CN105617148B - One kind building bent preparation method - Google Patents

One kind building bent preparation method Download PDF

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Publication number
CN105617148B
CN105617148B CN201610073537.XA CN201610073537A CN105617148B CN 105617148 B CN105617148 B CN 105617148B CN 201610073537 A CN201610073537 A CN 201610073537A CN 105617148 B CN105617148 B CN 105617148B
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parts
fermentation
flour
bent
wheat bran
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CN105617148A (en
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茅仁刚
代向向
金箭飞
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Shanxi Challenge & Young Pharmaceutical Group Co Ltd
Sichuan C&y Traditional Chinese Medicine Co Ltd
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Shanxi Challenge & Young Pharmaceutical Group Co Ltd
Sichuan C&y Traditional Chinese Medicine Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8998—Hordeum (barley)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment

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Abstract

The invention discloses one kind to build bent preparation method, including sorting weighs, and crushes, paste producing, mixes, ferment, pelletizes, dry, briquetting, packaging and other steps.The present invention by change first form post-fermentation re-dry tradition build bent production technology be first ferment pelletize again it is dry after molding production technology, and strict control fermentation condition and fermentation termination, it improves and builds bent appearance character, reduce content of toxins, improve product quality.Bent consolidation exquisiteness is built according to bulk made of new process, any surface finish, no clast falls off, uniform color, no mildew.

Description

One kind building bent preparation method
Technical field
The invention belongs to the field of Chinese medicines, and in particular to build bent preparation method to a kind of prepared slices of Chinese crude drugs.
Background technique
A kind of " building song " conventional Chinese medicine herbal leaven, is recorded in " Drug Standard of Ministry of Public Health of the Peoples Republic of China Chinese traditional patent formulation system Agent the 17th ", primary efficacy is inducing diaphoresis in, it has a headache for fever and chills, in food resistance, the diseases such as vomiting turgor.Build bent acrid flavour, It is sweet, warm-natured, slight bitter.Returns spleen, stomach meridian.Have the function of promoting digestion and removing indigestion, expelling cold, eliminating, strengthening the spleen and stomach, is eaten for cold headache, place Stagnant, fullness and oppression of chest and abdomen, splenasthenic diarrhea.Build song be tens kinds of Chinese medicines through spontaneous fermentation and made of herbal leaven, be filemot length Rectangular block, outer surface is coarse, yellowish-brown, there is white mould, and section is loose；Gas faint scent, mildly bitter flavor.Its prescription and preparation method are as follows:
Prescription: hairy knotweed herb or root 6.6g, Siberian cocklebur grass 6.6g, sweet wormwood 6.6g, semen armeniacae amarae 4g, rde bean 4g, malt 9g, hawthorn (stir-fry) 9g, dried orange peel 6g, Pogostemon cablin 6g, rhizoma atractylodis 6g, Cortex Magnoliae Officinalis 3g, radix jurineae 3g, root of Dahurain angelica 3g, Fructus Aurantii (bran stir-fry) 3g, betel nut 3g, purple perilla 6g, Peppermint 3g, rice sprout 9g, Cortex Cinnamomi 1.5g, rhizoma cyperi 6g, Radix Glycyrrhizae 1.5g, wheat bran 21.2g, flour 10.6g；
Preparation method: above 23 taste, in addition to wheat bran, flour, remaining polygonum flaccidum etc. 20 is ground into fine powder simply, mixed with wheat bran Even, then appropriate magma is made in flour by sieving, while hot uniformly with the kneading of above-mentioned medicinal powder, pinched with hand it is agglomerating, throw it is i.e. scattered be advisable, Square is made, sets in fermenting case, there are gap, upper cover gunnysack or straw between block, sets fermentation to medicine block time in confined chamber and plays a white mould, It takes out when there is aroma of wine, a heatable brick bed is dry.
Character: this product is filemot rectangular block, and outer surface is coarse, yellowish-brown, there is white mould, and section is loose, yellow Brown；Gas faint scent, mildly bitter flavor.
