CN101912546A - Preparing method of medicated leaven - Google Patents

Abstract

The invention discloses a preparing method of medicated leaven. The prescription of medicated leaven comprises the following components: on the basis of per 25kg of flour, 75kg of wheat bran, 4kg of bitter almond, 4kg of red bean, 7kg of ciderage and 7kg of artemisia apiacea. The method comprises the following steps: picking out impurities from the red bean; smashing the red bean into coarse powder, and sieving by a 30-mesh sieve; removing peels of the bitter almond, and sieving by a 20-mesh sieve; removing impurities from ciderage, artemisia apiacea and cocklebur grass; cleaning, removing root, and cutting into powder, sieving by a 30-mesh sieve; placing the above five-flavor drugs, flour and wheat bran into a mixer, spraying clear water, and evenly mixing to prepare into softwood; controlling water adding amount at 35-45% of total weight; taking the softwood out to be tightly covered; maintaining the temperature at 25-28 DEG C; maintaining the relative moisture at 70%-80%; stacking and fermenting for 7-8 days; stirring the fermented softwood by a stirrer after the surface of the fermented softwood overgrow with hyphae; dicing by a dicer; and placing into a bag-type microwave dryer for drying and sterilizing after shaping. The method of the invention utilizes a biological fermentation technology to lead drugs to generate new curative effect, optimizes production conditions, simplifies production process, and improves production efficiency.

Description

The concocting method of Massa Medicata Fermentata

[technical field]

The present invention relates to the concocting method of Chinese crude drug, more particularly, relate to the concocting method of Massa Medicata Fermentata.

[background technology]

Massa Medicata Fermentata is that medicines such as Semen Armeniacae Amarum, Semen Phaseoli, bright Herba Artemisiae Annuae, bright Herba Xanthii grass, bright Herba polygoni hydropiperis add flour (or Testa Tritici) mixing after the herbal leaven that fermentation forms.Shape is the cube fritter, and surperficial lark is coarse, and matter is crisp easily broken, and little have fragrance, and sweet in the mouth, suffering are warm in nature.Go into spleen, stomach warp, have spleen benefiting and stimulating the appetite, disperse the effect of inducing sweat.As being used to the dyspepsia that cures cold, normal and Fructus Crataegi, Folium Perillae, Herba Pogostemonis are used together; And for example control alleviating distention in middle-JIAO sending down the abnormal ascending QI soup burnt in the dyspepsia.

Massa Medicata Fermentata tradition concocting method is: get Semen Armeniacae Amarum, Semen Phaseoli is crushed into powder, with the flour mixing, add bright Herba Artemisiae Annuae, bright Herba polygoni hydropiperis, bright Herba Xanthii grass medicine juice, rub become to pinch agglomerating, the coarse granule shape soft material of throwing that both looses is put and is pressed into flat square (33cm * 20cm * 6.6cm) in the mould, with bright Herba Abutili leaf Bao Yan, put into case, press isosceles triangle and stack, cover bright Herba Artemisiae Annuae above.Put 30 ℃-37 ℃, can ferment, treat to take out when powder bears the mould clothing of yellow-white, remove the Herba Abutili leaf, be cut into the square fritter of 2.5cm, drying through 4-6 days.Every 100kg flour is with Semen Armeniacae Amarum, each 4kg of Semen Phaseoli, bright Herba Artemisiae Annuae, bright Herba polygoni hydropiperis, each 7kg of bright Herba Xanthii grass.Medicine juice is bright grass juice factor and the fried liquid of its medicinal residues.(" one one of one one of Chinese pharmacopoeia version in 2005 and version in 2010)

Traditional concocting method mainly relies on manual operations, and fermentation time is long, and floor space is big, and labor intensity is big, and sanitary condition is poor, is Chinese medicine industry technical barrier anxious to be solved.

Microorganism has profuse enzyme system, and powerful decomposition, the ability of transformation substance are arranged.Microbial fermentation Chinese medicine can make chemical composition of Chinese materia medica carry out biotransformation, produces new chemical compound or causes the variation of some component contents in the Chinese medicine.Modern Chinese medicine fermentation can be artificial the control developing direction, the directive breeding excellent species is regulated the control sweat, makes microorganism can produce a large amount of useful metabolites according to people's requirement.Can reach following purpose by fermentation: the one, change original performance, produce new therapeutical effect, enlarge medicine variety; The 2nd, heighten the effect of a treatment.In the Chinese medicine sweat, the molecular weight of product after microbial metabolism reduces, and macromolecular substances reduces, and the easier utilization that is absorbed by the body can make curative effect strengthen.The effect of concocting adjuvant in addition in the Chinese medicine sweat also makes curative effect strengthen.

