KR102432455B1 - A method of producing a pill to improve the effect on arthritis and the pill poduced by using the same as - Google Patents

Abstract

The present invention relates to a method for preparing a pill prepared by using a fermented glutinous rice binder capable of improving swelling and partial texture of glutinous rice flour used as a binder. The method for preparing a pill prepared by using a fermented glutinous rice binder according to the present invention comprises the following steps of: using a grinder to grind herbal medicines including Achyranthes, Eucommia ulmoides, golsaebo, frankincense, Isodon inflexus, Eleutherococcus sessiliflorus, Sinomenium acutum, Caragana sinica, Sorbus commixta, and Phellodendron amurense Rupr. Cortex; stirring the ground herbal medicine powder through a stirrer to prepare a herbal medicine mixture; pouring the prepared glutinous rice powder and loofah fresh juice or loofah stem decoction into a heating container at a weight ratio of 10: 1.0 to 2.0, mixing and heating the mixture, and then fermenting the mixture to prepare a fermented glutinous rice paste binder; preparing a mixed dough of the herbal medicine mixture and the fermented glutinous rice paste binder; and using a pill forming machine and a molding machine to make and mold the herbal medicine dough into a spherical shape.

Description

A method of producing a pill prepared by using a fermented glutinous rice binder {A method of producing a pill to improve the effect on arthritis and the pill poduced by using the same as}

The present invention relates to a method for manufacturing a pill prepared by using a fermented glutinous rice binder, and more particularly, fermented glutinous rice comprising hyssop, duchung, gorseulbo, frankincense, sokdan, ogapi, banggi, golddamcho, rowan, and hwangbaekpi as active ingredients. It relates to a method for producing a ring prepared using a binder.

In general, pills (丸劑) are one of the herbal medicine formulations, and are a binder in powdered oriental medicine powder or herbal soup concentrate. It is an oral tablet made into a round shape by mixing excipients. Hwanje (丸劑), depending on the type of binder, there are various types such as mil-hwan, su-hwan, compatibility, medicinal juice-hwan, lead-hwan, X-hwan, and hyeol-hwan. Pills are convenient to eat, absorb relatively slowly, and have a long-lasting medicinal effect. Among herbal medicines, it is desirable to make pills for medicines that have weak resistance to high temperatures, are not soluble in water, volatilize easily, and have relatively high toxicity.

Depending on the purpose of use, many types of pills have been developed, such as hangover pills to relieve hangover symptoms, digestive pills to relieve indigestion, diet pills to reduce body fat, and sexual function improvement pills. and are sold.

Among these pills, as an example of a digestive pill for relieving indigestion, Republic of Korea Patent Publication No. 10-1324733 (October 28, 2013) discloses a liver protection function, a liver disease improvement effect, anticancer, antibacterial, diuretic, anthelmintic Disclosed is a health pill using rice straw extract made from rice straw that has detoxification and fermentation effects, excellent digestion of milk products, can be used as a substitute for baby food, and has the effect of preventing adult diseases.

In addition, Republic of Korea Patent Publication No. 10-1965804 (March 29, 2019) discloses an unpleasant odor when fermented by adding a microbial fermenting agent to the dough of the pills in order to solve the phenomenon that the pills harden during storage and have difficulty in digestion. Disclosed are a microbial fermentation agent for improving the physical properties of pills capable of eliminating and preventing hardening, and a method for manufacturing pills for digestion and absorption using the same.

However, since one or more dried and pulverized herbal medicine powders are kneaded using glutinous rice paste or wheat flour paste when making a pill in such a conventional technique, even when using a good herbal medicine powder, the indigestible material lignin or Since it may contain a large amount of cellulose, etc., there is a problem that the digestion and absorption rate is lowered. Also, the herbal medicine powder or extract is mixed with an extender or excipient to make a pill, and after a certain period of time, the pill becomes hard with evaporation of moisture. When taking the pills, as well as having discomfort, there was a problem that the disintegration was not done well in the stomach of the user.

This problem is that when the pills are stored for a long time, moisture evaporates during storage, and the pills become hardened due to the binder using glutinous rice or wheat flour, which may further deteriorate the degree of disintegration and quick-acting.

Republic of Korea Patent Publication No. 10-1324733 (October 28, 2013) Republic of Korea Patent Publication No. 10-1965804 (March 29, 2019)

The present invention is to solve the problems of the prior art, and to provide a method of manufacturing a pill prepared using a fermented glutinous rice binder that can improve the swelling and partial texture of glutinous rice flour used as a binder. .

