CN109394850A - It is a kind of to have effects that the Chinese medicine composition of delay skin aging and its water extract and fermentation material and application - Google Patents
It is a kind of to have effects that the Chinese medicine composition of delay skin aging and its water extract and fermentation material and application Download PDFInfo
- Publication number
- CN109394850A CN109394850A CN201811551622.8A CN201811551622A CN109394850A CN 109394850 A CN109394850 A CN 109394850A CN 201811551622 A CN201811551622 A CN 201811551622A CN 109394850 A CN109394850 A CN 109394850A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- mass parts
- medicine composition
- radix
- skin aging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Birds (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to the technical field of traditional Chinese medicine of delay skin aging, in particular to a kind of to have effects that the Chinese medicine composition of delay skin aging and its water extract and fermentation material and application.The present invention is in order to achieve the purpose that delay skin aging, it is guidance with China's traditional Chinese medicine theory, pass through long-term a large amount of experiment screening Chinese medicine material, Radix Codonopsis, radix pseudostellariae, gynostemma pentaphylla, Radix Glycyrrhizae, cortex moutan are effectively combined in together, extract obtained and the composition are proposed through yeast fermentation fermentation material obtained through water, can be done directly on skin, have no toxic side effect, use is simple and safe, action temperature and.Have and repair the extrinsic aging damage of skin, promote dermal cell growth, remove free radical and oxidation resistant effect, it is possible to reduce wrinkle generates, and being applied in cosmetics has the effect of significant delay skin aging.
Description
Technical field
The present invention relates to the technical field of traditional Chinese medicine of delay skin aging, in particular to a kind of to have delaying skin old
The Chinese medicine composition and its water extract and fermentation material of change effect and application.
Background technique
Aging is an inevitable physiological phenomenon, and a part of skin aging as body entirety aging has prominent
Psychology and sociology meaning out because body aging show on the skin it is most clear, most intuitive, skin characteristic state
Variation is also by the important symbol as people's Age estimation.Skin aging is divided into natural aging and extrinsic aging.Naturally old
Change related with the factors such as human body age, heredity, is the irreversible natural law.It is extrinsic aging to refer to due to external factor such as
Solar UV irradiation smokes, drinks, skin various kinds of cell caused by weather, air pollution and contact harmful chemical etc.
Phenomena such as damage, degradation, denaturation caused skin aging occurs for ingredient and structure.
The most characteristic variation of skin aging is the variation of dermal matrix ingredient, and dermal matrix ingredient includes intradermal
All intercellular substances in addition to water, wherein most important ingredient is elastic fibers, collagenous fibres, glycosaminoglycan and albumen
Polysaccharide etc., these substances play an important role to the elasticity and compliance of skin.In ageing processes of skin, various factors leads to bullet
Power fiber and collagen fibril denaturing, degradation disappear, and skin elasticity and compliance then lose therewith, occur wrinkle, relaxation, atrophy,
The variation such as thinning, angling, pigmentation, telangiectasis, wherein wrinkle is the most basic clinical manifestation of skin aging.
Recently as the raising of Chinese society development and living standards of the people, production of the consumer for delay skin aging
Product demand growth quickly, and at present by oral drugs, health care product anti-aging there are certain toxic side effect, is subcutaneously injected, is outer
The human bodies intrusive mood medicine shapings such as section's operation improve skin appearance, and there is also certain infection risks.
Therefore the effective component that natural plant kind is directed to delay skin aging how safely, effectively, is simply obtained, and is answered
It uses in cosmetics, is current urgent problem to be solved.
Summary of the invention
In order to solve problems in the prior art, has effects that the Chinese traditional medicine composition of delay skin aging the present invention provides a kind of
Object and its water extract and fermentation material and application are selected from natural plants, mention extract obtained and the composition through ferment through water
Mother is fermented fermentation material obtained, be can be done directly on skin, is had no toxic side effect, use is simple and safe, action temperature and.Has reparation
The extrinsic aging damage of skin promotes dermal cell growth, removes free radical and oxidation resistant effect, it is possible to reduce wrinkle is raw
At to achieve the effect that delay skin aging.
The technical solution adopted in the present invention is as follows:
It is a kind of to have effects that the Chinese medicine composition of delay skin aging, it include following components according to mass fraction: Radix Codonopsis
200~350 mass parts, 200~350 mass parts of radix pseudostellariae, 100~200 mass parts of gynostemma pentaphylla, 100~200 mass parts of Radix Glycyrrhizae,
100~200 mass parts of cortex moutan.
A kind of water extract of Chinese medicine composition is that 10 times of weight pure water are added by the Chinese medicine composition, at 95~100 DEG C
Under, after extracting 1h in vacuum emulsifying pot, filtrate prepared by filtering.
A kind of fermentation material of Chinese medicine composition is the initial system being obtained by mixing by the Chinese medicine composition and zymophyte,
Be added 10 times of weight pure water, it is fermented obtained by fermentation liquid is sterilized again, filtrate obtained by filtering.
