CN110559418A - Traditional Chinese medicine composition with alopecia prevention effect and extract and application thereof - Google Patents
Traditional Chinese medicine composition with alopecia prevention effect and extract and application thereof Download PDFInfo
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- CN110559418A CN110559418A CN201910930934.8A CN201910930934A CN110559418A CN 110559418 A CN110559418 A CN 110559418A CN 201910930934 A CN201910930934 A CN 201910930934A CN 110559418 A CN110559418 A CN 110559418A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Abstract
The invention relates to the technical field of traditional Chinese medicine compositions for preventing alopecia, and particularly relates to a traditional Chinese medicine composition with an alopecia preventing effect, and an extract and application thereof. In order to achieve the aim of preventing alopecia, the invention takes the theory of the traditional Chinese medicine in China as guidance, screens the traditional Chinese medicine composition through a large number of long-term experiments, combines the salvia miltiorrhiza, the astragalus, the polygonum multiflorum, the radix pseudostellariae, the rehmannia, the glossy privet fruit, the cacumen biotae, the pawpaw, the codonopsis pilosula, the dried ginger, the cortex dictamni, the moutan bark, the liquorice, the blackberry lily and the gentian according to monarch, minister, assistant and guide compatibility to obtain the extract of the traditional Chinese medicine and the extract prepared by fermenting the composition by yeast, can enable the efficacy of each traditional Chinese medicine to generate synergistic effect, can directly act on scalp, is simple and safe to use, has mild effect of repairing scalp hair follicle injury, increasing scalp nutrition absorption and nourishing.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine compositions for preventing alopecia, and particularly relates to a traditional Chinese medicine composition with an alopecia preventing effect, and an extract and application thereof.
background
according to the 'alopecia population survey' published by the Chinese health promotion and education Association 2016, the results show that the Chinese alopecia population is about 2.5 hundred million, mainly between 20 and 40 years old, develops fastest about 30 years old, and is 20 years earlier than the alopecia age of the previous generation. Alopecia has become a common disease and a frequently-occurring disease in the clinical department of dermatology, and is also one of intractable diseases. The etiology of hair loss is generally thought to be related to the following factors: heredity, sex hormone balance disorder, sebaceous gland hypersecretion, sleep deficiency, long-term stress, stress and anxiety, etc. The disease affects the beauty and brings great psychological burden to patients.
The existing method for treating alopecia mainly comprises surgical hair transplantation, and medicinal treatment comprises finasteride, minoxidil and the like. The treatment methods have the defects of high risk in the operation process, high price, inconvenient operation, obvious side effect in long-term use of the medicine, easy generation of tolerance and the like. The invention can extract the traditional Chinese medicine composition with the anti-hair loss effect or extract the traditional Chinese medicine composition after fermentation and add the traditional Chinese medicine composition into medicines or cosmetics, and produce products which can be used for a long time, are safe and effective, are convenient to operate and have the functions of nourishing scalp and preventing hair loss.
Disclosure of Invention
In order to solve the problems of the prior art, the invention provides a traditional Chinese medicine composition with an anti-hair loss effect, an extract and an application thereof.
The technical scheme adopted by the invention is as follows:
A traditional Chinese medicine composition with an anti-hair loss effect comprises the following components in parts by mass: 70-100 parts of salvia miltiorrhiza, 70-100 parts of astragalus membranaceus, 70-100 parts of polygonum multiflorum, 70-100 parts of radix pseudostellariae, 70-100 parts of rehmannia, 70-100 parts of glossy privet fruit, 60-80 parts of cacumen biotae, 60-80 parts of pawpaw, 60-80 parts of codonopsis pilosula, 50-70 parts of dried ginger, 50-70 parts of cortex dictamni, 50-70 parts of moutan bark, 50-70 parts of liquorice, 10-30 parts of blackberrylily rhizome and 10-30 parts of gentian.
A traditional Chinese medicine composition extract is prepared by adding 5 times of pure water by weight into the traditional Chinese medicine composition, placing the traditional Chinese medicine composition into a decocting machine, extracting for 1.5h at 95-100 ℃, supplementing volatilized lost water, adding 5 times of ethanol with the purity of 95% by weight, sealing and standing for 15-30 days, filtering, and supplementing lost pure water and ethanol to the added amount to obtain a filtrate.
A fermentation extract of a traditional Chinese medicine composition is an initial system obtained by mixing the traditional Chinese medicine composition and zymophyte, 5 times of pure water by weight is added, a fermented product obtained by fermentation is placed in a decocting machine and extracted for 1.5 hours at the temperature of 95-100 ℃, ethanol with the purity of 95% by weight is added after the water lost by volatilization is supplemented, the mixture is sealed and kept stand for extraction for 15-30 days, and the lost pure water and ethanol are supplemented to the added amount after filtration to obtain a filtrate.
the zymocyte is saccharomycete, and the high-activity dry yeast is added into the traditional Chinese medicine composition according to 70-100 parts by mass.
in the fermentation step, the temperature is 25-45 ℃ and the time is 24-72 h.
