CN111110795A

CN111110795A - Medicated leaven and preparation method thereof

Info

Publication number: CN111110795A
Application number: CN202010142645.4A
Authority: CN
Inventors: 邢坤
Original assignee: Anhui Shengantang Pharmaceutical Co Ltd
Current assignee: Anhui Shengantang Pharmaceutical Co Ltd
Priority date: 2020-03-01
Filing date: 2020-03-01
Publication date: 2020-05-08

Abstract

The invention discloses medicated leaven and a preparation method thereof, wherein the medicated leaven consists of polygonum hydropiper, sweet wormwood, xanthium sibiricum, phaseolus calcaratus, bitter almond, wheat bran and flour; the invention is prepared by weighing the seven traditional Chinese medicines according to the parts by weight, removing dust and impurities, cleaning, sterilizing, crushing, filtering, fermenting, cutting into pieces and drying. The medicated leaven traditional Chinese medicine decoction pieces mainly have the main functions: strengthen spleen and stomach, promote digestion and regulate middle energizer. Can be used for treating weakness of spleen and stomach, diet stagnation, chest distress, abdominal distention, emesis, dysentery, and infantile dyspepsia.

Description

Medicated leaven and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicine products, in particular to medicated leaven and a preparation method thereof.

Background

Medicated leaven, also called medicated leaven, is a leaven prepared by mixing bitter apricot seed, red bean, sweet wormwood, xanthium sibiricum, red-knees herb and other traditional Chinese medicines with flour or wheat bran, and has remarkable effects of promoting digestion, regulating middle warmer, strengthening spleen and stomach, and has wide clinical application.

At present, the medicated leaven produced in different producing areas has different standards, the raw materials, the raw material proportion, the adding mode, the production process and the like are different, and the quality evaluation standard of the medicated leaven is not perfect. Because the traditional production process of the medicated leaven adopts a natural fermentation mode, the quality of products in different production places, even the same production place and different batches is different, and some mixed bacteria in the products can also generate toxic metabolites, such as aflatoxin, thereby greatly influencing the safety of the clinical application of the medicated leaven. Therefore, the establishment of perfect and objective quality evaluation indexes by standardizing the fermentation process of the medicated leaven is the primary task for stabilizing the quality of the medicated leaven.

At present, a plurality of enterprises still adopt the traditional ancient method for processing in the preparation process of the medicated leaven, and although the traditional ancient method is verified by a plurality of people, the standardization and the automation degree of the traditional ancient method are not high, the quality is difficult to control, and the production and preparation requirements of modern traditional Chinese medicine decoction piece production enterprises cannot be met.

Disclosure of Invention

In order to make the technical problems, technical solutions and advantageous effects to be solved by the present invention more apparent, the present invention is further described in detail below with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

In order to achieve the purpose, the invention provides the following technical scheme: medicated leaven is characterized by comprising the following components: polygonum hydropiper, sweet wormwood, xanthium sibiricum, red bean, bitter almond, wheat bran and flour.

Preferably, the medicated leaven comprises the following raw materials in parts by weight: 3-7 parts of polygonum flaccidum, 3-7 parts of sweet wormwood, 3-7 parts of xanthium sibiricum, 1-5 parts of phaseolus calcaratus, 1-5 parts of bitter almond, 50-100 parts of wheat bran and 50-100 parts of flour.

Preferably, the medicated leaven comprises the following raw materials in parts by weight: 5 parts of polygonum flaccidum, 5 parts of sweet wormwood, 5 parts of xanthium sibiricum, 2 parts of phaseolus calcaratus, 2 parts of bitter almond, 80 parts of wheat bran and 80 parts of flour.

The invention provides a preparation method of medicated leaven, which comprises the following steps: (1) preparing materials: weighing the raw materials of polygonum hydropiper, sweet wormwood, xanthium sibiricum, phaseolus calcaratus and bitter apricot kernel according to the weight parts, and removing dust and impurities; (2) pretreatment of raw materials: cleaning the raw materials weighed in the step (1) in a traditional Chinese medicine cleaning machine, airing all the cleaned raw materials, and drying and sterilizing the raw materials in a microwave dryer; (3) crushing: mixing the raw materials dried in the step (2) and putting the mixture into a superfine pulverizer for pulverization; (4) and (3) filtering: filtering the powder weighed in the step (3) through a 60-mesh sieve and mixing the powder with wheat bran and flour; (5) fermentation: adding water with the mass fraction of 5-7% into the raw materials in the form of atomization by an atomizer, stirring uniformly, then standing and fermenting for 5-10 days under a closed condition, wherein the fermentation temperature is 30-40 ℃, the fermentation humidity is 60-80%; (6) and (4) cutting the fermented medicated leaven obtained in the step (5) into blocks, and drying to obtain medicated leaven traditional Chinese medicine decoction pieces.