Another object of the present invention is to provide a method of manufacturing a pill prepared using a fermented glutinous rice binder capable of manufacturing a pill using lactic acid bacteria fermented glutinous rice paste so as to relatively lower the viscosity of glutinous rice flour used as a binder.

Another object of the present invention is to provide a method for manufacturing a pill prepared using a fermented glutinous rice binder that can suppress the occurrence of deterioration or mold even if the pill is stored for a certain period of time or longer.

The manufacturing method of a pill manufactured using the fermented glutinous rice binder according to the present invention for achieving the above object is a method for producing a pill prepared by using a fermented glutinous rice binder, a pulverizer of herbal medicines including hyssop, duchung, gorchaebo, frankincense, sokdan, ogapi, banggi, golddamcho, rowan, hwangbaekpi pulverizing using; preparing a herbal medicine mixture by stirring the pulverized herbal medicine powder through a stirrer; Preparing a fermented glutinous rice paste binder by mixing and heating the prepared glutinous rice powder and raw loofah juice or decoction of loofah stems in a heating container at a weight ratio of 10: 1.0-2.0; preparing a dough in which the herbal medicine mixture and the fermented glutinous rice paste binder are mixed; It characterized in that it comprises the step of ring-shaping and molding the oriental medicine dough into a ring shape using a ventilation machine and a molding machine.

In addition, the manufacturing method of the pill prepared using the fermented glutinous rice binder according to the present invention is a method of pulverizing oriental medicines including hyssop, duchung, golchwibo, frankincense, sokdan, ogapi, banggi, golddamcho, rowan, and hwangbaekpi using a grinder. step; preparing a herbal medicine mixture by stirring the pulverized herbal medicine powder through a stirrer; A step of heating glutinous rice powder and raw loofah juice or decoction of loofah stems in a heating container, and then gelatinizing and mixing; Inoculating and culturing Lactococcus lactis in a sterilized medium for lactic acid bacteria culture, aseptically centrifuging the culture medium to recover cells, and diluting with sterile water to make a fermentation start solution; Cooling the gelatinized and mixed glutinous rice powder and inoculating and culturing the fermentation start solution to prepare a fermented glutinous rice paste binder; preparing a dough in which the herbal medicine mixture and the fermented glutinous rice paste binder are mixed; It characterized in that it comprises the step of ring-shaping and molding the oriental medicine dough into a ring shape using a ventilation machine and a molding machine.

In this way, the method for manufacturing a ring prepared by using the fermented glutinous rice binder according to the present invention has the following effects.

First, the swelling and partial texture of glutinous rice flour used as a binder can be improved, and the viscosity when making the pills can be relatively lowered. has

In addition, the viscosity of glutinous rice flour used as a binder can be relatively lowered, so that the user can easily disintegrate in the stomach after taking the pill, thereby allowing the user to easily absorb the active ingredients of the herbal medicine constituting the pill. have an effect

In addition, by using fresh loofah juice or decoction of loofah stems instead of water in the glutinous rice paste manufacturing process, even if the pills are stored for a certain period of time or more, it has the effect of suppressing deterioration or the occurrence of mold.

1 is a view showing a manufacturing procedure of a pill prepared using a fermented glutinous rice binder according to a preferred embodiment of the present invention.

Hereinafter, with reference to the accompanying drawings, it will be described in detail a preferred embodiment of the manufacturing method of the pill prepared using the fermented glutinous rice binder according to the present invention according to the present invention.

Hereinafter, before explaining the specific manufacturing method, looking at the medicinal material used in the manufacturing method of the pill manufactured using the fermented glutinous rice binder according to the present invention is as follows.