An application of the extract of Chinese-medicinal composition in preparing the medicines or cosmetics for preventing and treating the diseases caused by diabetes is disclosed, which is prepared from the extract of Chinese-medicinal composition (1-100 wt.%).
An application of fermented extract of Chinese medicine composition is disclosed, which is proportionally mixed with medicine or cosmetics in 1-100 wt%.
Salvia miltiorrhiza, according to the "Chinese pharmacopoeia" 2015 edition 77 page of the national pharmacopoeia committee of the 6 th 1 st edition of the Chinese medical science and technology publishing company 2015, has the following effects: promoting blood circulation, dispelling blood stasis, dredging meridians, relieving pain, clearing away heart-fire, relieving restlessness, cooling blood, and eliminating carbuncle. According to the records on page 558 of the traditional Chinese medicine dictionary compiled by Nanjing university of traditional Chinese medicine of 6.2 th edition in Shanghai science and technology Press, the Salvia miltiorrhiza Bunge has the effects of anticoagulation, antithrombotic, anti-inflammatory, antiallergic, antioxidation and the like.
Astragalus membranaceus has the following effects according to the records of the first 302 pages of the national pharmacopoeia 2015 edition, which is compiled by the national pharmacopoeia committee of the 6 th 1 st edition of the published chinese medical science 2015: invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, inducing diuresis, relieving swelling, promoting fluid production, nourishing blood, removing stagnation, relieving arthralgia, expelling toxin, expelling pus, healing sore, and promoting granulation. According to records on page 2437 of traditional Chinese medicine dictionary, 6 th edition 2 nd edition of Shanghai science and technology Press, Nanjing university of traditional Chinese medicine, 2014, radix astragali has the effects of delaying aging, resisting thrombus, resisting virus, resisting oxidation, resisting inflammation, relieving pain and the like.
Polygonum multiflorum, according to the "Chinese pharmacopoeia" 2015 edition 176 page, which is written by the national pharmacopoeia committee of 6 months 1 edition 2015 of Chinese medical science and technology publishing house, has the following effects: detoxify, cure abscess, check malaria, moisten intestines to relieve constipation. According to records on page 1375 of traditional Chinese medicine dictionary, 6 th edition of Shanghai science and technology Press 2014, 2 nd edition of Nanjing university of traditional Chinese medicine, Polygonum multiflorum has the effects of reducing blood fat, resisting atherosclerosis, delaying aging, enhancing immunity, resisting genetic injury, resisting inflammation, relieving pain and the like.
Radix pseudostellariae has the following effects according to the 68 pages in the first part of the 2015 edition of the Chinese pharmacopoeia (national pharmacopoeia) which is edited by the national pharmacopoeia committee of the 1 st edition of 6 months in 2015 of the Chinese medical science and technology publishing company: to replenish qi, invigorate the spleen, promote the production of body fluid and moisten the lung. Can be used for treating spleen deficiency, asthenia, and deficiency of both qi and yin. According to the records on page 463 of traditional Chinese medicine dictionary, which is edited by Nanjing university of traditional Chinese medicine in 6 th edition, 2014, Shanghai science and technology publishing company, the radix pseudostellariae decoction prolongs the average life and the maximum life of fruit flies, and has the effect of delaying aging.
Dried rehmannia root, according to 125 pages of the national pharmacopoeia 2015 edition, which is written by the national pharmacopoeia committee of 6 months 1 st edition in 2015 of the pharmaceutical science publishing house, has the following effects: clearing away heat and cooling blood, nourishing yin and promoting the production of body fluid. Can be used for treating heat entering nutrient-blood, and macula due to warm toxicity. Dried rehmannia root has the functions of improving immunity, regulating endocrine and the like according to the record on page 3133 of traditional Chinese medicine dictionary compiled by Nanjing university of traditional Chinese medicine of 6 th edition, 2014, Shanghai science and technology Press.
fructus ligustri lucidi, according to 46 pages of the national pharmacopoeia 2015 edition, which is compiled by the national pharmacopoeia committee of 6 months 1 st edition of 2015 by the chinese medical science and technology publishing company, has the following effects: nourishing liver and kidney, improving eyesight and blackening hair. According to the records on page 281 of Chinese medicine dictionary, 6 th edition 2 nd edition of Shanghai science and technology Press, Nanjing Chinese medicine university, fructus Ligustri Lucidi has effects of resisting inflammation, promoting immunity, inhibiting allergy, and resisting female hormone.
