CN111567801A - Spina date seed and royal jelly tablet and preparation process thereof - Google Patents
Spina date seed and royal jelly tablet and preparation process thereof Download PDFInfo
- Publication number
- CN111567801A CN111567801A CN202010483990.4A CN202010483990A CN111567801A CN 111567801 A CN111567801 A CN 111567801A CN 202010483990 A CN202010483990 A CN 202010483990A CN 111567801 A CN111567801 A CN 111567801A
- Authority
- CN
- China
- Prior art keywords
- parts
- extract
- royal jelly
- mixing
- spina date
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 24
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a spina date seed and royal jelly tablet and a preparation process thereof, belonging to the technical field of health-care food. The pulp sheet comprises the following components in parts by weight: 27-32 parts of royal jelly freeze-dried powder, 27-32 parts of spina date seed extract, 12-17 parts of poria cocos extract, 4-6 parts of tea theanine, 7-11 parts of starch, 5-7 parts of microcrystalline cellulose, 1-2 parts of superfine silica gel powder, 1-2 parts of magnesium stearate, 0.1-0.2 part of orange essence, 1.0-1.4 parts of hydroxypropyl methyl cellulose, 4000 parts of polyethylene glycol, 0.3-0.5 part of titanium dioxide, 0.1-0.3 part of citrus yellow and 0.04-0.06 part of yuehu red. The paste tablet is a bee product health food with sleep improving effect, easy storage and administration, and has the advantages of convenient administration, hygiene, portability, and long storage period.
Description
Technical Field
The invention relates to a health food, in particular to a spina date seed and royal jelly tablet and a preparation process thereof, belonging to the technical field of health foods.
Background
The royal jelly is the secretion of pharyngeal gland of young worker bees for breeding larva in bee hive, is an emulsion secreted by young and strong bees after eating pollen, is generally milky white and yellowish, is the milk of mammals, is the food for larva to become queen bee, has high nutritive value and immune function, and is the food for the queen bee to live. It has the main functions of resisting oxidation, preventing and resisting cancer, improving sleep, etc.
The spina date seed is sweet and sour in taste, has the effects of tonifying liver, calming heart, arresting sweating and promoting fluid production, and is mainly used for treating deficiency sleep and insomnia, palpitation and dreaminess, body deficiency and hyperhidrosis, body fluid deficiency and thirst. Many documents report that jujuboside has obvious sedative-hypnotic effect.
The acanthopanax senticosus extract is pungent, slightly bitter, warm in nature and non-toxic, mainly enters spleen, kidney and heart channels, has the effects of tonifying qi and spleen, tonifying kidney and soothing nerves, and is used for treating symptoms such as spleen-kidney yang deficiency, body deficiency and hypodynamia, insomnia and dreaminess. Acanthopanax senticosus contains various eleutherosides and hyperin, has effects of regulating central nervous system and endocrine system, consolidating constitution, nourishing blood, tranquilizing mind, and has remarkable therapeutic effects on habitual insomnia and neurasthenia.
Ganoderma is dry fruiting body of Ganoderma lucidum or Ganoderma sinensis of Polyporaceae. It has the functions of replenishing qi, tranquilizing, relieving cough and asthma, and is mainly used for treating dizziness, insomnia, palpitation and shortness of breath. Various researches also show that the ganoderma lucidum has the functions of tranquilizing, hypnotizing and enhancing immunity.
Disclosure of Invention
The invention aims to provide a spina date seed and royal jelly tablet which is a bee product health food for improving sleep, is easy to store and take, and has the advantages of convenience and sanitation in taking, convenience in carrying, long storage period and the like.