(1) hyssop

The hyssop is also called iron knee because the shape of the node on the plant stem resembles that of a cow's knee. It contains saponin and a large amount of calcium as active ingredients, and it showed analgesic action in animal experiments. In addition, it enhances the contraction of the uterus, has a weak diuretic effect, and dilates blood vessels to temporarily lower blood pressure. Weakness is plain and taste is sour and bitter. Efficacy induces women's menstruation to normal and facilitates diuresis and defecation. As the shape resembles the knee, a remarkable effect is recognized for treating diseases of the knee (arthritis, rheumatoid arthritis, inflammation caused by bruises). It is also used a lot when the back and legs feel heavy and painful, and sometimes there are muscle spasms. It is also used when urinating with pain and blood mixed with urine due to kidney failure. When hypertension has symptoms such as headache, dizziness, or eye irritation, it lowers blood pressure and relaxes cerebral blood vessel spasms. In folklore, young shoots are eaten as a vegetable and the roots are also used for neuralgia. Contraindications: Do not use for diarrhea, uterine bleeding, or pregnant women. It is widely used in oriental medicine, and representative prescriptions include wooseultang (牛膝湯) used for arthritis and pyeonggangangaptang (平肝降壓湯) used for blood pressure.

(2) cephalothorax

Duchung trees are also called cotton wool because their leaves and bark have many transparent fibers like threads. The taste of this medicine is sweet and very sweet, and the nature is warm. It is effective in lowering blood pressure by treating low back pain caused by lack of hepatic function, knee pain, yangyi caused by body cold, cold feeling in the lower abdomen, frequent urination, fetal instability, and uterine bleeding. As pharmacological actions, blood pressure lowering, anti-aging, cholesterol lowering, anti-inflammatory, sedative, analgesic, immune regulation, blood coagulation, uterine contraction, anti-allergy, and antibacterial action have been reported. The headworm is plate-shaped, and the outer surface is gray or dark gray, and has many cell folds and small pores, which are small holes in the shell, and the inner surface is smooth and dark brown. When broken, a thin, white fibrous thread with tenacity is produced.

(3) Golchwaebo

The nature of Golchaebo is warm (also called flat), the taste is bitter, and there is no poison. It destroys blood stasis, stops blood, connects broken things, heals rot and kills worms. It is used for back pain with weakened bone quality due to renal function weakness, tooth shake, tinnitus, tinnitus, chronic diarrhea, blurred vision, bruise fractures, eohyeol retention, hair loss, and nourishment. As pharmacological actions, osteoporosis, bone metabolic diseases, fracture union, analgesia, sedation, osteoarthritis, hyperlipidemia prevention effect, and growth promotion have been reported. Its shape is flat, columnar, 10-20 cm long and 10-15 mm in diameter, and the outer surface is brown or reddish-brown, with traces of fallen petioles. The quality is soft and difficult to break, and the cut surface is yellowish brown. This medicine should be brown and hairless.

(4) Frankincense

Frankincense is a medicinal herb made by drying the sap of a frankincense tree belonging to the olive family. Weakness is mild, non-toxic, slightly spicy and bitter. Efficacy: It has excellent analgesic effect for bruises and pain in the extremities due to blood circulation disorders. It is often used for pain caused by muscle spasms, movement disorders, and joint pain. It is also effective for hemiplegia due to cerebral blood circulation disorders. When an ulcer is caused by a skin infection due to trauma, it is made into a powder and applied to the affected area to promote the formation of granulation tissue and relieve pain. It is usually used in combination with myrrh (沒藥), but it is not used for pregnant women. It is widely used in oriental medicine, and a representative prescription is yumolpyeon (乳沒片), which is used for the purpose of pain relief.

(5) quick cut

Sokdan is a herbaceous perennial plant belonging to the family Lamiaceae. The scientific name is Phlomis umbrosa TURCZ. As one of the herbal medicines, it was originally made by drying the roots of wild rabbit flowers. Currently, the wild rabbit flowers are rare, so the quickdan belonging to the family Lamiaceae is used as a substitute. The name Sokdan was given because it heals fractures well. Ingredients include alkaloids, essential oils, and vitamin E. Weakness is mild and the taste is bitter. It is effective for back pain caused by weakness of the liver or kidneys and for poor leg and skeletal muscle movements. It is also effective for arthritis and rheumatism, and is often used for back discs and bruises. For women, taking it during pregnancy can prevent miscarriage, and it is effective in stopping bleeding even when menstruation is excessive or uterine bleeding is severe. It is often used for numbness and pain in the elderly due to lack of strength in the lower body, or walking difficulties. It is better to avoid using it with Saengjihwang and do not use it for dysentery. A typical prescription is Sokdanhwan. Young shoots are also eaten as greens.

