| Group of | Total number of people | The number of people cured | Number of effective people | Number of effective persons | Number of invalid persons |
| Test group | 60 | 51 | 8 | 1 | 0 |
| Control group | 60 | 32 | 12 | 10 | 6 |
As can be seen from the results in table 1, the effect of the composition for treating gynecological inflammation of the present embodiment is significantly higher than that of the comparative example group, and the effective rate is 100%.
While the invention has been described in terms of specific process equipment and process steps, it will be understood by those skilled in the art that the invention is not limited to the embodiments described above, which are included to illustrate the principles of the invention, and that various changes and modifications, which will be apparent to those skilled in the art, may be made without departing from the spirit and scope of the invention and, therefore, the invention is to be limited only by the appended claims.
Claims (8)
1. The composition for treating gynecological inflammation is characterized by comprising the following components in parts by weight: 70-100 parts of an extract of the component A, 100-500 parts of an extract of the component B, 10-30 parts of glycerin, 80-100 parts of vaseline, 100-150 parts of beeswax and 2-8 parts of borneol; the component A comprises the following raw materials in parts by weight: 20-30 parts of birch and 50-70 parts of oak; the component B comprises the following raw materials in parts by weight: 10-18 parts of radix sophorae flavescentis, 20-30 parts of frankincense, 10-20 parts of caulis spatholobi and 5-10 parts of semen cuscutae.
2. A method for preparing a composition for the treatment of gynecological inflammation according to claim 1, characterized in that it comprises the following steps:
s1, treatment of the birch extract: heating the plant fragments of the birch to be carbonized, condensing and recovering discharged gas, standing for 3-4 months, distilling the middle layer liquid, taking distillate of fractions at 100-120 ℃, filtering by using filter paper, and taking a filtrate I;
s2, treating the oak extract: heating plant fragments of the oak tree to be carbonized, condensing and recovering discharged gas, standing for 2-3 months, distilling the middle layer liquid, taking distillate of distillate at 105-110 ℃, filtering by using filter paper, and taking filtrate II;
s3, placing the component B with the water content of 30-40% in a fermentation tank, adding a biological complex enzyme, uniformly stirring, treating by using microwave radiation under an aerobic condition, performing fermentation treatment with the microwave power of 500-800W and the microwave time of 100-200 min, and filtering after the fermentation is finished to obtain a filtrate and a filtrate III;
s4, adding 3-5 times of water into the first filtrate, the second filtrate and the third filtrate, boiling with strong fire, decocting with slow fire for 2-5 hours, decocting and extracting for 2-5 times, and taking supernate for later use;
s5, dissolving glycerol in purified water to obtain a uniform glycerol solution; adding the supernatant obtained in the step S4 into a glycerol solution, and uniformly stirring to obtain gel;
s6, heating the beeswax to melt to obtain a melt, adding vaseline and gel, uniformly stirring, cooling to room temperature, sterilizing, and packaging.
3. The method for preparing a composition for treating gynecological inflammation according to claim 2, wherein the carbonization in the step S1 is performed at a temperature of 500-580 ℃ under the protection of nitrogen atmosphere, and the carbonization is performed for 3-5 hours under the condition of heat preservation.
4. The method for preparing a composition for treating gynecological inflammation according to claim 2, wherein the carbonization in the step S2 is performed at 600-700 ℃ under the protection of nitrogen atmosphere, and the temperature is kept for 2-4 h.
5. The preparation method of the composition for treating gynecological inflammation according to claim 2, wherein the biological complex enzyme is prepared from the following raw materials, by weight, 10-15% of medium temperature α -amylase, 24-30% of xylanase, 10-20% of laccase, and the balance pectinase.
6. The method for preparing a composition for treating gynecological inflammation according to claim 2, wherein the fermentation time of step S3 is 3-10 days.
7. The method for preparing a composition for treating gynecological inflammation according to claim 2, wherein the mass ratio of glycerin to purified water in step S5 is 1: 1-2.
8. The method for preparing a composition for treating gynecological inflammation according to claim 2, wherein the melting temperature of step S6 is 60-80 ℃.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110038121A (en) * | 2019-04-23 | 2019-07-23 | 深圳前海千水生物科技有限公司 | A kind of plant complex enzyme gynaecology detoxicating gel |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110038121A (en) * | 2019-04-23 | 2019-07-23 | 深圳前海千水生物科技有限公司 | A kind of plant complex enzyme gynaecology detoxicating gel |
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