CN101574465B - Special acne removal traditional Chinese medicine tincture for ladies - Google Patents

Abstract

The invention relates to a special acne removal traditional Chinese medicine tincture for ladies, and is characterized in that each 100 volume parts of tincture contains 20 to 35 percent of ethanol extractive of composite traditional Chinese medicine raw materials and 0.05 to 5 parts of borneol according to parts by weight, wherein the composite traditional Chinese medicine raw materials include the following components: 10 to 60 parts of honeysuckle, 10 to 60 parts of china root, 10 to 60 parts of ginkgo, 10 to 50 parts of kuh-seng, 10 to 40 parts of angelica, 10 to 40 parts of atractylis ovata, 10 to 40 parts of red sage root, 10 to 40 parts of cortex moutan, 10 to 40 parts of radix scutellariae, 10 to 40 parts of glossy ganoderma and 10 to 40 parts of safflower. The tincture of the invention has fast and certain effect of treating the acne of ladies, has slight stimulation to skin and extremely low skin exuviation, and has no obvious toxic side effect. The technology of the tincture can guarantee the chemical stability of each component during production.

Description

A kind of acne Chinese medicine tincture of dispelling for ladies only

One, technical field

The present invention relates to a kind of medicine, particularly external used medicine, specifically a kind of Chinese medicine tincture of treatment acne for ladies only.

Two, background technology

Acne are called " skin sore ", " acne " again, are commonly called as " comedo ", are the chronic inflammatory diseases of a kind of skin follicle, sebaceous gland, good sending out in adolescence.Modern medicine is called that " acne vulgaris hinders the capacitive dermatosis for teenager is modal, not only influence attractive in appearancely, deals with improperly and also can leave over little concavity cicatrix.Main clinical manifestation is hoary hair and blackhead, pimple, pustule, tuberosity and cyst.

Doctor trained in Western medicine it is generally acknowledged: the adolescence androgen secretion increases, and causes the sebaceous gland enlargement, and smegma increases, and makes hair follicle, sebaceous gland conduit keratinization thromboembolism simultaneously, and sebum deposits and forms the fat bolt in hair follicle.Under anaerobic environment; The a large amount of hypertrophy breedings of anaerobe such as propionibacterium acnes, staphylococcus aureus, pityrosporum furfur produce fat dissolving enzyme, separate sebum and produce free acid; Hair follicle stimulating causes inflammation; Hair follicles wall damage is broken, and the sebum of alluvial gets into intradermal, thus start degree around the hair follicle that possibly participate in by IL-1 (interleukin-1) do not wait the inflammation cascade reaction.In addition; Immunoreation, heredity, dyshormonia (androgen secretion too much or target organ androgen sensitivity is increased), greasiness polysaccharide and zest diet, high temperature and some chemical factor are all participated in the whole pathogenic process of acne, and also have certain influencing each other between these factors.The traditional Chinese medical science it is generally acknowledged: wind and heat in the lung meridian, the intestines and stomach are damp and hot, dysfunction of the spleen in transportation is the etiology and pathology that acne produce.

The clinical treatment method is various, generally based on its mechanism of production, from Bergamot Mint Extract, anti-epidermis cell dyskeratosis, degerming, anti-inflammatory, antiallergic, antioxidation, invigorate blood circulation and the treatment of starting with of aspects such as careful pore, anti-pigmentation, dark scar reparation.

Therapeutic modality commonly used at present has:

1, the psychotherapy improves patient's quality of life.

2, Drug therapy

(1) the for example oral isotretinoin class of oral drug therapy medicine

(2) local external use treats like benzoyl peroxide, tretinoin medicine, salicylic acid, Chinese medicine compound lotion, tincture, facial film, cream frost etc.

3, naturopathy

To kill the narrow spectrum blue light therapy electrostatic therapeutic apparatus treatment that anaerobe such as causing Propiobacterium is started with.

No matter Ms and man's skin is on the anatomical structure or on the physiological function, and significant difference is all arranged.Usually performance has following six aspects:

(1) Ms's dermal layer of the skin is thin and skin epidermis is slightly thick, and the man is then opposite;

(2) the Ms's skin surface bacterial species and quantity of carrying is few than the man;

(3) secretion of Ms's perspiration and lactic acid is few than the man, and the skin surface pH value is higher;

(4) average little than the man of Ms's sebaceous gland body of gland, fat secretion is few relatively;

(5) Ms's pore is careful relatively;

(6) in immunoreation, during Ms's skin wound healing inflammatory reaction than the man a little less than, healing time also will be lacked relatively.

