CN103599281B - Traditional Chinese medicinal composition for treating obsessive-compulsive disorder and application thereof - Google Patents
Traditional Chinese medicinal composition for treating obsessive-compulsive disorder and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating obsessive-compulsive disorder and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicinal composition is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 50-80 parts of willow twig, 15-30 parts of fructus arctii, 15-30 parts of acorus tatarinowii and 15-30 parts of mulberry leaf. The traditional Chinese medicinal composition has a remarkable curative effect in treating obsessive-compulsive disorder, does not have remarkable side effect or adverse influence on a cardiovascular system, and has popularization value.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to one and treat compulsive Chinese medicine composition and application thereof.
Background technology
Obsession (Obsessive compulsive disorder, OCD) forces with uncontrollable the neurosis that thinking and compulsive act are feature.Its symptom obviously affects the activity of daily living of patient, and course of disease delay, often cause serious functional lesion.It is generally acknowledged that just having a people in every 50 people must cross obsession, just there are more than 100 ten thousand patients with OCDs in such as Britain, teenager prevalence is very high, it is generally acknowledged that adolescence suffers from obsession all can rehabilitation before growing up, external report sickness rate is 2%, also psychologist is had to think sickness rate at least 10%, without difference on Sex distribution.Along with the development of society, modern, as geek's residence female, if people is lonely for a long time be also easy to the seed that occurs forcing psychology in specific minor matter in the face of computer.Prevention obsession needs sufficient sleep, suitable motion, frequent joined body doings.
Compulsive morbidity is unbalance relevant with various neurotransmitters in brain, and main manifestations is the disorder of 5-hydroxy tryptamine systemic-function.The anti-medicine that forces of current use is all antidepressants, and its feature is just to regulate the function of the neurotransmitter such as 5-hydroxy tryptamine in brain, thus reaches the effect improving obsessive symptoms.Use and many be mainly selective serotonin reuptake inhibitor (SSRIs), comprise fluvoxamine, paroxetine, Sertraline, fluoxetine, citalopram etc., and tricyclic antidepressant clomipramine, also use propranolol and benzodiazepine to assist reduction of patient anxiety if desired clinically, improve insomnia.As synergist, curative effect is improved for the normal use in conjunction risperidone of refractory obsessive-compulsive, Quetiapine, olanzapine, Aripiprazole etc.
Obsession treatment needs Long-term taking medicine, and Western medicine has larger side effect, as xerostomia, feel sick, constipation, tachycardia, dizziness, tremble, dysuria etc., and easily cause ECG change, be unfavorable for the interdependence improving patient medication.Therefore, develop a kind of good effect, instant effect, the medicine that toxic and side effects is little seems particularly important.
Summary of the invention
An object of the present invention is, by prescription again after studying Chinese medicine pharmacology, to provide a kind of good effect, instant effect, the compulsive Chinese medicine composition of the treatment that toxic and side effects is little.
The object of the present invention is achieved like this:
One treats compulsive Chinese medicine composition, is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Ramulus Salicis Babylonicae 50-80 part, Fructus Arctii 15-30 part, Rhizoma Acori Graminei 15-30 part, Folium Mori 15-30 part.
Preferably, the compulsive Chinese medicine composition for the treatment of as mentioned above, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Ramulus Salicis Babylonicae 60-70 part, Fructus Arctii 20-25 part, Rhizoma Acori Graminei 20-25 part, Folium Mori 20-25 part.
In the present invention's most preferred embodiment, the compulsive Chinese medicine composition for the treatment of as mentioned above, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Ramulus Salicis Babylonicae 66 parts, Fructus Arctii 20 parts, Rhizoma Acori Graminei 20 parts, 20 parts, Folium Mori.
Further preferably, the compulsive Chinese medicine composition for the treatment of as above, it is oral formulations, comprises tablet, capsule, granule and oral liquid.
Found by lot of experiments research, the pharmaceutical composition be made up of above-mentioned traditional Chinese medicinal material raw materials has significant curative effect in treatment patients with OCD.Therefore, second object of the present invention is to provide a kind of new medical use, the application of namely above-mentioned Chinese medicine composition in the compulsive medicine of preparation treatment.
