CN111073768A - Medical sol and preparation method thereof - Google Patents

Medical sol and preparation method thereof Download PDF

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CN111073768A
CN111073768A CN201911287752.XA CN201911287752A CN111073768A CN 111073768 A CN111073768 A CN 111073768A CN 201911287752 A CN201911287752 A CN 201911287752A CN 111073768 A CN111073768 A CN 111073768A
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parts
fraction
viscosity
dodecyl sulfate
sodium dodecyl
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CN111073768B (en
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胡娟娟
朱海霞
徐芷馨
李盈
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Tongji Medical College of Huazhong University of Science and Technology
Union Hospital Tongji Medical College Huazhong University of Science and Technology
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Union Hospital Tongji Medical College Huazhong University of Science and Technology
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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/83—Mixtures of non-ionic with anionic compounds
    • C11D1/831—Mixtures of non-ionic with anionic compounds of sulfonates with ethers of polyoxyalkylenes without phosphates
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/162—Organic compounds containing Si
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C11D3/2006—Monohydric alcohols
    • C11D3/201—Monohydric alcohols linear
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C11D3/2006—Monohydric alcohols
    • C11D3/2017—Monohydric alcohols branched
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2075—Carboxylic acids-salts thereof
    • C11D3/2079—Monocarboxylic acids-salts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2093—Esters; Carbonates
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02—Anionic compounds
    • C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
    • C11D1/14—Sulfonic acids or sulfuric acid esters; Salts thereof derived from aliphatic hydrocarbons or mono-alcohols
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/72—Ethers of polyoxyalkylene glycols

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Abstract

The invention provides a medical sol agent, which comprises the following components in parts by weight: 15-25 parts of dibasic ester, 20-35 parts of ethanol, 5-10 parts of isopropanol, 10-15 parts of stearic acid, 20-30 parts of trisiloxane, 15-25 parts of polysorbate, 10-15 parts of sodium dodecyl sulfate, 95-150 parts of deionized water and fatty alcohol-polyoxyethylene ether; wherein the fatty alcohol-polyoxyethylene ether satisfies the following requirements in parts by weight:
Figure DDA0002318512790000011
in the formula, afIs fatty alcohol polyoxyethyleneFraction of alkenyl ether atIs the fraction of sodium dodecyl sulfate, aoIs the fraction of stearic acid, apIs the number of polysorbate portions, awIs the fraction of deionized water, aeIs the fraction of ethanol, agIs a large fraction of isopropanol, asIs the fraction of trisiloxane ajIn parts of dibasic ester. The invention also provides a preparation method of the medical sol agent, which is used for efficiently preparing the medical sol agent by optimally controlling the weight parts of the fatty alcohol-polyoxyethylene ether and accurately controlling the reaction degree, the reaction temperature and the stirring speed.

Description

Medical sol and preparation method thereof
Technical Field
The invention relates to the technical field of medical supplies, in particular to a medical sol and a preparation method thereof.
Background
Peripherally Inserted Central Catheter (PICC) is a deep venous catheter technique that is introduced from the peripheral vein with the end located in the central vein and is made of silica gel. In the use, in order to prevent the infection of pipe, keep the pipe unobstructed, need regularly carry out PICC pipe maintenance, specifically include change the malleation joint, wash the pipe, change transparent dressing. And when carrying out PICC pipe maintenance, often can have on the patient's pipe that partial transparent dressing and the viscose on the dressing can not tear down, when using tweezers to tear the viscose, can produce the risk that the pipe deviates from, is unfavorable for maintaining the operation and does.
The Chinese patent 200810035524.9 discloses a strong sol and a preparation method thereof, and the strong sol comprises the following components: 2-4 ml of phenol, 3-5 ml of liquid paraffin, 8-10.5 g of sodium hydroxide, 4-5.6 ml of ethanol, 5-5.4 g of stearic acid, 803-5 ml of tween, 70-75 ml of water and 13-15.5 g of sodium dodecyl sulfate. The gel has strong dissolving capacity, but the raw material contains sodium hydroxide, and the sodium hydroxide can dissolve silica gel, which is equivalent to dissolving the PICC tube while dissolving the viscose on the PICC tube, so even if the gel can strongly dissolve the viscose, the gel cannot be applied to the medical catheter.
