CN104547767B - A kind of concocting method for building bent particle - Google Patents
A kind of concocting method for building bent particle Download PDFInfo
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- CN104547767B CN104547767B CN201410824312.4A CN201410824312A CN104547767B CN 104547767 B CN104547767 B CN 104547767B CN 201410824312 A CN201410824312 A CN 201410824312A CN 104547767 B CN104547767 B CN 104547767B
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Abstract
The invention discloses a kind of concocting method for building bent particle, comprise the following steps:Take polygonum flaccidum 6.6g, semen armeniacae amarae 4.0g, hawthorn (stir-fry) 9.0g, rhizoma atractylodis 6.0g, root of Dahurain angelica 3.0g, purple perilla 6.0g, official osmanthus 1.5g, wheat bran 21.2g, Siberian cocklebur grass 6.6g, rde bean 4.0g, dried orange peel 6.0g, bark of official magnolia 3.0g, betel nut 3.0g, peppermint 3.0g, rhizoma cyperi 6.0g, sweet wormwood 6.6g, malt 9.0g, Pogostemon cablin 6.0g, radix jurineae 3.0g, Fructus Aurantii (bran stir-fry) 3.0g, rice sprout 9.0g, radix glycyrrhizae 1.5g are mixed with wheat bran 21.2g, and most fine powder is ground under 20 DEG C ~ 30 DEG C low temperature, sieving;Flour 10.6g is taken to be placed in after being well mixed with most fine powder in secret room, a fermentation extremely time white mould, takes out drying when having wine aroma, produce and build bent particle in the environment of 30 35 DEG C of temperature, humidity 85 90%;Originally building bent particle can directly take after mixing it with water, and without crushing or decoct soup, reduce medication difficulty, without decoct soup during medication, reduce the loss of effective ingredient, while in manufacture craft, by pulverizing medicinal materials into most fine powder, the availability of medicine, the absorption of release and human body to medicine beneficial to medicine are improved.
Description
Technical field
The present invention relates to pharmaceutical formulating art, specially a kind of concocting method for building bent particle.
Background technology
Song is built to record in Drug Standard of Ministry of Public Health of the Peoples Republic of China《Traditional Chinese medicine historical preparation》(17th)In
In Z17-142 page number, its mildly bitter flavor, gas delicate fragrance, have inducing diaphoresis and it is middle the effect of, be mainly used in fever and chills headache, food stagnation resistance
In, vomit turgor.Its preparation method is that the herbal medicine of semen armeniacae amarae, rhizoma atractylodis, root of Dahurain angelica etc. 21 is ground into fine powder, is mixed with wheat bran
Uniformly, sieve, then magma is made in flour, it is soft uniform with above-mentioned medicinal powder while hot, square is made, ferments white all over rising to medicine block
It is mould, when having wine aroma, taking-up is drying to obtain.Meanwhile ministry of Health of China ministry standard《Build bent quality standard》(Standard code WS-
B-3238-98)It is as follows that prepared by middle regulation builds Qu Xingzhuan:This product is filemot rectangle block, and outer surface is coarse, yellowish-brown
Color, there is white mould, section is loose, yellowish-brown;Gas delicate fragrance, mildly bitter flavor.
At present, the song of founding a capital of commercial type is the block being made using traditional handicraft, and manufacture craft is original, product
Matter is more coarse.Applicant has found that the Koji effect of building processed using traditional handicraft is difficult to protect in medicine preparation practice for many years
Barrier, while medication is also inconvenient, it is impossible to fully meet medication demand.