(6) scallops

It has a peculiar smell, and the taste is spicy and bitter, and the nature is warm. Ogapi is used for quadriplegia, cramps, weakness in the lower back and knees, weakness in the lower extremities, fractures, bruises, and edema, etc. Pharmacological effects have been reported to include immune enhancement, antioxidant, anti-fatigue, anti-high temperature, anti-stimulation, endocrine function control, blood pressure control, anti-radiation, and detoxification. Looking at the appearance, the outer surface is yellowish brown or dark gray, flat, with thorns or thorn marks in some places, and gray-white spots are observed on the skin of relatively young branches. The inner side is yellowish white and fibrous, so it is difficult to cut.

(7) Bangui

The weakness of Bangui is bitter, bitter, and cold. Efficacy is used in the case of customs-type limb joint pain, hand and foot cramps, paralysis, guanwasa, edema, beriberi, and ascites. As pharmacological actions, analgesic action, anti-inflammatory action, antipyretic action, striated muscle relaxation action, bronchial smooth muscle relaxation action, antibacterial action, and antitumor action were reported. Banggi is a circular or oval-shaped section with dark gray-brown sides and vertical grooves and hump-shaped protrusions. The neck has a unique pattern as the gray-brown conduit part and the dark brown radial tissue are alternately arranged radially.

(8) Goldamcho

Goldamcho is the dried root of Caragana chamlagu Lam., a legume plant. It is also grown and planted in the central part of our country. The roots are collected in autumn and dried in the sun. Eliminates wind and wind and relieves pain. It is eaten as a decoction for arthritis, neuralgia, and hypertension.

(9) rowan

Rowan trees are mainly grown in mountainous areas. It is about 8m in height, but grows as a shrub of 2~3m in high mountains. The leaves are alternate and pinnately compound. Small leaves are lanceolate, 5-7 pairs, without petioles, with saw teeth on the edge, and the back side is white. Winter snow has a sticky mucus. The flowers are white in May and June, forming a multi-stemmed inflorescence at the tip of the branch. The calyx is in the shape of a wine glass, divided into 5 pieces, and the piece is a wide triangle, and the petals are 5, flat round, with hairs on the inside. There are about 20 stamens, and there are 3-4 pistils with hairs at the bottom. The fruits are round and ripen in red from September to October. In oriental medicine, the fruits and bark are used medicinally. In autumn, the leaves turn red. It is distributed in Korea, Japan, and China. Similar to this, but those with fine hairs on the midrib of the back of the leaves are called var. pilosa, and those with sparse hairs on the back of the leaves are from the order for. rufo-hirtella, especially those with brown hairs on the midrib. It is called var. rufo-ferruginea.

(10) Yellow white skin

Hwangbaekpi is the dried bark of Phellodendron amurense Rupr. The Hwanggyeongpi tree grows in the deep mountains of various places. From spring to summer, peel off the outer skin and dry in the sun. The taste is bitter and the nature is cold. Nerve (腎经), bladder (膀胱经), colon (大腸经), simpokyung (心包经) works. Relieves heat, removes dampness, and removes poison. It has been found that Hwangbaek decoction and berberine have antibacterial and anti-inflammatory actions against a series of pathogenic microorganisms including Mycobacterium tuberculosis, blood pressure lowering action, blood coagulation promoting action, diaphragm action, uterine contraction action, and Mycobacterium tuberculosis. Berberine also shows the action of glutinous rice (苦味健胃) action, antipyretic action, antispasmodic action on the small intestine, and enhancing the phagocytic action of white blood cells. It is used for moist heat diarrhea, dysentery, jaundice, auro (惡露), impotence (淋證), pulmonary tuberculosis, oil welling (遺精), genital itchiness, boils, and eczema. Bacterial redness (赤痢), intestinal tuberculosis, bladder and urethral inflammation, osteoarthritis, tuberculosis, etc. are also used in high blood pressure and no appetite. Take 6~9g per day in the form of soup, powder, or pills. When used as an external medicine, powder it and apply it to the basic (medicine) preparation. Berberine is extracted to produce hydrochloride or lactate, which is used for cholecystitis, cholelithiasis, and chronic hepatitis.

(11) sticky rice

Glutinous rice is a word that corresponds to non-glutinous rice, and is also called nami or jeommi. Non-glutinous rice, which is usually cooked, has a translucent endosperm, whereas glutinous rice is opaque and milky, so it can be distinguished. Also, since the starch of glutinous rice is mostly composed of amylopectin, it is clearly distinguished because the iodine reaction takes on a reddish-brown color.