According to Chinese medicine Historical Data Data About, above-mentioned traditional Chinese medicinal material raw materials has following pharmacologically active and function cures mainly:
Ramulus Salicis Babylonicae: dispel the wind, diuresis, pain relieving, detumescence.Dispelling the wind and dampness pathogens arthralgia pain, gonorrhea, nebulousurine, urinary obstruction, infectious hepatitis, swelling due to wind, furuncle, erysipelas, dental caries, swelling of the gum.Select the dry branch of Salicaceous Plants Salix babylonica L..
Rhizoma Acori Graminei: removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.Derive from the rhizome of acorus gramineus araceae plant.
Fructus Arctii: the effect with dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, removing toxic substances and promoting subsidence of swelling, cure mainly cough due to pathogenic wind-heat, laryngopharynx swelling and pain, macule not thoroughly, rubella pruritus, sore swollen toxin.Be selected from the dry mature fruit of feverfew Fructus Arctii Arctium lappa L..
Folium Mori: there is dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing liver-YANG, liver heat removing and eyesight improving, effect of cooling blood for hemostasis.Select the dried leaves of Moraceae Moraceae plant Mulberry Morus alba L..
Above-mentioned each Chinese crude drug is prepared into the preparation method of compound preparation of the present invention, comprises the steps:
(1) take above-mentioned each traditional Chinese medicinal material raw materials, clean roguing, dry, be ground into granule;
(2) graininess medical material is added water cover powder 2cm again, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material volume the water of 8-10 times amount, decoct 2h, get decocting liquid, filter, second time adds up the water of the 6-8 times amount of medical material volume, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.10;
(3) concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of appropriate 0.3%, filter, filtrate reconcentration contains 2.5-3.0g crude drug amount to every milliliter, then adds the potassium sorbate of 0.2%, stirs, set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is filtered, obtains oral liquid.
Test through embodiment 4 and prove, compared with prior art, the traditional Chinese medicine composition for treating that the present invention relates to is compulsive evident in efficacy, and non-evident effect, cardiovascular system is had no adverse effects, is worth at clinical expansion.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
the preparation of embodiment 1 Chinese medicine oral liquid
Crude drug prescription: Ramulus Salicis Babylonicae 6.6 kilograms, Fructus Arctii 2 kilograms, Rhizoma Acori Graminei 2 kilograms, 2 kilograms, Folium Mori.
Preparation method:
(1) take above-mentioned Chinese crude drug, clean roguing, dry, pulverize;
(2) graininess medical material is added water cover powder 2cm again, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material volume the water of 8 times amount, decoct 2h, get decocting liquid, filter, second time adds up the water of 8 times amount of medical material volume, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.10;
(3) concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of appropriate 0.3%, filter, filtrate reconcentration containing 2.5g crude drug amount, then adds the potassium sorbate of appropriate 0.2% to every milliliter, stirs, put 5 DEG C of deepfreeze 24h, cold preservation liquid is filtered, obtains oral liquid.
the preparation of embodiment 2 Chinese medicine oral liquid
Crude drug prescription: Ramulus Salicis Babylonicae 6 kilograms, Fructus Arctii 1.8 kilograms, Rhizoma Acori Graminei 3.0 kilograms, 2.5 kilograms, Folium Mori.
Preparation method:
(1) take above-mentioned Chinese crude drug, clean roguing, dry, pulverize;
(2) graininess medical material is added water cover powder 2cm again, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material volume the water of 10 times amount, decoct 2h, get decocting liquid, filter, second time adds up the water of 8 times amount of medical material volume, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.10;
(3) concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of appropriate 0.3%, filter, filtrate reconcentration containing 2.5g crude drug amount, then adds the potassium sorbate of appropriate 0.2% to every milliliter, stirs, set to 0 a DEG C deepfreeze 24h, cold preservation liquid is filtered, obtains oral liquid.
the preparation of embodiment 3 Chinese medicine oral liquid
Crude drug prescription: Ramulus Salicis Babylonicae 7.2 kilograms, Fructus Arctii 2.6 kilograms, Rhizoma Acori Graminei 2.2 kilograms, 1.8 kilograms, Folium Mori.