Preferably, the product fermented in step (6) is dried at 40-50 ℃ for 10-15 hours.

Preferably, the preparation method (5) further comprises the steps of fermenting for 6-9 days at the fermentation temperature of 35-50 ℃ and the fermentation humidity of 65-80%.

Pharmacological description:

polygonum hydropiper, named as traditional Chinese medicine. Is the whole plant of Polygonum hydropiper of Polygonum of Polygonaceae. Is distributed in the provinces of south and north China. Has the effects of dispelling wind and promoting diuresis, removing blood stasis and relieving pain, detoxifying and reducing swelling, and killing parasites and relieving itching. It is used for treating dysentery, gastroenteritis, diarrhea, rheumatic arthralgia, traumatic injury, swelling and pain, and functional uterine bleeding; it can be used for treating venomous snake bite and skin eczema.

Artemisia annua is Artemisia annua of Compositae and annual herbaceous plant. Distributed in China, Korea, Japan, Vietnam (North), Burma, India (North), Nipol, etc.; the common planets are scattered in low-altitude and wet riparian sand lands, valleys, forest edges, roadside and the like. Has the effects of clearing heat, cooling blood, relieving steaming, relieving summer-heat, dispelling pathogenic wind and relieving itching, is used as antipyretic for hectic fever due to yin deficiency, also can stop night sweat, heatstroke and the like, but does not contain artemisinin and has no antimalarial effect.

Xanthium sibiricum is sweet and warm in fruit flavor; the root is slightly bitter and mild in taste. The fruit is a sweating, diuresis, antipyretic and poison expelling medicine. Has spasmolytic and analgesic effects. It can be used for treating muscle and nerve paralysis, arthralgia, and edema. Pounding stem and leaf, spreading scabies, dampness and insect damage. Can be used for treating leprosy and dysentery. It can be used for the radical treatment of hypertension.

Red bean, also known as red bean, red bean and vermilion bean, is a mature seed of leguminous plant red bean, which is a half-year-old wound herbaceous plant, and is cultivated all over the country, and the pods are harvested in summer and autumn when mature, dried in the sun, and collected for later use. Seeds are eaten; when used as a medicine, has the effects of promoting blood circulation, tonifying blood, invigorating spleen, eliminating dampness, inducing diuresis and relieving swelling.

Bitter apricot kernel is a common Chinese medicinal material, and the product collected in pharmacopoeia is dry mature seed of Rosaceae plants such as mountain, Siberian apricot P, and northeast apricot. Collecting mature fruits in summer, removing pulp and nucleocapsid, taking out seeds, and drying in the sun. Ku xing ren has the actions of depressing qi, relieving cough and asthma, moistening intestines and relaxing bowels. Can be used for treating cough, asthma, fullness in chest, excessive phlegm, intestinal dryness, and constipation.

Wheat bran, i.e. wheat bran, a by-product of wheat processing flour, wheat yellow, flakes or powder. Is suitable for treating deficiency of qi and blood, diabetes, constipation, spontaneous perspiration, night sweat, dysentery, rheumatalgia, tinea pedis, stomatitis, and hematuria.

The honeysuckle is mainly used for clearing heat and removing toxicity, enhancing immunity, resisting early pregnancy, protecting liver, resisting tumor, diminishing inflammation, relieving fever, stopping bleeding (blood coagulation), inhibiting intestinal absorption of cholesterol and the like.

The pericarpium Citri Tangerinae contains volatile oil, hesperidin, vitamin B, C, etc., and the volatile oil has mild irritation effect on gastrointestinal tract, and has effects of promoting secretion of digestive juice, eliminating intestinal tract pneumatosis, and stimulating appetite.

The herba Menthae has antiseptic, antibacterial, diuretic, expectorant, stomach invigorating, and digestion promoting effects.

Hawthorn is mainly used for relieving dyspepsia, dissipating blood stasis and expelling tapeworm. It is used for treating meat stagnation, abdominal mass, phlegm retention, abdominal distention, acid regurgitation, dysentery, intestinal wind, lumbago, infantile colic, abdominal pain, lochiorrhea, and infantile dyspepsia. Promote digestion, invigorate stomach, promote qi circulation and dissipate blood stasis. Can be used for treating dyspepsia, flatulence, dysentery, abdominal pain, blood stasis, amenorrhea, puerperal stagnation, heart and abdominal pain, hernia pain, and hyperlipidemia.