The invention also aims to provide a preparation process of the spina date seed and royal jelly tablet.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a spina date seed and royal jelly tablet comprises the following components in parts by weight: 27-32 parts of royal jelly freeze-dried powder, 27-32 parts of spina date seed extract, 12-17 parts of poria cocos extract, 4-6 parts of tea theanine, 7-11 parts of starch, 5-7 parts of microcrystalline cellulose, 1-2 parts of superfine silica gel powder, 1-2 parts of magnesium stearate, 0.8-1.2 parts of orange essence, 1.0-1.4 parts of hydroxypropyl methyl cellulose, 4000 parts of polyethylene glycol, 0.3-0.5 part of titanium dioxide, 0.1-0.3 part of citrus yellow and 0.04-0.06 part of yuehu red.
Preferably, the spina date seed and royal jelly tablet consists of the following components in parts by weight: 28 parts of royal jelly freeze-dried powder, 32 parts of spina date seed extract, 17 parts of poria cocos extract, 3 parts of tea theanine, 8 parts of starch, 7 parts of microcrystalline cellulose, 1.7 parts of superfine silica gel powder, 1.3 parts of magnesium stearate, 0.1 part of orange essence, 1.2 parts of hydroxypropyl methyl cellulose, 4000 parts of polyethylene glycol, 0.4 part of titanium dioxide, 0.05 part of citrus yellow and 0.05 part of Yuehu red.
The invention relates to a spina date seed and royal jelly tablet, which is prepared by the following steps:
(1) sieving: sieving Lac Regis Apis lyophilized powder, semen Ziziphi Spinosae extract, radix Acanthopanacis Senticosi extract, Ganoderma extract, starch, silica gel micropowder, and microcrystalline cellulose with 80 mesh sieve respectively;
(2) mixing: weighing royal jelly lyophilized powder, semen Ziziphi Spinosae extract, radix Acanthopanacis Senticosi extract, Ganoderma extract, starch, silica gel micropowder, and microcrystalline cellulose according to formula ratio; mixing the weighed royal jelly lyophilized powder, semen Ziziphi Spinosae extract, radix Acanthopanacis Senticosi extract, and Ganoderma extract, and stirring for 20min to obtain mixture 1; mixing the weighed starch, the micro silica gel powder and the microcrystalline cellulose, and stirring for 20min to obtain a mixture 2; mixing the mixture 1 and the mixture 2, and stirring for 30min to obtain a mixture;
(3) dry pressing: pressing the mixture prepared in the step (2) to obtain a sheet;
(4) and (3) granulating: crushing the slices prepared in the step (3) through a granulator, and sieving the crushed slices through a 16-mesh sieve to obtain granules;
(5) mixing: sieving magnesium stearate with a 80-mesh sieve, weighing according to the formula amount, and mixing with the granules prepared in the step (4) to obtain a compound;
(6) tabletting: tabletting the compound prepared in the step (5) to obtain plain tablets, wherein the weight of the plain tablets is 0.49 g;
(7) coating: weighing hydroxypropyl methyl cellulose according to the formula, soaking the hydroxypropyl methyl cellulose in 95% ethanol overnight, adding purified water, polyethylene glycol 4000, orange yellow, yuanju red, titanium dioxide and orange essence, uniformly mixing, grinding and mixing by a colloid mill to prepare coating liquid, and performing film coating on the plain tablets prepared in the step (6), wherein the weight of the coating tablets is 0.5g, so as to obtain the spina date seed and royal jelly tablets.
The product of the invention is a tablet, and all the steps are carried out in a 30 ten thousand grade clean production area.
Compared with the prior art, the invention has the following beneficial effects:
(1) the spina date seed and royal jelly tablets of the invention adopt royal jelly freeze-dried powder, spina date seed extract, acanthopanax extract and lucid ganoderma extract as main raw materials, the raw materials can improve sleep, and the auxiliary materials are selected from starch, microcrystalline cellulose, superfine silica gel powder, magnesium stearate, orange essence, hydroxypropyl methyl cellulose, polyethylene glycol 4000, titanium dioxide, citrus yellow and yue ju hong;
(2) the film coating material adopted by the invention can resist moisture and heat, so that the film coated tablet is firm and wear-resistant and is not easy to crack, and the quality of the product can be improved;
(3) the invention adopts film coating on the selection of dosage form, thus being moisture-proof and preventing royal jelly freeze-dried powder from being oxidized;
(4) the production process of the product is controlled to be carried out under the condition of low temperature as much as possible, and dry-pressing granulation is adopted to replace wet-method granulation, so that the stability of the functional factor 10-hydroxy-alpha-decenoic acid can be improved;
(5) convenient administration, hygiene, portability, and long shelf life.