Biota orientalis has the following effects according to the description on 216 pages in the first part of the 2015 edition of the Chinese pharmacopoeia 2015, which is edited by the national pharmacopoeia committee of 6 months 1 st edition of the Chinese medical science and technology publishing company 2015: cool blood to stop bleeding, resolve phlegm to stop cough, promote hair growth and blacken hair. According to the record on page 1674 of the traditional Chinese medicine dictionary compiled by Nanjing university of traditional Chinese medicine of 6.2 th edition in 2014, the Chinese arborvitae twig has the functions of stopping bleeding, resisting pathogenic microorganisms, calming and the like.
Pawpaw, according to the Chinese pharmacopoeia 2015, which is edited by the national pharmacopoeia committee of 1 st edition of 6 months in 2015 of the Chinese medical science and technology publishing house, has the following effects: relaxing tendons and activating collaterals, regulating stomach function and eliminating dampness. According to the records on page 412 of the traditional Chinese medicine dictionary, which is compiled by Nanjing university of traditional Chinese medicine in 6.2 th edition of Shanghai science and technology Press, the pawpaw has the effects of inhibiting inflammation, enhancing immunity, resisting bacteria and the like.
Codonopsis pilosula, according to 282 pages of the first part of the 2015 edition of "Chinese pharmacopoeia" edited by the national pharmacopoeia committee of 1 st edition of 6 months in 2015 of Chinese pharmaceutical science and technology publishing house, the following effects are recorded: to invigorate the spleen, benefit the lung, nourish blood and promote the production of body fluid. Can be used for treating deficiency of qi of spleen and lung, deficiency of qi and blood, and sallow complexion. According to the record of 2235 page of traditional Chinese medicine dictionary of Nanjing university of traditional Chinese medicine, 6 th edition, 2014, Shanghai science and technology Press, radix Codonopsis has effects of enhancing stress ability, enhancing immunity, and delaying aging.
Dried ginger has the following effects according to 15 pages of the first part of the 2015 edition of "chinese pharmacopoeia" 2015 edition, which is compiled by the national pharmacopoeia committee of the 1 st edition of 6 months in 2015 of chinese medical science and technology publishing company: warming the middle energizer to dispel cold, restoring yang to activate collaterals, warming the lung to resolve retained fluid. According to the records on page 86 of the Chinese medicinal dictionary compiled by Nanjing Chinese medicinal university at 6 th edition of 2014, Shanghai science and technology Press, rhizoma Zingiberis has effects of tranquilizing, anticoagulating blood, resisting anoxia, resisting inflammation, and relieving pain.
The dittany bark has the following effects according to 110 pages of the first part of the 2015 edition of the Chinese pharmacopoeia (Chinese pharmacopoeia) which is edited by the national pharmacopoeia committee of the 1 st edition of 6 months in 2015 of Chinese medical science and technology publishing company: clear heat and dry dampness, dispel wind and remove toxicity. According to the records on page 882 of the traditional Chinese medicine dictionary compiled by Nanjing traditional Chinese medicine university at 6.2 th edition of Shanghai science and technology Press 2014, the cortex dictamni has the effects of resisting bacteria, enhancing the immune function, stopping bleeding and the like.
Moutan bark, according to the first 172 pages of "chinese pharmacopoeia" 2015 edition, published by the national pharmacopoeia committee of 6 months 1 edition 2015 of chinese medical science and technology publishing house, has the following effects: clear heat and cool blood, activate blood and resolve stasis. According to the records on page 1367 of the Chinese medicinal dictionary compiled by Nanjing Chinese medicinal university at 6.2 th edition of Shanghai science and technology Press, cortex moutan has anticoagulant, antiinflammatory, and immunity enhancing effects.
Licorice root, according to the Chinese pharmacopoeia 2015, published by the national pharmacopoeia committee of 1 st edition of 6 months in 2015, the first 87 pages of which have the following effects: tonify spleen and qi, remove heat and toxic materials, relieve spasm and pain, and harmonize the drugs. According to the records on page 685 of traditional Chinese medicine dictionary, 6 th edition 2 nd edition of Nanjing university of traditional Chinese medicine, Shanghai science and technology Press, Glycyrrhiza uralensis has the effects of resisting microorganisms, adrenocortical hormone-like, resisting inflammation, resisting oxidation, removing toxic substances, etc.
blackberrykiky has the following effects according to 285 pages of the first part of the national pharmacopoeia 2015 edition, which is compiled by the national pharmacopoeia committee of 6 th 1 st edition in 2015 of the pharmaceutical science publishing company: clearing away heat and toxic material. Can be used for treating heat-toxin, phlegm-fire, and sore throat. Belamcanda chinensis has the effects of resisting inflammation, resisting allergy, resisting microorganisms, and being like female hormone according to the record of the Chinese medicinal dictionary on page 2305 of Nanjing Chinese medicinal university, 6.6.2 edition, Shanghai science and technology Press 2014.
