CN113440583B - Traditional Chinese medicine composition with functions of clearing heat and removing internal heat, preparation method and application thereof, and product containing traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition with functions of clearing heat and removing internal heat, preparation method and application thereof, and product containing traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition with functions of clearing heat and reducing internal heat, a preparation method and application thereof, wherein the traditional Chinese medicine composition is at least prepared from the following raw material medicines: fructus Gardeniae, flos Chrysanthemi, plumula Nelumbinis, corm Eleocharitis, rhizoma Phragmitis, herba Taraxaci, flos Lonicerae, folium forsythiae, flos Sophorae Immaturus, herba Houttuyniae, and herba Portulacae. The disclosure also relates to products containing the traditional Chinese medicine composition.
Description
Technical Field
The disclosure relates to the technical field of medicines, health-care foods and foods, in particular to a traditional Chinese medicine composition with functions of clearing heat and reducing internal heat, a preparation method and application thereof, and a product containing the traditional Chinese medicine composition.
Background
The modern society has fast pace of life, fierce social competition and great life pressure, and almost everyone can possibly have the condition of getting inflamed. For example, some people still keep the eating habits in winter after spring, for example, people like to eat spicy and warm food such as hot pepper, and the like, and the internal accumulated dry fire is easily caused. Some people are used to cover the clothes in spring, but the temperature is too high, and the internal fire is increased if the clothes are not reduced.
Stomach fire, liver fire, lung fire and the like belong to one of the excessive internal heat, and the specific symptoms comprise red and swollen eyes, erosion of mouth and corners, yellow urine, toothache, sore throat, dry stool, constipation and the like, and the excessive internal heat causes the immunity of the organism to be reduced, thereby not only affecting the mood of people, but also being directly related to the health of the human body.
Therefore, the research and development of a medicament with good heat-clearing and internal-heat-reducing effects is a problem to be solved urgently.
Disclosure of Invention
According to an embodiment of the present disclosure, there is provided a Chinese medicinal composition, wherein the Chinese medicinal composition is prepared from at least the following raw material herbs: fructus Gardeniae, flos Chrysanthemi, plumula Nelumbinis, corm Eleocharitis, rhizoma Phragmitis, herba Taraxaci, flos Lonicerae, folium forsythiae, flos Sophorae Immaturus, herba Houttuyniae, and herba Portulacae.
According to an embodiment of the present disclosure, there is provided a method for preparing a Chinese medicinal composition according to the present disclosure, comprising the following steps:
(1) Mixing the raw materials except for herba Houttuyniae, wherein the raw materials comprise fructus Gardeniae, flos Chrysanthemi, plumula Nelumbinis, corm Eleocharitis, rhizoma Phragmitis, herba Taraxaci, flos Lonicerae, folium forsythiae, flos Sophorae Immaturus, herba Houttuyniae, and herba Portulacae, soaking in water, heating and reflux extracting, adding herba Houttuyniae before extraction, and filtering to obtain filtrate;
(2) Concentrating the filtrate obtained in the step (1) and drying.
According to an embodiment of the present disclosure, there may be provided a use of the traditional Chinese medicine composition according to the present disclosure in preparing a medicine, health food or food having a function of clearing heat and reducing internal heat.
According to an embodiment of the present disclosure, there may be provided a product comprising a Chinese medicinal composition as described in the present disclosure.
Detailed Description
Unless otherwise indicated, all numbers expressing volumes, weights, temperatures, times, densities, parts by weight, technical effects, and so forth, used in the specification and claims are to be understood as being modified in all instances by the term "about" or "approximately". Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and attached claims are approximations. Unless otherwise defined, terms used herein have their commonly understood meanings to those skilled in the art. To those skilled in the art, which may vary depending on the desired properties and effects sought to be obtained by the present disclosure, each numerical parameter should be construed in light of the number of significant digits and ordinary rounding approaches or ways understood by those skilled in the art.
Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the disclosure are approximations, the numerical values set forth in the specific examples are provided as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements. Every numerical range given throughout this specification will include every narrower numerical range that falls within such broader numerical range, as if such narrower numerical ranges were all expressly written herein.
The inventor of the invention creatively discovers a traditional Chinese medicine composition with the functions of clearing heat and removing internal heat, which is prepared from at least the following raw material medicines: gardenia, chrysanthemum, lotus plumule, water chestnut, reed rhizome, dandelion, honeysuckle, weeping forsythia leaves, sophora flower bud, heartleaf houttuynia herb and purslane. In the traditional Chinese medicine composition, gardenia is a monarch drug, chrysanthemum and lotus plumule are ministerial drugs, sophora flower bud, water chestnut, weeping forsythia leaves, reed rhizome, honeysuckle and dandelion are adjuvant drugs, and houttuynia and purslane are conductant drugs. Experiments show that the traditional Chinese medicine composition disclosed by the invention can promote defecation and relieve fever, has remarkable effects of clearing heat and reducing internal heat, and can be used for treating sore throat, aphtha in the mouth and tongue, vexation due to fever, insomnia, amnesia, constipation and the like.
According to an embodiment of the present disclosure, there is provided a Chinese medicinal composition, wherein the Chinese medicinal composition is prepared from at least the following raw material herbs: fructus Gardeniae, flos Chrysanthemi, plumula Nelumbinis, corm Eleocharitis, rhizoma Phragmitis, herba Taraxaci, flos Lonicerae, folium forsythiae, flos Sophorae Immaturus, herba Houttuyniae, and herba Portulacae.
In some embodiments of the present disclosure, the following raw material drugs may be in parts by weight: 3-6 parts of cape jasmine, 4-7 parts of chrysanthemum and 1-3 parts of lotus plumule, wherein the parts by weight are all dry weight of the raw material medicines.
In some embodiments of the present disclosure, the following raw material drugs may be in parts by weight: 4-5 parts of cape jasmine, 4-6 parts of chrysanthemum and 2-3 parts of lotus plumule, wherein the parts by weight are all dry weight of the raw material medicines.
In some embodiments of the present disclosure, the following raw material drugs may be in parts by weight: 3 parts of cape jasmine, 4 parts of chrysanthemum and 1 part of lotus plumule, wherein the parts by weight are all dry weight of the raw material medicines.
In some embodiments of the present disclosure, the following raw material drugs may be in parts by weight: 6 parts of cape jasmine, 7 parts of chrysanthemum and 3 parts of lotus plumule, wherein the parts by weight are all dry weight of the raw material medicines.
In some embodiments of the present disclosure, the following raw material drugs may be in parts by weight: 5 parts of cape jasmine, 5 parts of chrysanthemum and 3 parts of lotus plumule, wherein the parts by weight are all dry weight of the raw material medicines.
In some embodiments of the present disclosure, the following raw material drugs may be in parts by weight: 10-20 parts of water chestnuts, 7-15 parts of reed rhizome, 5-12 parts of dandelion, 3-10 parts of honeysuckle, 3-8 parts of forsythia leaves, 3-7 parts of sophora flower buds, 7-14 parts of houttuynia cordata and 4-9 parts of purslane, wherein the weight parts are the dry weight of the raw material medicines.
