CN113425774A - Herbal wrapped moxibustion liquid medicine for treating rheumatic ostealgia and preparation method thereof - Google Patents

Herbal wrapped moxibustion liquid medicine for treating rheumatic ostealgia and preparation method thereof Download PDF

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CN113425774A
CN113425774A CN202110711445.0A CN202110711445A CN113425774A CN 113425774 A CN113425774 A CN 113425774A CN 202110711445 A CN202110711445 A CN 202110711445A CN 113425774 A CN113425774 A CN 113425774A
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杨建民
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Abstract

The invention relates to a herbal moxibustion liquid for rheumatic ostealgia and a preparation method thereof, relating to the technical field of traditional Chinese medicine preparation; the feed is prepared from the following raw materials: radix Aconiti Preparata, radix Aconiti Kusnezoffii Preparata, herba Ephedrae, cortex Cinnamomi, herba asari, Eupolyphaga Seu Steleophaga, nidus Vespae, Carthami flos, semen Persicae, folium Artemisiae Argyi, herba Speranskiae Tuberculatae, herba Lycopodii, semen Strychni, radix Clematidis, radix Tripterygii Wilfordii, and Glycyrrhrizae radix; the specific method comprises the following steps: the monarch drug is subjected to alcohol extraction and then is subjected to primary fermentation by lactic acid and acetic acid, and the ministerial drug is added for further fermentation; adding adjuvant, performing ultrasonic oscillation treatment at low temperature, adding acid-treated messenger medicine, and performing microwave treatment; the wrapped moxibustion liquid medicine is suitable for being used for treatment by a wrapped moxibustion method, the medicinal components contained in the liquid medicine are improved, the molecular weight is small, the wrapped moxibustion liquid medicine is more beneficial to skin permeation and rapid subcutaneous introduction, the used treatment course is short, the effect is quick, the curative effect is good, the rheumatism and osteodynia are treated, and the effective rate reaches over 95 percent.

