CN103599281A - Traditional Chinese medicinal composition for treating obsessive-compulsive disorder and application thereof - Google Patents
Traditional Chinese medicinal composition for treating obsessive-compulsive disorder and application thereof Download PDFInfo
- Publication number
- CN103599281A CN103599281A CN201310569977.0A CN201310569977A CN103599281A CN 103599281 A CN103599281 A CN 103599281A CN 201310569977 A CN201310569977 A CN 201310569977A CN 103599281 A CN103599281 A CN 103599281A
- Authority
- CN
- China
- Prior art keywords
- traditional chinese
- compulsive
- chinese medicinal
- parts
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicinal composition for treating obsessive-compulsive disorder and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicinal composition is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 50-80 parts of willow twig, 15-30 parts of fructus arctii, 15-30 parts of acorus tatarinowii and 15-30 parts of mulberry leaf. The traditional Chinese medicinal composition has a remarkable curative effect in treating obsessive-compulsive disorder, does not have remarkable side effect or adverse influence on a cardiovascular system, and has popularization value.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of treat compulsive Chinese medicine composition and application thereof.
Background technology
Obsession (Obsessive compulsive disorder, OCD) is to take the uncontrollable neurosis that thinking and compulsive act are feature of forcing.Its symptom obviously affects patient's activity of daily living, and course of disease delay, often causes serious functional lesion.It is generally acknowledged that in every 50 people, just having a people must cross obsession, such as just there are more than 100 ten thousand patients with OCDs in Britain, teenager prevalence is very high, it is generally acknowledged that adolescence is suffered from obsession all can rehabilitation before growing up, external report sickness rate is 2%, also have psychologist to think sickness rate at least 10%, on Sex distribution without difference.Along with social development, modern, as geek's residence female, if a long-time lonely computer of facing of people is also easy to occur forcing in specific minor matter psychological seed.Prevention obsession need to have sufficient sleep, suitable motion, often joined body doings.
Compulsive morbidity is unbalance relevant with various neurotransmitters in brain, and main manifestations is the disorder of 5-hydroxy tryptamine systemic-function.The anti-medicine that forces using is at present all antidepressants, and its feature is just to regulate the function of the neurotransmitteies such as the interior 5-hydroxy tryptamine of brain, thereby reach, improves the effect that forces symptom.Use many selective serotonin reuptake inhibitors (SSRIs) that is mainly, comprise fluvoxamine, paroxetine, Sertraline, fluoxetine, citalopram etc., and tricyclic antidepressant clomipramine, also use clinically if desired propranolol and benzodiazepine to assist reduction of patient anxiety, improve insomnia.For the normal use in conjunction risperidone of refractory obsessive-compulsive, Quetiapine, olanzapine, Aripiprazole etc., as synergist, improve curative effect.
Obsession treatment needs Long-term taking medicine, Western medicine to have larger side effect, as xerostomia, feel sick, constipation, tachycardia, dizziness, tremble, dysuria etc., and easily cause ECG change, be unfavorable for improving the interdependence of patient's medication.Therefore, develop a kind of good effect, instant effect, it is particularly important that the medicine that toxic and side effects is little seems.
Summary of the invention
One of object of the present invention is, by prescription again after Chinese medicine pharmacology is studied, to provide a kind of good effect, instant effect, the compulsive Chinese medicine composition for the treatment of that toxic and side effects is little.
The object of the present invention is achieved like this:
Treat a compulsive Chinese medicine composition, by the traditional Chinese medicinal material raw materials of following weight portion, be prepared from: Ramulus Salicis Babylonicae 50-80 part, Fructus Arctii 15-30 part, Rhizoma Acori Graminei 15-30 part, Folium Mori 15-30 part.
Preferably, treat as mentioned above compulsive Chinese medicine composition, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Ramulus Salicis Babylonicae 60-70 part, Fructus Arctii 20-25 part, Rhizoma Acori Graminei 20-25 part, Folium Mori 20-25 part.
In most preferred embodiment of the present invention, treat as mentioned above compulsive Chinese medicine composition, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 66 parts of Ramulus Salicis Babylonicaes, 20 parts of Fructus Arctiis, 20 parts of Rhizoma Acori Graminei, 20 parts, Folium Mori.
Further preferably, the compulsive Chinese medicine composition for the treatment of as above, it is oral formulations, comprises tablet, capsule, granule and oral liquid.
By lot of experiments, study discovery, the pharmaceutical composition being comprised of above-mentioned traditional Chinese medicinal material raw materials has significant curative effect aspect treatment patients with OCD.Therefore, second object of the present invention is to provide a kind of new medical use, i.e. the application of above-mentioned Chinese medicine composition in the compulsive medicine of preparation treatment.