Zymophyte is saccharomycete, and Chinese medicine group is added by 100~350 mass parts of mass fraction in the form of high activity dried yeast
Close object.
In fermentation step, temperature is 25~45 DEG C；Speed of agitator is 0~50rpm；Time be 4~for 24 hours.
A kind of application of the water extract of Chinese medicine composition is the ratio incorporationization for being 1%~60% according to weight percent
In cosmetic.
A kind of application of the fermentation material of Chinese medicine composition is the ratio incorporationization for being 1%~60% according to weight percent
In cosmetic.
Cosmetics range used in water extract or fermentation material are as follows: liquid type, type of latex type, cream kind, thermophilic curry class, powder class or
Powder compacting class.
Radix Codonopsis the, according to " China that June in 2015, the 1st edition Chinese Pharmacopoeia Commission write, China Medical Science Press
Pharmacopeia " 2015 years one page 282 of version record following effect: strengthening spleen and tonifying lung, nourishes blood and promotes the production of body fluid.For spleen-lung Qi deficiency, insufficiency of vital energy and blood,
Sallow complexion." the big diction of Chinese medicine write according to the Nanjing University of Traditional Chinese Medicine of Shanghai science tech publishing house in June, 2014 second edition
Allusion quotation " page 3836 record, Radix Codonopsis feeds silkworm after there is delaying senility function, 20% Radix Codonopsis decocting liquid to impregnate mulberry leaf, can extend the children of silkworm
Worm phase, full life cycle, and put on weight.In vitro test shows that Radix Codonopsis extract can improve the superoxide dismutase of people's blood
(SOD) active, the ability of free radical is removed in enhancing, and Radix Codonopsis is prompted to have certain delaying senility function.Radix Codonopsis has enhancing machine
Body immunity function, Radix Codonopsis injection can be such that the quantity of Turnover of Mouse Peritoneal Macrophages increases, and cell volume increases, and pseudopodium increases, gulps down
Bite power reinforcement；Intracellular DNA, RNA, carbohydrate, acid phosphatase (ACP), ATP enzyme, acidity α-acetic acid naphthols esterase (ANAE), amber
Amber dehydrogenase activity is remarkably reinforced.
Radix pseudostellariae, according to China Medical Science Press the 1st edition Chinese Pharmacopoeia Commission writes June in 2015 " in
State's pharmacopeia " 2015 years one page 68 of version record following effect: replenish qi to invigorate the spleen, it is promoting production of body fluid and nourishing the lung.Tired for spleen deficiency body, gas yin is not
Foot." dictionary of medicinal plant " 463 write according to the Nanjing University of Traditional Chinese Medicine of Shanghai science tech publishing house in June, 2014 second edition
Page is recorded, and radix pseudostellariae water decoction extends average life span and the maximum life span of drosophila, has delaying senility function.
Gynostemma pentaphylla, according to the Nanjing University of Traditional Chinese Medicine of Shanghai science tech publishing house in June, 2014 second edition write " in
Medicine voluminous dictionary " 2133-2134 pages record following effect: heat-clearing, qi-restoratives, removing toxic substances.Asthenia is cured mainly, nephrasthenia emission is white thin
Born of the same parents reduce disease.And have the effect that immunoregulation effect: gypenoside GPs (50,100mg/kg) has normal mouse double
To immunoregulation effect.GPs can enhance breeder reaction of the mouse boosting cell to mitogen ConA, PHA, LPS in vitro, to mixing
T cell in lymphocyte has humidification, and rat spleen cells secretion IL-2 and rat peritoneal macrophages can be promoted to generate
IL-1.Delaying senility function: gynostemma pentaphylla can be obviously prolonged the passage algebra of cell culture.Make in vitro culture with human skin cell,
Adding the culture solution of GPs200 μ g/ml can make cell reach for 27 generations, and control group is only capable of reaching for 22 generations.With human fetal lungs diploid fiber
Cell secondary culture also obtains similar results, and control group reached for 51 generations, and GPs group can reach for 59 generations.5 monthly age mouse, which use, contains gynostemma pentaphylla
Decoction feed (2.5g basal feed crude drug containing 0.1g) is raised 4 months, survival 50%, control group survival 0%, is within feeding 2 months
SOD in Mice activity can be improved.The mouse subacute aging model that d- galactolipin induces such as is injected intraperitoneally to every mouse daily simultaneously
Gynostemma pentaphyllum extract suspension 15mg, totally 40 days, can significantly fight exhausted mining areas study active fugue reaction ability decline,
The abnormal raising of intracerebral monoamine oxidase (MAO-B) vigor and the increasing collection of brain lipofuscin, make the thymus gland of exhausted mining areas atrophy
It is restored to normal level, the spleen of increase also returns to normal level.Antioxidation: GPs reduces people and bites in neutrophil leucocyte
Superoxide anion and amount of hydrogen peroxide, lower the person monocytic cell caused by zymosan and mouse macrophage chemiluminescence aoxidizes
Excitation, have significant antioxidation.It is thin for the reduction and blood vessel endothelium of arterial dilation caused by oxygen radical
The damage of born of the same parents, GPs also have improvement and protective effect.