Three, summary of the invention

The present invention aims to provide a kind of acne Chinese medicine tincture of dispelling for ladies only, and technical problem to be solved is that the Chinese medicine of selecting compatibility is processed into tincture.

Technical scheme of the present invention is the ethanol extraction that contains the former material of 20～35 weight portion herbal mixtures in per 100 parts by volume tinctures, 0.05～5 weight portion Borneolum Syntheticum.The former material of described herbal mixture has each component of following weight portion:

10～50 parts of 10～60 parts of Radix Sophorae Flavescentiss of 10～60 portions of Semen Ginkgoes of 10～60 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae

10～40 parts of 10～40 parts of Cortex Moutans of 10～40 parts of Radix Salviae Miltiorrhizaes of 10～40 parts of Rhizoma Atractylodis Macrocephalaes of Radix Angelicae Sinensis

10～40 parts on 10～40 parts of Flos Carthamis of 10～40 portions of Ganodermas of Radix Scutellariae

Contain ethanol extraction, the 1 weight portion Borneolum Syntheticum of the former material of 25 weight portion herbal mixtures in preferred per 100 parts by volume tinctures, the former material of described herbal mixture has each component of following weight portion:

25 parts of 30 parts of Radix Sophorae Flavescentiss of 30 portions of Semen Ginkgoes of 30 parts of Rhizoma Smilacis Glabraes of Flos Lonicerae

20 parts of 20 parts of Cortex Moutans of 20 parts of Radix Salviae Miltiorrhizaes of 20 parts of Rhizoma Atractylodis Macrocephalaes of Radix Angelicae Sinensis

20 parts on 20 parts of Flos Carthamis of 20 portions of Ganodermas of Radix Scutellariae

Parts by volume is got liter (L) or milliliter (ml), and weight portion is got kilogram (kg) or gram (g).

This tincture uses infusion process to prepare, and can certainly prepare with other known dilution methods or percolation.

Infusion process is exactly that the former material of the herbal mixture of proportional quantity was pulverized 40～60 mesh sieves, in airtight container, floods 5～7 days, regularly stirs once.Dipping finishes the back and separates waste, in filtrating, adds Borneolum Syntheticum, regulates pH value and ethanol content by the pharmacopeia regulation at last.

Dilution method is exactly the fluid extract of the former material of herbal mixture behind extraction, precipitation of getting proportional quantity, uses ethanol dilution, separates waste, adds Borneolum Syntheticum filtrating, stipulates to regulate pH value and ethanol content by pharmacopeia at last.

Percolation is exactly at first to add ethanol after the former material of the herbal mixture of proportional quantity is pulverized to make it moistening, in the percolator of packing into behind the airtight certain hour, adds ethanol infiltration medicated powder and collects this tincture of percolate reprocessing.

The present invention generates inducement, pathology and Ms's skin characteristics according to acne, preferably has composite the forming of several kinds of Chinese medicinal materials of effects such as anti-epidermis cell dyskeratosis, Bergamot Mint Extract, degerming, anti-inflammatory allergy, removing free radical and light speckle.Promote microcirculatory Chinese medicine in addition; The natural skin penetrating agents such as fatty acid that utilize Borneolum Syntheticum to combine Chinese medicine self to contain; Active constituents of medicine is sent to a plurality of action target spots such as keratodermatitis, epidermal area, skin corium and subcutaneous tissue stage by stage, at many levels, provide a kind of safe, dispel the product of acne fast.

These article are applied to Ms's acne treatment, and carry out controlled observation with our company's " ZEPING FENCI LIXIAOJING " (universal), and clinical test results is following:

One, physical data: 120 example checking patients are outpatient service acne female patient, and wherein 60 examples are organized in checking, matched group 40 examples.

Checking is organized in 60 examples: 15～25 years old 27 age example, 25～40 years old 33 example; Clinical grading I degree 15 examples, II degree 36 examples, III degree 9 examples, IV degree 0 example.