In some embodiments of the present disclosure, the following raw material drugs may be in parts by weight: 12-17 parts of water chestnuts, 9-12 parts of reed rhizome, 6-10 parts of dandelion, 5-9 parts of honeysuckle, 4-6 parts of forsythia leaves, 4-6 parts of sophora flower buds, 10-14 parts of houttuynia cordata and 5-8 parts of purslane, wherein the weight parts are the dry weight of the raw material medicines.
In some embodiments of the present disclosure, the following raw material drugs may be in parts by weight: 20 parts of water chestnuts, 15 parts of reed rhizome, 12 parts of dandelion, 10 parts of honeysuckle, 8 parts of forsythia suspense leaves, 7 parts of sophora flower buds, 14 parts of houttuynia cordata and 9 parts of purslane, wherein the parts by weight are all dry weight of the raw material medicines.
In some embodiments of the present disclosure, the following raw material drugs may be in parts by weight: 10 parts of water chestnut, 7 parts of reed rhizome, 5 parts of dandelion, 3 parts of honeysuckle, 3 parts of forsythia suspense leaves, 3 parts of sophora flower bud, 7 parts of houttuynia cordata and 4 parts of purslane, wherein the parts by weight are all dry weight of the raw material medicines.
In some embodiments of the present disclosure, the following raw material drugs may be in parts by weight: 15 parts of water chestnut, 10 parts of reed rhizome, 10 parts of dandelion, 8 parts of honeysuckle, 5 parts of forsythia suspense leaves, 5 parts of sophora flower bud, 13 parts of houttuynia cordata and 8 parts of purslane, wherein the parts by weight are all dry weight of the raw material medicines.
In some embodiments of the present disclosure, the following raw material drugs may be in parts by weight: 10-20 parts of water chestnut, 14-30 parts of reed rhizome, 5-12 parts of dandelion, 3-10 parts of honeysuckle, 3-8 parts of forsythia suspense leaves, 3-7 parts of sophora flower bud, 14-28 parts of houttuynia cordata and 4-9 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated by fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw materials are calculated by dry weight of the reed rhizome and the houttuynia cordata.
In some embodiments of the present disclosure, the following raw material drugs may be in parts by weight: 12-17 parts of water chestnut, 18-24 parts of reed rhizome, 6-10 parts of dandelion, 5-9 parts of honeysuckle, 4-6 parts of forsythia suspense leaves, 4-6 parts of sophora flower bud, 20-28 parts of houttuynia cordata and 5-8 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated by fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw materials are calculated by dry weight of the reed rhizome and the houttuynia cordata.
In some embodiments of the present disclosure, the following raw material drugs may be in parts by weight: 20 parts of water chestnut, 30 parts of reed rhizome, 12 parts of dandelion, 10 parts of honeysuckle, 8 parts of forsythia suspense leaves, 7 parts of sophora flower bud, 28 parts of houttuynia cordata and 9 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated by fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw material medicines are calculated by dry weight of the reed rhizome and the houttuynia cordata.
In some embodiments of the present disclosure, the following raw material drugs may be in parts by weight: 10 parts of water chestnut, 14 parts of reed rhizome, 5 parts of dandelion, 3 parts of honeysuckle, 3 parts of forsythia suspense leaves, 3 parts of sophora flower bud, 14 parts of houttuynia cordata and 4 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated by fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw material medicines are calculated by dry weight of the reed rhizome and the houttuynia cordata.
In some embodiments of the present disclosure, the following raw material drugs may be in parts by weight: 15 parts of water chestnut, 20 parts of reed rhizome, 10 parts of dandelion, 8 parts of honeysuckle, 5 parts of forsythia suspense leaves, 5 parts of sophora flower bud, 26 parts of houttuynia cordata and 8 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated by fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw material medicines are calculated by dry weight of the reed rhizome and the houttuynia cordata.
In some embodiments of the present disclosure, the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight:
3-6 parts of cape jasmine, 4-7 parts of chrysanthemum, 1-3 parts of lotus plumule, 10-20 parts of water chestnut, 7-15 parts of reed rhizome, 5-12 parts of dandelion, 3-10 parts of honeysuckle, 3-8 parts of forsythia suspense leaf, 3-7 parts of sophora flower bud, 7-14 parts of houttuynia cordata and 4-9 parts of purslane, wherein the parts by weight are based on the dry weight of the raw material medicines.
In some embodiments of the present disclosure, the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight:
4-5 parts of cape jasmine, 4-6 parts of chrysanthemum, 2-3 parts of lotus plumule, 12-17 parts of water chestnut, 9-12 parts of reed rhizome, 6-10 parts of dandelion, 5-9 parts of honeysuckle, 4-6 parts of forsythia suspense leaves, 4-6 parts of sophora flower bud, 10-14 parts of houttuynia cordata and 5-8 parts of purslane, wherein the parts by weight are based on the dry weight of the raw material medicines.
In some embodiments of the present disclosure, the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight:
3 parts of cape jasmine, 4 parts of chrysanthemum, 1 part of lotus plumule, 20 parts of water chestnut, 15 parts of reed rhizome, 12 parts of dandelion, 10 parts of honeysuckle, 8 parts of forsythia suspense leaves, 7 parts of sophora flower bud, 14 parts of houttuynia cordata and 9 parts of purslane, wherein the parts by weight are the dry weight of the raw materials.
In some embodiments of the present disclosure, the traditional Chinese medicine composition is prepared from at least the following raw materials in parts by weight:
6 parts of cape jasmine, 7 parts of chrysanthemum, 3 parts of lotus plumule, 10 parts of water chestnut, 7 parts of reed rhizome, 5 parts of dandelion, 3 parts of honeysuckle, 3 parts of forsythia suspense leaves, 3 parts of sophora flower bud, 7 parts of houttuynia cordata and 4 parts of purslane, wherein the parts by weight are the dry weight of the raw materials.
In some embodiments of the present disclosure, the traditional Chinese medicine composition is prepared from at least the following raw materials in parts by weight:
6 parts of cape jasmine, 7 parts of chrysanthemum, 3 parts of lotus plumule, 20 parts of water chestnut, 15 parts of reed rhizome, 12 parts of dandelion, 10 parts of honeysuckle, 8 parts of forsythia suspense leaves, 7 parts of sophora flower bud, 14 parts of houttuynia cordata and 9 parts of purslane, wherein the parts by weight are the dry weight of the raw materials.
In some embodiments of the present disclosure, the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight:
3 parts of cape jasmine, 4 parts of chrysanthemum, 1 part of lotus plumule, 10 parts of water chestnut, 7 parts of reed rhizome, 5 parts of dandelion, 3 parts of honeysuckle, 3 parts of forsythia suspense leaves, 3 parts of sophora flower bud, 7 parts of houttuynia cordata and 4 parts of purslane, wherein the parts by weight are the dry weight of the raw material medicines.