It has high energy and digests better than non-glutinous rice. It is used to make various types of rice cakes such as glutinous rice cake, injeolmi, dumplings, and danja, and is also used to make sticky rice, yakshik, sikhye, alcohol, and red pepper paste.

Hereinafter, with reference to the accompanying Figure 1 will be described the manufacturing procedure of the pill prepared using the preferred fermented glutinous rice binder of the present invention.

[Oriental medicine preparation stage: S10 stage]

Prepare oriental medicines including hyssop, duchung, bone chrysanthemum, frankincense, sokdan, sagebrush, banggi, goldenrod, rowan, and hwangbaekpi. Wash the herbal medicines thoroughly under running water and dry them in the shade so that the moisture content is less than 14%, and powder or extract the medicinal herbs. It is preferred to mince it to a suitable size for manufacturing.

Here, the moisture content is the amount of moisture contained in the medicinal material, and the moisture content can be measured using a moisture content meter. Although there is no standard for moisture content of herbal medicines, it is known that it is desirable to maintain 14% or less.

[Oriental medicine powdering step: S20 step]

Among the herbal preparations prepared in step S10, 8 to 12 parts by weight of hyssop, 2 to 6 parts by weight of duchung, 2 to 6 parts by weight of sagebrush, 2 to 6 parts by weight of frankincense, 2 to 6 parts by weight of fast-cutting, 2 to 6 parts by weight of sagebrush, relative to the total herbal medicine mixture prepared in step S10. ~6 parts by weight, 2 to 6 parts by weight of Bangi, 2 to 6 parts by weight of Goldenrod, 2 to 6 parts by weight of rowan, 2 to 6 parts by weight of Hwangbaekpi, dried under reduced pressure, and then using a grinder to reduce the size within the range of 0.4 to 1.0mm. After pulverization, each herbal medicine powder is made by filtering it through a filter through which 0.4-1.0 mm passes.

Here, the reason why the content of hyssop is relatively higher than that of other herbal medicines is to strengthen the active ingredients of herbal medicines having the effect of reducing joint inflammation.

Here, in the reduced pressure drying method, herbal medicines including hyssopus, duchung, bone chrysanthemum, frankincense, sokdan, ogapi, banggi, goldenrod, rowan, and hwangbaekpi are frozen for at least 20 to 28 hours in a freezer, and then finely chopped using a grinder. It is a method of crushing and drying under reduced pressure in a temperature range of 100 to 140°C using a reduced pressure dryer.

[Chinese herbal medicine powder stirring step: S30 step]

The herbal medicine mixture in which the herbal medicine powder is mixed is stirred through a stirrer, and the herbal medicine mixture consisting of hyssopus, duchung, goolchwibo, frankincense, sokdan, ogapi, banggi, gordamcho, rowan, and hwangbaekpi is evenly stirred to complete the herbal medicine mixture.

[Glutinous rice paste binder manufacturing step: S40 step]

Next, a decoction of glutinous rice powder and raw loofah juice or loofah stems is mixed and heated at a set weight ratio, and then fermented to prepare a fermented glutinous rice paste binder, which will be described in detail below.

(1) Step of improving the swelling and texture of raw glutinous rice

Change the water periodically while submerging raw glutinous rice in water for 2 to 14 days, then take it out and dry it. In the water immersion process, various organic acids including lactic acid produced by natural fermenting microorganisms and extracellularly secreted hydrolytic enzymes work to improve the swelling and partial texture of glutinous rice flour.

(2) Glutinous rice powder manufacturing step

Grind the dried glutinous rice with improved bulkiness and texture to a size of 100 mesh using a grinder to make glutinous rice powder. At this time, the powder of glutinous rice contains 26% carbohydrate, 13% protein, 2% fat, and 1% sodium as degree.

(3) Lactic acid strain culture step

On the other hand, for the production of lactic acid bacteria fermented glutinous rice paste, Lactococcus lactis KCCM 40104 strain was received from the Korea Microbial Conservation Center affiliated with the Korea Seed Seed Association and used. Inoculate a certain amount of L. lactis and incubate at 37°C for 36 hours. Then, the culture medium is aseptically centrifuged (3,000 rpm, 30 minutes) to recover the cells, and appropriately diluted with sterile water to a concentration of 1.5 to 2.0 × 107 cells/mL and used as a fermentation start solution.