Gentiana, according to the "chinese pharmacopoeia" 2015 edition 96 page of the national pharmacopoeia committee of the 1 st edition of 6 months in 2015 of chinese medical science and technology publishing house, the following effects are described: clear heat and dry dampness, purge liver and gallbladder fire. Can be used for treating jaundice due to damp-heat pathogen, eczema, pruritus, and conjunctival congestion due to liver fire. According to the records of the traditional Chinese medicine dictionary on page 754 of Nanjing traditional Chinese medicine university, 6.2 th edition, 2014, the aqueous extract of gentian is administrated before sensitization and before and after attack, is similar to cortical hormone, can obviously inhibit mouse delayed type hypersensitivity caused by picryl chloride, and has antiallergic effect.
The technical scheme provided by the invention has the beneficial effects that:
In order to achieve the aim of preventing alopecia, the invention takes the theory of the traditional Chinese medicine in China as guidance, screens the traditional Chinese medicine composition through a large number of long-term experiments, combines the salvia miltiorrhiza, the astragalus, the polygonum multiflorum, the radix pseudostellariae, the rehmannia, the glossy privet fruit, the cacumen biotae, the pawpaw, the codonopsis pilosula, the dried ginger, the cortex dictamni, the moutan bark, the liquorice, the blackberry lily and the gentian according to monarch, minister, assistant and guide compatibility to obtain the extract of the traditional Chinese medicine and the extract prepared by fermenting the composition by yeast, can enable the efficacy of each traditional Chinese medicine to generate synergistic effect, can directly act on scalp, is simple and safe to use, has mild effect of repairing scalp hair follicle injury, increasing scalp nutrition absorption and nourishing.
The extract and the fermented extract of the traditional Chinese medicine composition have wide application range, are safe and effective, can be used for a long time, are well compatible with most of medicine or cosmetic raw materials, have simple process when being added into the medicine or the cosmetic, and are suitable for industrial production.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the following detailed description is further provided in conjunction with the embodiments.
Example 1: is the application of the extract of the traditional Chinese medicine composition in the scalp care essence.
Preparing an extract of the traditional Chinese medicine composition: weighing 100g of salvia miltiorrhiza, 100g of astragalus, 100g of polygonum multiflorum, 100g of radix pseudostellariae, 100g of rehmannia, 100g of glossy privet fruit, 80g of cacumen biotae, 80g of pawpaw, 80g of codonopsis pilosula, 70g of rhizoma zingiberis, 70g of cortex dictamni, 70g of moutan bark, 70g of liquorice, 30g of blackberry lily and 30g of gentian, cleaning, packaging with a sterilized gauze bag, putting into a decocting machine, adding 5 times of pure water according to the weight of the traditional Chinese medicine composition, extracting for 1.5 hours at 100 ℃, supplementing volatile lost water, adding 95% ethanol in an amount which is 5 times of the weight of the traditional Chinese medicine composition, sealing and standing for 30 days, filtering to obtain filtrate, and supplementing lost pure water and ethanol to the added amount to obtain the extract of the traditional Chinese medicine composition.
The formula of the extract scalp care essence containing 98.46 wt% of the traditional Chinese medicine composition is shown in table 1:
TABLE 1
the components of the formulation of table 1 were prepared according to the following process:
(1) Mixing and stirring 5 components in the phase A until the components are completely dissolved;
(2) Stirring and adding the phase B until all the components are uniformly mixed and completely dissolved, and discharging.
Example 2: is the application of the extract of the traditional Chinese medicine composition in scalp care moisturizing water.
Preparing an extract of the traditional Chinese medicine composition: weighing 70g of salvia miltiorrhiza, 70g of astragalus, 70g of polygonum multiflorum, 70g of radix pseudostellariae, 70g of rehmannia, 70g of glossy privet fruit, 60g of cacumen biotae, 60g of pawpaw, 60g of codonopsis pilosula, 50g of rhizoma zingiberis, 50g of cortex dictamni, 50g of moutan bark, 50g of liquorice, 10g of blackberry lily and 10g of gentian, cleaning, packaging with a sterilized gauze bag, putting into a decocting machine, adding 5 times of pure water according to the weight of the traditional Chinese medicine composition, extracting for 1.5 hours at 100 ℃, supplementing volatile lost water, adding 95% ethanol in an amount which is 5 times of the weight of the traditional Chinese medicine composition, sealing and standing for 15 days, filtering to obtain filtrate, and supplementing lost pure water and ethanol to the added amount to obtain the extract of the traditional Chinese medicine composition.
the formula of the extract scalp care moisturizing lotion containing 30 wt% of the traditional Chinese medicine composition is shown in table 2:
TABLE 2
The components of the formulation of table 2 were prepared according to the following process:
(1) mixing and stirring 7 components in the phase A until the components are completely dissolved;
(2) Stirring and adding the phase B until all the components are uniformly mixed and completely dissolved, and discharging.