The whole nation has more than 20 family's pharmacy corporations to obtain the authentication code for building bent national drug standard at present, but due to the preparation Technique has only crushed 20 medicinal materials simply, and the auxiliary material wheat bran of slabbing, size distribution unevenness is not ground into fine powder, and adopts With the traditional processing technology for first forming post-fermentation re-dry.Loose, the surface of building Qu Chengpin quality traditionally produced It is coarse, easy to break, the chips affect to fall off the presentation quality of whole product of contracting for fixed output quotas.And build the mould mark of white of curved surface, Chang Rangren The prepared slices of Chinese crude drugs of moldy metamorphism are mistaken for, bring power-assisted to the sale of product.Our enterprises are passed through to be studied repeatedly, is developed Fermentation procedure and molding procedure have only been carried out the exchange of order, have increased sieving process, object by new production technology, new process The variation of reason process will not have a negative impact to bent inherent quality is built, and can improve again and build bent appearance character.Using new Closer, any surface finish of building bent quality of technique preparation effectively prevents fragmentation during packaging, transport and storage, de- Phenomenon is fallen, the white mould phenomenon for allowing people to misunderstand especially is a cancellation, avoids issuable misunderstanding, and it is conventionally produced Song of building compare, new process, which improves, builds bent appearance character, improves image product, helps to build the bent market expansion.This Outside, due to supplementary material huge number, quality is not tight to check on and production environment, fermentation time, fermentation temperature and fermentation termination etc. Fermentation is not tight, cause to bring into supplementary material or/and fermentation process in newborn aflatoxins, significantly reduce build it is bent Traction has seriously affected and has built bent market sale.
Summary of the invention
The purpose of the present invention is to provide it is a kind of it is more scientific reasonably build bent preparation method, it is bent thick to overcome tradition to build Rough, easy fragmentation has the shortcomings that mould mark, and blocks bringing into for aflatoxins by strict control supplementary material quality；By stringent Control technological condition for fermentation and fermentation termination prevent newborn aflatoxins during the fermentation, have prevented aflatoxins from source Equal toxic components excessive problem, improves and builds bent product quality.
It is provided by the invention to build bent preparation method, including sorting weighing, it crushes, paste producing, mixes, ferment, pelletize, drying, Briquetting and packaging process, the specific process steps are as follows:
1) sorting weighs: supplementary material of the selection without mildew is weighed by prescription: 6.6 parts of hairy knotweed herb or root, 6.6 parts of Siberian cocklebur grass, green 6.6 parts of wormwood artemisia, 4 parts of semen armeniacae amarae, 4 parts of rde bean, 9 parts of malt, 9 parts of hawthorn (stir-fry) is 6 parts of dried orange peel, 6 parts of Pogostemon cablin, 6 parts of rhizoma atractylodis, thick 3 parts of Piao, 3 parts of radix jurineae, 3 parts of the root of Dahurain angelica, 3 parts of Fructus Aurantii (bran stir-fry), 3 parts of betel nut, 6 parts of purple perilla, 3 parts of peppermint, 9 parts of rice sprout, Cortex Cinnamomi 1.5 parts, 6 parts of rhizoma cyperi, 1.5 parts of Radix Glycyrrhizae, 21.2 parts of wheat bran, 10.6 parts of flour；The above are parts by weight；
2) it crushes: by addition to wheat bran, flour, remaining 20 was ground into 80~120 purposes simply in above 23 taste Fine powder；It is preferred that crushed the wheat bran fine powder of 80~120 mesh.
3) paste producing: flour being melted with 5-10 times of weight water, is mixed well, and magma is made in heating；
4) it mixes: fine powder obtained by step 2) and wheat bran is mixed, be added in magma made from step 3) while hot, kneading Uniformly, it is pinched agglomerating, is laid in stainless steel pallet, thickness is in 1-5cm, preferably 2-4cm with hand；
5) ferment: set in fermenting case in 15-30 DEG C fermentation 24-72 hours, until fermentation termination taking-up；The fermentation termination is Medicine block does not have variegated spore to generate and when there is aroma of wine all over a white hypha body is played；It is preferred that technological condition for fermentation is temperature 20-26 DEG C, time 36-48 hour.