The Chinese patent 200910197910.2 discloses a sol agent and its preparation method, which comprises liquid paraffin 1-3%, trichloroethylene 5-10%, ethyl acetate 5-10%, span-800.1-1%, sodium dodecyl sulfate 0.1-1%, and water in balance. The paper can be quickly peeled off, but the raw material contains trichloroethylene, which belongs to accumulative anesthetic and can be absorbed by respiratory tract, digestive tract and skin. Has strong inhibiting effect on central nervous system and certain post-effect. Thus, it is not suitable for treating adhesive on PICC tubes, and is less suitable for treating medical catheters.
Therefore, the research on a sol in the medical field becomes a problem which needs to be solved urgently at present.
Disclosure of Invention
The invention aims to design and develop a medical sol, optimally control the weight parts of fatty alcohol-polyoxyethylene ether, effectively clean medical dressing and viscose thereon, facilitate PICC maintenance and be safe and harmless.
The invention also aims to design and develop a preparation method of the medical sol agent, which is used for efficiently preparing the medical sol agent by optimally controlling the weight parts of the fatty alcohol-polyoxyethylene ether and accurately controlling the reaction degree, the reaction temperature and the stirring speed.
The technical scheme provided by the invention is as follows:
the medical sol agent comprises the following components in parts by weight: 15-25 parts of dibasic ester, 20-35 parts of ethanol, 5-10 parts of isopropanol, 10-15 parts of stearic acid, 20-30 parts of trisiloxane, 15-25 parts of polysorbate, 10-15 parts of sodium dodecyl sulfate, 95-150 parts of deionized water and fatty alcohol-polyoxyethylene ether;
wherein the fatty alcohol-polyoxyethylene ether satisfies the following requirements in parts by weight:
Figure BDA0002318512780000021
in the formula, afIs the portion of fatty alcohol-polyoxyethylene ether, atIs the fraction of sodium dodecyl sulfate, aoIs the fraction of stearic acid, apIs the number of polysorbate portions, awIs the fraction of deionized water, aeIs the fraction of ethanol, agIs a large fraction of isopropanol, asIs the fraction of trisiloxane ajIn parts of dibasic ester.
Preferably, the weight ratio of the polysorbate to the sodium dodecyl sulfate is as follows: 1.5 to 2.5.
Preferably, the weight ratio of the polysorbate to the total parts of ethanol and isopropanol is: 0.3 to 0.8.
Preferably, the weight ratio of the sodium dodecyl sulfate to the stearic acid is: 0.6 to 1.5.
Preferably, the dibasic acid ester is one or more of dimethyl succinate, dimethyl glutarate and dimethyl adipate.
Preferably, the dibasic ester is a mixture of dimethyl succinate, dimethyl glutarate and dimethyl adipate in a weight ratio of 1: 1: 1.
a preparation method of the medical sol comprises the following steps:
step 1: adding ethanol and isopropanol into deionized water, stirring for 15-20 min, adding sodium dodecyl sulfate, continuously stirring, heating to 50-60 ℃, and continuously stirring until the sodium dodecyl sulfate is completely dissolved;
wherein the ethanol comprises 20-35 parts of isopropanol, 5-10 parts of sodium dodecyl sulfate and 95-150 parts of deionized water;
step 2: and continuously and sequentially adding stearic acid, trisiloxane, polysorbate and fatty alcohol-polyoxyethylene ether, heating and stirring until the viscosity of the mixed liquid meets the following requirements:
Figure BDA0002318512780000031
wherein, the heating temperature is controlled to satisfy:
Figure BDA0002318512780000032
the stirring speed satisfies:
Figure BDA0002318512780000033
and
10-15 parts of stearic acid, 20-30 parts of trisiloxane and 15-25 parts of polysorbate, wherein the fatty alcohol-polyoxyethylene ether is prepared by the following raw materials in parts by weight:
Figure BDA0002318512780000034
in the formula, ηmFor the viscosity of the mixed liquid, T is the heating temperature of step 2, T0At normal temperature of 25 ℃, ηoViscosity of stearic acid at ordinary temperature, ηsViscosity of trisiloxane at ambient temperature, ηpIs viscosity of polysorbate at room temperature, ηwIs the viscosity of deionized water at normal temperature, T1Is the heating temperature of step 1, n2The stirring speed of step 2, n1The stirring speed in the step 1 is shown, and e is the base number of the natural logarithm; a isfIs the portion of fatty alcohol-polyoxyethylene ether, atIs the fraction of sodium dodecyl sulfate, aoIs the fraction of stearic acid, apIs the number of polysorbate portions, awIs the fraction of deionized water, aeIs the fraction of ethanol, agIs a large fraction of isopropanol, asIs the fraction of trisiloxane ajAs part of the dibasic ester, atotalIs the total parts;
and step 3: adding dibasic ester, continuously stirring for 60-90 min, and cooling in a water bath for 30-45 min to obtain the medical sol;
wherein the dibasic acid ester accounts for 15-25 parts.