example 3: is the application of the traditional Chinese medicine composition in the amino acid hair loss preventing shampoo.
preparing an extract of the traditional Chinese medicine composition: weighing 90g of salvia miltiorrhiza, 90g of astragalus, 90g of polygonum multiflorum, 90g of radix pseudostellariae, 90g of rehmannia, 90g of glossy privet fruit, 70g of cacumen biotae, 70g of pawpaw, 70g of codonopsis pilosula, 60g of dried ginger, 60g of cortex dictamni, 60g of moutan bark, 60g of liquorice, 20g of blackberry lily and 20g of gentian, cleaning, packaging with a sterilized gauze bag, putting into a decocting machine, adding 5 times of pure water according to the weight of the traditional Chinese medicine composition, extracting for 1.5 hours at 100 ℃, supplementing volatile lost water, adding 95% ethanol in an amount which is 5 times of the weight of the traditional Chinese medicine composition, sealing and standing for 20 days, filtering to obtain filtrate, and supplementing lost pure water and ethanol to the added amount to obtain the extract of the traditional Chinese medicine composition.
the formula of the amino acid anti-hair loss shampoo containing 15 wt% of the Chinese medicinal composition is shown in table 3:
TABLE 3
the components of the formulation of table 3 were prepared according to the following process:
(1) Mixing and stirring the components of the phase A until the components are completely dissolved, and heating to 82 ℃;
(2) mixing the components of phase B, heating to 82 ℃, and uniformly stirring;
(3) Adding phase A into phase B, stirring, cooling to 70 deg.C, sequentially adding phase C, stirring for dissolving, stirring, cooling to 40 deg.C, and discharging.
example 4: is the application of the fermented extract of the traditional Chinese medicine composition in the scalp care essence.
Preparing a fermentation extract of the traditional Chinese medicine composition: weighing 100g of salvia miltiorrhiza, 100g of astragalus, 100g of polygonum multiflorum, 100g of radix pseudostellariae, 100g of rehmannia, 100g of glossy privet fruit, 80g of cacumen biotae, 80g of pawpaw, 80g of codonopsis pilosula, 70g of dried ginger, 70g of cortex dictamni, 70g of moutan bark, 70g of liquorice, 30g of blackberry lily and 30g of gentian, cleaning, placing in a fermentation tank, adding 100g of high-activity dry yeast and 5 times of pure water by weight, fermenting at 36 ℃ for 48 hours, placing in a decocting machine, extracting at 100 ℃ for 1.5 hours, supplementing volatile lost water, adding 95% ethanol by weight which is 5 times of the weight of the traditional Chinese medicine composition, sealing and standing the mixture for 30 days, filtering to obtain filtrate, and supplementing lost pure water and ethanol to the added amount to obtain the fermented extract of the traditional Chinese medicine composition.
the formula of the fermented extract scalp care essence containing 98.46 wt% of the traditional Chinese medicine composition is shown in table 1:
TABLE 4
Table 4 the ingredients in the formulation were prepared according to the following process:
(1) Mixing and stirring 5 components in the phase A until the components are completely dissolved;
(2) Stirring and adding the phase B until all the components are uniformly mixed and completely dissolved, and discharging.
example 5: is the application of the fermented extract of the traditional Chinese medicine composition in scalp care moisturizing water.
Preparing a fermentation extract of the traditional Chinese medicine composition: weighing 70g of salvia miltiorrhiza, 70g of astragalus, 70g of polygonum multiflorum, 70g of radix pseudostellariae, 70g of rehmannia, 70g of glossy privet fruit, 60g of cacumen biotae, 60g of pawpaw, 60g of codonopsis pilosula, 50g of dried ginger, 50g of cortex dictamni, 50g of moutan bark, 50g of liquorice, 10g of blackberry lily and 10g of gentian, cleaning, placing in a fermentation tank, adding 80g of high-activity dry yeast and 5 times of pure water by weight, fermenting at 40 ℃ for 24h, placing in a decocting machine, extracting at 100 ℃ for 1.5h, supplementing volatile lost water, adding 95% ethanol by weight which is 5 times of the weight of the traditional Chinese medicine composition, sealing and standing the mixture for 15 days, filtering to obtain filtrate, and supplementing lost pure water and ethanol to the added amount to obtain the fermented extract of the traditional Chinese medicine composition.
The formula of the scalp care moisturizing lotion containing 30 wt% of the fermented extract of the traditional Chinese medicine composition is shown in table 2:
TABLE 5
The components of the formulation of table 5 were prepared according to the following procedure:
(1) mixing and stirring 7 components in the phase A until the components are completely dissolved;
(2) Stirring and adding the phase B until all the components are uniformly mixed and completely dissolved, and discharging.