The content of the invention
The invention discloses a kind of processing procedure and method for building bent particle, it is therefore an objective to builds song in the bent class prepared slices of Chinese crude drugs of tradition
On the basis of innovate it is a kind of it is new build bent processing procedure and method, obtain it is a kind of it is new build it is bent process specification, to solve existing build
Bent processing procedure is original, quality matte, drug effect Customers ' Legal Right, and medication is inconvenient, it is impossible to the problem of meeting medication demand, the technique and
Concocting method comprises the following steps:
To achieve these goals, the present invention adopts the following technical scheme that:
A kind of concocting method for building bent particle, comprises the following steps:
(1), polygonum flaccidum 6.6g, semen armeniacae amarae 4.0g, hawthorn (stir-fry) 9.0g, rhizoma atractylodis 6.0g, root of Dahurain angelica 3.0g, purple perilla 6.0g, official are taken
Osmanthus 1.5g, wheat bran 21.2g, Siberian cocklebur grass 6.6g, rde bean 4.0g, dried orange peel 6.0g, bark of official magnolia 3.0g, betel nut 3.0g,
Peppermint 3.0g, rhizoma cyperi 6.0g, sweet wormwood 6.6g, malt 9.0g, Pogostemon cablin 6.0g, radix jurineae 3.0g, Fructus Aurantii (bran
Fry) 3.0g, rice sprout 9.0g, radix glycyrrhizae 1.5g;
(2), by step (1) in medicine mixed with wheat bran 21.2g, be ground into most fine powder under 20 DEG C ~ 30 DEG C cryogenic conditions,
Sieving;
(3), take the most fine powders of flour 10.6g with step to be (2) well mixed;
(4), being placed in secret room (3) by step, fermentation is to white all over rising in the environment of 30-35 DEG C of temperature, humidity 85-90%
It is mould, taken out when having wine aroma;
(5), the pharmaceutical granulation for (4) taking out step is dried, and is produced and is built bent particle.
Further, step(2)Described crushing is that medicine first is ground into coarse powder, and then low temperature is ground in ball mill
Into most fine powder.
Further, step(2)Described sieving refers to that most fine powder can be all by No. six sieves, and can pass through No. seven sieves
No less than 95%.
By adopting the above-described technical solution, produced by the present invention build bent particle in the case of patient medication, can be direct
Take after mixing it with water, without being ground into powder or decoct soup, reduce medication difficulty, without decoct soup during due to medication, reduce effective ingredient
Loss, while in manufacture craft, due into most fine powder, pulverizing medicinal materials are improved into the availability of medicine, in favor of medicine
Absorption to medicine of release and human body.
Compared with prior art, the beneficial effects of the invention are as follows:
1. a pair prescription medicinal material takes low-temperature grinding, to retain effective ingredient in medicinal material to greatest extent.Due to dried orange peel in prescription,
Pogostemon cablin, peppermint, purple perilla are conventional to crush containing a large amount of fragrance and volatilization effective constituents, easily cause loss of effective components, this work
Skill can retain medicinal material active ingredient to greatest extent.
2. mixing while crushing wheat bran with medicinal material, while process procedure is reduced, medicinal material can be reduced in crushing process
Produce bonding, the more conducively crushing of medicinal material.
3. by pulverizing medicinal materials into most fine powder, cell-wall breaking ratio is high, is advantageous to the release and absorption of medicine, is advantageous to finished product clothes
With rear increase drug absorption rate, its bioavilability is improved, drug effect is improved, is more favorable to grain forming.
4. flour paste is not made, and take flour directly with medicinal powder mixing after fermentation, while processing step is reduced, mesh
Be easy for ensure mixing uniformity, also allow for high-volume mixture manufacturing.
5. pelletizing forming after first fermenting, is more first molded after fermentation, finished product character can be effectively ensured, compared with clamp dog after fermentation work
Skill, more conducively ensure the uniformity of pharmaceutical fermentation degree.
6. fermentation temperature controls 30-35 DEG C, ferment humid control 85-90%, is advantageous to zymogenic growth, shortens fermentation
In the cycle, ensure fermented quality.
7. utilizing modern pharmaceutical equipment technology, using one-step palletizing dry technology, realize granulation, dry integrated and
The modernization of quality control, while product quality is improved, production efficiency is greatly improved, reduces labor intensity.