In matched group 40 examples: 15～25 years old 18 age example, 25～40 years old 22 example; Clinical grading I degree 12 examples, II degree 22 examples, III degree 6 examples, IV degree 0 example.

Treatment group and matched group are at sex, age, Clinical typing, and through statistical procedures, P＞0.05 has comparability.

Two, case is selected

1, diagnostic criteria:

I degree (slightly), blackhead is distributed to multiple struvite erythra, distributes.

II degree (medium degree), I degree+shallow in the property pustule, the struvite erythra a few days increases, and is confined to face.

III degree (severe), II degree+, betide face, cervical region, chest and back deeply in the struvite erythra of property.

IV degree (severe-collection bunch property), III degree+cyst is prone to form cicatrix, betides above the waist.

2, MethodsThe cases enrolled standard:

All selected cases all meet above diagnostic criteria.

3, get rid of the case standard:

The person that do not meet the inclusion criteria, or the acneform eruptions that causes of some drugs;

Merge to have the inclination, liver, renal function injury person, the psychotic;

Test in the last week or in the process of the test and take or be coated with similar medicine person outward;

, can't not judge that curative effect or data are not congruent, affect the treatment or safety judgement person by the regulation medication.

Three, Therapeutic Method:

By 1: 1 pair principle, each 40 example of checking group and matched group, the checking group enlarges 20 examples, totally 100 examples.Checking group: use these article.Matched group: use ZEPING FENCI LIXIAOJING (plain edition)

The course of treatment: both continuous uses 15 days were 1 course of treatment, and meter is observed 2 courses of treatment.

Four, curative effect judging standard:

1, recovery from illness: inflammation disappears, wound healing, and deflorescence leaves temporary pigmentation spots.

2, produce effects: inflammation disappears, and wound healing is more than 70%, deflorescence 70% or more or rising twice.

3, effective: inflammation disappears more than 30%, and deflorescence is more than 30%, and pain, pruritus alleviate or once rise.

4, invalid: erythra changes not obvious or increases the weight of.

Five, therapeutic outcome:

1, clinical efficacy

Table 1 checking group and matched group Comparison of therapeutic

Can be known that by last table the clinical total effective rate of these article is 96.67%, matched group is 92.5%, both statistical procedures, P＞0.05; It is 91.67% that total obvious effective rate is organized in checking, and matched group is 75%, X ²=5.23, P＜0.05, significant difference.

Four, the specific embodiment

With the infusion process is example, and non-limiting examples is narrated as follows:

Extracting honeysuckle 300g, Rhizoma Smilacis Glabrae 300g, Semen Ginkgo 300g, Radix Sophorae Flavescentis 250g, Radix Angelicae Sinensis 200g, Rhizoma Atractylodis Macrocephalae 200g, Radix Salviae Miltiorrhizae 200g, Flos Carthami 200g, Radix Scutellariae 200g, Ganoderma 200g, Cortex Moutan 150g mix and pulverized 40～60 mesh sieves.The former material powder of compound recipe is dropped in the diffuser, add 75% (concentration expressed in percentage by volume) ethanol, amount of alcohol covers medicine, and airtight dipping 7 days is every other day stirred once.Isolated by filtration.To 7500ml, add Borneolum Syntheticum 100g with 65% ethanol dilution, regulate pH value 5, ethanol content 70%.

Claims (1)

1. acne Chinese medicine tincture of dispelling for ladies only; It is characterized in that: contain in every 7500mL tincture ten simply the former material of herbal mixture with the airtight dipping of concentration expressed in percentage by volume 75% ethanol 7 days; Isolated by filtration and with 65% ethanol dilution to 7500ml, adding 100g Borneolum Syntheticum; Regulate pH value 5, ethanol content 70%, described ten simply the former material of herbal mixture and weight thereof be:

Flos Lonicerae 300g Rhizoma Smilacis Glabrae 300g Semen Ginkgo 300g Radix Sophorae Flavescentis 250g

Radix Angelicae Sinensis 200g Rhizoma Atractylodis Macrocephalae 200g Radix Salviae Miltiorrhizae 200g Cortex Moutan 150g

Radix Scutellariae 200g Ganoderma 200g Flos Carthami 200g.