Radix Glycyrrhizae the, according to " China that June in 2015, the 1st edition Chinese Pharmacopoeia Commission write, China Medical Science Press
Pharmacopeia " 2015 years one page 87 of version record following effect: invigorate the spleen and benefit qi, clearing heat and detoxicating, relieving spasm to stop pain, coordinating the drug actions of a prescription.It can use
In carbuncle sore tumefacting virus, alleviate drug toxicity, strong.According to the Nanjing traditional Chinese medicine of Shanghai science tech publishing house in June, 2014 second edition
" dictionary of medicinal plant " records of page 685 that university writes, licorice extract inhibit Escherichia coli, staphylococcus aureus, copper in vitro
Green pseudomonad, beta streptococcus etc., Radix Glycyrrhizae hot water extract have insecticidal action to clonorchis sinensis, have antimicrobial work
With.Rat oral gavage glycyrrhiza glabra is freeze-dried water extract, inhibits adrenal gland-pituitary s function, and kidney feritin is promoted to produce
Raw, glycyrrhiza preparation has adrenocortical hormones fuction.According to the 1st edition Liu Huagang in China Traditional Chinese Medicine Publishing House's November in 2005
" Chinese medicine cosmetic " records of page 38 of chief editor, Radix Glycyrrhizae have the function of antiallergic action and removing toxic substances, can eliminate the inflammation of skin
Disease and poisonous substance stimulation, neutralization, the noxious material for releasing or reducing cosmetics, mistake of the cosmetics being also possible to prevent to certain people
Quick reaction.
Cortex moutan, according to China Medical Science Press the 1st edition Chinese Pharmacopoeia Commission writes June in 2015 " in
State's pharmacopeia " 2015 years one page 172 of version record following effect: clearing heat and cooling blood, activating microcirculation and removing stasis medicinal.Enter ying blood, epidemic heat syndrome hair for heat
Spot, carbuncle sore tumefacting virus.According to the Nanjing University of Traditional Chinese Medicine of Shanghai science tech publishing house in June, 2014 second edition write " Chinese medicine is big
Dictionary " records of page -1368 of page 1367, the total glycosides of the root bark of tree peony 25,50,100mg/kg administration can significantly inhibit the big of carrageenan induction
The mouse auricle oedema of the acute sufficient pawl swelling of mouse and dimethylbenzene induction, and be in apparent dose-dependent relationship, it causes before inflammation 1 hour
Giving the total glycosides of the root bark of tree peony (20~100mg/kg) has obvious inhibiting effect to adjuvant arthritis rats primary inflammatory, and after causing inflammation
The total glycosides of the beginning stomach-filling root bark of tree peony (25~100mg/kg) on the 12nd, continuous 11 days, can significantly inhibit the secondary of adjuvant arthritis rats
Property inflammatory reaction.Carrageenan, egg white, formaldehyde, group is injected intraperitoneally in 0.5~1g/kg of paeonol stomach-filling or 50~200mg/kg
Amine, serotonin and bradykinin rat are swollen enough, abdominal cavity capillary caused by dimethylbenzene mouse auricle swelling and acetic acid and endotoxin
Vasopermeability increases, and significantly inhibits effect.It (is processed and is extracted and manufactured white is micro- with cortex moutan with 5% root bark of tree peony pollen
Yellow creme), at the local skin lesion of outer painting.Clinical treatment limitation acute eczema 27, seborrhea 10, contact dermatitis 2
Example, neurodermatitis 1；The course of disease 3 days to 3 years, most of courses of disease were 1 month discontented.As a result: 27 acute eczema medications 2~20
Day, 8 recoveries from illness, 5 are effective, and 6 improvements, 8 are invalid；10 seborrhea medication 5~14 days, 2 recovery from illness, 6 improvement,
2 invalid；2 contact dermatitis medication 3~5 days, 1 recovery from illness, 1 is invalid；1 neurodermatitis medication half a month is invalid.Have
Imitate in case 4 be discontinued after a few days fash recur, another 2 medications locally occur flush, itch with it is scorching hot and be discontinued.
The above traditional Chinese medicine ingredients occurred in text are in INCI (International Nomenclature Cosmetic
Ingredient, i.e. international cosmetic raw material name) it has been respectively as follows: Radix Codonopsis (CODONOPSIS using cosmetic material title
PILOSULA) extract, radix pseudostellariae (PSEUDOSTELLARIA HETEROPHYLLA) extract, gynostemma pentaphylla (GYNOSTEMMA
PENTAPHYLLUM) extract, Radix Glycyrrhizae (GLYCYRRHIZA URALENSIS) root extract, tree peony (PAEONIA
SUFFRUTICOSA) root bark extract.