Description

Herbal wrapped moxibustion liquid medicine for treating rheumatic ostealgia and preparation method thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparation, relates to an external medicinal liquid for rheumatism, and particularly relates to a herbal wrapped moxibustion medicinal liquid for rheumatic bone pain and a preparation method thereof.
Background
Rheumatism refers to a disease that mainly invades joints, muscles, bones and soft tissues around the joints, such as tendons, ligaments, bursa, fascia and the like. The traditional Chinese medicine considers that the rheumatic bone pain is caused by the mixture of wind, cold and damp, and is a arthralgia syndrome formed by mixing various pathogenic factors. Wind, cold and dampness stagnate in joints to block channels and vessels, and the circulation of qi and blood is not smooth, which can be classified as "wind-damp", "damp arthralgia" and "wind-cold-damp arthralgia" to cause arthralgia, numbness, swelling, stiffness and even paralysis. Especially, neck, shoulder, waist and leg pains are caused by middle-aged and elderly people, and the living health of people is seriously influenced.
At present, the traditional Chinese medicines for treating the rheumatism bone disease comprise oral medicines and external medicines, the oral medicines generally cannot directly reach focus parts, the curative effect of the medicines cannot be efficiently utilized, and the treatment effect is easily influenced. The externally applied medicine belongs to an externally applied medicine, can be directly pasted on a diseased part, but if the efficacy of the medicine cannot reliably permeate into a focus part in a body from the body surface, the ideal curative effect cannot be achieved, the medicine can only be used for alleviating symptoms, the cost is high, the treatment course is long, and the effect is not good especially for people or patients suffering from wind-cold type, wind-damp type and blood stasis type osteodynia.
Disclosure of Invention
The invention overcomes the defects of the prior art and provides herbal wrapped moxibustion liquid for treating rheumatic bone pain and a preparation method thereof; has obvious effects of eliminating dampness and dispelling cold, and has safe and reliable use effect.
In order to achieve the above object, the present invention is achieved by the following technical solutions.
A herbal moxibustion liquid medicine for treating rheumatic ostealgia is prepared from the following raw materials in parts by weight: 20-40 parts of prepared common monkshood mother root, 20-40 parts of prepared kusnezoff monkshood root, 20-25 parts of ephedra herb, 15-20 parts of cassia bark, 15-25 parts of manchurian wildginger herb, 15-20 parts of eupolyphaga, 15-20 parts of honeycomb, 25-30 parts of safflower, 15-30 parts of peach seed, 15-20 parts of Chinese mugwort leaf, 35-45 parts of garden balsam stem, 35-45 parts of common clubmoss herb, 3-10 parts of nux vomica, 20-35 parts of clematis root, 30-40 parts of common threewingnut root and 20-30 parts of raw liquoric root.
Preferably, the feed is prepared from the following raw materials in parts by weight: 30 parts of prepared common monkshood mother root, 30 parts of prepared kusnezoff monkshood root, 22 parts of ephedra herb, 15 parts of cassia bark, 20 parts of manchurian wildginger, 15 parts of ground beetle, 20 parts of honeycomb, 25 parts of safflower, 20 parts of peach kernel, 16 parts of Chinese mugwort leaf, 40 parts of garden balsam stem, 39 parts of common clubmoss herb, 8 parts of nux vomica, 28 parts of clematis root, 36 parts of common threewingnut root and 25 parts of.
A preparation method of herbal moxibustion liquid medicine for treating rheumatic ostealgia comprises the following steps:
a) mixing radix Aconiti Preparata, radix Aconiti Kusnezoffii Preparata and herba asari, pulverizing, adding alcohol 2-3 times of the total weight of the three materials, and leaching for 7-12 days to obtain ethanol extractive mixture; inoculating lactobacillus and acetic acid bacteria in the alcohol extraction mixture, and fermenting for 2-3 days to obtain a fermentation product A.
b) Mixing and pulverizing herba Ephedrae, cortex Cinnamomi, folium Artemisiae Argyi, herba Speranskiae Tuberculatae and herba Lycopodii, adding into the fermented product A, stirring well, and continuing to ferment for 3-5 days to obtain fermented product B.
c) Mixing radix Clematidis and radix Tripterygii Wilfordii, grinding into powder, adding into the fermented product B to obtain mixture C, controlling the temperature of the mixture C at 2-8 deg.C, performing ultrasonic oscillation treatment for 30-60min, adding semen Persicae and Carthami flos into the mixture C, and continuing ultrasonic oscillation treatment for 20-30min to obtain mixture D.
d) Pulverizing Eupolyphaga Seu Steleophaga, nidus Vespae, Glycyrrhrizae radix and semen Strychni, adding 15-20% of total weight of vinegar, microwave treating for 20-40s to obtain mixture E, adding mixture E into mixture D, stirring, and filtering to obtain the final product.
Preferably, the percentage concentration of said alcohol is 60-75%.
Preferably, the fermentation temperature after inoculation of the lactic acid bacteria and the acetic acid bacteria is 35-38 ℃.
Preferably, the power of the ultrasonic oscillation treatment is 1 to 3 kW.
Preferably, the power of the microwave treatment is 1200-1500W.
Compared with the prior art, the invention has the following beneficial effects:
the liquid medicine takes processed radix aconiti, processed radix aconiti kusnezoffii and asarum as monarch drugs, and the three monarch drugs are firstly extracted by alcohol and fermented by lactic acid and acetic acid in a short period; during the fermentation process, acetic acid bacteria convert alcohol into acetic acid to make the whole environment acidic, part of organic components are degraded and fully dissolved out, and then ministerial drugs consisting of ephedra, cinnamon, folium artemisiae argyi, speranskia herb and lycopodium clavatum are added for further fermentation; at the moment, under an acidic condition, lactic acid bacteria are further degraded by using carbohydrates in a newly added medicine to form lactic acid, meanwhile, in the synergistic metabolic process of two microorganisms, various secondary metabolites are generated, various organic matters in the monarch medicine and the ministerial medicine are dissolved out, and aldehydes, esters and acidic components which play a role in the ministerial medicine assist the monarch medicine to improve the effects of stimulating the menstrual flow and dispelling cold. The concentration and the variety of dissolved components in a fermentation system are improved by step-by-step and synergistic fermentation; meanwhile, the effects of expelling wind and removing dampness, warming channels and expelling cold, activating collaterals and relieving pain of monarch drugs and adjuvant drugs are improved.