(4) Fermented glutinous rice paste manufacturing step

Next, glutinous rice powder: fresh loofah juice or decoction of stems is placed in a heating container in a weight ratio of 1: 2.0 to 3.5 (preferably 2.7), and heated until the temperature of the water reaches 90 ° C, respectively, and 5 at 120 rpm. Glaze and mix to disperse evenly for minutes.

Then, the gelatinized and mixed glutinous rice powder is cooled to 37°C, inoculated with 0.7 mL (1.5∼2.0×107 cell/mL) of lactic acid bacteria fermentation start solution, and cultured at 30°C for 15 hours to complete the fermented glutinous rice paste.

Here, the reason for using the fresh loofah juice or stem decoction is that the loofah produces a component called flavonoid to protect itself from parasites, bacteria, and cell damage, which has anti-inflammatory, antifungal, analgesic, cardiovascular protection, and hyperlipidemia improvement in the body. It has the effect of inhibiting the release of histamine that causes allergy while also preventing the occurrence of deterioration or mold that may occur if the pill is stored incorrectly.

[Oriental medicine paste manufacturing step: S50 step]

Next, the prepared herbal medicine powder and fermented glutinous rice paste are mixed in a weight ratio of 10: 1.0 to 2.0, and then kneaded to prepare a herbal medicine paste. At this time, it is preferable that the content of the fermented glutinous rice paste is controlled within the range of 10: 1.0 to 10: 3.0 according to the moisture content of the oriental medicinal product.

[Low-temperature aging stage of herbal medicine dough: S60 stage]

In order to soften the low-temperature aged herbal medicine dough, it is aged at room temperature for a set time (18 to 24 hours). When aging at room temperature, the temperature itself cannot be said to be low, but quality can be improved by aging at room temperature to prevent browning that may occur when aging at a high temperature.

[Repurchase stage: S70 stage]

The aged medicinal herb dough is circulated to 3-7 mm using a ventilator.

[Pill forming step: S80 step]

The drug mixture is molded into a round shape using a molding machine.

[Phone drying step: S90 step]

The round-shaped ring-shaped product is dried for 16-24 hours at 35-45° C. using a dryer.

The manufacturing method of the pill prepared using the fermented glutinous rice binder according to the present invention will be described in more detail by the following examples, but the scope of the present invention cannot be limited thereby.

Example 1

Wash the oriental medicines including hyssop, duchung, goolchaebo, frankincense, sokdan, ogapi, banggi, golddamcho, rowan, and hwangbaekpi under running water and dry in the shade.

Next, compared to the total herbal medicine mixture among the prepared herbal medicines, 10 parts by weight of hyssop, 10 parts by weight of duchung, 4 parts by weight of gorseulbo, 4 parts by weight of frankincense, 4 parts by weight of sokdan, 4 parts by weight of orchard, 4 parts by weight of bangi, 4 parts by weight of gordamcho After drying 4 parts by weight of part, rowan tree, and 4 parts by weight of yellow white bark under reduced pressure, pulverize it to a size within the range of 0.4 to 1.0 mm using a grinder, and filter it through a filter through which 0.4 to 1.0 mm passes to make each herbal medicine powder. .

Then, the herbal medicine mixture in which the herbal medicine powder is mixed is stirred through a stirrer to evenly stir the herbal medicine mixture consisting of hyssop, duchung, goolchwibo, frankincense, sokdan, ogapi, bangi, gordamcho, rowan, and hwangbaekpi.

Then, glutinous rice powder and raw loofah juice or stem decoction are put in a heating container at a set weight ratio, mixed and heated, and then fermented to prepare a fermented glutinous rice paste binder.

To explain this in detail, in order to improve the bulkiness and texture of glutinous rice, the raw glutinous rice is immersed in water for 2 to 14 days while periodically changing the water, then taken out and dried. Then, in order to make glutinous rice powder, the dried glutinous rice with improved swelling properties and texture is finely ground using a grinder to make glutinous rice powder. Then, Lactococcus lactis KCCM 40104 lactic acid bacteria culture medium was inoculated with a certain amount of L. lactis in MRS broth (Difco, USA) medium sterilized at 121°C for 15 minutes, and cultured at 37°C for 36 hours. Then, the culture medium is aseptically centrifuged (3,000 rpm, 30 minutes) to recover the cells, and appropriately diluted with sterile water to a concentration of 1.5 to 2.0 × 107 cells/mL to make a fermentation start solution. Then, put 72 mL of fresh loofah juice or decoction of stems in a 250 mL heating container and heat until the temperature of the water is 90°C, respectively, add 28 g of glutinous rice powder, and then gelatinize it so that it is evenly dispersed at 120 rpm for 5 minutes and mixing. Then, the gelatinized and mixed glutinous rice powder is cooled to 37°C, inoculated with 0.7 mL (1.5∼2.0×107 cell/mL) of lactic acid bacteria fermentation start solution, and cultured at 30°C for 15 hours to complete the fermented glutinous rice paste.