According to Chinese medicine Historical Data Data About, above-mentioned traditional Chinese medicinal material raw materials has following pharmacologically active and function cures mainly:
Ramulus Salicis Babylonicae: dispel the wind, diuresis, pain relieving, detumescence.Dispelling the wind and dampness pathogens arthralgia pain, gonorrhea, nebulousurine, urinary obstruction, infectious hepatitis, swelling due to wind, furuncle, erysipelas, dental caries, swelling of the gum.Select the dry branch of Salicaceous Plants Salix babylonica L..
Rhizoma Acori Graminei: removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.Derive from the rhizome of acorus gramineus araceae plant.
Fructus Arctii: there is the effect of dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, removing toxic substances and promoting subsidence of swelling, cure mainly cough due to pathogenic wind-heat, laryngopharynx swelling and pain, macule not thoroughly, rubella pruritus, sore swollen toxin.Be selected from the dry mature fruit of feverfew Fructus Arctii Arctium lappa L..
Folium Mori: there is dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing liver-YANG, liver heat removing and eyesight improving, the effect of cooling blood for hemostasis.Select the dried leaves of Moraceae Moraceae plant Mulberry Morus alba L..
The preparation method that above-mentioned each Chinese crude drug is prepared into compound preparation of the present invention, comprises the steps:
(1) take above-mentioned each traditional Chinese medicinal material raw materials, clean roguing, dry, be ground into granule;
(2) again graininess medical material is added to water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up for the first time the water that the 8-10 of medical material volume doubly measures, decoct 2h, get decocting liquid, filter, add up for the second time the water that the 6-8 of medical material volume doubly measures, decoct 1h, get twice decocting liquid and merge, filter the concentrated solution that while being concentrated into 90 ℃, relative density is 1.10;
(3) concentrated solution is set to 0 to-5 ℃ of deepfreeze 24h, cold preservation liquid is added to appropriate 0.3% filter aid kieselguhr, filter, filtrate reconcentration containing 2.5-3.0g crude drug amount, then adds 0.2% potassium sorbate to every milliliter, stirs, set to 0-5 ℃ of deepfreeze 24h, cold preservation liquid is filtered, obtain oral liquid.
Through embodiment 4 evidences, compared with prior art, the traditional Chinese medicine composition for treating the present invention relates to is compulsive evident in efficacy, and non-evident effect, and cardiovascular system is had no adverse effects, and is worth at clinical expansion.
The specific embodiment
Be below specific embodiments of the invention, technical scheme of the present invention is done to further description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
the preparation of embodiment 1 Chinese medicine oral liquid
Crude drug prescription: 6.6 kilograms of Ramulus Salicis Babylonicaes, 2 kilograms of Fructus Arctiis, 2 kilograms of Rhizoma Acori Graminei, 2 kilograms, Folium Mori.
Preparation method:
(1) take above-mentioned Chinese crude drug, clean roguing, dry, pulverize;
(2) again graininess medical material is added to water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up for the first time the water of 8 times of amounts of medical material volume, decoct 2h, get decocting liquid, filter, add up for the second time the water of 8 times of amounts of medical material volume, decoct 1h, get twice decocting liquid and merge, filter the concentrated solution that while being concentrated into 90 ℃, relative density is 1.10;
(3) concentrated solution is set to 0 to-5 ℃ of deepfreeze 24h, cold preservation liquid is added to appropriate 0.3% filter aid kieselguhr, filter, filtrate reconcentration containing 2.5g crude drug amount, then adds appropriate 0.2% potassium sorbate to every milliliter, stirs, put 5 ℃ of deepfreeze 24h, cold preservation liquid is filtered, obtain oral liquid.
the preparation of embodiment 2 Chinese medicine oral liquid
Crude drug prescription: 6 kilograms of Ramulus Salicis Babylonicaes, 1.8 kilograms of Fructus Arctiis, 3.0 kilograms of Rhizoma Acori Graminei, 2.5 kilograms, Folium Mori.
Preparation method:
(1) take above-mentioned Chinese crude drug, clean roguing, dry, pulverize;
(2) again graininess medical material is added to water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up for the first time the water of 10 times of amounts of medical material volume, decoct 2h, get decocting liquid, filter, add up for the second time the water of 8 times of amounts of medical material volume, decoct 1h, get twice decocting liquid and merge, filter the concentrated solution that while being concentrated into 90 ℃, relative density is 1.10;
(3) concentrated solution is set to 0 to-5 ℃ of deepfreeze 24h, cold preservation liquid is added to appropriate 0.3% filter aid kieselguhr, filter, filtrate reconcentration containing 2.5g crude drug amount, then adds appropriate 0.2% potassium sorbate to every milliliter, stirs, set to 0 a ℃ deepfreeze 24h, cold preservation liquid is filtered, obtain oral liquid.
the preparation of embodiment 3 Chinese medicine oral liquid
Crude drug prescription: 7.2 kilograms of Ramulus Salicis Babylonicaes, 2.6 kilograms of Fructus Arctiis, 2.2 kilograms of Rhizoma Acori Graminei, 1.8 kilograms, Folium Mori.