In some embodiments of the present disclosure, the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight:
5 parts of cape jasmine, 5 parts of chrysanthemum, 3 parts of lotus plumule, 15 parts of water chestnut, 10 parts of reed rhizome, 10 parts of dandelion, 8 parts of honeysuckle, 5 parts of forsythia suspense leaves, 5 parts of sophora flower bud, 13 parts of houttuynia cordata and 8 parts of purslane, wherein the parts by weight are the dry weight of the raw materials.
In some embodiments of the present disclosure, the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight:
3-6 parts of cape jasmine fruit, 4-7 parts of chrysanthemum, 1-3 parts of lotus plumule, 10-20 parts of water chestnut, 14-30 parts of reed rhizome, 5-12 parts of dandelion, 3-10 parts of honeysuckle, 3-8 parts of forsythia suspense leaves, 3-7 parts of sophora flower bud, 14-28 parts of houttuynia cordata and 4-9 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated by fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw materials are calculated by dry weight of the raw materials.
In some embodiments of the present disclosure, the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight:
4-5 parts of cape jasmine, 4-6 parts of chrysanthemum, 2-3 parts of lotus plumule, 12-17 parts of water chestnut, 18-24 parts of reed rhizome, 6-10 parts of dandelion, 5-9 parts of honeysuckle, 4-6 parts of weeping forsythia leaf, 4-6 parts of sophora flower bud, 20-28 parts of houttuynia cordata and 5-8 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated by fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw materials are calculated by dry weight of the reed rhizome and the houttuynia cordata.
In some embodiments of the present disclosure, the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight:
3 parts of cape jasmine, 4 parts of chrysanthemum, 1 part of lotus plumule, 20 parts of water chestnut, 30 parts of reed rhizome, 12 parts of dandelion, 10 parts of honeysuckle, 8 parts of forsythia suspense leaves, 7 parts of sophora flower bud, 28 parts of houttuynia cordata and 9 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated by fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw materials are calculated by dry weight of the reed rhizome and the houttuynia cordata.
In some embodiments of the present disclosure, the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight:
6 parts of cape jasmine, 7 parts of chrysanthemum, 3 parts of lotus plumule, 10 parts of water chestnut, 14 parts of reed rhizome, 5 parts of dandelion, 3 parts of honeysuckle, 3 parts of forsythia suspense leaves, 3 parts of sophora flower bud, 14 parts of houttuynia cordata and 4 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated by fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw materials are calculated by dry weight of the reed rhizome and the houttuynia cordata.
In some embodiments of the present disclosure, the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight:
6 parts of cape jasmine, 7 parts of chrysanthemum, 3 parts of lotus plumule, 20 parts of water chestnut, 30 parts of reed rhizome, 12 parts of dandelion, 10 parts of honeysuckle, 8 parts of forsythia suspense leaves, 7 parts of sophora flower bud, 28 parts of houttuynia cordata and 9 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated according to the fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw materials are calculated according to the dry weight of the raw materials.
In some embodiments of the present disclosure, the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight:
3 parts of cape jasmine, 4 parts of chrysanthemum, 1 part of lotus plumule, 10 parts of water chestnut, 14 parts of reed rhizome, 5 parts of dandelion, 3 parts of honeysuckle, 3 parts of forsythia suspense leaves, 3 parts of sophora flower bud, 14 parts of houttuynia cordata and 4 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated according to the fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw materials are calculated according to the dry weight of the raw materials.
In some embodiments of the present disclosure, the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight:
5 parts of cape jasmine, 5 parts of chrysanthemum, 3 parts of lotus plumule, 15 parts of water chestnut, 20 parts of reed rhizome, 10 parts of dandelion, 8 parts of honeysuckle, 5 parts of forsythia suspense leaves, 5 parts of sophora flower bud, 26 parts of houttuynia cordata and 8 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated according to the fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw materials are calculated according to the dry weight of the raw materials.
The various embodiments and preferences described above for the traditional Chinese medicine compositions of the present disclosure can be combined with each other (as long as they are not inherently contradictory to each other), and the various embodiments formed by such combinations are considered to be part of the present disclosure.
According to an embodiment of the present disclosure, there may be provided a method of preparing a traditional Chinese medicine composition according to the present disclosure, the method comprising the steps of:
(1) Mixing the raw materials except herba Houttuyniae, wherein the raw materials comprise fructus Gardeniae, flos Chrysanthemi, plumula Nelumbinis, corm Eleocharitis, rhizoma Phragmitis, herba Taraxaci, flos Lonicerae, folium forsythiae, flos Sophorae Immaturus, herba Houttuyniae, and herba Portulacae, soaking in water, heating and reflux extracting, adding herba Houttuyniae before extraction, and filtering to obtain filtrate;
(2) Concentrating the filtrate obtained in the step (1) and drying.
In some embodiments of the disclosure, step (2) comprises:
(2-1) concentrating the filtrate obtained in the step (1) to obtain thick paste;
(2-2) drying the thick paste obtained in the step (2-1) to obtain an extract dry extract;
and (2-3) crushing the dry extract obtained in the step (2-2) to obtain dry extract powder.
In some embodiments of the present disclosure, the houttuynia cordata of the above step (1) is added for 10 to 20 minutes before the end of the extraction. In some embodiments of the present disclosure, the houttuynia cordata of step (1) above is added about 15 minutes before the end of the extraction.
In some embodiments of the present disclosure, in the step (1), except for water chestnut and forsythia suspense leaves, other raw material medicines are medicinal decoction pieces thereof.
In some embodiments of the present disclosure, the ratio of the water used for soaking in step (1) to the mixture of the raw material medicines may be: 5-15mL:1g of the total weight of the composition. In some embodiments of the present disclosure, the ratio of the water used for soaking in step (1) to each mixture of the raw material drugs may be 10mL:1g of the total weight of the composition. The water can be used for completely soaking the extracted material (raw material medicine) so as to be beneficial to fully extracting the effective components in the material.
In some embodiments of the present disclosure, in step (1), the soaking time may be 0.5 to 2 hours. In some embodiments of the present disclosure, in step (1), the time for soaking may be 1h.
In some embodiments of the present disclosure, in step (1), the heating reflux extraction temperature may be 80-100 ℃. In some embodiments of the present disclosure, in step (1), the heating reflux extraction temperature may be 95 ℃.
In some embodiments of the present disclosure, in step (1), the heating reflux extraction may be performed 1 to 3 times. In some embodiments of the present disclosure, in step (1), the heating reflux extraction may be performed 2 times.
In some embodiments of the present disclosure, in step (1), the time for each heating reflux extraction may be 0.5 to 2 hours. In some embodiments of the present disclosure, in step (1), the time for each heating reflux extraction may be 1 hour.