Embodiment
Embodiment 1:
(1), polygonum flaccidum 6.6g, semen armeniacae amarae 4.0g, hawthorn (stir-fry) 9.0g, rhizoma atractylodis 6.0g, root of Dahurain angelica 3.0g, purple perilla 6.0g, official are taken
Osmanthus 1.5g, wheat bran 21.2g, Siberian cocklebur grass 6.6g, rde bean 4.0g, dried orange peel 6.0g, bark of official magnolia 3.0g, betel nut 3.0g,
Peppermint 3.0g, rhizoma cyperi 6.0g, sweet wormwood 6.6g, malt 9.0g, Pogostemon cablin 6.0g, radix jurineae 3.0g, Fructus Aurantii (bran
Fry) 3.0g, rice sprout 9.0g, radix glycyrrhizae 1.5g;
(2), by step (1) in medicine mixed with wheat bran 21.2g, most fine powder is ground under the conditions of 20 DEG C, sieve;
(3), take the most fine powders of flour 10.6g with step to be (2) well mixed, pinched with hand agglomerating;
(4), being placed in secret room (3) by step, fermentation is to white all over rising in the environment of 30-35 DEG C of temperature, humidity 85-90%
It is mould, taken out when having wine aroma;
(5), the pharmaceutical granulation for (4) taking out step is dried, and is produced and is built bent particle.
Embodiment 2:
(1), polygonum flaccidum 6.6g, semen armeniacae amarae 4.0g, hawthorn (stir-fry) 9.0g, rhizoma atractylodis 6.0g, root of Dahurain angelica 3.0g, purple perilla 6.0g, official are taken
Osmanthus 1.5g, wheat bran 21.2g, Siberian cocklebur grass 6.6g, rde bean 4.0g, dried orange peel 6.0g, bark of official magnolia 3.0g, betel nut 3.0g,
Peppermint 3.0g, rhizoma cyperi 6.0g, sweet wormwood 6.6g, malt 9.0g, Pogostemon cablin 6.0g, radix jurineae 3.0g, Fructus Aurantii (bran
Fry) 3.0g, rice sprout 9.0g, radix glycyrrhizae 1.5g;
(2), by step (1) in medicine mixed with wheat bran 21.2g, most fine powder is ground under the conditions of 24 DEG C, sieve;
(3), take the most fine powders of flour 10.6g with step to be (2) well mixed, pinched with hand agglomerating;
(4), being placed in secret room (3) by step, fermentation is to white all over rising in the environment of 30-35 DEG C of temperature, humidity 85-90%
It is mould, taken out when having wine aroma;
(5), the pharmaceutical granulation for (4) taking out step is dried, and is produced and is built bent particle.
Embodiment 3:
(1), polygonum flaccidum 6.6g, semen armeniacae amarae 4.0g, hawthorn (stir-fry) 9.0g, rhizoma atractylodis 6.0g, root of Dahurain angelica 3.0g, purple perilla 6.0g, official are taken
Osmanthus 1.5g, wheat bran 21.2g, Siberian cocklebur grass 6.6g, rde bean 4.0g, dried orange peel 6.0g, bark of official magnolia 3.0g, betel nut 3.0g,
Peppermint 3.0g, rhizoma cyperi 6.0g, sweet wormwood 6.6g, malt 9.0g, Pogostemon cablin 6.0g, radix jurineae 3.0g, Fructus Aurantii (bran
Fry) 3.0g, rice sprout 9.0g, radix glycyrrhizae 1.5g;
(2), by step (1) in medicine mixed with wheat bran 21.2g, most fine powder is ground under the conditions of 27 DEG C, sieve;
(3), take the most fine powders of flour 10.6g with step to be (2) well mixed, pinched with hand agglomerating;
(4), being placed in secret room (3) by step, fermentation is to white all over rising in the environment of 30-35 DEG C of temperature, humidity 85-90%
It is mould, taken out when having wine aroma;
(5), the pharmaceutical granulation for (4) taking out step is dried, and is produced and is built bent particle.
Embodiment 4:
(1), polygonum flaccidum 6.6g, semen armeniacae amarae 4.0g, hawthorn (stir-fry) 9.0g, rhizoma atractylodis 6.0g, root of Dahurain angelica 3.0g, purple perilla 6.0g, official are taken
Osmanthus 1.5g, wheat bran 21.2g, Siberian cocklebur grass 6.6g, rde bean 4.0g, dried orange peel 6.0g, bark of official magnolia 3.0g, betel nut 3.0g,
Peppermint 3.0g, rhizoma cyperi 6.0g, sweet wormwood 6.6g, malt 9.0g, Pogostemon cablin 6.0g, radix jurineae 3.0g, Fructus Aurantii (bran
Fry) 3.0g, rice sprout 9.0g, radix glycyrrhizae 1.5g;
(2), by step (1) in medicine mixed with wheat bran 21.2g, most fine powder is ground under the conditions of 30 DEG C, sieve;
(3), take the most fine powders of flour 10.6g with step to be (2) well mixed, pinched with hand agglomerating;
(4), being placed in secret room (3) by step, fermentation is to white all over rising in the environment of 30-35 DEG C of temperature, humidity 85-90%
It is mould, taken out when having wine aroma;
(5), the pharmaceutical granulation for (4) taking out step is dried, and is produced and is built bent particle.