6) it pelletizes: being placed in oscillating granulator and cross the granulation of 12-20 mesh, share in stainless steel disc；
7) dry: to be placed in 60-105 DEG C of drying in drying box；
8) whole grain: 12-20 mesh whole grain is crossed；
9) briquetting: briquetting is carried out with every piece of weight 3-15g, the shape of block includes cube, cuboid, cylindrical body, oval master One or more of body.
10) it packs.
The present invention by change first form post-fermentation re-dry build bent production technology be first ferment pelletize again after molding life Production. art, and strict control fermentation termination improve and build bent appearance character, reduce aflatoxin content, improve Product quality.
Detailed description of the invention
Fig. 1 builds Qu Chengpin photo for prepared by embodiment 1.
Fig. 2 builds Qu Chengpin photo for prepared by comparative examples 4.
Specific embodiment
Present pre-ferred embodiments are provided with reference to the accompanying drawing, in order to explain the technical scheme of the invention in detail.
Embodiment 1
The supplementary material without mildew is chosen, is weighed by prescription: hairy knotweed herb or root 6.6g, Siberian cocklebur grass 6.6g, sweet wormwood 6.6g, semen armeniacae amarae 4g, rde bean 4g, malt 9g, hawthorn (stir-fry) 9g, dried orange peel 6g, Pogostemon cablin 6g, rhizoma atractylodis 6g, Cortex Magnoliae Officinalis 3g, radix jurineae 3g, root of Dahurain angelica 3g, Fructus Aurantii (bran stir-fry) 3g, betel nut 3g, purple perilla 6g, peppermint 3g, rice sprout 9g, Cortex Cinnamomi 1.5g, rhizoma cyperi 6g, Radix Glycyrrhizae 1.5g, wheat bran 21.2g, Flour 10.6g；Above 23 taste, in addition to wheat bran, flour, remaining hairy knotweed herb or root etc. 20 was ground into 80 targeted fine powders simply, It is uniformly mixed；Flour is opened with 5 times of amount (G/G) aquations, is mixed well, magma is made in heating；By the above fine powder, magma is added while hot, Kneading uniformly, pinched with hand it is agglomerating, throw it is i.e. scattered be advisable, be laid in stainless steel pallet, with a thickness of 2cm；It sets in fermenting case in 20 DEG C fermentation 48 hours, until medicine block all over rise a white mould, taking-up when having wine aroma and non-variegation spore；It is placed in oscillating granulator and crosses 14 Mesh granulation, shares in stainless steel disc；It is placed in 60 DEG C of dryings in drying box；Cross 16 mesh whole grains；It is pressed into cuboid fritter: every Block weight 5g；Packaging to get.Refer to according to mycotoxin measurement in the Pharmacopoeia of the People's Republic of China four 9305 Chinese medicines of version in 2015 Principle measurement aflatoxin B1 is led, as a result builds and aflatoxin B1 is not detected in Qu Chengpin.It builds Qu Chengpin photo and sees attached drawing 1.