In some embodiments of the present disclosure, in step (1), the heating reflux extraction may be: mixing the raw materials except for herba Houttuyniae, soaking in 10 times of water for 0.5 hr, heating under reflux for extraction at 95 deg.C for 1 hr, and filtering to obtain filtrate 1; adding 8 times of water to the residue, extracting at 95 deg.C for 1 hr, adding herba Houttuyniae 15min before the second extraction, filtering the extractive solution to obtain filtrate 2, and mixing filtrate 1 and 2.
In some embodiments of the present disclosure, the concentrating in step (2) above is concentrating under reduced pressure. In some embodiments of the disclosure, reduced pressure concentration is performed at a temperature of 60-80 ℃ under a vacuum of-0.07 to-0.10 MPa.
In some embodiments of the present disclosure, the thick paste has a relative density with respect to water of 1.05 to 1.3.
In some embodiments of the present disclosure, the drying in step (2) or (2-2) above is any one of vacuum drying, forced air drying, freeze drying, spray drying or a combination thereof.
In some embodiments of the present disclosure, vacuum drying is performed, wherein the drying temperature is 50-80 ℃. In some embodiments of the disclosure, forced air drying is performed, wherein the drying temperature is 60-100 ℃. In some embodiments of the present disclosure, freeze-drying is performed, wherein the prefreezing temperature is-40 ℃ to-20 ℃, the sublimation temperature is-20 ℃ to 25 ℃, and the desorption temperature is 25 ℃ to 55 ℃. In some embodiments of the present disclosure, spray drying is performed, wherein the inlet air temperature is 120-210 ℃ and the outlet air temperature is 60-110 ℃.
In some embodiments of the present disclosure, the mesh size of the extract dry extract powder is about 60-100 mesh. In some embodiments of the present disclosure, the mesh size of the extract dry extract powder is about 80 mesh.
In some embodiments of the present disclosure, the method of making further comprises: and (3) sieving the product of the step (2) or the step (2-3) by a 80-mesh sieve.
In some embodiments of the present disclosure, the dry extract powder may be packaged without flavoring, directly processed according to the formulation.
In some embodiments of the present disclosure, the dry extract powder may be added with corresponding flavoring agents and food additives for flavoring according to taste requirements, and added with forming auxiliary materials for process forming, and the medicated diet vegetable products with various tastes are obtained after packaging.
According to an embodiment of the present disclosure, there may be provided a product comprising a pharmaceutical composition of the present disclosure.
In some embodiments of the present disclosure, the product may be in the form of a solid (powder, granules, block, tablet, capsule, pill, gel candy), liquid, paste, or the like. In some embodiments of the present disclosure, the product may be in the form of a decoction, pill, powder, paste, pellet, tea, tablet, capsule, granule, aerosol, injection, film, and any other suitable known dosage form.
The disclosure further provides application of the traditional Chinese medicine composition in preparation of medicines, health-care foods or foods with the functions of clearing heat and reducing internal heat.
The various embodiments and preferences described above for the Chinese medicinal composition of the present disclosure are also applicable to the preparation method, use and product of the present disclosure, and they can also be combined with each other (as long as they are not inherently contradictory to each other), and the various embodiments formed by the combination are all considered to be part of the disclosure of the present application.
The present disclosure also relates to the following embodiments:
the embodiment 1 discloses a traditional Chinese medicine composition, which is characterized by being prepared from at least the following raw material medicines: fructus Gardeniae, flos Chrysanthemi, plumula Nelumbinis, corm Eleocharitis, rhizoma Phragmitis, herba Taraxaci, flos Lonicerae, folium forsythiae, flos Sophorae Immaturus, herba Houttuyniae, and herba Portulacae.
Embodiment 2. The traditional Chinese medicine composition according to embodiment 1, wherein the following raw material medicines are in parts by weight: 3-6 parts of cape jasmine, 4-7 parts of chrysanthemum and 1-3 parts of lotus plumule, wherein the parts by weight are all dry weight of the raw material medicines.
Embodiment 3. The traditional Chinese medicine composition according to embodiment 1, wherein the following raw material medicines are in parts by weight: 4-5 parts of cape jasmine, 4-6 parts of chrysanthemum and 2-3 parts of lotus plumule, wherein the parts by weight are based on the dry weight of the raw material medicines.
Embodiment 4. The traditional Chinese medicine composition according to embodiment 1, wherein the following raw material medicines are in parts by weight: 3 parts of cape jasmine, 4 parts of chrysanthemum and 1 part of lotus plumule, wherein the parts by weight are all dry weight of the raw material medicines.
Embodiment 5. The traditional Chinese medicine composition according to embodiment 1, wherein the following raw material medicines are in parts by weight: 6 parts of cape jasmine, 7 parts of chrysanthemum and 3 parts of lotus plumule, wherein the parts by weight are all dry weight of the raw material medicines.
Embodiment 6. The traditional Chinese medicine composition according to embodiment 1, wherein the following raw material medicines are in parts by weight: 5 parts of cape jasmine, 5 parts of chrysanthemum and 3 parts of lotus plumule, wherein the parts by weight are all dry weight of the raw material medicines.
Embodiment 7. The traditional Chinese medicine composition according to any one of the preceding embodiments, wherein the following raw material medicines are in parts by weight: 10-20 parts of water chestnuts, 7-15 parts of reed rhizome, 5-12 parts of dandelion, 3-10 parts of honeysuckle, 3-8 parts of forsythia leaves, 3-7 parts of sophora flower buds, 7-14 parts of houttuynia cordata and 4-9 parts of purslane, wherein the weight parts are the dry weight of the raw material medicines.
The embodiment 8. The traditional Chinese medicine composition according to any one of the preceding embodiments, wherein the following raw material medicines are in parts by weight: 12-17 parts of water chestnuts, 9-12 parts of reed rhizome, 6-10 parts of dandelion, 5-9 parts of honeysuckle, 4-6 parts of forsythia leaves, 4-6 parts of sophora flower buds, 10-14 parts of houttuynia cordata and 5-8 parts of purslane, wherein the weight parts are the dry weight of the raw material medicines.
Embodiment 9. The traditional Chinese medicine composition according to any one of the preceding embodiments, wherein the following raw material medicines are in parts by weight: 20 parts of water chestnuts, 15 parts of reed rhizome, 12 parts of dandelion, 10 parts of honeysuckle, 8 parts of forsythia suspense leaves, 7 parts of sophora flower buds, 14 parts of houttuynia cordata and 9 parts of purslane, wherein the parts by weight are all dry weight of the raw material medicines.
Embodiment 10 the traditional Chinese medicine composition according to any one of the preceding embodiments, wherein the following raw material medicines are in parts by weight: 10 parts of water chestnut, 7 parts of reed rhizome, 5 parts of dandelion, 3 parts of honeysuckle, 3 parts of forsythia suspense leaves, 3 parts of sophora flower bud, 7 parts of houttuynia cordata and 4 parts of purslane, wherein the parts by weight are all dry weight of the raw material medicines.