Embodiment 5:
(1), polygonum flaccidum 6.6g, semen armeniacae amarae 4.0g, hawthorn (stir-fry) 9.0g, rhizoma atractylodis 6.0g, root of Dahurain angelica 3.0g, purple perilla 6.0g, official are taken
Osmanthus 1.5g, wheat bran 21.2g, Siberian cocklebur grass 6.6g, rde bean 4.0g, dried orange peel 6.0g, bark of official magnolia 3.0g, betel nut 3.0g,
Peppermint 3.0g, rhizoma cyperi 6.0g, sweet wormwood 6.6g, malt 9.0g, Pogostemon cablin 6.0g, radix jurineae 3.0g, Fructus Aurantii (bran
Fry) 3.0g, rice sprout 9.0g, radix glycyrrhizae 1.5g;
(2), by step (1) in medicine mixed with wheat bran 21.2g, most fine powder is ground under the conditions of 20 DEG C, sieve;
(3), take the most fine powders of flour 10.6g with step to be (2) well mixed, pinched with hand agglomerating;
(4), being placed in secret room (3) by step, in the environment of 30 DEG C of temperature, humidity 85% fermentation have wine to all over a white mould is played
Taken out during fragrance;
(5), the pharmaceutical granulation for (4) taking out step is dried, and is produced and is built bent particle.
Embodiment 6:
(1), polygonum flaccidum 6.6g, semen armeniacae amarae 4.0g, hawthorn (stir-fry) 9.0g, rhizoma atractylodis 6.0g, root of Dahurain angelica 3.0g, purple perilla 6.0g, official are taken
Osmanthus 1.5g, wheat bran 21.2g, Siberian cocklebur grass 6.6g, rde bean 4.0g, dried orange peel 6.0g, bark of official magnolia 3.0g, betel nut 3.0g,
Peppermint 3.0g, rhizoma cyperi 6.0g, sweet wormwood 6.6g, malt 9.0g, Pogostemon cablin 6.0g, radix jurineae 3.0g, Fructus Aurantii (bran
Fry) 3.0g, rice sprout 9.0g, radix glycyrrhizae 1.5g;
(2), by step (1) in medicine mixed with wheat bran 21.2g, most fine powder is ground under the conditions of 20 DEG C, sieve;
(3), take the most fine powders of flour 10.6g with step to be (2) well mixed, pinched with hand agglomerating;
(4), being placed in secret room (3) by step, in the environment of 30 DEG C of temperature, humidity 90% fermentation have wine to all over a white mould is played
Taken out during fragrance;
(5), the pharmaceutical granulation for (4) taking out step is dried, and is produced and is built bent particle.
Embodiment 7:
(1), polygonum flaccidum 6.6g, semen armeniacae amarae 4.0g, hawthorn (stir-fry) 9.0g, rhizoma atractylodis 6.0g, root of Dahurain angelica 3.0g, purple perilla 6.0g, official are taken
Osmanthus 1.5g, wheat bran 21.2g, Siberian cocklebur grass 6.6g, rde bean 4.0g, dried orange peel 6.0g, bark of official magnolia 3.0g, betel nut 3.0g,
Peppermint 3.0g, rhizoma cyperi 6.0g, sweet wormwood 6.6g, malt 9.0g, Pogostemon cablin 6.0g, radix jurineae 3.0g, Fructus Aurantii (bran
Fry) 3.0g, rice sprout 9.0g, radix glycyrrhizae 1.5g;
(2), by step (1) in medicine mixed with wheat bran 21.2g, most fine powder is ground under the conditions of 30 DEG C, sieve;
(3), take the most fine powders of flour 10.6g with step to be (2) well mixed, pinched with hand agglomerating;
(4), being placed in secret room (3) by step, in the environment of 35 DEG C of temperature, humidity 85% fermentation have wine to all over a white mould is played
Taken out during fragrance;
(5), the pharmaceutical granulation for (4) taking out step is dried, and is produced and is built bent particle.