Technical solution provided by the invention has the benefit that
The present invention is guidance with China's traditional Chinese medicine theory, by long-term to achieve the purpose that delay skin aging
A large amount of experiment screening Chinese medicine material, Radix Codonopsis, radix pseudostellariae, gynostemma pentaphylla, Radix Glycyrrhizae, cortex moutan is effectively combined in together, through water
Extract obtained and the composition are proposed through yeast fermentation fermentation material obtained, skin is can be done directly on, has no toxic side effect,
Using simple and safe, action temperature and.Have and repairs the extrinsic aging damage of skin, promote dermal cell growth, remove free radical
With oxidation resistant effect, it is possible to reduce wrinkle generates, and is applied to the function in cosmetics with significant delay skin aging
Effect.
The water extract of Chinese medicine composition of the invention is that 10 times of weight pure water are added by the Chinese medicine composition 95~100
At DEG C, after extracting 1h in vacuum emulsifying pot, filtrate prepared by filtering；Herb fermenting object of the invention is a kind of Chinese medicine
The initial system that composition and zymophyte are obtained by mixing, is added 10 times of weight pure water, it is fermented obtained by fermentation liquid it is sterilized again,
Filtrate obtained by filtering.Action temperature and non-stimulated, safely and effectively, can be used for a long time, add it to simple process in cosmetics,
Adapt to industrialized production.
The water extract and fermentation material of Chinese medicine composition of the invention have a wide range of application, good with most of cosmetic material compatibilities
It is good, it can be applied in the major dosage form of cosmetics, add simple and convenient.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, make below in conjunction with specific embodiment into one
Step ground detailed description.
Embodiment 1: the application in Essence is being repaired for the water extract of Chinese medicine composition.
Prepared by the water extract of Chinese medicine composition: weighing Radix Codonopsis 200g, radix pseudostellariae 200g, gynostemma pentaphylla 100g, Radix Glycyrrhizae 100g, male
Root bark of tree peony 100g, it is packed good with sterile gauze after cleaning, it is placed in vacuum emulsifying pot, by the weight of Chinese medicine composition, is added
10 times of pure water filters to take its decoction, can be prepared by the water extract of Chinese medicine composition after extracting 1h at 95~100 DEG C.
The formula that the water extract of the Chinese medicine composition containing 20wt% repairs Essence is as shown in table 1:
Table 1
Each component is prepared by following technique in the formula of table 1:
(1) first by above table ingredient names and weight weigh each component investment agitated kettle；
(2) 8 kinds of components in A phase are mixed to and is completely dissolved；
(3) B phase is added in stirring, until each component is uniformly mixed, is completely dissolved, discharging.
Embodiment 2: for application of the water extract in repair cream of Chinese medicine composition.
Prepared by the water extract of Chinese medicine composition: weighing Radix Codonopsis 350g, radix pseudostellariae 350g, gynostemma pentaphylla 200g, Radix Glycyrrhizae 200g, male
Root bark of tree peony 200g, it is packed good with sterile gauze after cleaning, it is placed in vacuum emulsifying pot, by the weight of Chinese medicine composition, is added
10 times of pure water filters to take its decoction, can be prepared by the water extract of Chinese medicine composition after extracting 1h at 95~100 DEG C.
The formula of the water extract repair cream of the Chinese medicine composition containing 15wt% is as shown in table 2:
Table 2
Each component is prepared by following technique in the formula of table 2:
(1) first by above table ingredient names and weight weigh each component；
(2) 82 DEG C are heated to after mixing A phase each component, is stirred evenly；
(3) B phase each component is mixed to and all dissolves and is heated to 82 DEG C；
(4) B is added to A phase, the 3000rmp homogeneous 5min in vacuum emulsification pot, stirring is cooled to 40 DEG C, discharging.
Embodiment 3: the application for being Chinese medicine composition in repair latex.
Prepared by the water extract of Chinese medicine composition: weighing Radix Codonopsis 300g, radix pseudostellariae 250g, gynostemma pentaphylla 150g, Radix Glycyrrhizae 150g, male
Root bark of tree peony 150g, it is packed good with sterile gauze after cleaning, it is placed in vacuum emulsifying pot, by the weight of Chinese medicine composition, is added
10 times of pure water filters to take its decoction, can be prepared by the water extract of Chinese medicine composition after extracting 1h at 95~100 DEG C.
The formula of the water extract repair latex of the Chinese medicine composition containing 25wt% is as shown in table 3:
Table 3
Each component is prepared by following technique in the formula of table 3:
(1) first by above table ingredient names and weight weigh each component；
(2 will be heated to 82 DEG C after the mixing of A phase each component, stir evenly；
(3) B phase each component is mixed to and all dissolves and is heated to 82 DEG C；
(4) B is added to A phase, the 3000rmp homogeneous 5min in vacuum emulsification pot, stirring is cooled to 40 DEG C, discharging.