Embodiment 11 the traditional Chinese medicine composition according to any one of the preceding embodiments, wherein the following raw material medicines are in parts by weight: 15 parts of water chestnut, 10 parts of reed rhizome, 10 parts of dandelion, 8 parts of honeysuckle, 5 parts of forsythia suspense leaves, 5 parts of sophora flower bud, 13 parts of houttuynia cordata and 8 parts of purslane, wherein the parts by weight are all dry weight of the raw material medicines.
Embodiment 12 the traditional Chinese medicine composition according to any one of embodiments 1 to 6, wherein the following raw material medicines are in parts by weight: 10-20 parts of water chestnut, 14-30 parts of reed rhizome, 5-12 parts of dandelion, 3-10 parts of honeysuckle, 3-8 parts of forsythia suspense leaves, 3-7 parts of sophora flower bud, 14-28 parts of houttuynia cordata and 4-9 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated by fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw materials are calculated by dry weight of the reed rhizome and the houttuynia cordata.
Embodiment 13 the traditional Chinese medicine composition according to any one of embodiments 1 to 6, wherein the following raw material medicines are in parts by weight: 12-17 parts of water chestnut, 18-24 parts of reed rhizome, 6-10 parts of dandelion, 5-9 parts of honeysuckle, 4-6 parts of forsythia suspense leaves, 4-6 parts of sophora flower bud, 20-28 parts of houttuynia cordata and 5-8 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated by fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw materials are calculated by dry weight of the reed rhizome and the houttuynia cordata.
Embodiment 14 the traditional Chinese medicine composition according to any one of embodiments 1 to 6, wherein the following raw material medicines are in parts by weight: 20 parts of water chestnut, 30 parts of reed rhizome, 12 parts of dandelion, 10 parts of honeysuckle, 8 parts of forsythia suspense leaves, 7 parts of sophora flower bud, 28 parts of houttuynia cordata and 9 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated by fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw material medicines are calculated by dry weight of the reed rhizome and the houttuynia cordata.
An embodiment 15. The traditional Chinese medicine composition according to any one of embodiments 1 to 6, wherein the following raw material medicines are in parts by weight: 10 parts of water chestnut, 14 parts of reed rhizome, 5 parts of dandelion, 3 parts of honeysuckle, 3 parts of forsythia suspense leaves, 3 parts of sophora flower bud, 14 parts of houttuynia cordata and 4 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated by fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw material medicines are calculated by dry weight of the reed rhizome and the houttuynia cordata.
Embodiment 16 the traditional Chinese medicine composition according to any one of embodiments 1 to 6, wherein the following raw material medicines are in parts by weight: 15 parts of water chestnut, 20 parts of reed rhizome, 10 parts of dandelion, 8 parts of honeysuckle, 5 parts of forsythia suspense leaves, 5 parts of sophora flower bud, 26 parts of houttuynia cordata and 8 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated by fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw material medicines are calculated by dry weight of the reed rhizome and the houttuynia cordata.
Embodiment 17 the traditional Chinese medicine composition according to embodiment 1, wherein the traditional Chinese medicine composition is at least prepared from the following raw material medicines in parts by weight: 3 parts of cape jasmine, 4 parts of chrysanthemum, 1 part of lotus plumule, 20 parts of water chestnut, 15 parts of reed rhizome, 12 parts of dandelion, 10 parts of honeysuckle, 8 parts of forsythia suspense leaves, 7 parts of sophora flower bud, 14 parts of houttuynia cordata and 9 parts of purslane, wherein the parts by weight are the dry weight of the raw materials.
Embodiment 18 the traditional Chinese medicine composition of embodiment 1, wherein the traditional Chinese medicine composition is at least prepared from the following raw materials in parts by weight: 6 parts of cape jasmine, 7 parts of chrysanthemum, 3 parts of lotus plumule, 10 parts of water chestnut, 7 parts of reed rhizome, 5 parts of dandelion, 3 parts of honeysuckle, 3 parts of forsythia suspense leaves, 3 parts of sophora flower bud, 7 parts of houttuynia cordata and 4 parts of purslane, wherein the parts by weight are the dry weight of the raw materials.
Embodiment 19. The traditional Chinese medicine composition according to embodiment 1, wherein the traditional Chinese medicine composition is at least prepared from the following raw material medicines in parts by weight: 6 parts of cape jasmine, 7 parts of chrysanthemum, 3 parts of lotus plumule, 20 parts of water chestnut, 15 parts of reed rhizome, 12 parts of dandelion, 10 parts of honeysuckle, 8 parts of forsythia suspense leaves, 7 parts of sophora flower bud, 14 parts of houttuynia cordata and 9 parts of purslane, wherein the parts by weight are the dry weight of the raw materials.
Embodiment 20 the traditional Chinese medicine composition according to embodiment 1, wherein the traditional Chinese medicine composition is at least prepared from the following raw material medicines in parts by weight: 3 parts of cape jasmine, 4 parts of chrysanthemum, 1 part of lotus plumule, 10 parts of water chestnut, 7 parts of reed rhizome, 5 parts of dandelion, 3 parts of honeysuckle, 3 parts of forsythia suspense leaves, 3 parts of sophora flower bud, 7 parts of houttuynia cordata and 4 parts of purslane, wherein the parts by weight are the dry weight of the raw materials.
Embodiment 21 the traditional Chinese medicine composition according to embodiment 1, wherein the traditional Chinese medicine composition is at least prepared from the following raw material medicines in parts by weight: 5 parts of cape jasmine, 5 parts of chrysanthemum, 3 parts of lotus plumule, 15 parts of water chestnut, 10 parts of reed rhizome, 10 parts of dandelion, 8 parts of honeysuckle, 5 parts of forsythia suspense leaves, 5 parts of sophora flower bud, 13 parts of houttuynia cordata and 8 parts of purslane, wherein the parts by weight are the dry weight of the raw materials.
Embodiment 22. The traditional Chinese medicine composition according to embodiment 1, wherein the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight: 3 parts of cape jasmine, 4 parts of chrysanthemum, 1 part of lotus plumule, 20 parts of water chestnut, 30 parts of reed rhizome, 12 parts of dandelion, 10 parts of honeysuckle, 8 parts of forsythia suspense leaves, 7 parts of sophora flower bud, 28 parts of houttuynia cordata and 9 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated according to the fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw materials are calculated according to the dry weight of the raw materials.
Embodiment 23. The traditional Chinese medicine composition according to embodiment 1, wherein the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight: 6 parts of cape jasmine, 7 parts of chrysanthemum, 3 parts of lotus plumule, 10 parts of water chestnut, 14 parts of reed rhizome, 5 parts of dandelion, 3 parts of honeysuckle, 3 parts of forsythia suspense leaves, 3 parts of sophora flower bud, 14 parts of houttuynia cordata and 4 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated according to the fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw materials are calculated according to the dry weight of the raw materials.