Flos Sophorae Immaturus is bitter in taste, mild in nature, and nontoxic, and has effects of clearing heat, cooling blood, stopping bleeding, and lowering blood pressure.

The longan contains various nutrient substances, and has the effects of enriching blood, soothing nerves, strengthening brain, improving intelligence and nourishing heart and spleen.

Burdock root: has the effects of dispelling wind heat, and sterilizing swelling. It is commonly used for wind-heat type common cold, headache, cough, heat-toxin swelling of face, sore throat, swelling and pain of gum, rheumatic arthralgia, abdominal mass and mass, carbuncle, furuncle, malignant boil, hemorrhoid and rectocele.

Has the advantages that: the invention has the beneficial effects that: the invention is prepared by weighing the seven traditional Chinese medicines according to the parts by weight, removing dust and impurities, cleaning, sterilizing, crushing, filtering, fermenting, cutting into pieces and drying. The medicated leaven traditional Chinese medicine decoction pieces mainly have the main functions: strengthen spleen and stomach, promote digestion and regulate middle energizer. Can be used for treating weakness of spleen and stomach, diet stagnation, chest distress, abdominal distention, emesis, dysentery, and infantile dyspepsia.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

The invention provides medicated leaven and a preparation method thereof, wherein the preparation method of the medicated leaven comprises the following steps:

(1) taking 3 parts of polygonum flaccidum, 3 parts of sweet wormwood, 3 parts of xanthium sibiricum, 1 part of phaseolus calcaratus, 1 part of bitter almond, 50 parts of wheat bran and 50 parts of flour as raw materials, and removing dust and impurities; (2) pretreatment of raw materials: cleaning the raw materials weighed in the step (1) in a traditional Chinese medicine cleaning machine, airing all the cleaned raw materials, and drying and sterilizing the raw materials in a microwave dryer; (3) crushing: mixing the raw materials dried in the step (2) and putting the mixture into a superfine pulverizer for pulverization; (4) and (3) filtering: filtering the powder weighed in the step (3) through a 60-mesh sieve and mixing the powder with wheat bran and flour; (5) fermentation: adding water with the mass fraction of 5% of the raw materials into the raw materials in an atomizer atomization mode, uniformly stirring, then standing and fermenting for 5 days under a closed condition, wherein the fermentation temperature is 30 ℃, the fermentation humidity is 60%; (6) and (4) cutting the fermented medicated leaven obtained in the step (5) into blocks, and drying to obtain medicated leaven traditional Chinese medicine decoction pieces, wherein the product is dried for 10 hours at 40 ℃.

Example 2

(1) taking 7 parts of polygonum flaccidum, 7 parts of sweet wormwood, 7 parts of xanthium sibiricum, 5 parts of phaseolus calcaratus, 5 parts of bitter almond, 100 parts of wheat bran and 100 parts of flour as raw materials, and removing dust and impurities; (2) pretreatment of raw materials: cleaning the raw materials weighed in the step (1) in a traditional Chinese medicine cleaning machine, airing all the cleaned raw materials, and drying and sterilizing the raw materials in a microwave dryer; (3) crushing: mixing the raw materials dried in the step (2) and putting the mixture into a superfine pulverizer for pulverization; (4) and (3) filtering: filtering the powder weighed in the step (3) through a 60-mesh sieve and mixing the powder with wheat bran and flour; (5) fermentation: adding water with the mass fraction of 7% of the raw materials into the raw materials in an atomizer atomization mode, uniformly stirring, then standing and fermenting for 10 days under a closed condition, wherein the fermentation temperature is 50 ℃, the fermentation humidity is 80%; (6) and (4) cutting the fermented medicated leaven obtained in the step (5) into blocks, and drying to obtain medicated leaven traditional Chinese medicine decoction pieces, wherein the product is dried for 15 hours at 50 ℃.

Example 3

(1) taking 5 parts of polygonum flaccidum, 5 parts of sweet wormwood, 5 parts of xanthium sibiricum, 2 parts of phaseolus calcaratus, 2 parts of bitter almond, 80 parts of wheat bran and 80 parts of flour as raw materials, and removing dust and impurities; (2) pretreatment of raw materials: cleaning the raw materials weighed in the step (1) in a traditional Chinese medicine cleaning machine, airing all the cleaned raw materials, and drying and sterilizing the raw materials in a microwave dryer; (3) crushing: mixing the raw materials dried in the step (2) and putting the mixture into a superfine pulverizer for pulverization; (4) and (3) filtering: filtering the powder weighed in the step (3) through a 60-mesh sieve and mixing the powder with wheat bran and flour; (5) fermentation: adding water with the mass fraction of 6% of the raw materials into the raw materials in an atomizer atomization mode, uniformly stirring, then standing and fermenting for 7 days under a closed condition, wherein the fermentation temperature is 35 ℃, the fermentation humidity is 70%; (6) and (4) cutting the fermented medicated leaven obtained in the step (5) into blocks, and drying to obtain medicated leaven traditional Chinese medicine decoction pieces, wherein the product is dried for 12 hours at the temperature of 45 ℃.