The effect of embodiment 1 to embodiment 3, is as follows:
The present embodiment 1-3, by 48 person on probations observation and record, data it is as follows:
(1) 48 person on probation's age between 30~68 years old, wherein 12 people of male, 36 people of women.It is old with reference to skin light
Its skin of face is pressed following parting: wherein 12 application on human skin according to the existence of wrinkle by the Glogau typing for changing clinical classification
Wrinkle promising I type skin during exercise；Wherein 18 application on human skin wrinkles promising II type skin in static；Wherein 18 application on human skin wrinkle
Dense distribution is type III skin.The personnel of above-mentioned every kind of skin type are equally divided into tri- groups: A group of A, B, C and use embodiment 1
The reparation Essence of preparation；The repair cream that B group uses embodiment 2 to prepare；C group makes repair latex prepared with embodiment 3.
(2) application method: taking product of the present invention, after cleaning face, respectively persistently uses 90 days using once sooner or later.
(3) effect judgment criteria:
Effective: wrinkle significantly disappears or reduces；
It is effective: wrinkle partial disappearance or reduction；
Invalid: wrinkle is without change, or changes unobvious.
Test result:
The reparation Essence that table 4:A group is prepared using embodiment 1 is as follows: the repairing effect of facial wrinkles
The repair cream that table 5:B group is prepared using embodiment 2 is as follows: the repairing effect of facial wrinkles
| Skin type | Number | It is effective | Effectively | In vain | Obvious effective rate+effective percentage |
| I type skin | 4 | 1 | 1 | 2 | 50.0% |
| II type skin | 6 | 2 | 3 | 1 | 83.3% |
| Type III skin | 6 | 3 | 1 | 2 | 66.7% |
Table 6:C group is as follows: repair latex prepared with embodiment 3 to the repairing effect of facial wrinkles
| Skin type | Number | It is effective | Effectively | In vain | Obvious effective rate+effective percentage |
| I type skin | 4 | 3 | 0 | 1 | 75.0% |
| II type skin | 6 | 4 | 2 | 0 | 100% |
| Type III skin | 6 | 3 | 2 | 1 | 83.3% |
Conclusion 1: the water extract of the traditional chinese medicine composition of the invention is applied in cosmetics to reparation facial wrinkles significant effect.
Conclusion 2: it is directed to slight wrinkle, that is, I type skin；Moderate wrinkle, that is, II type skin；Severe wrinkle, that is, type III skin is each
The service condition of group personnel can illustrate that three kinds of cosmetics of Examples 1 to 3 preparation can obtain really effective reparation effect,
Obvious effective rate+effective percentage minimum 50.0%, highest 100%.
Embodiment 4: the application in Essence is being repaired for herb fermenting object.
The preparation of herb fermenting object: Radix Codonopsis 200g, radix pseudostellariae 200g, gynostemma pentaphylla 100g, Radix Glycyrrhizae 100g, cortex moutan are weighed
100g is cleaned and is placed in fermentor, high activity dried yeast 100g and 10 times of weight pure water is added, in 42 DEG C and the condition of 0rpm
Lower fermentation 4h sterilizes, filters to take to obtain filtrate, can be prepared by herb fermenting object.
The formula of the reparation Essence of the object of herb fermenting containing 20wt% is as shown in table 7:
Table 7
Each component is prepared by following technique in the formula of table 7:
(1) first by above table ingredient names and weight weigh each component investment agitated kettle；
(2) 8 kinds of components in A phase are mixed to and is completely dissolved；
(3) B phase is added in stirring, until each component is uniformly mixed, is completely dissolved, discharging.
Embodiment 5: for application of the herb fermenting object in repair cream.
The preparation of herb fermenting object: Radix Codonopsis 350g, radix pseudostellariae 350g, gynostemma pentaphylla 200g, Radix Glycyrrhizae 200g, cortex moutan are weighed
200g is cleaned and is placed in fermentor, high activity dried yeast 350g and 10 times of weight pure water is added, in 36 DEG C and the item of 10rpm
Ferment 8h under part, sterilizes, filters to take to obtain filtrate, can be prepared by herb fermenting object.
The formula of the repair cream of the object of herb fermenting containing 15wt% is as shown in table 8:
Table 8
Each component is prepared by following technique in the formula of table 8:
(1) first by above table ingredient names and weight weigh each component；
(2) 82 DEG C are heated to after mixing A phase each component, is stirred evenly；
(3) B phase each component is mixed to and all dissolves and is heated to 82 DEG C；
(4) B is added to A phase, the 3000rmp homogeneous 5min in vacuum emulsification pot, stirring is cooled to 40 DEG C, discharging.
Embodiment 6: for application of the herb fermenting object in repair latex.