Example 6: is the application of the fermented extract of the traditional Chinese medicine composition in the amino acid anti-hair loss shampoo.
Preparing a fermentation extract of the traditional Chinese medicine composition: weighing 90g of salvia miltiorrhiza, 90g of astragalus, 90g of polygonum multiflorum, 90g of radix pseudostellariae, 90g of rehmannia, 90g of glossy privet fruit, 70g of cacumen biotae, 70g of pawpaw, 70g of codonopsis pilosula, 60g of dried ginger, 60g of cortex dictamni, 60g of moutan bark, 60g of liquorice, 20g of blackberry lily and 20g of gentian, cleaning, placing in a fermentation tank, adding 90g of high-activity dry yeast and 5 times of pure water by weight, fermenting at 28 ℃ for 72 hours, placing in a decocting machine, extracting at 100 ℃ for 1.5 hours, supplementing volatile lost water, adding 95% ethanol by weight which is 5 times of the weight of the traditional Chinese medicine composition, sealing and standing for 20 days, filtering to obtain filtrate, and supplementing lost pure water and ethanol to the added amount to obtain the fermented extract of the traditional Chinese medicine composition.
The formula of the fermented extract amino acid anti-hair loss shampoo containing 15 wt% of the traditional Chinese medicine composition is shown in table 6:
TABLE 6
The components of the formulation of table 6 were prepared according to the following procedure:
(1) Mixing and stirring the components of the phase A until the components are completely dissolved, and heating to 82 ℃;
(2) Mixing the components of phase B, heating to 82 ℃, and uniformly stirring;
(3) Adding phase A into phase B, stirring, cooling to 70 deg.C, sequentially adding phase C, stirring for dissolving, stirring, cooling to 40 deg.C, and discharging.
test example 1:
(1) according to Hamilton typing (Hamilton-Norwood typing), 50 male testers with alopecia degrees of 2-5 grades are randomly selected, the age is 50-70 years, and the scalp care essence liquid in the embodiment 1 is used.
(2) The using method comprises the following steps: the product of the invention is uniformly smeared on scalp and can be naturally absorbed, and the product is used once in the morning and at night and is continuously used for ninety days.
(3) Effect judgment standard and experimental result:
The effect is shown: the alopecia condition is obviously improved, and the alopecia amount is obviously reduced. 15 persons, the proportion is 30%.
The method has the following advantages: the alopecia condition is improved, and the alopecia amount is reduced but not obvious. 29 persons, accounting for 58 percent.
and (4) invalidation: the alopecia condition is not improved, and the alopecia amount is not reduced. 6 persons, accounting for 12 percent.
Test example 2:
(1) According to Hamilton typing (Hamilton-Norwood typing), 50 female testers with the hair loss degree of 1-4 grades are randomly selected, the age is 25-50 years, and the scalp care moisturizing lotion in the embodiment 2 is used.
(2) The using method comprises the following steps: the product of the invention is uniformly smeared on scalp and can be naturally absorbed, and the product is used once in the morning and at night and is continuously used for ninety days.
(3) Effect judgment standard and experimental result:
The effect is shown: the alopecia condition is obviously improved, and the alopecia amount is obviously reduced. 10 people, accounting for 20 percent.
The method has the following advantages: the alopecia condition is improved, and the alopecia amount is reduced but not obvious. 30 persons, accounting for 60 percent.
And (4) invalidation: the alopecia condition is not improved, and the alopecia amount is not reduced. 10 people, accounting for 20 percent.
test example 3:
(1) According to Hamilton typing (Hamilton-Norwood typing), 50 male testers with the hair loss degree of 1-4 grades are randomly selected, the age is 25-50 years, and the amino acid anti-hair loss shampoo in the embodiment 3 is used.
(2) the using method comprises the following steps: the product of the invention is used for washing hair in a daily use mode, is used once a day and is used for ninety days continuously.
(3) effect judgment standard and experimental result:
the effect is shown: the alopecia condition is obviously improved, and the alopecia amount is obviously reduced. 8 persons, accounting for 16 percent.
The method has the following advantages: the alopecia condition is improved, and the alopecia amount is reduced but not obvious. 20 persons, 40% of the ratio.
and (4) invalidation: the alopecia condition is not improved, and the alopecia amount is not reduced. 22 persons, accounting for 44 percent.
Test example 4:
(1) According to Hamilton typing (Hamilton-Norwood typing), 50 male testers with alopecia degrees of 2-5 grades are randomly selected, the age is 50-70 years, and the scalp care essence liquid in the embodiment 4 is used.
(2) The using method comprises the following steps: the product of the invention is uniformly smeared on scalp and can be naturally absorbed, and the product is used once in the morning and at night and is continuously used for ninety days.