Next, the herbal medicine powder and fermented glutinous rice paste are mixed in a weight ratio of 10: 1.0, and then kneaded to prepare a herbal medicine paste.

Then, in order to soften the low-temperature aged herbal medicine dough, it is aged for 18 to 24 hours at room temperature.

Next, the aged medicinal herb dough is recirculated to a size of 3 to 7 mm using a ventilation machine.

Then, the drug mixture is molded into a round shape using a molding machine.

Then, the round-shaped ring-shaped product is dried for 16 to 24 hours at a temperature range of 35 to 45° C. using a dryer.

Example 2

The second preferred embodiment of the present invention is the same as the first preferred embodiment of the present invention, except that the herbal medicine powder and fermented glutinous rice paste are mixed in a weight ratio of 10:2.0 and kneaded to prepare a herbal medicine dough.

Example 3

The third preferred embodiment of the present invention is the same as the first preferred embodiment of the present invention, except that the herbal medicine powder and the fermented glutinous rice paste are mixed in a weight ratio of 10: 3.0 and kneaded to prepare a herbal medicine paste.

<Comparative example>

Wash the oriental medicines including hyssop, duchung, golchaebo, frankincense, sokdan, ogapi, banggi, golddamcho, rowan, and hwangbaekpi under running water and dry in the shade.

Next, 10 parts by weight of the prepared hyssop, 10 parts by weight of duchung, 4 parts by weight of gorseulbo, 4 parts by weight of frankincense, 4 parts by weight of sokdan, 4 parts by weight of sagebrush, 4 parts by weight of bangi, 4 parts by weight of goldenrod, 4 parts by weight of rowan, 4 parts by weight of hwangbaekpi After drying 4 parts by weight in a reduced pressure drying method, pulverize to a size of 0.4 to 1.0 mm using a grinder.

Then, by stirring the herbal medicine powder through a stirrer, the herbal medicine powder consisting of hyssop, duchung, goolchwibo, frankincense, sokdan, ogapi, banggi, gordamcho, rowan, and hwangbaekpi is evenly mixed.

Then, to prepare a glutinous rice paste binder, glutinous rice is finely ground using a grinder to make glutinous rice powder.

Then, put it in a heating container in a weight ratio of glutinous rice powder: water 10:2, stir it over low heat to make glutinous rice paste, and then cool it down to room temperature.

Next, the herbal medicine powder and glutinous rice paste are mixed in a weight ratio of 10: 1 and kneaded to prepare a herbal medicine paste.

Then, in order to soften the low-temperature aged herbal medicine dough, it is aged for 18 to 24 hours at room temperature.

Next, the matured medicinal herb dough is recirculated to 3 to 7 mm using a ventilation machine.

Then, the drug mixture is molded into a round shape using a molding machine.

Then, the round-shaped ring-shaped product is dried at 35-45° C. and 16-24 hours using a dryer.

<Experimental Example 1> <Evaluation of disintegration degree of ring>

According to Experimental Example 1 below, 0.2 to 0.4 g of the ring prepared by using the fermented glutinous rice binder prepared according to the first to third preferred embodiments of the present invention and the ring prepared by the comparative example were dissolved in 2.0 mL of lukewarm water. Each was administered, and the melting state of the pills and the viscosity were determined accordingly.

division Evaluation items 3 minutes elapsed 5 minutes passed 7 minutes elapsed 10 minutes passed Example 1 start to disintegrate partial disintegration complete disintegration - Example 2 start to disintegrate partial disintegration complete disintegration - Example 3 start to disintegrate partial disintegration mostly disintegrate complete disintegration comparative example start to disintegrate start to disintegrate partial disintegration mostly disintegrate

According to Table 1, it was found that most of the pills prepared using the fermented glutinous rice binder prepared according to the first to third preferred embodiments of the present invention disintegrate within 5 to 7 minutes after administration to water, which While it can be seen that the viscosity of the glutinous rice paste is relatively weak compared to the ring of Comparative Example, it was found that most of the ring prepared by Comparative Example 1 disintegrated after 7 minutes or more. As described above, the reason why the viscosity of glutinous rice paste according to a preferred embodiment of the present invention is low is judged to be because it is possible to improve the swelling and partial texture of glutinous rice flour used as a binder. It can be easily disintegrated in the, and this can have the advantage that the user can easily absorb the active ingredients of the herbal medicine constituting the pill.