Preparation method:
(1) take above-mentioned Chinese crude drug, clean roguing, dry, pulverize;
(2) again graininess medical material is added to water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up for the first time the water of 8 times of amounts of medical material volume, decoct 2h, get decocting liquid, filter, add up for the second time the water of 6 times of amounts of medical material volume, decoct 1h, get twice decocting liquid and merge, filter the concentrated solution that while being concentrated into 90 ℃, relative density is 1.10;
(3) concentrated solution is set to 0 to-5 ℃ of deepfreeze 24h, cold preservation liquid is added to appropriate 0.3% filter aid kieselguhr, filter, filtrate reconcentration containing 3.0g crude drug amount, then adds appropriate 0.2% potassium sorbate to every milliliter, stirs, set to 0 a ℃ deepfreeze 24h, cold preservation liquid is filtered, obtain oral liquid.
the effectiveness study of embodiment 4 Chinese medicine composition of the present invention to patients with OCD
32 routine patients with OCDs, meet the compulsive diagnostic criteria of CCMD-2-R: obsession scale (Y-BOCS) scoring > 16 minutes, and the age is in 18-56 year; Get rid of brain organic disease and serious physical disease.All patients are divided into following two groups at random: each 8 examples of Chinese drug-treated group men and women, mean age (35.7 ± 13.1) year; Western medicine group man 9 examples, female's 7 examples, mean age (36.4 ± 14.2) year.The sex of two groups, age and coincident with severity degree of condition are learned processing there was no significant difference by statistics.Chinese drug-treated group patient takes the Chinese medicine oral liquid of the embodiment of the present invention 1 preparation, early, respectively take 40mL evening.The oral Clomipramine treatment of Western medicine group, initial dose 25mg/d, increases to 100-250mg/d gradually according to the state of an illness.Two groups of equal medications of patient are treated 2 months.
Two groups of patients all evaluate once with Y-BOCS for before treatment and after treatment every 2 weeks, with it, subtract a minute rate evaluation clinical efficacy (>=50% is recovery from illness, and >=35% is effective, and >=20% is that effectively < 20% is invalid).When entering to organize and when treatment finishes, have a blood test respectively, routine urinalysis, liver function, electrocardiogram etc.
By above efficacy assessment standard, medication finishes rear Chinese drug-treated group 6 examples of fully recovering, effective 4 examples, effective 4 examples, invalid 2 examples; Western medicine group 4 examples of fully recovering, effective 3 examples, effective 5 examples, invalid 4 examples.Two groups of obvious effective rates are respectively 62.5% and 43.8%, and effective percentage is respectively 87.5% and 75%, learn by statistics and process there was no significant difference.
Y-BOCS scoring situation before and after table 1 treatment
It is relatively front with treatment,
★ p< 0.05,
★ ★ p< 0.01.
Result by table 1 shows, after two groups of Y-BOCS scoring treatments with before treating, compares and all has significant difference.The difference of comparing between two groups after treatment is not obvious.In addition, Chinese drug-treated group patient is without obviously side reaction after treatment, and electrocardiogram is also without changing; The side reaction of Western medicine group is more, as xerostomia, feel sick, constipation, tachycardia, dizziness, tremble, dysuria, ECG change etc.In side effect, two groups relatively have significant difference.
Claims (5)
1. the compulsive Chinese medicine composition for the treatment of, is characterized in that being prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Ramulus Salicis Babylonicae 50-80 part, Fructus Arctii 15-30 part, Rhizoma Acori Graminei 15-30 part, Folium Mori 15-30 part.
2. the compulsive Chinese medicine composition for the treatment of according to claim 1, is characterized in that being prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Ramulus Salicis Babylonicae 60-70 part, Fructus Arctii 20-25 part, Rhizoma Acori Graminei 20-25 part, Folium Mori 20-25 part.
3. the compulsive Chinese medicine composition for the treatment of according to claim 1, is characterized in that being prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 66 parts of Ramulus Salicis Babylonicaes, 20 parts of Fructus Arctiis, 20 parts of Rhizoma Acori Graminei, 20 parts, Folium Mori.
4. according to the compulsive Chinese medicine composition for the treatment of described in claim 1,2 or 3, it is characterized in that: described Chinese medicine composition is tablet, capsule, granule and oral liquid.