(3) Effect judgment standard and experimental result:
the effect is shown: the alopecia condition is obviously improved, and the alopecia amount is obviously reduced. 18 people, accounting for 36 percent.
the method has the following advantages: the alopecia condition is improved, and the alopecia amount is reduced but not obvious. 28 persons, accounting for 56 percent.
And (4) invalidation: the alopecia condition is not improved, and the alopecia amount is not reduced. 4 persons, accounting for 8 percent.
Test example 5:
(1) according to Hamilton typing (Hamilton-Norwood typing), 50 female testers with the hair loss degree of 1-4 grades are randomly selected, the age is 25-50 years, and the scalp care moisturizing lotion in the embodiment 5 is used.
(2) the using method comprises the following steps: the product of the invention is uniformly smeared on scalp and can be naturally absorbed, and the product is used once in the morning and at night and is continuously used for ninety days.
(3) Effect judgment standard and experimental result:
The effect is shown: the alopecia condition is obviously improved, and the alopecia amount is obviously reduced. 9 persons, the proportion is 18%.
The method has the following advantages: the alopecia condition is improved, and the alopecia amount is reduced but not obvious. 34 people, accounting for 68 percent.
And (4) invalidation: the alopecia condition is not improved, and the alopecia amount is not reduced. 7 persons, accounting for 14 percent.
Test example 6:
(1) according to Hamilton typing (Hamilton-Norwood typing), 50 male testers with the hair loss degree of 1-4 grades are randomly selected, the age is 25-50 years, and the amino acid anti-hair loss shampoo in the embodiment 6 is used.
(2) the using method comprises the following steps: the product of the invention is used for washing hair in a daily use mode, is used once a day and is used for ninety days continuously.
(3) Effect judgment standard and experimental result:
The effect is shown: the alopecia condition is obviously improved, and the alopecia amount is obviously reduced. 7 persons, accounting for 14 percent.
the method has the following advantages: the alopecia condition is improved, and the alopecia amount is reduced but not obvious. 26 persons, accounting for 52 percent.
And (4) invalidation: the alopecia condition is not improved, and the alopecia amount is not reduced. 17 persons, accounting for 34%.
And (3) test results:
And (4) conclusion: aiming at the use condition that the alopecia degree belongs to 1-5 levels of test example personnel, 6 kinds of cosmetics prepared in examples 1-6 can achieve the actual and effective alopecia prevention effect, and the obvious effect rate and the effective rate are 56% at the lowest and 92% at the highest.
In the above embodiments, the traditional Chinese medicine composition is a crude medicinal material or a traditional Chinese medicine decoction piece, and the extract, the fermentation extract and the application of the traditional Chinese medicine composition with the alopecia prevention effect in the embodiments include the composition and the preparation of the extract and the fermentation extract of the traditional Chinese medicine composition, and the application of the extract and the fermentation extract of the traditional Chinese medicine composition in the preparation of medicines or cosmetics with the alopecia prevention, aging prevention, repair, moisture preservation, oxidation resistance, allergy resistance, free radical removal and anti-inflammatory effects.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (10)
1. A traditional Chinese medicine composition with an anti-hair loss effect comprises the following components in parts by mass: 70-100 parts of salvia miltiorrhiza, 70-100 parts of astragalus membranaceus, 70-100 parts of polygonum multiflorum, 70-100 parts of radix pseudostellariae, 70-100 parts of rehmannia, 70-100 parts of glossy privet fruit, 60-80 parts of cacumen biotae, 60-80 parts of pawpaw, 60-80 parts of codonopsis pilosula, 50-70 parts of dried ginger, 50-70 parts of cortex dictamni, 50-70 parts of moutan bark, 50-70 parts of liquorice, 10-30 parts of blackberrylily rhizome and 10-30 parts of gentian.
2. The traditional Chinese medicine composition with the alopecia preventing effect according to claim 1, which is characterized by comprising the following components in part by weight:
100 parts of salvia miltiorrhiza, 100 parts of astragalus, 100 parts of polygonum multiflorum, 100 parts of radix pseudostellariae, 100 parts of rehmannia, 100 parts of glossy privet fruit, 80 parts of cacumen biotae, 80 parts of pawpaw, 80 parts of codonopsis pilosula, 70 parts of dried ginger, 70 parts of cortex dictamni, 70 parts of moutan bark, 70 parts of liquorice, 30 parts of blackberry lily and 30 parts of gentian.
3. the traditional Chinese medicine composition with the alopecia preventing effect according to claim 1, which is characterized by comprising the following components in part by weight:
70 parts of salvia miltiorrhiza, 70 parts of astragalus, 70 parts of polygonum multiflorum, 70 parts of radix pseudostellariae, 70 parts of rehmannia, 70 parts of glossy privet fruit, 60 parts of cacumen biotae, 60 parts of pawpaw, 60 parts of codonopsis pilosula, 50 parts of dried ginger, 50 parts of cortex dictamni, 50 parts of moutan bark, 50 parts of liquorice, 10 parts of blackberry lily and 10 parts of gentian.