<Experimental Example 2> Preference evaluation of pills prepared using fermented glutinous rice binder

The following sensory experiments were carried out to confirm the performance of the pills prepared using the fermented glutinous rice binder prepared in Examples 1 to 3 and the pills prepared in Comparative Examples.

The sensory experiment was evaluated using a 9-point hedonic scale method (9 points: very good, 7 points: good, 5 points: average, 3 points: bad, 1 point: very bad ) The evaluation items were flavor, taste, texture, and overall satisfaction. The sensory test subjects were 20 men and women from middle and high school located in Sancheong-gun, and 30 men and women in their 40s and 60s from the village senior citizen center. The average values of are shown in Table 2 below.

division Evaluation items flavor bitter texture overall satisfaction Example 1 7.4 7.6 7.7 7.6 Example 2 7.3 7.4 7.4 7.3 Example 3 7.2 7.7 7.0 6.9 comparative example 5.91 5.6 6.1 6.0

As shown in Table 2, it can be seen that the flavor and bitter taste of the pills prepared using the fermented glutinous rice binder prepared according to the first to third preferred embodiments of the present invention do not have a significant difference, and the fermented glutinous rice paste As a result, it was found that the bitter taste had a large difference compared to the comparative example. On the other hand, it can be seen that the ring prepared by Comparative Example 1 was evaluated relatively poorly in flavor, taste, texture and overall satisfaction compared to Examples 1 to 3 according to the present invention.

This evaluation is judged to have a greater difference when the pill is taken after long-term storage for a certain period of time.

In addition, using fresh loofah juice or decoction of stems in the manufacturing stage of fermented glutinous rice paste, it has anti-inflammatory, antifungal, analgesic, cardiovascular protection, and hyperlipidemia improvement, and at the same time suppresses the release of histamine that causes allergies. Even if the pill is stored for a long time, it can help prevent deterioration or the occurrence of mold.

According to the manufacturing method of the pills prepared using the fermented glutinous rice binder according to the preferred embodiment of the present invention, since the glutinous rice paste used as the binder is fermented and used, it creates an uncomfortable and negative image of the overall herbal medicine. It is expected that it will be possible to improve the image of oriental medicine.

The present invention described above is limited to the above-described embodiment and the accompanying drawings because various substitutions and modifications are possible within the scope of the present invention for those of ordinary skill in the art to which the invention pertains. it's not going to be

Claims (3)

pulverizing herbal medicines including hyssop, duchung, golchwibo, frankincense, sokdan, ogapi, banggi, golddamcho, rowan, and hwangbaekpi using a grinder;
preparing a herbal medicine mixture by stirring the pulverized herbal medicine powder through a stirrer;
Preparing a fermented glutinous rice paste binder by mixing and heating the prepared glutinous rice powder and raw loofah juice or decoction of loofah stems in a heating container at a weight ratio of 10: 1.0-2.0;
preparing a dough in which the herbal medicine mixture and the fermented glutinous rice paste binder are mixed;
Method for producing a ring manufactured using a fermented glutinous rice binder, characterized in that it comprises the step of ring-shaping and molding the oriental medicine dough into a ring shape using a ventilation machine and a molding machine.
According to claim 1,
The fermented glutinous rice paste binder,
Grinding the water-immersed and dried glutinous rice using a grinder to make glutinous rice powder;
heating and mixing the glutinous rice powder and raw loofah juice or decoction of loofah stems in a heating container, followed by gelatinization and mixing;
Inoculating and culturing Lactococcus lactis in a sterilized medium for lactic acid bacteria culture, aseptically centrifuging the culture medium to recover cells, and diluting with sterile water to make a fermentation start solution;
Cooling the gelatinized and mixed glutinous rice powder and inoculating and culturing the fermentation start solution to prepare the fermented glutinous rice binder. delete

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