The preparation of herb fermenting object: Radix Codonopsis 300g, radix pseudostellariae 250g, gynostemma pentaphylla 150g, Radix Glycyrrhizae 150g, cortex moutan are weighed
150g is cleaned and is placed in fermentor, high activity dried yeast 220g and 10 times of weight pure water is added, in 28 DEG C and the condition of 5rpm
Lower fermentation for 24 hours, sterilizes, filters to take to obtain filtrate, can be prepared by herb fermenting object.
The formula of the repair latex of the object of herb fermenting containing 25wt% is as shown in table 9:
Table 9
Each component is prepared by following technique in the formula of table 9:
(1) first by above table ingredient names and weight weigh each component；
(2 will be heated to 82 DEG C after the mixing of A phase each component, stir evenly；
(3) B phase each component is mixed to and all dissolves and is heated to 82 DEG C；
(4) B is added to A phase, the 3000rmp homogeneous 5min in vacuum emulsification pot, stirring is cooled to 40 DEG C, discharging.
The effect of embodiment 4 to embodiment 6, is as follows:
The present embodiment 4-6, by 48 person on probations observation and record, data it is as follows:
(1) 48 person on probation's age between 30~68 years old, wherein 12 people of male, 36 people of women.It is old with reference to skin light
Its skin of face is pressed following parting: wherein 12 application on human skin according to the existence of wrinkle by the Glogau typing for changing clinical classification
Wrinkle promising I type skin during exercise；Wherein 18 application on human skin wrinkles promising II type skin in static；Wherein 18 application on human skin wrinkle
Dense distribution is type III skin.The personnel of above-mentioned every kind of skin type are equally divided into tri- groups: A group of A, B, C and use embodiment 4
The reparation Essence of preparation；The repair cream that B group uses embodiment 5 to prepare；The repair latex that C group uses embodiment 6 to prepare.
(2) application method: taking product of the present invention, after cleaning face, respectively persistently uses 90 days using once sooner or later.
(3) effect judgment criteria:
Effective: wrinkle significantly disappears or reduces；
It is effective: wrinkle partial disappearance or reduction；
Invalid: wrinkle is without change, or changes unobvious.
Test result:
The reparation Essence that table 10:A group is prepared using embodiment 4 is as follows: the repairing effect of facial wrinkles
| Skin type | Number | It is effective | Effectively | In vain | Obvious effective rate+effective percentage |
| I type skin | 4 | 2 | 2 | 0 | 100% |
| II type skin | 6 | 2 | 3 | 1 | 83.3% |
| Type III skin | 6 | 3 | 2 | 1 | 83.3% |
The repair cream that table 11:B group is prepared using embodiment 5 is as follows: the repairing effect of facial wrinkles
| Skin type | Number | It is effective | Effectively | In vain | Obvious effective rate+effective percentage |
| I type skin | 4 | 1 | 2 | 1 | 75.0% |
| II type skin | 6 | 2 | 2 | 2 | 66.7% |
| Type III skin | 6 | 1 | 2 | 3 | 50.0% |
The repair latex that table 12:C group is prepared using embodiment 6 is as follows: the repairing effect of facial wrinkles
| Skin type | Number | It is effective | Effectively | In vain | Obvious effective rate+effective percentage |
| I type skin | 4 | 1 | 3 | 0 | 100% |
| II type skin | 6 | 3 | 2 | 1 | 83.3% |
| Type III skin | 6 | 1 | 2 | 3 | 50.0% |
Conclusion 1: the fermentation material of the traditional chinese medicine composition of the invention is applied in cosmetics to reparation facial wrinkles significant effect.
Conclusion 2: each for slight wrinkle, that is, I type skin, moderate wrinkle, that is, II type skin, severe wrinkle, that is, type III skin
The service condition of group personnel can illustrate that three kinds of cosmetics prepared by embodiment 4~6 can obtain really effective reparation effect,
Obvious effective rate+effective percentage minimum 50.0%, highest 100%.
Components of cosmetics title involved in embodiment 1-6 is embodied in the publication of state food pharmaceuticals administration general bureau
Cosmetic material Names Catalogue (2015 editions) are used.
In above embodiments, Chinese medicine composition is primary crude drug or the prepared slices of Chinese crude drugs.One kind having effects that delay skin aging
Chinese medicine composition and its fermentation material and application, composition and the preparation of water extract and herb fermenting object including Chinese medicine composition,
And the water extract and herb fermenting object of Chinese medicine composition have delay skin aging, anti-aging, reparation wrinkle, guarantor in preparation
Application in wet, anti-oxidant, removing free radical, anti-inflammatory, effect drug or cosmetics.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
- It include following components according to mass fraction 1. a kind of have effects that the Chinese medicine composition of delay skin aging: Radix Codonopsis 200 ~350 mass parts, 200~350 mass parts of radix pseudostellariae, 100~200 mass parts of gynostemma pentaphylla, 100~200 mass parts of Radix Glycyrrhizae, tree peony 100~200 mass parts of skin.