5. the application in the compulsive medicine of preparation treatment according to the compulsive Chinese medicine composition for the treatment of described in claim 1,2 or 3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310569977.0A CN103599281B (en) | 2013-11-16 | 2013-11-16 | Traditional Chinese medicinal composition for treating obsessive-compulsive disorder and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310569977.0A CN103599281B (en) | 2013-11-16 | 2013-11-16 | Traditional Chinese medicinal composition for treating obsessive-compulsive disorder and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103599281A true CN103599281A (en) | 2014-02-26 |
| CN103599281B CN103599281B (en) | 2015-07-15 |
Family
ID=50117587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310569977.0A Active CN103599281B (en) | 2013-11-16 | 2013-11-16 | Traditional Chinese medicinal composition for treating obsessive-compulsive disorder and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103599281B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188447A (en) * | 2014-08-22 | 2014-12-10 | 何贞芳 | Physiotherapeutic pillow for treating obsessive-compulsive disorder |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101934057A (en) * | 2010-10-12 | 2011-01-05 | 姚春雨 | Traditional Chinese medicine for treating schizophrenia |
| CN103285251A (en) * | 2012-02-29 | 2013-09-11 | 黑龙江康元神经专科医院有限责任公司 | Traditional Chinese medicine preparation for treating obsessive-compulsive disorder |
-
2013
- 2013-11-16 CN CN201310569977.0A patent/CN103599281B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101934057A (en) * | 2010-10-12 | 2011-01-05 | 姚春雨 | Traditional Chinese medicine for treating schizophrenia |
| CN103285251A (en) * | 2012-02-29 | 2013-09-11 | 黑龙江康元神经专科医院有限责任公司 | Traditional Chinese medicine preparation for treating obsessive-compulsive disorder |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188447A (en) * | 2014-08-22 | 2014-12-10 | 何贞芳 | Physiotherapeutic pillow for treating obsessive-compulsive disorder |
| CN104188447B (en) * | 2014-08-22 | 2016-05-11 | 何贞芳 | One is exclusively used in compulsive therapy pillow |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103599281B (en) | 2015-07-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102988772B (en) | TCM (Traditional Chinese medicine) composition for treating infantile acute infantile convulsions and preparation method thereof | |
| CN100536901C (en) | Chinese medicine for treating burn, scald and frostbite | |
| CN103919952A (en) | Gel preparation for treating hemorrhoids and preparation method thereof | |
| CN103599281B (en) | Traditional Chinese medicinal composition for treating obsessive-compulsive disorder and application thereof | |
| CN107412661A (en) | A kind of Chinese medicine composition for treating impotence, premature ejaculation and preparation method thereof | |
| CN101249231B (en) | Medicine composition for treating lithiasis and preparation thereof | |
| CN103599409A (en) | Traditional Chinese medicinal composition for treating prosopalgia | |
| CN101194982B (en) | Antidepressive Chinese medicine composition and method of preparing the same | |
| CN103611027B (en) | The pharmaceutical composition of a kind of clinical prevention, nursing and treatment trichomonal vaginitis | |
| CN103386101B (en) | Traditional Chinese medicine preparation for nonspecific cystitis treatment and preparation method thereof | |
| CN101829188B (en) | Medicament for treating urinary infection and lithiasis | |
| CN102526520B (en) | Medicament for treating epilepsy and preparation method thereof | |
| CN101623457B (en) | Traditional Chinese medicine for treating chronic prostatitis | |
| CN1286515C (en) | Medicinal composition for treating cyst | |
| CN104367939A (en) | Chinese traditional medicine for treating hypochondriacal neurosis and preparation method thereof | |
| CN101618118B (en) | Application of Chinese medicinal composition in preparing medicament for treating cystitis | |
| CN1981835B (en) | Chinese-medicinal contraceptive liquid and its production | |
| CN102274362B (en) | Plaster for treating mastopathy and preparation method thereof | |
| CN1899428B (en) | Chinese medicine preparation for treating pain and its preparing method | |
| CN100534482C (en) | Soft capsule for treating vascular headaehe | |
| CN105079717A (en) | Pharmaceutical preparation for treating depression | |
| CN104784567B (en) | A kind of pharmaceutical composition for the treatment of urinary system infection | |
| CN100531767C (en) | Capsules for treating prostatauxe | |
| CN104436017A (en) | Traditional Chinese medicine composition containing caulis akebiae for treating gout | |
| CN1448167A (en) | Medicine for treatment of pelvic inflammation, its preparation and preparing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Ma Zhiwen Inventor after: Liu Haozhi Inventor before: Liu Xuejian |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: LIU XUEJIAN TO: MA ZHIWEN LIU HAOZHI |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170505 Address after: 226200 Jiangsu province Nantong Jiulong Zhen Yuan Dong Cun highstar Chemical Co. Ltd. in Patentee after: Qidong Su Xing carbon dioxide Co., Ltd. Address before: Jimo City, Shandong province 266200 Jhengtong street Qingdao City No. 20 Patentee before: Li Weili |