Embodiment 24. The traditional Chinese medicine composition according to embodiment 1, wherein the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight: 6 parts of cape jasmine, 7 parts of chrysanthemum, 3 parts of lotus plumule, 20 parts of water chestnut, 30 parts of reed rhizome, 12 parts of dandelion, 10 parts of honeysuckle, 8 parts of forsythia suspense leaves, 7 parts of sophora flower bud, 28 parts of houttuynia cordata and 9 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated according to the fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw materials are calculated according to the dry weight of the raw materials.
Embodiment 25 the traditional Chinese medicine composition according to embodiment 1, wherein the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight: 3 parts of cape jasmine, 4 parts of chrysanthemum, 1 part of lotus plumule, 10 parts of water chestnut, 14 parts of reed rhizome, 5 parts of dandelion, 3 parts of honeysuckle, 3 parts of forsythia suspense leaves, 3 parts of sophora flower bud, 14 parts of houttuynia cordata and 4 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated according to the fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw materials are calculated according to the dry weight of the raw materials.
Embodiment 26 the traditional Chinese medicine composition according to embodiment 1, wherein the traditional Chinese medicine composition is prepared from at least the following raw material medicines in parts by weight: 5 parts of cape jasmine, 5 parts of chrysanthemum, 3 parts of lotus plumule, 15 parts of water chestnut, 20 parts of reed rhizome, 10 parts of dandelion, 8 parts of honeysuckle, 5 parts of forsythia suspense leaves, 5 parts of sophora flower bud, 26 parts of houttuynia cordata and 8 parts of purslane, wherein the weight parts of the reed rhizome and the houttuynia cordata are calculated according to the fresh weight of the reed rhizome and the houttuynia cordata, and the weight parts of the rest raw materials are calculated according to the dry weight of the raw materials.
Embodiment 27. A method of preparing a traditional Chinese medicine composition according to any one of embodiments 1 to 26, comprising the steps of:
(1) Mixing the raw materials except herba Houttuyniae, wherein the raw materials comprise fructus Gardeniae, flos Chrysanthemi, plumula Nelumbinis, corm Eleocharitis, rhizoma Phragmitis, herba Taraxaci, flos Lonicerae, folium forsythiae, flos Sophorae Immaturus, herba Houttuyniae, and herba Portulacae, soaking in water, heating and reflux extracting, adding herba Houttuyniae before extraction, and filtering to obtain filtrate;
(2) Concentrating the filtrate obtained in the step (1) and drying.
Embodiment 28 the preparation process according to embodiment 27, wherein step (2) comprises:
(2-1) concentrating the filtrate obtained in the step (1) to obtain thick paste;
(2-2) drying the thick paste obtained in the step (2-1) to obtain an extract dry extract;
(2-3) crushing the dry extract obtained in the step (2-2) to obtain dry extract powder.
Embodiment 29. The preparation process according to embodiment 27 or 28, wherein in the step (1), the houttuynia cordata is added for 10 to 20 minutes before the end of the extraction.
Embodiment 30. The preparation method according to any one of embodiments 27 to 29, wherein in the step (1), the raw materials except for chufa and forsythia suspensa leaves are decoction pieces of the raw materials.
31. The preparation method according to any one of embodiments 27 to 30, wherein the ratio of water used for soaking in step (1) to each bulk drug mixture is 5 to 15mL:1g of the total weight of the composition.
Embodiment 32. The preparation process according to any one of embodiments 27 to 31, wherein the soaking time in step (1) is 0.5 to 2h.
Embodiment 33. The production method according to any one of embodiments 27 to 32, wherein the temperature at which the heating reflux extraction in step (1) is performed is 80 to 100 ℃.
Embodiment 34. The preparation process according to any one of embodiments 27 to 33, wherein the heating reflux extraction in step (1) is carried out 1 to 3 times, each for 0.5 to 2 hours.
Embodiment 35. The preparation process according to any one of embodiments 27 to 34, wherein the concentration is concentration under reduced pressure.
Embodiment 36. The preparation process of embodiment 35, wherein the concentration under reduced pressure is carried out at a temperature of 60 to 80 ℃ and a vacuum of-0.07 to-0.10 MPa.
Embodiment 37. The preparation process according to embodiment 28, wherein the thick paste has a relative density with respect to water of 1.05 to 1.3.
Embodiment 38. The preparation process of any one of embodiments 27 to 37, wherein the drying is any one of vacuum drying, forced air drying, freeze drying, spray drying or a combination thereof.
Embodiment 39. According to the preparation process of embodiment 38, the drying temperature of the vacuum drying is 50 to 80 ℃.
Embodiment 40 according to the preparation process of embodiment 38, the drying temperature of the forced air drying is 60 to 100 ℃.
Embodiment 41. According to the preparation process of embodiment 38, the pre-freezing temperature of the freeze-drying is-40 ℃ to-20 ℃, the sublimation temperature is-20 ℃ to 25 ℃, and the desorption temperature is 25 ℃ to 55 ℃.
Embodiment 42. According to the preparation process of embodiment 38, the inlet air temperature of the spray drying is 120 to 210 ℃ and the outlet air temperature is 60 to 110 ℃.
Embodiment 43. The preparation process according to embodiment 27 or 28, further comprising: and (3) sieving the product of the step (2) or the step (2-3) by a 80-mesh sieve.
Embodiment 44. The preparation process of embodiment 28, wherein the mesh size of the extract dry extract powder is 60-100 mesh.
Embodiment 45. Use of the Chinese medicinal composition according to any one of embodiments 1 to 26 in the preparation of a medicament, health food or food having the function of clearing heat and reducing internal heat.
Embodiment 46. A product comprising the traditional Chinese medicine composition of any one of embodiments 1-26.
The technical solutions of the present disclosure will be more clearly and clearly illustrated by way of examples in the following. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present disclosure in any way. The scope of the present disclosure is limited only by the claims.
Examples
Example 1: chinese medicinal composition 1
The composition and preparation method of the raw material medicine of the traditional Chinese medicine composition 1 are as follows: taking 3 parts of gardenia, 4 parts of chrysanthemum, 1 part of lotus plumule, 20 parts of water chestnut, 15 parts of reed rhizome, 12 parts of dandelion, 10 parts of honeysuckle, 8 parts of forsythia suspense leaves, 7 parts of sophora flower bud and 9 parts of purslane (all parts are parts by weight, based on dry weight). Mixing the raw materials, and then mixing the raw materials according to a material-liquid ratio (g: mL) of 1:10, adding deionized water, soaking for 0.5h, heating and refluxing at 95 ℃ for 1h, and filtering an extracting solution to obtain a filtrate 1; adding 10 times of water to the residue, extracting at 95 deg.C for 1h, adding 14 parts (by weight, based on dry weight) of herba Houttuyniae 15min before extraction, filtering the extractive solution to obtain filtrate 2, mixing filtrates 1 and 2, concentrating under reduced pressure at 60 deg.C and vacuum degree of-0.09 MPa to obtain fluid extract with relative density (relative to water) of 1.1, and spray drying at 170 deg.C and 90 deg.C to obtain spray dried powder, and sieving with 80 mesh sieve.