The clematis root, the tripterygium wilfordii, the peach kernel and the safflower are used as adjuvant drugs in the liquid medicine, are added into the monarch and minister drugs in two steps, are treated by ultrasonic oscillation, and form short-chain state in molecular form of effective components in the adjuvant drugs in the process of oscillating and shearing, so that the effect of assisting and enhancing the monarch and minister drugs is gradually enhanced, and the effect of activating blood and dissolving stasis in the drugs is more prominent.
The ground beetle, the honeycomb, the raw liquorice and the nux vomica are taken as guiding drugs, vinegar is added for modulation, then microwave treatment is carried out, and then the mixture is added into the mixed drug, so that the guiding drugs can play a role in balancing and coordinating themselves and the guiding drugs can be harmonized.
The wrapped moxibustion liquid medicine is suitable for being used in wrapped moxibustion treatment, has improved medicinal components, small molecular weight, short treatment course and good curative effect, and is more beneficial to skin permeation and rapid subcutaneous introduction. The clinical observation of results of 600 patients with rheumatic bone pain shows that the effective rate reaches more than 95 percent.
Detailed Description
In order to make the technical problems, technical solutions and advantageous effects to be solved by the present invention more clearly apparent, the present invention is further described in detail with reference to the embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. The technical solutions of the present invention are described in detail below with reference to examples, but the scope of protection is not limited thereto.
A herbal wrapped moxibustion liquid for rheumatic ostealgia is prepared from the following raw materials:
prepared common monkshood mother root 3 jin, prepared kusnezoff monkshood root 3 jin, ephedra 2.2 jin, cinnamon 1.5 jin, asarum herb 2 jin, eupolyphaga 1.5 jin, honeycomb 2 jin, safflower 2.5 jin, peach kernel 2 jin, Chinese mugwort leaf 1.6 jin, speranskia herb 4 jin, buck grass 3.9 jin, nux vomica 0.8 jin, clematis root 2.8, tripterygium wilfordii 3.6 jin and raw licorice root 2.5 jin.
The preparation method comprises the following steps:
the method comprises the following steps: mixing radix Aconiti Preparata, radix Aconiti Kusnezoffii Preparata and herba asari, pulverizing to 80 mesh, adding 75% ethanol 2.5 times of the total weight of the three materials, stirring, standing, and leaching for 10d to obtain ethanol extractive mixture; inoculating lactobacillus and acetic acid bacteria in the alcohol extraction mixture, and fermenting for 2-3 days to obtain a fermentation product A. Wherein the lactobacillus and the acetic acid bacteria are conventional fermentation microbial inoculum sold in the market, the inoculation amount of the two bacteria is 0.1-0.2% of the total amount of the ethanol extraction mixture, and the fermentation temperature after inoculation of the lactobacillus and the acetic acid bacteria is 35-38 ℃.
Step two: mixing herba Ephedrae, cortex Cinnamomi, folium Artemisiae Argyi, herba Speranskiae Tuberculatae and herba Lycopodii, pulverizing to 80 mesh, adding into the fermented product A, stirring well, and continuing to ferment for 4d to obtain fermented product B.
Step three: mixing radix Clematidis and radix Tripterygii Wilfordii, grinding into 200 mesh powder, adding into the fermented product B to obtain mixture C, controlling the temperature of the mixture C at 4 deg.C, performing ultrasonic oscillation treatment for 60min, adding semen Persicae and Carthami flos into the mixture C, and continuing ultrasonic oscillation treatment for 30min to obtain mixture D. Wherein the peach kernel and the safflower are both in powder shape, and the power of ultrasonic oscillation treatment is 2 kW.
Step four: pulverizing Eupolyphaga Seu Steleophaga, nidus Vespae, Glycyrrhrizae radix and semen Strychni, adding 15% of vinegar, microwave treating for 20s to obtain mixture E, adding mixture E into mixture D, stirring, and filtering to obtain the final product. Wherein the power of the microwave treatment is 1200W. After that, the concentration treatment may be performed according to the specific use case. The use of this example did not perform a concentration treatment.
The specific using method comprises the following steps: soaking carrier such as gauze and cavernous body in 10-15ml of medicinal liquid, applying to affected part, wrapping the whole body, and gasifying the medicinal liquid at 45-60 deg.C while opening pores of patient skin to promote absorption of the medicinal liquid. Each treatment period is 14 days, and each treatment period is 60 minutes.
Case statistics: 600 patients were treated, 300 men and 300 women with the age distribution: 100 cases aged 30-40, 150 cases aged 41-50, 200 cases aged 51-60, 150 cases aged 60 or more, 72 years old at maximum age, and 30 years old at minimum age;
wherein, the usage of 121 cases of rheumatoid arthritis is 3-6 courses of treatment; 155 cases of rheumatoid arthritis, 3-8 courses of treatment are used; 103 cases of cervical spondylosis, 4-6 courses of treatment; 147 cases of scapulohumeral periarthritis, 4-7 courses of treatment are used; for 74 cases of sciatica, 3-9 courses of treatment are used.
And (3) curing: the pain symptom basically disappears, and the joint mobility is basically normal;
the method has the following advantages: the pain symptoms are reduced; the joint mobility is increased;
and (4) invalidation: the pain symptoms were not reduced and there was no change in joint mobility.
Figure DEST_PATH_IMAGE002
While the invention has been described in further detail with reference to specific preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (7)