- A kind of has effects that the Chinese medicine composition of delay skin aging 2. according to claim 1, which is characterized in that described Component specifically include:200 mass parts of Radix Codonopsis, 200 mass parts of radix pseudostellariae, 100 mass parts of gynostemma pentaphylla, 100 mass parts of Radix Glycyrrhizae, 100 mass of cortex moutan Part.
- A kind of has effects that the Chinese medicine composition of delay skin aging 3. according to claim 1, which is characterized in that described Component specifically include:350 mass parts of Radix Codonopsis, 350 mass parts of radix pseudostellariae, 200 mass parts of gynostemma pentaphylla, 200 mass parts of Radix Glycyrrhizae, 200 mass of cortex moutan Part.
- A kind of has effects that the Chinese medicine composition of delay skin aging 4. according to claim 1, which is characterized in that described Component specifically include:300 mass parts of Radix Codonopsis, 250 mass parts of radix pseudostellariae, 150 mass parts of gynostemma pentaphylla, 150 mass parts of Radix Glycyrrhizae, 150 mass of cortex moutan Part.
- 5. a kind of water extract of the Chinese medicine composition as described in claim 1-4 any one, which is characterized in that be by described 10 times of weight pure water are added in drug composition, at 95~100 DEG C, after extracting 1h in vacuum emulsifying pot, filter and are made Filtrate.
- 6. a kind of fermentation material of the Chinese medicine composition as described in claim 1-4 any one, which is characterized in that be by described The initial system that drug composition and zymophyte are obtained by mixing, is added 10 times of weight pure water, it is fermented obtained by fermentation liquid again through going out Filtrate obtained by bacterium, filtering.
- 7. a kind of fermentation material of Chinese medicine composition according to claim 6, which is characterized in that the zymophyte is yeast Chinese medicine composition is added by 100~350 mass parts of mass fraction in the form of high activity dried yeast in bacterium.
- 8. a kind of fermentation material of Chinese medicine composition according to claim 6, which is characterized in that in the fermentation step, Temperature is 25~45 DEG C；Speed of agitator is 0~50rpm；Time be 4~for 24 hours.
- 9. a kind of application of the water extract of Chinese medicine composition as claimed in claim 5, which is characterized in that be according to weight percent Than being mixed in cosmetics for 1%~60% ratio.
- 10. a kind of application of the fermentation material of the Chinese medicine composition as described in claim 6-8, which is characterized in that be according to weight The ratio that percentage is 1%~60% mixes in cosmetics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811551622.8A CN109394850B (en) | 2018-12-17 | 2018-12-17 | Traditional Chinese medicine composition with skin aging delaying effect, aqueous extract and fermentation product of traditional Chinese medicine composition and application of traditional Chinese medicine composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811551622.8A CN109394850B (en) | 2018-12-17 | 2018-12-17 | Traditional Chinese medicine composition with skin aging delaying effect, aqueous extract and fermentation product of traditional Chinese medicine composition and application of traditional Chinese medicine composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109394850A true CN109394850A (en) | 2019-03-01 |
| CN109394850B CN109394850B (en) | 2021-06-29 |
Family
ID=65460939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811551622.8A Active CN109394850B (en) | 2018-12-17 | 2018-12-17 | Traditional Chinese medicine composition with skin aging delaying effect, aqueous extract and fermentation product of traditional Chinese medicine composition and application of traditional Chinese medicine composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109394850B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110559418A (en) * | 2019-09-29 | 2019-12-13 | 温州古木生物科技有限公司 | Traditional Chinese medicine composition with alopecia prevention effect and extract and application thereof |
| CN112546107A (en) * | 2019-09-10 | 2021-03-26 | 百岳特生物技术（上海）有限公司 | Use of bergamot fermented juice for preparing composition for improving skin aging |
| CN114344455A (en) * | 2022-01-19 | 2022-04-15 | 宝莱福健康科技研究(中山)有限公司 | Preparation method and application of anti-aging composition |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068606A (en) * | 2010-11-26 | 2011-05-25 | 新时代健康产业（集团）有限公司 | Wrinkle-removing and anti-wrinkle Chinese medicinal composition, preparation and preparation method thereof |
-
2018
- 2018-12-17 CN CN201811551622.8A patent/CN109394850B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068606A (en) * | 2010-11-26 | 2011-05-25 | 新时代健康产业（集团）有限公司 | Wrinkle-removing and anti-wrinkle Chinese medicinal composition, preparation and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘莎莎: "补益类中药抗衰老活性成分研究概况", 《湖南中医药大学学报》 * |
| 蒲秀瑛: "《抗衰老药物药理学概论》", 31 October 2015, 北京：军事医学科学出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112546107A (en) * | 2019-09-10 | 2021-03-26 | 百岳特生物技术（上海）有限公司 | Use of bergamot fermented juice for preparing composition for improving skin aging |
| CN110559418A (en) * | 2019-09-29 | 2019-12-13 | 温州古木生物科技有限公司 | Traditional Chinese medicine composition with alopecia prevention effect and extract and application thereof |