Example 2: chinese medicinal composition 2
The composition and preparation method of the raw material medicine of the traditional Chinese medicine composition 2 are as follows: taking 6 parts of cape jasmine, 7 parts of chrysanthemum, 3 parts of lotus plumule, 10 parts of water chestnut, 7 parts of reed rhizome, 5 parts of dandelion, 3 parts of honeysuckle, 3 parts of forsythia suspense leaves, 3 parts of sophora flower bud and 4 parts of purslane (all parts are parts by weight, calculated by dry weight). Mixing the raw materials, and then mixing the raw materials according to a material-liquid ratio (g: mL) of 1:10, adding deionized water, soaking for 0.5h, heating and refluxing at 95 ℃ for 1h, and filtering an extracting solution to obtain a filtrate 1; adding 10 times of water to the residue, extracting at 95 deg.C for 1h, adding 7 parts (by weight, based on dry weight) of herba Houttuyniae 15min before extraction, filtering the extractive solution to obtain filtrate 2, mixing filtrates 1 and 2, concentrating under reduced pressure at 60 deg.C and vacuum degree of-0.09 MPa to obtain fluid extract with relative density (relative to water) of 1.1, and spray drying at 170 deg.C and 90 deg.C to obtain spray dried powder, and sieving with 80 mesh sieve.
Example 3: chinese medicinal composition 3
The composition and preparation method of the raw material medicine of the traditional Chinese medicine composition 3 are as follows: taking 6 parts of cape jasmine, 7 parts of chrysanthemum, 3 parts of lotus plumule, 20 parts of water chestnut, 15 parts of reed rhizome, 12 parts of dandelion, 10 parts of honeysuckle, 8 parts of forsythia suspense leaves, 7 parts of sophora flower bud and 9 parts of purslane (all parts are parts by weight, based on dry weight). Mixing the raw materials, and then mixing the raw materials according to a material-liquid ratio (g: mL) of 1:10, adding deionized water, soaking for 0.5h, heating and refluxing at 95 ℃ for 1h, and filtering an extracting solution to obtain a filtrate 1; adding 10 times of water to the residue, extracting at 95 deg.C for 1h, adding 14 parts (by weight, based on dry weight) of herba Houttuyniae 15min before extraction, filtering the extractive solution to obtain filtrate 2, mixing filtrates 1 and 2, concentrating under reduced pressure at 60 deg.C and vacuum degree of-0.09 MPa to obtain fluid extract with relative density (relative to water) of 1.1, and spray drying at 170 deg.C and 90 deg.C to obtain spray dried powder, and sieving with 80 mesh sieve.
Example 4: chinese medicinal composition 4
The traditional Chinese medicine composition 4 comprises the following raw material medicines: taking 3 parts of gardenia, 4 parts of chrysanthemum, 1 part of lotus plumule, 10 parts of water chestnut, 7 parts of reed rhizome, 5 parts of dandelion, 3 parts of honeysuckle, 3 parts of forsythia suspense leaves, 3 parts of sophora flower bud and 4 parts of purslane (all parts are parts by weight, based on dry weight). Mixing the raw materials, and then mixing the raw materials according to a material-liquid ratio (g: mL) of 1:10, adding deionized water, soaking for 0.5h, heating and refluxing at 95 ℃ for 1h, and filtering an extracting solution to obtain a filtrate 1; adding 10 times of water to the residue, extracting at 95 deg.C for 1h, adding 7 parts (by weight, based on dry weight) of herba Houttuyniae 15min before extraction, filtering the extractive solution to obtain filtrate 2, mixing filtrates 1 and 2, concentrating under reduced pressure at 60 deg.C and vacuum degree of-0.09 MPa to obtain fluid extract with relative density (relative to water) of 1.1, and spray drying at 170 deg.C and 90 deg.C to obtain spray dried powder, and sieving with 80 mesh sieve.
Example 5: chinese medicinal composition 5
The traditional Chinese medicine composition 5 comprises the following raw material medicines in percentage by weight: taking 5 parts of gardenia, 5 parts of chrysanthemum, 3 parts of lotus plumule, 15 parts of water chestnut, 10 parts of reed rhizome, 10 parts of dandelion, 8 parts of honeysuckle, 5 parts of forsythia suspense leaves, 5 parts of sophora flower bud and 8 parts of purslane (all parts are parts by weight, calculated by dry weight). Mixing the raw materials, and then mixing the raw materials according to a material-liquid ratio (g: mL) of 1:10, adding deionized water, soaking for 0.5h, heating and refluxing at 95 ℃ for 1h, and filtering an extracting solution to obtain a filtrate 1; adding 10 times of water to the residue, extracting at 95 deg.C for 1h, adding 13 parts (by weight, based on dry weight) of herba Houttuyniae 15min before extraction, filtering the extractive solution to obtain filtrate 2, mixing filtrates 1 and 2, concentrating under reduced pressure at 60 deg.C under vacuum degree of-0.09 MPa to obtain fluid extract with relative density (relative to water) of 1.1, and spray drying at 170 deg.C under air outlet temperature of 90 deg.C to obtain spray dried powder, and sieving with 80 mesh sieve.
Example 6: laxative function test of Chinese medicinal composition 1-5
1. Experimental method
60 SPF-grade ICR mice of 7 weeks old, half male and female, purchased from Beijing Huafukang Biotechnology GmbH, and having license number: SCXK (Beijing) 2019-0008, which is bred in SPF level experimental animal center of Life academy of sciences of Beijing university of science and engineering, circulates day and night for 12 hours in a room with the temperature (22 +/-2) DEG C and the humidity of 50 +/-5 percent, and all animals can eat and drink water freely. The mice are adaptively bred for 7 days before the experiment, and are randomly divided into a blank control group, a traditional Chinese medicine composition 1 group, a traditional Chinese medicine composition 2 group, a traditional Chinese medicine composition 3 group, a traditional Chinese medicine composition 4 group and a traditional Chinese medicine composition 5 group according to the body weight, wherein each group comprises 10 mice.
Mice are fasted for 12 hours, each administration group is respectively infused with 2% ink diluted liquid medicine, the intragastric administration dose is 780mg/kg (the maximum dose of human is 6 g/day, the weight of human body is calculated according to 70kg, the administration dose of mice is determined according to the equivalent dose conversion requirement between human and animals in pharmacological experiment methodology), and the intragastric administration volume is 0.1mL/10g. The blank control group was drenched with an equal volume of 2% ink. Each group of mice is fed in a single cage, filter paper is padded at the bottom of the cage, and water is normally supplied for feeding.
2. Results of the experiment
The results of 6h continuous observation of the initial black stool discharging time, dry stool particle number, dry stool weight and diarrhea of each group of mice are shown in Table 1.
TABLE 1 defecation status of mice in each group
Note: p <0.05, P <0.01, P <0.001 compared to the blank control group.