Preparation method:
(1) take above-mentioned Chinese crude drug, clean roguing, dry, pulverize;
(2) graininess medical material is added water cover powder 2cm again, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material volume the water of 8 times amount, decoct 2h, get decocting liquid, filter, second time adds up the water of 6 times amount of medical material volume, decoct 1h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.10;
(3) concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of appropriate 0.3%, filter, filtrate reconcentration containing 3.0g crude drug amount, then adds the potassium sorbate of appropriate 0.2% to every milliliter, stirs, set to 0 a DEG C deepfreeze 24h, cold preservation liquid is filtered, obtains oral liquid.
embodiment 4 Chinese medicine composition of the present invention is to the effectiveness study of patients with OCD
32 routine patients with OCDs, meet the compulsive diagnostic criteria of CCMD-2-R: obsession scale (Y-BOCS) is marked > 16 points, and the age is in 18-56 year; Get rid of brain organic disease and severe physical disease.All patients are divided into following two groups at random: Chinese drug-treated group men and women each 8 example, the mean age (35.7 ± 13.1) year; Western medicine group man 9 example, female 7 example, the mean age (36.4 ± 14.2) year.The sex of two groups, age and coincident with severity degree of condition are through statistical procedures there was no significant difference.Chinese drug-treated group patient takes Chinese medicine oral liquid prepared by the embodiment of the present invention 1, and early, evening respectively takes 40mL.The oral Clomipramine treatment of Western medicine group, initial dose 25mg/d, increases to 100-250mg/d gradually according to the state of an illness.Two groups of equal medications of patient treat 2 months.
Two groups of patients all evaluate once with Y-BOCS for before treatment and after treatment every 2 weeks, with its deduction rate evaluation clinical efficacy (>=50% is recovery from illness, and >=35% is effective, and >=20% is that effectively < 20% is invalid).In time entering to organize and treatment at the end of have a blood test respectively, routine urinalysis, liver function, electrocardiogram etc.
By above efficacy assessment standard, medication terminates rear Chinese drug-treated group recovery from illness 6 example, effective 4 examples, effective 4 examples, invalid 2 examples; Western medicine group recovery from illness 4 example, effective 3 examples, effective 5 examples, invalid 4 examples.Two groups of obvious effective rates are respectively 62.5% and 43.8%, and effective percentage is respectively 87.5% and 75%, through statistical procedures there was no significant difference.
Front and back Y-BOCS scoring situation treated by table 1
Compare with before treatment,
★ p< 0.05,
★ ★ p< 0.01.
Shown by the result of table 1, after two groups of Y-BOCS scoring treatments, all have significant difference compared with before treatment.Difference of comparing between two groups after treatment is not obvious.In addition, Chinese drug-treated group patient is without obvious side reaction after treatment, and electrocardiogram is also without change; The side reaction of Western medicine group is more, as xerostomia, feel sick, constipation, tachycardia, dizziness, tremble, dysuria, ECG change etc.In side effect, two groups are compared and have significant difference.
Claims (3)
1. treat a compulsive Chinese medicine composition, it is characterized in that: described Chinese medicine composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Ramulus Salicis Babylonicae 66 parts, Fructus Arctii 20 parts, Rhizoma Acori Graminei 20 parts, 20 parts, Folium Mori.
2. the compulsive Chinese medicine composition for the treatment of according to claim 1, is characterized in that: described Chinese medicine composition is tablet, capsule, granule and oral liquid.
3. the application of the compulsive Chinese medicine composition for the treatment of according to claim 1 in the compulsive medicine of preparation treatment.
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Inventor after: Ma Zhiwen Inventor after: Liu Haozhi Inventor before: Liu Xuejian |
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Effective date of registration: 20170505 Address after: 226200 Jiangsu province Nantong Jiulong Zhen Yuan Dong Cun highstar Chemical Co. Ltd. in Patentee after: Qidong Su Xing carbon dioxide Co., Ltd. Address before: Jimo City, Shandong province 266200 Jhengtong street Qingdao City No. 20 Patentee before: Li Weili |