Embodiment 8:
(1), polygonum flaccidum 6.6g, semen armeniacae amarae 4.0g, hawthorn (stir-fry) 9.0g, rhizoma atractylodis 6.0g, root of Dahurain angelica 3.0g, purple perilla 6.0g, official are taken
Osmanthus 1.5g, wheat bran 21.2g, Siberian cocklebur grass 6.6g, rde bean 4.0g, dried orange peel 6.0g, bark of official magnolia 3.0g, betel nut 3.0g,
Peppermint 3.0g, rhizoma cyperi 6.0g, sweet wormwood 6.6g, malt 9.0g, Pogostemon cablin 6.0g, radix jurineae 3.0g, Fructus Aurantii (bran
Fry) 3.0g, rice sprout 9.0g, radix glycyrrhizae 1.5g;
(2), by step (1) in medicine mixed with wheat bran 21.2g, most fine powder is ground under the conditions of 30 DEG C, sieve;
(3), take the most fine powders of flour 10.6g with step to be (2) well mixed, pinched with hand agglomerating;
(4), being placed in secret room (3) by step, in the environment of 35 DEG C of temperature, humidity 90% fermentation have wine to all over a white mould is played
Taken out during fragrance;
(5), the pharmaceutical granulation for (4) taking out step is dried, and is produced and is built bent particle.
Claims (4)
1. a kind of concocting method for building bent particle, it is characterised in that comprise the following steps:
(1), polygonum flaccidum 6.6g, semen armeniacae amarae 4.0g, stir-baked FRUCTUS CRATAEGI 9.0g taken, rhizoma atractylodis 6.0g, root of Dahurain angelica 3.0g, purple perilla 6.0g, official osmanthus 1.5g,
Wheat bran 21.2g, Siberian cocklebur grass 6.6g, rde bean 4.0g, dried orange peel 6.0g, bark of official magnolia 3.0g, betel nut 3.0g,
Peppermint 3.0g, rhizoma cyperi 6.0g, sweet wormwood 6.6g, malt 9.0g, Pogostemon cablin 6.0g, radix jurineae 3.0g, stir-baked FRUCTUS AURANTII in bran 3.0g,
Rice sprout 9.0g, radix glycyrrhizae 1.5g;
(2), by step (1) in medicine mixed with wheat bran 21.2g, be ground under the temperature conditionss of 20 DEG C ~ 30 DEG C of temperature most thin
Powder, sieving;
(3), take the most fine powders of flour 10.6g with step to be (2) well mixed;
(4), the mixed most fine powder of step (3) is placed in secret room, sent out in the environment of 30-35 DEG C of temperature, humidity 85-90%
Ferment takes out to all over white mould is played when having wine aroma;
(5), the medicine for (4) taking out step synchronously granulation drying, produces and builds bent particle.
A kind of 2. concocting method for building bent particle according to claim 1, it is characterised in that:Step(2)Described crushing
It is that medicine is first ground into coarse powder, then low temperature is milled to most fine powder in ball mill.
A kind of 3. concocting method for building bent particle according to claim 1, it is characterised in that:Step(2)Described sieving
Refer to that most fine powder can be all by No. six sieves, and 95% can be no less than by No. seven sieves.
A kind of 4. concocting method for building bent particle according to claim 1, it is characterised in that:Step(3)Described mixing
Uniformly, agglomerating, to throw i.e. scattered state is pinched with hand.
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CN105617148B (en) * | 2016-02-01 | 2019-11-08 | 四川仟源中药饮片有限公司 | One kind building bent preparation method |
CN109908242A (en) * | 2019-03-15 | 2019-06-21 | 湖南德康制药股份有限公司 | A kind of preparation method of Simotang Granule agent |
CN111388520A (en) * | 2019-11-18 | 2020-07-10 | 浙江桐君堂中药饮片有限公司 | Fermentation method of Jianqu |
CN113713061B (en) * | 2021-08-27 | 2022-05-06 | 四川百胜药业有限公司 | Jian qu and preparation method thereof |
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