The results show that, compared with the blank control, the traditional Chinese medicine compositions 1 to 5 have the function of promoting defecation, can shorten the primary defecation time to different degrees and increase the defecation amount of mice. Wherein the initial defecation time of the traditional Chinese medicine composition 2 group is obviously lower than that of a blank control group (P < 0.05). The results of the dry feces grain number and the dry feces weight show that the traditional Chinese medicine composition 1-5 groups are obviously higher than the blank control group (P < 0.05-0.001), wherein the traditional Chinese medicine composition 5 has the most obvious effect (P < 0.001).
The traditional Chinese medicine composition 2 causes 4 tested mice to have slight diarrhea and loose stool which cannot be weighed, so that the statistical result of the dry stool particle number and the dry stool weight is reduced to a certain extent.
Example 7: determination of antipyretic effect of traditional Chinese medicine composition 1-5 on rats with heat syndrome
The Chinese medicinal composition 1-5 acts on rats with interior heat syndrome, and the heat-clearing and fire-reducing effects of the Chinese medicinal composition are preliminarily examined. 42 Wistar rats (basal body temperature 37.5. + -. 0.5 ℃) were selected, and fed under the same conditions as in the experimental example, and randomly divided into 7 groups: blank control group, model control group, chinese medicinal composition 1 group, chinese medicinal composition 2 group, chinese medicinal composition 3 group, chinese medicinal composition 4 group and Chinese medicinal composition 5 group, each group comprises 6. Rats in each group are fasted for 6 hours, and a blank control group is injected with 7.5mL/kg of physiological saline subcutaneously; the model control group and each administration group are injected with equal volume of 40% yeast solution subcutaneously to replicate the heat syndrome rat model. And (3) carrying out modeling, wherein each administration group is respectively filled with 540mg/kg of each traditional Chinese medicine composition by intragastric administration, the intragastric administration volume is 0.1mL/10g, and the blank control group and the model control group are filled with water with equal volume. The body temperature was measured 4h after molding and administered by gavage again, and the anus temperature was measured 6h and 8h after molding for each group of rats, and the results are shown in Table 2.
TABLE 2 body temperature Change Table (. Degree. C.) for each group of rats
Note: p compared to blank control group<0.05，**P<0.01，***P<0.001; compared with the model control group,#P<0.05，##P<0.01，###P<0.001。
the results show that compared with the blank control group, the body temperature of the model control group is obviously increased (P is less than 0.05-0.001) at 4h, 6h and 8h after the subcutaneous injection of 40% yeast solution, and the body temperature of mice in each administration group is also increased to different degrees. Compared with the body temperature change result of a model control group, the body temperatures of mice in the traditional Chinese medicine composition groups 1-5 are reduced to different degrees after administration for 4 hours, wherein the body temperature of the traditional Chinese medicine composition group 2 is obviously reduced (P is less than 0.05) within 6 hours, and the body temperature of the traditional Chinese medicine composition group 5 is obviously reduced (P is less than 0.05) within 6 hours and 8 hours. Therefore, the traditional Chinese medicine compositions in the patent have the antipyretic effect, and the antipyretic effect of the traditional Chinese medicine composition 2 and the traditional Chinese medicine composition 5 is better.
In conclusion, the results of experimental examples 6 and 7 are combined, so that the traditional Chinese medicine composition has obvious effects of relaxing bowels, clearing heat and reducing internal heat, and particularly the traditional Chinese medicine composition 5 has the optimal effect.
Claims (21)
1. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 5 parts of cape jasmine, 5 parts of chrysanthemum, 3 parts of lotus plumule, 15 parts of water chestnut, 10 parts of reed rhizome, 10 parts of dandelion, 8 parts of honeysuckle, 5 parts of forsythia suspense leaves, 5 parts of sophora flower bud, 13 parts of houttuynia cordata and 8 parts of purslane, wherein the parts by weight are the dry weight of the raw materials.
2. A method for preparing the traditional Chinese medicine composition of claim 1, which comprises the following steps:
(1) Mixing the raw materials except herba Houttuyniae, wherein the raw materials comprise fructus Gardeniae, flos Chrysanthemi, plumula Nelumbinis, corm Eleocharitis, rhizoma Phragmitis, herba Taraxaci, flos Lonicerae, folium forsythiae, flos Sophorae Immaturus, and herba Portulacae, soaking in water, heating under reflux, adding herba Houttuyniae before extraction, and filtering to obtain filtrate;
(2) Concentrating the filtrate obtained in the step (1) and drying.
3. The production method according to claim 2, wherein step (2) comprises:
(2-1) concentrating the filtrate obtained in the step (1) to obtain thick paste;
(2-2) drying the thick paste obtained in the step (2-1) to obtain an extract dry extract;
and (2-3) crushing the dry extract obtained in the step (2-2) to obtain dry extract powder.
4. The preparation method according to claim 2, wherein in the step (1), the houttuynia cordata is added for 10 to 20 minutes before the end of the extraction.
5. The preparation method according to claim 2, wherein in the step (1), the raw materials except for the water chestnut and the forsythia suspensa leaf are prepared into decoction pieces.
6. The preparation method according to claim 2, wherein the ratio of the water used for soaking in step (1) to the mixture of the raw materials is 5-15mL:1g of the total weight of the composition.
7. The method of claim 2, wherein the soaking time in step (1) is 0.5-2h.
8. The production method according to claim 2, wherein the temperature at which the heating reflux extraction in step (1) is carried out is 80-100 ℃.
9. The production method according to claim 2, wherein the heating reflux extraction in the step (1) is performed 1 to 3 times each for 0.5 to 2 hours.
10. The production method according to claim 2, wherein the concentration is concentration under reduced pressure.
11. The production process according to claim 10, wherein the concentration under reduced pressure is carried out at a temperature of 60 to 80 ℃ and a vacuum degree of-0.07 to-0.10 MPa.
12. The production method according to claim 3, wherein the thick paste has a relative density with respect to water of 1.05 to 1.3.
13. The production method according to any one of claims 2 to 12, wherein the drying is any one of vacuum drying, forced air drying, freeze drying, spray drying or a combination thereof.
14. The method according to claim 13, wherein the drying temperature of the vacuum drying is 50 to 80 ℃.
15. The production method according to claim 13, wherein the drying temperature of the air-blast drying is 60 to 100 ℃.
16. The method of claim 13, wherein the freeze-drying is performed at a pre-freezing temperature of-40 ℃ to-20 ℃, a sublimation temperature of-20 ℃ to 25 ℃, and a desorption temperature of 25 ℃ to 55 ℃.
17. The method of claim 13, wherein the inlet air temperature of the spray drying is 120-210 ℃ and the outlet air temperature is 60-110 ℃.
18. The production method according to claim 2 or 3, further comprising: and (3) sieving the product of the step (2) or the step (2-3) by a 80-mesh sieve.
19. The method of claim 3, wherein the mesh size of the dry extract powder is 60-100 mesh.
20. The use of the Chinese medicinal composition of claim 1 in the preparation of a medicament, health food or food with the functions of clearing heat and reducing internal heat.
21. Use of the Chinese medicinal composition of claim 1 in the preparation of a medicament, health food or food for promoting defecation.
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