Detailed Description
The products of the invention are further illustrated by the following specific examples.
Example 1
A spina date seed and royal jelly tablet comprises the following components in parts by weight: 28 parts of royal jelly freeze-dried powder, 32 parts of spina date seed extract, 17 parts of poria cocos extract, 3 parts of tea theanine, 8 parts of starch, 7 parts of microcrystalline cellulose, 1.7 parts of superfine silica gel powder, 1.3 parts of magnesium stearate, 0.1 part of orange essence, 1.2 parts of hydroxypropyl methyl cellulose, 4000 parts of polyethylene glycol, 0.4 part of titanium dioxide, 0.2 part of citrus yellow and 0.05 part of Yuehu red.
The invention relates to a spina date seed and royal jelly tablet, which is prepared by the following steps:
(1) sieving: sieving Lac Regis Apis lyophilized powder, semen Ziziphi Spinosae extract, radix Acanthopanacis Senticosi extract, Ganoderma extract, starch, silica gel micropowder, and microcrystalline cellulose with 80 mesh sieve respectively;
(2) mixing: weighing royal jelly lyophilized powder, semen Ziziphi Spinosae extract, radix Acanthopanacis Senticosi extract, Ganoderma extract, starch, silica gel micropowder, and microcrystalline cellulose according to formula ratio; mixing the weighed royal jelly lyophilized powder, semen Ziziphi Spinosae extract, radix Acanthopanacis Senticosi extract, and Ganoderma extract, and stirring for 20min to obtain mixture 1; mixing the weighed starch, the micro silica gel powder and the microcrystalline cellulose, and stirring for 20min to obtain a mixture 2; mixing the mixture 1 and the mixture 2, and stirring for 30min to obtain a mixture;
(3) dry pressing: pressing the mixture prepared in the step (2) to obtain a sheet;
(4) and (3) granulating: crushing the slices prepared in the step (3) through a granulator, and sieving the crushed slices through a 16-mesh sieve to obtain granules;
(5) mixing: sieving magnesium stearate with a 80-mesh sieve, weighing according to the formula amount, and mixing with the granules prepared in the step (4) to obtain a compound;
(6) tabletting: tabletting the compound prepared in the step (5) to obtain plain tablets, wherein the weight of the plain tablets is 0.49 g;
(7) coating: weighing hydroxypropyl methyl cellulose according to the formula, soaking the hydroxypropyl methyl cellulose in 95% ethanol overnight, adding purified water, polyethylene glycol 4000, orange yellow, yuanju red, titanium dioxide and orange essence, uniformly mixing, grinding and mixing by a colloid mill to prepare coating liquid, and performing film coating on the plain tablets prepared in the step (6), wherein the weight of the coating tablets is 0.5g, so as to obtain the spina date seed and royal jelly tablets.
The product of the invention is a tablet, and all the steps are carried out in a 30 ten thousand grade clean production area.
Example 2
A spina date seed and royal jelly tablet comprises the following components in parts by weight: 29 parts of royal jelly freeze-dried powder, 31 parts of spina date seed extract, 16 parts of poria cocos extract, 4 parts of tea theanine, 9 parts of starch, 6 parts of microcrystalline cellulose, 1.6 parts of superfine silica gel powder, 1.4 parts of magnesium stearate, 0.1 part of orange essence, 1.2 parts of hydroxypropyl methyl cellulose, 4000 parts of polyethylene glycol, 0.4 part of titanium dioxide, 0.05 part of citrus yellow and 0.05 part of Yuehu red.