Embodiment 2
The supplementary material without mildew is chosen, is weighed by prescription: hairy knotweed herb or root 6.6g, Siberian cocklebur grass 6.6g, sweet wormwood 6.6g, semen armeniacae amarae 4g, rde bean 4g, malt 9g, hawthorn (stir-fry) 9g, dried orange peel 6g, Pogostemon cablin 6g, rhizoma atractylodis 6g, Cortex Magnoliae Officinalis 3g, radix jurineae 3g, root of Dahurain angelica 3g, Fructus Aurantii (bran stir-fry) 3g, betel nut 3g, purple perilla 6g, peppermint 3g, rice sprout 9g, Cortex Cinnamomi 1.5g, rhizoma cyperi 6g, Radix Glycyrrhizae 1.5g, wheat bran 21.2g, Flour 10.6g；Above 23 taste, in addition to wheat bran, flour, remaining hairy knotweed herb or root etc. 20 was ground into 100 targeted fine powders simply, It is uniformly mixed；Flour is opened with 8 times of amount (G/G) aquations, is mixed well, magma is made in heating；By the above fine powder, magma is added while hot, Kneading uniformly, pinched with hand it is agglomerating, throw it is i.e. scattered be advisable, be laid in stainless steel pallet, with a thickness of 3cm；It sets in fermenting case in 26 DEG C fermentation 36 hours, until medicine block all over rise a white mould, taking-up when having wine aroma and non-variegation spore；It is placed in oscillating granulator and crosses 12 Mesh granulation, shares in stainless steel disc；It is placed in 60 DEG C of dryings in drying box；Cross 14 mesh whole grains；It is pressed into cylindrical fritter: Every piece of weight 10g；Packaging to get.It is surveyed according to mycotoxin in the Pharmacopoeia of the People's Republic of China four 9305 Chinese medicines of version in 2015 Determine guideline measurement aflatoxin B1, the content for as a result building aflatoxin B1 in Qu Chengpin is 0.1 μ g/kg.
Embodiment 3
The supplementary material without mildew is chosen, is weighed by prescription: hairy knotweed herb or root 6.6g, Siberian cocklebur grass 6.6g, sweet wormwood 6.6g, semen armeniacae amarae 4g, rde bean 4g, malt 9g, hawthorn (stir-fry) 9g, dried orange peel 6g, Pogostemon cablin 6g, rhizoma atractylodis 6g, Cortex Magnoliae Officinalis 3g, radix jurineae 3g, root of Dahurain angelica 3g, Fructus Aurantii (bran stir-fry) 3g, betel nut 3g, purple perilla 6g, peppermint 3g, rice sprout 9g, Cortex Cinnamomi 1.5g, rhizoma cyperi 6g, Radix Glycyrrhizae 1.5g, wheat bran 21.2g, Flour 10.6g；Above 23 taste, in addition to the flour, 22 taste such as remaining hairy knotweed herb or root were ground into 120 targeted fine powders, mixing Uniformly；Flour is opened with 10 times of amount (G/G) aquations, is mixed well, magma is made in heating；By the above fine powder, magma is added while hot, integrates Uniformly, pinched with hand it is agglomerating, throw i.e. dissipate be advisable, be laid in stainless steel pallet, with a thickness of 4cm；It sets in fermenting case and is sent out in 22 DEG C Ferment 42 hours, until medicine block time plays a white mould, taking-up when having wine aroma and non-variegation spore；It is placed in oscillating granulator and crosses 20 meshes Granulation, shares in stainless steel disc；It is placed in 105 DEG C of dryings in drying box；Cross 20 mesh whole grains；It is pressed into cube shaped fritter: every Block weight 30g；Packaging to get.It is measured according to mycotoxin in the Pharmacopoeia of the People's Republic of China four 9305 Chinese medicines of version in 2015 Guideline measures aflatoxin B1, as a result builds and aflatoxin B1 is not detected in Qu Chengpin.