Three hundred cases of dampness dispelling tea are drunk by people with symptoms of weakness of spleen and stomach, food stagnation and the like, and the statistical data are as follows:

234 cases of symptoms of weakness of the spleen and the stomach obviously increase the spirit and eliminate fatigue for one hour after drinking 221 cases, and the effective rate reaches 94.4 percent; after drinking 175 cases of diet stagnation, 153 cases were relieved next day, 137 cases were completely improved, and all symptoms did not occur after three days of continuous drinking; 139 cases of chest stuffiness and abdominal distension, wherein the affected part does not have pimple and itch on the next day after drinking, and the skin of the affected part does not drop any more after drinking for three days, is good as before and is completely cured; in 65 cases of emesis and dysentery, the soles can not itch after continuously drinking for two days, and the soles have no desquamation and itching symptoms after continuously drinking for seven days; food stagnation in children is 83 cases, and 78 cases are completely improved after drinking for three days.

The data show that the traditional Chinese medicine composition has the effects of strengthening spleen and stomach, resolving food stagnation and removing food retention, and is good in effect, quick in effect, high in effective rate and free of toxic and side effects.

The invention is prepared by weighing the seven traditional Chinese medicines according to the parts by weight, removing dust and impurities, cleaning, sterilizing, crushing, filtering, fermenting, cutting into pieces and drying. The medicated leaven traditional Chinese medicine decoction pieces mainly have the main functions: strengthen spleen and stomach, promote digestion and regulate middle energizer. Can be used for treating weakness of spleen and stomach, diet stagnation, chest distress, abdominal distention, emesis, dysentery, and infantile dyspepsia.

The embodiments described above are preferred embodiments of the present invention, and not all embodiments. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims

1. Medicated leaven is characterized by comprising the following components: polygonum hydropiper, sweet wormwood, xanthium sibiricum, red bean, bitter almond, wheat bran and flour.

2. The medicated leaven and the preparation method thereof according to claim 1, characterized by comprising the following raw materials in parts by weight: 3-7 parts of polygonum flaccidum, 3-7 parts of sweet wormwood, 3-7 parts of xanthium sibiricum, 1-5 parts of phaseolus calcaratus, 1-5 parts of bitter almond, 50-100 parts of wheat bran and 50-100 parts of flour.

3. The medicated leaven and the preparation method thereof according to claim 2, characterized by comprising the following raw materials in parts by weight: 5 parts of polygonum flaccidum, 5 parts of sweet wormwood, 5 parts of xanthium sibiricum, 2 parts of phaseolus calcaratus, 2 parts of bitter almond, 80 parts of wheat bran and 80 parts of flour.

4. A process for the preparation of a medicated leaven according to any one of claims 1 to 4, wherein the process comprises the steps of: (1) preparing materials: weighing the raw materials of polygonum hydropiper, sweet wormwood, xanthium sibiricum, phaseolus calcaratus and bitter apricot kernel according to the weight parts, and removing dust and impurities; (2) pretreatment of raw materials: cleaning the raw materials weighed in the step (1) in a traditional Chinese medicine cleaning machine, airing all the cleaned raw materials, and drying and sterilizing the raw materials in a microwave dryer; (3) crushing: mixing the raw materials dried in the step (2) and putting the mixture into a superfine pulverizer for pulverization; (4) and (3) filtering: filtering the powder weighed in the step (3) through a 60-mesh sieve and mixing the powder with wheat bran and flour; (5) fermentation: adding water with the mass fraction of 5-7% into the raw materials in the form of atomization by an atomizer, stirring uniformly, then standing and fermenting for 5-10 days under a closed condition, wherein the fermentation temperature is 30-40 ℃, the fermentation humidity is 60-80%; (6) and (4) cutting the fermented medicated leaven obtained in the step (5) into blocks, and drying to obtain medicated leaven traditional Chinese medicine decoction pieces.

5. The method for preparing medicated leaven according to claim 4, wherein the method comprises the following steps: and (3) drying the product fermented in the step (6) at 40-50 ℃ for 10-15 hours.

6. The method for preparing medicated leaven according to claim 4, wherein the method comprises the following steps: the preparation method (5) also comprises the steps of fermenting for 6-9 days at the fermentation temperature of 35-50 ℃ and the fermentation humidity of 65-80%.