| CN110559418B (en) * | 2019-09-29 | 2022-02-01 | 温州古木生物科技有限公司 | Traditional Chinese medicine composition with alopecia prevention effect and extract and application thereof |
| CN114344455A (en) * | 2022-01-19 | 2022-04-15 | 宝莱福健康科技研究(中山)有限公司 | Preparation method and application of anti-aging composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109394850B (en) | 2021-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109394850A (en) | It is a kind of to have effects that the Chinese medicine composition of delay skin aging and its water extract and fermentation material and application | |
| CN107349302A (en) | It is a kind of that there is the Chinese medicine composition for repairing sensitive skin effect and its fermentate and application | |
| CN109394959A (en) | It is a kind of to have effects that repair the Chinese medicine composition of keratoderma and its water extract and fermentation material and application | |
| CN111067974A (en) | Chinese herbal medicine preparation for preventing African swine fever virus and preparation method thereof | |
| CN101574465B (en) | Special acne removal traditional Chinese medicine tincture for ladies | |
| CN111514161B (en) | Anti-oral ulcer preparation and application thereof | |
| CN111568947A (en) | Preparation method of traditional Chinese medicine dandruff-removing and itching-relieving agent | |
| CN103599455B (en) | Traditional Chinese medicine capsule for removing freckle | |
| CN109453327A (en) | A kind of Chinese medicine composition and its water extract and fermentation material and application with acne-removing | |
| CN1327830C (en) | Traditional Chinese medicine Babuji for treating arthritis, omitis and hyperosteogeny and its prepn. method | |
| CN103719542B (en) | Compound microorganism active additive and applications thereof | |
| CN108175801B (en) | Traditional Chinese medicine composition with chemical liver injury health care function and preparation method thereof | |
| CN113144115A (en) | Traditional Chinese medicine composition for treating verruca vulgaris and application thereof | |
| CN105535866A (en) | Medicine for treating hyperlipidemia and preparation method thereof | |
| CN102698202B (en) | Chinese medicinal composition for treating gall-stone and preparation method and application of Chinese medicinal composition | |
| CN101564499B (en) | Acne dispelling Chinese medicament tincture special for men | |
| CN112237604A (en) | Traditional Chinese medicine incense for reducing epidemic infection and preparation process thereof | |
| CN1582989A (en) | Medicine for hyperplasia of mammary glands and its preparation | |
| CN102406832B (en) | Chlorogenic acid ecological agent derived from arctium lappa L | |
| CN109331153A (en) | A kind of Medical-use cold compress gel and preparation method thereof for treating children's dermatitis and eczema | |
| CN109481366A (en) | It is a kind of to have effects that repair the Chinese medicine composition of skin sunburn and its water extract and fermentation material and application | |
| CN108721607A (en) | A kind of collagen-rich anti-senility oral liquid and preparation method thereof | |
| CN102764208A (en) | Formula and preparation method of anti-dandruff itching-relieving shampoo | |
| CN114796337A (en) | Compound phellodendron bark preparation and application thereof | |
| CN102488835B (en) | Preparation process for chlorogenic acid ecological preparation originating from Arctium lappa Linne leaves |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20190301 Assignee: Wenzhou Gumu Trading Co.,Ltd. Assignor: WENZHOU GUMU BIOTECHNOLOGY CO.,LTD. Contract record no.: X2022330000275 Denomination of invention: A traditional Chinese medicine composition with the effect of delaying skin aging, its water extract and fermentation and its application Granted publication date: 20210629 License type: Common License Record date: 20220706 |
|
| EE01 | Entry into force of recordation of patent licensing contract | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20190301 Assignee: Wenzhou Jiupai Technology Co.,Ltd. Assignor: WENZHOU GUMU BIOTECHNOLOGY CO.,LTD. Contract record no.: X2023330000507 Denomination of invention: A traditional Chinese medicine composition with the effect of delaying skin aging, its water extract and fermented substance, and its application Granted publication date: 20210629 License type: Common License Record date: 20230814 Application publication date: 20190301 Assignee: Wenzhou Sanzhiyan Technology Co.,Ltd. Assignor: WENZHOU GUMU BIOTECHNOLOGY CO.,LTD. Contract record no.: X2023330000506 Denomination of invention: A traditional Chinese medicine composition with the effect of delaying skin aging, its water extract and fermented substance, and its application Granted publication date: 20210629 License type: Common License Record date: 20230814 Application publication date: 20190301 Assignee: Wenzhou Zhichuang Information Technology Co.,Ltd. Assignor: WENZHOU GUMU BIOTECHNOLOGY CO.,LTD. Contract record no.: X2023330000505 Denomination of invention: A traditional Chinese medicine composition with the effect of delaying skin aging, its water extract and fermented substance, and its application Granted publication date: 20210629 License type: Common License Record date: 20230814 |