4. The traditional Chinese medicine composition with the alopecia preventing effect according to claim 1, which is characterized by comprising the following components in part by weight:
90 parts by mass of salvia miltiorrhiza, 90 parts by mass of astragalus, 90 parts by mass of polygonum multiflorum, 90 parts by mass of radix pseudostellariae, 90 parts by mass of rehmannia, 90 parts by mass of glossy privet fruit, 70 parts by mass of cacumen biotae, 70 parts by mass of pawpaw, 70 parts by mass of codonopsis pilosula, 60 parts by mass of dried ginger, 60 parts by mass of cortex dictamni, 60 parts by mass of moutan bark, 60 parts by mass of liquorice, 20 parts by mass of blackberry lily and 20 parts by mass of gentiana scabra bunge.
5. An extract of the Chinese medicinal composition as claimed in any one of claims 1 to 4, which is a filtrate prepared by adding 5 times of pure water by weight to the Chinese medicinal composition, placing the mixture in a decocting machine, extracting at 95-100 ℃ for 1.5h, replenishing water lost by volatilization, adding 5 times of ethanol with a purity of 95% by weight, sealing and standing for 15-30 days, and filtering to replenish lost pure water and ethanol to the added amount.
6. A fermented extract of the Chinese medicinal composition according to any one of claims 1 to 4, which is an initial system obtained by mixing the Chinese medicinal composition with fermentation tubes, adding 5 times of weight of pure water, fermenting to obtain a fermented product, placing the fermented product in a decocting machine, extracting at 95-100 ℃ for 1.5h, replenishing water lost by volatilization, adding 5 times of weight of ethanol with a purity of 95%, sealing, standing, extracting for 15-30 days, filtering, and replenishing lost pure water and ethanol to the added amount to obtain a filtrate.
7. The fermented extract of a Chinese medicinal composition according to claim 6, wherein the fermentation bacteria is yeast, and the Chinese medicinal composition is added in the form of high-activity dry yeast in an amount of 70-100 parts by mass.
8. The fermented extract of the Chinese medicinal composition according to claim 6, wherein the fermentation is carried out at 25-45 ℃ for 24-72 hours.
9. The use of an extract of the composition of claim 5, wherein the extract is incorporated into a pharmaceutical or cosmetic product in an amount of 1-100% by weight.
10. Use of a fermented extract of a Chinese medicinal composition according to any one of claims 6 to 8, wherein the fermented extract is incorporated into a pharmaceutical or cosmetic product in an amount of 1 to 100% by weight.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112618475A (en) * | 2021-01-22 | 2021-04-09 | 上海加新生物科技有限公司 | Anti-inflammatory, anti-allergic and itching-relieving plant composition and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129735A (en) * | 2007-08-29 | 2008-02-27 | 北京艺信堂医药研究所 | Chinese patent drug for treating alopecia areata |
| CN101804117A (en) * | 2010-04-16 | 2010-08-18 | 袁仲元 | Hair growing and blacking liquid and preparation process thereof |
| CN107397938A (en) * | 2017-07-28 | 2017-11-28 | 四川兴聚焦医药科技有限责任公司 | A kind of decoction medicine for treating alopecia seborrheica and preparation method thereof |
| CN109394850A (en) * | 2018-12-17 | 2019-03-01 | 温州古木生物科技有限公司 | It is a kind of to have effects that the Chinese medicine composition of delay skin aging and its water extract and fermentation material and application |
-
2019
- 2019-09-29 CN CN201910930934.8A patent/CN110559418B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101129735A (en) * | 2007-08-29 | 2008-02-27 | 北京艺信堂医药研究所 | Chinese patent drug for treating alopecia areata |
| CN101804117A (en) * | 2010-04-16 | 2010-08-18 | 袁仲元 | Hair growing and blacking liquid and preparation process thereof |
| CN107397938A (en) * | 2017-07-28 | 2017-11-28 | 四川兴聚焦医药科技有限责任公司 | A kind of decoction medicine for treating alopecia seborrheica and preparation method thereof |
| CN109394850A (en) * | 2018-12-17 | 2019-03-01 | 温州古木生物科技有限公司 | It is a kind of to have effects that the Chinese medicine composition of delay skin aging and its water extract and fermentation material and application |
Non-Patent Citations (1)
| Title |
|---|
| 杜长明等: "益气养血法为主治脱发1例", 《山东中医杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112618475A (en) * | 2021-01-22 | 2021-04-09 | 上海加新生物科技有限公司 | Anti-inflammatory, anti-allergic and itching-relieving plant composition and preparation method and application thereof |
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