Comparative examples 4
Supplementary material is weighed by prescription: hairy knotweed herb or root 6.6g, Siberian cocklebur grass 6.6g, sweet wormwood 6.6g, semen armeniacae amarae 4g, rde bean 4g, wheat Bud 9g, hawthorn (stir-fry) 9g, dried orange peel 6g, Pogostemon cablin 6g, rhizoma atractylodis 6g, Cortex Magnoliae Officinalis 3g, radix jurineae 3g, root of Dahurain angelica 3g, Fructus Aurantii (bran stir-fry) 3g, Betel nut 3g, purple perilla 6g, peppermint 3g, rice sprout 9g, Cortex Cinnamomi 1.5g, rhizoma cyperi 6g, Radix Glycyrrhizae 1.5g, wheat bran 21.2g, flour 10.6g；More than 23 tastes, in addition to wheat bran, flour, remaining polygonum flaccidum etc. 20 is ground into fine powder simply, is uniformly mixed；By about 10 times of amounts of flour Aquation is opened, and is mixed well, and magma is made in heating；Appropriate magma is made in flour again, while hot uniformly with the kneading of above-mentioned fine powder, is pinched into hand Group, dissipating for throwing are advisable, square are made, sets in fermenting case, there are gap, upper cover gunnysack or straw between block, set hair in confined chamber Ferment, all over a white mould is played, takes out when there is aroma of wine to medicine block, and a heatable brick bed is dry, packaging to get.According to the Pharmacopoeia of the People's Republic of China 2015 One annex of version: aflatoxin measuring method measures aflatoxin B1, and as a result aflatoxin B1 is 6.1 μ g/kg.Build song Finished product photo is shown in attached drawing 2.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this The principle of invention, various changes and improvements may be made to the invention without departing from the spirit and scope of the present invention, these changes Change and improvement all fall within the protetion scope of the claimed invention.

Claims (5)

1. one kind builds bent preparation method, which is characterized in that using first ferment pelletize again it is dry after molding production technology, it is specific to walk Suddenly are as follows:
1) sorting weighs: choosing the supplementary material without mildew, weighs by following parts by weight: is 6.6 parts of hairy knotweed herb or root, 6.6 parts of Siberian cocklebur grass, green 6.6 parts of wormwood artemisia, 4 parts of semen armeniacae amarae, 4 parts of rde bean, 9 parts of malt, 9 parts of stir-baked FRUCTUS CRATAEGI, 6 parts of dried orange peel, 6 parts of Pogostemon cablin, 6 parts of rhizoma atractylodis, Cortex Magnoliae Officinalis 3 Part, it is 3 parts of radix jurineae, 3 parts of the root of Dahurain angelica, 3 parts of stir-baked FRUCTUS AURANTII in bran, 3 parts of betel nut, 6 parts of purple perilla, 3 parts of peppermint, 9 parts of rice sprout, 1.5 parts of Cortex Cinnamomi, fragrant Attached 6 parts, 1.5 parts of Radix Glycyrrhizae, 21.2 parts of wheat bran, 10.6 parts of flour；The above are parts by weight；
2) it crushes: by remaining 20 powder for being ground into 80-120 mesh simply in above 23 taste in addition to wheat bran, flour；
3) paste producing: flour being melted with 5-10 times of weight water, is mixed well, and magma is made in heating；
4) it mixes: fine powder obtained by step 2) and wheat bran is mixed, be added in magma made from step 3) while hot, mixing is equal It is even, it is laid in stainless steel pallet, thickness is in 1-5cm；
5) ferment: set in fermenting case in 15-30 DEG C fermentation 24-72 hours, until fermentation termination taking-up；The fermentation termination is medicine block All over rise a white hypha, news have wine aroma, but do not have variegated spore generation when；
6) it pelletizes: being placed in oscillating granulator and cross the granulation of 12-20 mesh；
7) dry: to share in stainless steel disc, be placed in 60-105 DEG C of drying in drying box；
8) whole grain: 12-20 mesh sieve is crossed；
9) briquetting briquetting: is carried out with every piece of weight 5-30g；
10) it packs.
2. according to claim 1 build bent preparation method, which is characterized in that the wheat bran in step 2) is that crushed 80 meshes Fine powder.
3. according to claim 1 build bent preparation method, which is characterized in that the tiling in step 4) is with a thickness of 2-4cm.
4. according to claim 1 build bent preparation method, which is characterized in that the technological condition for fermentation in step 5) is temperature 20-26 DEG C, time 36-48 hour.
5. according to claim 1 build bent preparation method, which is characterized in that the shape of briquet includes vertical in step 9) One or more of cube, cuboid, cylindrical body, Elliptic Cylinder.
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