The invention relates to a spina date seed and royal jelly tablet, which is prepared by the following steps:
(1) sieving: sieving Lac Regis Apis lyophilized powder, semen Ziziphi Spinosae extract, radix Acanthopanacis Senticosi extract, Ganoderma extract, starch, silica gel micropowder, and microcrystalline cellulose with 80 mesh sieve respectively;
(2) mixing: weighing royal jelly lyophilized powder, semen Ziziphi Spinosae extract, radix Acanthopanacis Senticosi extract, Ganoderma extract, starch, silica gel micropowder, and microcrystalline cellulose according to formula ratio; mixing the weighed royal jelly lyophilized powder, semen Ziziphi Spinosae extract, radix Acanthopanacis Senticosi extract, and Ganoderma extract, and stirring for 20min to obtain mixture 1; mixing the weighed starch, the micro silica gel powder and the microcrystalline cellulose, and stirring for 20min to obtain a mixture 2; mixing the mixture 1 and the mixture 2, and stirring for 30min to obtain a mixture;
(3) dry pressing: pressing the mixture prepared in the step (2) to obtain a sheet;
(4) and (3) granulating: crushing the slices prepared in the step (3) through a granulator, and sieving the crushed slices through a 16-mesh sieve to obtain granules;
(5) mixing: sieving magnesium stearate with a 80-mesh sieve, weighing according to the formula amount, and mixing with the granules prepared in the step (4) to obtain a compound;
(6) tabletting: tabletting the compound prepared in the step (5) to obtain plain tablets, wherein the weight of the plain tablets is 0.49 g;
(7) coating: weighing hydroxypropyl methyl cellulose according to the formula, soaking the hydroxypropyl methyl cellulose in 95% ethanol overnight, adding purified water, polyethylene glycol 4000, orange yellow, yuanju red, titanium dioxide and orange essence, uniformly mixing, grinding and mixing by a colloid mill to prepare coating liquid, and performing film coating on the plain tablets prepared in the step (6), wherein the weight of the coating tablets is 0.5g, so as to obtain the spina date seed and royal jelly tablets.
The product of the invention is a tablet, and all the steps are carried out in a 30 ten thousand grade clean production area.
Example 3
A spina date seed and royal jelly tablet comprises the following components in parts by weight: 29 parts of royal jelly freeze-dried powder, 31 parts of spina date seed extract, 14 parts of poria cocos extract, 6 parts of tea theanine, 8 parts of starch, 7 parts of microcrystalline cellulose, 1.9 parts of superfine silica gel powder, 1.1 parts of magnesium stearate, 0.1 part of orange essence, 1.2 parts of hydroxypropyl methyl cellulose, 4000 parts of polyethylene glycol, 0.4 part of titanium dioxide, 0.2 part of orange yellow and 0.05 part of Yuehu red.
The invention relates to a spina date seed and royal jelly tablet, which is prepared by the following steps:
(1) sieving: sieving Lac Regis Apis lyophilized powder, semen Ziziphi Spinosae extract, radix Acanthopanacis Senticosi extract, Ganoderma extract, starch, silica gel micropowder, and microcrystalline cellulose with 80 mesh sieve respectively;
(2) mixing: weighing royal jelly lyophilized powder, semen Ziziphi Spinosae extract, radix Acanthopanacis Senticosi extract, Ganoderma extract, starch, silica gel micropowder, and microcrystalline cellulose according to formula ratio; mixing the weighed royal jelly lyophilized powder, semen Ziziphi Spinosae extract, radix Acanthopanacis Senticosi extract, and Ganoderma extract, and stirring for 20min to obtain mixture 1; mixing the weighed starch, the micro silica gel powder and the microcrystalline cellulose, and stirring for 20min to obtain a mixture 2; mixing the mixture 1 and the mixture 2, and stirring for 30min to obtain a mixture;
(3) dry pressing: pressing the mixture prepared in the step (2) to obtain a sheet;
(4) and (3) granulating: crushing the slices prepared in the step (3) through a granulator, and sieving the crushed slices through a 16-mesh sieve to obtain granules;
(5) mixing: sieving magnesium stearate with a 80-mesh sieve, weighing according to the formula amount, and mixing with the granules prepared in the step (4) to obtain a compound;
(6) tabletting: tabletting the compound prepared in the step (5) to obtain plain tablets, wherein the weight of the plain tablets is 0.49 g;
(7) coating: weighing hydroxypropyl methyl cellulose according to the formula, soaking the hydroxypropyl methyl cellulose in 95% ethanol overnight, adding purified water, polyethylene glycol 4000, orange yellow, yuanju red, titanium dioxide and orange essence, uniformly mixing, grinding and mixing by a colloid mill to prepare coating liquid, and performing film coating on the plain tablets prepared in the step (6), wherein the weight of the coating tablets is 0.5g, so as to obtain the spina date seed and royal jelly tablets.