1. The herbal moxibustion liquid for treating rheumatic ostealgia is characterized by being prepared from the following raw materials in parts by weight: 20-40 parts of prepared common monkshood mother root, 20-40 parts of prepared kusnezoff monkshood root, 20-25 parts of ephedra herb, 15-20 parts of cassia bark, 15-25 parts of manchurian wildginger herb, 15-20 parts of eupolyphaga, 15-20 parts of honeycomb, 25-30 parts of safflower, 15-30 parts of peach seed, 15-20 parts of Chinese mugwort leaf, 35-45 parts of garden balsam stem, 35-45 parts of common clubmoss herb, 3-10 parts of nux vomica, 20-35 parts of clematis root, 30-40 parts of common threewingnut root and 20-30 parts of raw liquoric root.
2. The herbal wrapped moxibustion liquid for rheumatic bone pain according to claim 1, which is prepared from the following raw materials in parts by weight: 30 parts of prepared common monkshood mother root, 30 parts of prepared kusnezoff monkshood root, 22 parts of ephedra herb, 15 parts of cassia bark, 20 parts of manchurian wildginger, 15 parts of ground beetle, 20 parts of honeycomb, 25 parts of safflower, 20 parts of peach kernel, 16 parts of Chinese mugwort leaf, 40 parts of garden balsam stem, 39 parts of common clubmoss herb, 8 parts of nux vomica, 28 parts of clematis root, 36 parts of common threewingnut root and 25 parts of raw liquoric root.
3. The method for preparing herbal moxibustion liquid medicine for rheumatic bone pain as claimed in claim 1 or 2, comprising the steps of:
a) mixing radix Aconiti Preparata, radix Aconiti Kusnezoffii Preparata and herba asari, pulverizing, adding alcohol 2-3 times of the total weight of the three materials, and leaching for 7-12 days to obtain ethanol extractive mixture; inoculating lactobacillus and acetic acid bacteria in the alcohol extraction mixture, and fermenting for 2-3 days to obtain a fermented product A;
b) mixing and crushing ephedra herb, cinnamon, folium artemisiae argyi, garden balsam stem and lycopodium clavatum, adding into the fermentation product A, uniformly stirring, and continuously fermenting for 3-5 days to obtain a fermentation product B;
c) mixing radix Clematidis and radix Tripterygii Wilfordii, grinding into powder, adding into the fermented product B to obtain mixture C, controlling the temperature of the mixture C at 2-8 deg.C, performing ultrasonic oscillation treatment for 30-60min, adding semen Persicae and Carthami flos into the mixture C, and continuing ultrasonic oscillation treatment for 20-30min to obtain mixture D;
d) pulverizing Eupolyphaga Seu Steleophaga, nidus Vespae, Glycyrrhrizae radix and semen Strychni, adding 15-20% of total weight of vinegar, microwave treating for 20-40s to obtain mixture E, adding mixture E into mixture D, stirring, and filtering to obtain the final product.
4. The method as claimed in claim 3, wherein the percentage concentration of the alcohol is 60-75%.
5. The method for preparing a herbal moxibustion liquid medicine for rheumatic ostealgia according to claim 3, wherein the fermentation temperature after inoculation of lactic acid bacteria and acetic acid bacteria is 35-38 ℃.
6. The method for preparing herbal moxibustion liquid medicine for rheumatic bone pain as claimed in claim 3, wherein the power of ultrasonic oscillation treatment is 1-3 kW.
7. The method for preparing a herbal moxibustion liquid medicine for rheumatic ostealgia according to claim 3, wherein the power of the microwave treatment is 1200-1500W.
CN202110711445.0A 2021-06-25 2021-06-25 Herbal wrapped moxibustion liquid medicine for treating rheumatic ostealgia and preparation method thereof Pending CN113425774A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107582774A (en) * 2017-08-23 2018-01-16 廖艳卿 One kind treats rheumatalgia pain monkshood dip and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107582774A (en) * 2017-08-23 2018-01-16 廖艳卿 One kind treats rheumatalgia pain monkshood dip and preparation method thereof

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