Preferably, in the step 3, the stirring speed is controlled to satisfy:
Figure BDA0002318512780000041
in the formula, n3The stirring speed in step 3, ηjIs the viscosity of the dibasic ester at normal temperature.
Preferably, the temperature of the water bath is 15-20 ℃.
Preferably, the dibasic ester is a mixture of dimethyl succinate, dimethyl glutarate and dimethyl adipate in a weight ratio of 1: 1: 1.
the invention has the following beneficial effects:
(1) the medical sol designed and developed by the method optimally controls the weight parts of the fatty alcohol-polyoxyethylene ether, can effectively clean medical dressing and viscose thereon, is beneficial to PICC maintenance, and is safe and harmless.
(2) The preparation method of the medical sol designed and developed by the invention can be used for efficiently preparing the medical sol by optimally controlling the weight parts of the fatty alcohol-polyoxyethylene ether and accurately controlling the reaction degree, the reaction temperature and the stirring speed.
Detailed Description
The present invention is described in further detail below to enable those skilled in the art to practice the invention with reference to the description.
This invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, but rather as being provided for the purpose of illustration and description.
The invention provides a medical sol agent, which comprises the following components in parts by weight: 15-25 parts of dibasic ester, 20-35 parts of ethanol, 5-10 parts of isopropanol, 10-15 parts of stearic acid, 20-30 parts of trisiloxane, 15-25 parts of polysorbate, 10-15 parts of sodium dodecyl sulfate, 95-150 parts of deionized water and fatty alcohol-polyoxyethylene ether;
wherein, the weight portion of the fatty alcohol-polyoxyethylene ether satisfies the following requirements:
Figure BDA0002318512780000051
in the formula, afIs the portion of fatty alcohol-polyoxyethylene ether, atIs the fraction of sodium dodecyl sulfate, aoIs the fraction of stearic acid, apIs the number of polysorbate portions, awIs the fraction of deionized water, aeIs the fraction of ethanol, agIs a large fraction of isopropanol, asIs the fraction of trisiloxane ajIn parts of dibasic ester.
The dibasic acid ester is an environment-friendly high-boiling-point solvent (universal solvent) with low toxicity, low odor and biodegradability, deionized water is a solvent carrier, ethanol, isopropanol and stearic acid are cosolvent, trisiloxane, polysorbate and sodium dodecyl sulfate are surfactants, and fatty alcohol-polyoxyethylene ether is an auxiliary solvent, so that the dissolving agent has the effects of promoting the permeation, dispersion and diffusion of the dissolving agent, and the dissolving of viscose can be accelerated.
As another embodiment of the present invention, the weight ratio of polysorbate to sodium dodecylsulfate is: 1.5 to 2.5. The weight ratio of the polysorbate to the total parts of ethanol and isopropanol is as follows: 0.3 to 0.8. The weight ratio of the sodium dodecyl sulfate to the stearic acid is as follows: 0.6 to 1.5.
As another embodiment of the invention, the dibasic acid ester is one or more of dimethyl succinate, dimethyl glutarate and dimethyl adipate. Preferably, the dibasic ester is a mixture of dimethyl succinate, dimethyl glutarate and dimethyl adipate in a weight ratio of 1: 1: 1.
the medical sol designed and developed by the method optimally controls the weight parts of the fatty alcohol-polyoxyethylene ether, can effectively clean medical dressing and viscose thereon, is beneficial to PICC maintenance, and is safe and harmless.