The product of the invention is a tablet, and all the steps are carried out in a 30 ten thousand grade clean production area.
Experimental example 1
SPF-grade ICR female mice with the weight of 19-24g are selected, the female mice are randomly divided into 4 groups after being adaptively fed for 3 days, the control group and three dosage groups, namely low, medium and high (0.33 g/kg.bw, 0.67g/kg.bw and 1.0 g/kg.bw) are prepared into aqueous solution of the dosage group for intragastric administration, the intragastric administration is carried out once a day according to the volume of 2 percent for 30 days continuously, and the intragastric administration is carried out by using equal volume of distilled water for the control group.
Pentobarbital sodium subthreshold dose hypnosis test: after 30 minutes of the last gastric lavage of the test sample or distilled water, injecting sodium pentobarbital normal saline solution into the abdominal cavity of each group of animals according to the dosage of 27mg/kg.
The specific experimental results are shown in table 1.
TABLE 1 Effect of sub-threshold dose of sodium pentobarbital on the incidence of sleep induction in mice
As can be seen from the results in Table 1, compared with the control group, the sleep incidence rate of the mice in the low-dose group is remarkably improved (P is less than 0.05), and the sleep incidence rate of the mice in the medium-dose group is remarkably improved (P is less than 0.01), which indicates that the spina date seed royal jelly tablets have the effect of inducing the mice to sleep.
Test example 2
Barbiturate sodium sleep latency test: after 30 minutes of the last gastric lavage of the test sample or distilled water, the animals in each group are injected with the normal saline solution of barbital sodium in the abdominal cavity at the dosage of 240mg/kg. The average sleep latency (i.e., time to fall asleep-time to barbiturate sodium injection) was calculated for each group of animals, and the results are shown in table 2.
TABLE 2 Effect of sodium pentobarbital on the mean sleep latency of mice
As can be seen from the results in Table 2, the sleep latency time of the mice in the low-dose group is very significantly reduced (P is less than 0.01) compared with the control group, which indicates that the spina date seed and royal jelly tablet has the function of improving sleep.
Test 3: stability test of spina date seed and royal jelly tablets
Taking 40 tablets of the film-coated spina date seed and royal jelly tablets and 10 tablets of the uncoated spina date seed and royal jelly tablets, dividing the 40 tablets into 4 groups, and performing the following tests:
1. disintegration time limit: the disintegration test is firstly carried out in a hydrochloric acid solution, and after 2 hours of inspection, the phenomena of crack, disintegration, softening and the like do not occur in each tablet; and then taking out, washing with a small amount of water, and then completely disintegrating in 1 hour by using a phosphate buffer solution, if 1 tablet cannot be completely disintegrated, retesting, and the experimental results are shown in table 3.
2. And (3) impact strength test: the sample piece was dropped from a height of 1m onto a glass plate, and the appearance of the meter was abnormally changed, and the experimental results are shown in Table 4.
3. Heat resistance test: the sample piece is placed under a 250W infrared lamp for 15cm to be heated for 4h, and the experimental results are shown in Table 5 after observation.
4. Moisture resistance test, the sample piece was placed in a constant temperature and humidity apparatus, and after 1 hour, the increase in mass of the piece was used as an index to indicate moisture resistance, and the test results are shown in table 6.