[summary of the invention]

Technical problem to be solved by this invention is to provide a kind of new technology of the Massa Medicata Fermentata process of preparing Chinese medicine, utilizes biofermentation technique, by means of the effect of microorganism and enzyme, messenger drug produce tissue regeneration promoting curative effect, the present invention has optimized working condition, has simplified production procedure, improve production efficiency, guaranteed product quality.

The present invention solves the problems of the technologies described above by the following technical programs:

1, Massa Medicata Fermentata prescription:

Every 25kg flour: Testa Tritici 75kg, Semen Armeniacae Amarum 4kg, Semen Ormosiae Hosiei 4kg, Herba polygoni hydropiperis 7kg, Herba Artemisiae Annuae 7kg, Herba Xanthii grass 7kg.

Production technology:

Semen Ormosiae Hosiei is chosen clean impurity be ground into coarse powder, Semen Armeniacae Amarum is removed corium farinosum and is broken into coarse powder, again Herba polygoni hydropiperis, Herba Artemisiae Annuae, Herba Xanthii grass are removed impurity, clean, remove root, be cut into broken end, above-mentioned five kinds of Chinese medicine is put in the blender together with flour and Testa Tritici, sprayed clear water, stir, make soft material, amount of water is the 35%-45% of above-mentioned material gross weight.Taking-up covers completely, and temperature keeps 25～28 ℃, and heap fermentation 7～8 days treats that the surface covers with mycelia, the reuse blender is mixed 2～3 times, puts in the dicer to dice, after the molding, change over to belt microwave dryer inner drying, the sterilization get final product, the dry sterilization temperature is the 60-80 degree, persistent period 3-5 hour.

Principle of the present invention is: in the Massa Medicata Fermentata Study on Fermentation, the result shows, Herba Artemisiae Annuae, Herba Xanthii, Herba polygoni hydropiperis all do not have significant difference with sample enzyme activity, the thin-layer chromatogram that bright product or dry product make in the raw material, squeeze the juice with the aquatic foods product and to fry in shallow oil soup, technology is loaded down with trivial details, and be subject to seasonal restrictions, and be that raw material can make production not be subject to seasonal restrictions with the dry product; The sample protein enzyme activity and the thin layer chromatogram there was no significant difference of different flour, Testa Tritici proportioning, but amylase activity is minimum with full bran, with other samples significant difference is arranged, consider bent material stickiness, mix the bent complexity and the economy of raw material, so select flour: Testa Tritici=be best proportioning at 25: 75 will reach the degree of " that holds is agglomerating; that throws is promptly diffusing " simultaneously, according to the difference of face, bran proportioning, amount of water should be at 35%-45%, and ferment effect is better; The sample that fermented 7 days, its enzyme activity is all higher, compares with 5 days samples of fermentation that there were significant differences, compares there was no significant difference with 9 days sample of fermentation, can think tentatively that the best fermentation period of Massa Medicata Fermentata is about 7 days; About the fermentation temperature of Massa Medicata Fermentata, research thinks that what play a major role in the Massa Medicata Fermentata sweat is mycete, and optimum fermentation temp should be the mycete optimum growth temperature, promptly 25-28 ℃, rather than 30-37 ℃.In the raw material of Massa Medicata Fermentata is investigated, also compared in the prescription with living Semen Armeniacae Amarum and the amygdalate difference of system, the result shows, no matter adopting living Semen Armeniacae Amarum still to steam its amygdaloside of Semen Armeniacae Amarum in the Massa Medicata Fermentata prescription all promptly disappears in the near future in fermentation, amygdaloside may be continued to use living Semen Armeniacae Amarum and get final product by the new enzyme institute enzymolysis that produces of Massa Medicata Fermentata sweat in the Massa Medicata Fermentata prescription.

The invention has the advantages that: this technology is compared with traditional processing procedure, has following advantage:

(1) shortens the production time, reduced the production land used, improved production efficiency.Traditional handicraft was produced a collection of common needs 10 days, and new technology only needs 8 days.

(2) improve sanitary condition and production environment, made things convenient for the cleaning and the production management in place.