TABLE 3 disintegration time limit test results
TABLE 4 impact Strength test results
TABLE 5 results of heat resistance test
TABLE 6 moisture resistance test results
As shown in the experimental results of tables 3-6, the film-coated wild jujube seed royal jelly tablets have better stability than those without coating.
Claims (3)
1. The wild jujube seed-royal jelly tablet is characterized by comprising the following components in parts by weight: 27-32 parts of royal jelly freeze-dried powder, 27-32 parts of spina date seed extract, 12-17 parts of poria cocos extract, 4-6 parts of tea theanine, 7-11 parts of starch, 5-7 parts of microcrystalline cellulose, 1-2 parts of superfine silica gel powder, 1-2 parts of magnesium stearate, 0.1-0.2 part of orange essence, 1.0-1.4 parts of hydroxypropyl methyl cellulose, 4000 parts of polyethylene glycol, 0.3-0.5 part of titanium dioxide, 0.1-0.3 part of citrus yellow and 0.04-0.06 part of yuehu red.
2. The spina date seed and royal jelly tablet according to claim 1, which consists of the following components in parts by weight: 28 parts of royal jelly freeze-dried powder, 32 parts of spina date seed extract, 17 parts of poria cocos extract, 3 parts of tea theanine, 8 parts of starch, 7 parts of microcrystalline cellulose, 1.7 parts of superfine silica gel powder, 1.3 parts of magnesium stearate, 0.1 part of orange essence, 1.2 parts of hydroxypropyl methyl cellulose, 4000 parts of polyethylene glycol, 0.4 part of titanium dioxide, 0.05 part of citrus yellow and 0.05 part of Yuehu red.
3. The spina date seed and royal jelly tablet according to claim 1 or 2, characterized in that the process preparation comprises the following steps:
(1) sieving: sieving Lac Regis Apis lyophilized powder, semen Ziziphi Spinosae extract, radix Acanthopanacis Senticosi extract, Ganoderma extract, starch, silica gel micropowder, and microcrystalline cellulose with 80 mesh sieve respectively;
(2) mixing: weighing royal jelly lyophilized powder, semen Ziziphi Spinosae extract, radix Acanthopanacis Senticosi extract, Ganoderma extract, starch, silica gel micropowder, and microcrystalline cellulose according to formula ratio; mixing the weighed royal jelly lyophilized powder, semen Ziziphi Spinosae extract, radix Acanthopanacis Senticosi extract, and Ganoderma extract, and stirring for 20min to obtain mixture 1; mixing the weighed starch, the micro silica gel powder and the microcrystalline cellulose, and stirring for 20min to obtain a mixture 2; mixing the mixture 1 and the mixture 2, and stirring for 30min to obtain a mixture;
(3) dry pressing: pressing the mixture prepared in the step (2) to obtain a sheet;
(4) and (3) granulating: crushing the slices prepared in the step (3) through a granulator, and sieving the crushed slices through a 16-mesh sieve to obtain granules;
(5) mixing: sieving magnesium stearate with a 80-mesh sieve, weighing according to the formula amount, and mixing with the granules prepared in the step (4) to obtain a compound;
(6) tabletting: tabletting the compound prepared in the step (5) to obtain plain tablets, wherein the weight of the plain tablets is 0.49 g;
(7) coating: weighing hydroxypropyl methyl cellulose according to the formula, soaking the hydroxypropyl methyl cellulose in 95% ethanol overnight, adding purified water, polyethylene glycol 4000, orange yellow, yuanju red, titanium dioxide and orange essence, uniformly mixing, grinding and mixing by a colloid mill to prepare coating liquid, and performing film coating on the plain tablets prepared in the step (6), wherein the weight of the coating tablets is 0.5g, so as to obtain the spina date seed and royal jelly tablets.
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| CN112641839A (en) * | 2020-12-24 | 2021-04-13 | 中国科学院城市环境研究所 | Composition for improving sleep quality, traditional Chinese medicine preparation and application |
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