(3) simplified production procedure, production process is easy to control, has helped realizing automatization, scale and the standardization of concocting.New technology adopts mechanized operation in a large number, as: blender, dicer, microwave oven, traditional handicraft then adopt a large amount of rustless steel table tops and vessel, and it is big to take up room, and are not easy to control and operation.

[specific embodiment]

1, prepare burden according to the prescription ratio:

Flour 25kg; Testa Tritici 75kg; Semen Armeniacae Amarum 4kg; Semen Ormosiae Hosiei 4kg; Herba polygoni hydropiperis 7kg; Herba Artemisiae Annuae 7kg; Herba Xanthii grass 7kg.

2, production technology:

Semen Ormosiae Hosiei is chosen clean impurity be ground into coarse powder, cross 30 mesh sieves, Semen Armeniacae Amarum is removed corium farinosum and is broken into coarse powder, cross 20 mesh sieves, again Herba polygoni hydropiperis, Herba Artemisiae Annuae, Herba Xanthii grass are removed impurity, clean, remove root, be cut into broken end, cross 30 mesh sieves, together put blender in flour and Testa Tritici above-mentioned five kinds of Chinese medicine, spray clear water, stir, make soft material, amount of water should be controlled at the 35%-45% of above-mentioned material gross weight.Taking-up covers completely, temperature keeps 25～28 ℃, relative humidity remains on 70%-80%, and heap fermentation 7～8 days treats that the surface covers with mycelia, the reuse blender is mixed 2～3 times, put in the dicer and dice, after the molding, change belt microwave dryer inner drying over to, sterilization gets final product, the dry sterilization temperature is the 60-80 degree, persistent period 3-5 hour.

3, quality inspection of finished products: 1. tasteless: have aroma, it is good not having the smelly abnormal smells from the patient of going rotten.2. outward appearance: the surface is abound with yellow-white mycelia and the black spore of minority, and the knee-piece edge is foresythia.Observe with magnifier, the bulge of visible yellow color conidinphore also has therebetween and gives birth to the black spore.If bent dry tack free, conidium even all aplasia are bad song.3. inner: good bent piece is solid, and is not broken but the finished product monoblock is taken out, if song in bulk not, or in bulk is shaky, all is the bad cause of hyphal development, and bent inside is observed with magnifier, and also have mycelia and an immature spore more.

The technology of the present invention advanced person, technological design is scientific and reasonable, and production efficiency improves greatly, and can guarantee product quality, satisfies the effective demand of people to health care.The present invention is fit to scale, automated production, is convenient to operation control, and exemplary role is played in the industrial structure optimization and the technology upgrading of prepared slices of Chinese crude drugs production.

Though more than described the specific embodiment of the present invention; but being familiar with those skilled in the art is to be understood that; our described specific embodiment is illustrative; rather than be used for qualification to scope of the present invention; those of ordinary skill in the art are in the modification and the variation of the equivalence of doing according to spirit of the present invention, all should be encompassed in the scope that claim of the present invention protects.

Claims (1)

1. the concocting method of a Massa Medicata Fermentata is characterized in that: described Massa Medicata Fermentata prescription: every 25kg flour: Testa Tritici 75kg, Semen Armeniacae Amarum 4kg, Semen Ormosiae Hosiei 4kg, Herba polygoni hydropiperis 7kg, Herba Artemisiae Annuae 7kg, Herba Xanthii grass 7kg; Its concocting method comprises:

Semen Ormosiae Hosiei is chosen clean impurity be ground into coarse powder, cross 30 mesh sieves, Semen Armeniacae Amarum is removed corium farinosum and is broken into coarse powder, cross 20 mesh sieves, again with Herba polygoni hydropiperis, Herba Artemisiae Annuae, Herba Xanthii grass is removed impurity, cleans, and removes root, be cut into broken end, cross 30 mesh sieves, above-mentioned five kinds of Chinese medicine is put in the blender together with flour and Testa Tritici, spray clear water, stir, make soft material, amount of water should be controlled at the 35%-45% of above-mentioned material gross weight, and taking-up covers completely, temperature keeps 25～28 ℃, relative humidity remains on 70%-80%, and heap fermentation 7～8 days treats that the surface covers with mycelia, the reuse blender is mixed 2～3 times, put in the dicer and dice, after the molding, change the sterilization of belt microwave dryer inner drying over to, the dry sterilization temperature is the 60-80 degree, persistent period 3-5 hour.