The invention also provides a preparation method of the medical sol, which comprises the following steps:
step 1: adding ethanol and isopropanol into deionized water, stirring for 15-20 min, adding sodium dodecyl sulfate, continuously stirring, heating to 50-60 ℃, and continuously stirring until the sodium dodecyl sulfate is completely dissolved;
wherein the ethanol comprises 20-35 parts of isopropanol, 5-10 parts of sodium dodecyl sulfate and 95-150 parts of deionized water;
step 2: and continuously and sequentially adding stearic acid, trisiloxane, polysorbate and fatty alcohol-polyoxyethylene ether, heating and stirring until the viscosity of the mixed liquid meets the following requirements:
Figure BDA0002318512780000061
wherein, the heating temperature is controlled to satisfy:
Figure BDA0002318512780000062
the stirring speed satisfies:
Figure BDA0002318512780000063
and
10-15 parts of stearic acid, 20-30 parts of trisiloxane and 15-25 parts of polysorbate, wherein the fatty alcohol-polyoxyethylene ether is prepared by the following raw materials in parts by weight:
Figure BDA0002318512780000064
in the formula, ηmFor the viscosity of the mixed liquid, T is the heating temperature of step 2, T0At normal temperature of 25 ℃, ηoViscosity of stearic acid at ordinary temperature, ηsViscosity of trisiloxane at ambient temperature, ηpIs viscosity of polysorbate at room temperature, ηwIs the viscosity of deionized water at normal temperature, T1Is the heating temperature of step 1, n2The stirring speed of step 2, n1The stirring speed in the step 1 is shown, and e is the base number of the natural logarithm; a isfIs the portion of fatty alcohol-polyoxyethylene ether, atIs the fraction of sodium dodecyl sulfate, aoIs the fraction of stearic acid, apIs the number of polysorbate portions, awIs the fraction of deionized water, aeIs the fraction of ethanol, agIs a large fraction of isopropanol, asIs the fraction of trisiloxane ajAs part of the dibasic ester, atotalIs the total parts;
and step 3: adding dibasic ester, continuously stirring for 60-90 min, and cooling in a water bath for 30-45 min to obtain the medical sol agent, wherein the temperature of the water bath is 15-20 ℃ generally;
controlling the stirring speed to meet the following requirements:
Figure BDA0002318512780000071
in the formula, n3The stirring speed in step 3, ηjIs twoViscosity of the acid ester at ordinary temperature.
The dibasic ester is a mixture of dimethyl succinate, dimethyl glutarate and dimethyl adipate, and the weight ratio of the dibasic ester to the dimethyl glutarate is 1: 1: 1.
in order to further illustrate the present invention, the following embodiments are described in detail, but they should not be construed as limiting the scope of the present invention.
Example 1
The medical sol comprises the following components in parts by weight: 15 parts of dibasic ester (a mixture of dimethyl succinate, dimethyl glutarate and dimethyl adipate in a weight ratio of 1: 1: 1), 20 parts of ethanol, 5 parts of isopropanol, 10 parts of stearic acid, 20 parts of trisiloxane, 15 parts of polysorbate, 10 parts of sodium dodecyl sulfate, 95 parts of deionized water and fatty alcohol-polyoxyethylene ether;
wherein, the weight portion of the fatty alcohol-polyoxyethylene ether satisfies the following requirements:
Figure BDA0002318512780000072
the preparation method comprises the following steps:
step 1: mixing ethanol (viscosity 1.08170 × 10)-3Pa.s) and isopropanol (viscosity 9.04936X 10)-4Pa · s) was added to deionized water (viscosity 8.90036X 10)-4Pa.s), adding sodium dodecyl sulfate after stirring for 15min, continuously stirring, heating to 50 ℃, and continuously stirring at the stirring speed of 500r/min until the sodium dodecyl sulfate is completely dissolved;
step 2: stearic acid (viscosity 0.0439Pa · s) and trisiloxane (viscosity 8.31073 × 10) were added successively- 4Pa · s), polysorbate (viscosity 8.67384 × 10)-3Pa.s) and fatty alcohol polyoxyethylene ether (viscosity 1.95303X 10)- 3Pa s), heating and stirring until the viscosity of the mixed liquid meets the following conditions:
Figure BDA0002318512780000081
wherein, the heating temperature is controlled to satisfy:
Figure BDA0002318512780000082
the stirring speed satisfies:
Figure BDA0002318512780000083
and step 3: the dibasic ester (viscosity 5.78038X 10) was added-4Pa.s), continuously stirring for 60min, and cooling in water bath for 30min to obtain the medical sol agent, wherein the temperature of the water bath is 20 ℃;
controlling the stirring speed to meet the following requirements:
Figure BDA0002318512780000084
example 2
The medical sol comprises the following components in parts by weight: 25 parts of dibasic ester (a mixture of dimethyl succinate, dimethyl glutarate and dimethyl adipate in a weight ratio of 1: 1: 1), 35 parts of ethanol, 10 parts of isopropanol, 15 parts of stearic acid, 30 parts of trisiloxane, 25 parts of polysorbate, 15 parts of sodium dodecyl sulfate, 150 parts of deionized water and fatty alcohol-polyoxyethylene ether;
wherein, the weight portion of the fatty alcohol-polyoxyethylene ether satisfies the following requirements:
Figure BDA0002318512780000085
the preparation method comprises the following steps:
step 1: mixing ethanol (viscosity 1.08170 × 10)-3Pa.s) and isopropanol (viscosity 9.04936X 10)-4Pa · s) was added to deionized water (viscosity 8.90036X 10)-4Pa.s), adding sodium dodecyl sulfate after stirring for 20min, continuously stirring, heating to 60 ℃, and continuously stirring at the stirring speed of 600r/min until the sodium dodecyl sulfate is completely dissolved;
step 2: continue to useStearic acid (viscosity 0.0439Pa · s) and trisiloxane (viscosity 8.31073 × 10) were added in succession- 4Pa · s), polysorbate (viscosity 8.67384 × 10)-3Pa.s) and fatty alcohol polyoxyethylene ether (viscosity 1.95303X 10)- 3Pa s), heating and stirring until the viscosity of the mixed liquid meets the following conditions:
Figure BDA0002318512780000091
wherein, the heating temperature is controlled to satisfy:
Figure BDA0002318512780000092
the stirring speed satisfies:
Figure BDA0002318512780000093
and step 3: the dibasic ester (viscosity 5.78038X 10) was added-4Pa.s), continuously stirring for 90min, and cooling in water bath for 45min to obtain the medical sol agent, wherein the temperature of the water bath is 15 ℃;
controlling the stirring speed to meet the following requirements:
Figure BDA0002318512780000094
example 3
The medical sol comprises the following components in parts by weight: 20 parts of dibasic ester (a mixture of dimethyl succinate, dimethyl glutarate and dimethyl adipate in a weight ratio of 1: 1: 1), 25 parts of ethanol, 8 parts of isopropanol, 13 parts of stearic acid, 25 parts of trisiloxane, 20 parts of polysorbate, 13 parts of sodium dodecyl sulfate, 120 parts of deionized water and fatty alcohol-polyoxyethylene ether;
wherein, the weight portion of the fatty alcohol-polyoxyethylene ether satisfies the following requirements:
Figure BDA0002318512780000095
the preparation method comprises the following steps:
step 1: mixing ethanol (viscosity 1.08170 × 10)-3Pa.s) and isopropanol (viscosity 9.04936X 10)-4Pa · s) was added to deionized water (viscosity 8.90036X 10)-4Pa.s), adding sodium dodecyl sulfate after stirring for 15min, continuously stirring, heating to 60 ℃, and continuously stirring at the stirring speed of 550r/min until the sodium dodecyl sulfate is completely dissolved;
step 2: stearic acid (viscosity 0.0439Pa · s) and trisiloxane (viscosity 8.31073 × 10) were added successively- 4Pa · s), polysorbate (viscosity 8.67384 × 10)-3Pa.s) and fatty alcohol polyoxyethylene ether (viscosity 1.95303X 10)- 3Pa s), heating and stirring until the viscosity of the mixed liquid meets the following conditions:
Figure BDA0002318512780000101
wherein, the heating temperature is controlled to satisfy:
Figure BDA0002318512780000102
the stirring speed satisfies:
Figure BDA0002318512780000103
and step 3: the dibasic ester (viscosity 5.78038X 10) was added-4Pa.s), continuously stirring for 75min, and cooling in water bath for 40min to obtain the medical sol agent, wherein the temperature of the water bath is 18 ℃;
controlling the stirring speed to meet the following requirements:
Figure BDA0002318512780000104
example 4
The invention provides a medical sol agent, which comprises the following components in parts by weight: 21 parts of dibasic ester (a mixture of dimethyl succinate, dimethyl glutarate and dimethyl adipate in a weight ratio of 1: 1: 1), 30 parts of ethanol, 10 parts of isopropanol, 14 parts of stearic acid, 25 parts of trisiloxane, 20 parts of polysorbate, 13 parts of sodium dodecyl sulfate, 130 parts of deionized water and fatty alcohol-polyoxyethylene ether;
wherein, the weight portion of the fatty alcohol-polyoxyethylene ether satisfies the following requirements:
Figure BDA0002318512780000105
the preparation method comprises the following steps:
step 1: mixing ethanol (viscosity 1.08170 × 10)-3Pa.s) and isopropanol (viscosity 9.04936X 10)-4Pa · s) was added to deionized water (viscosity 8.90036X 10)-4Pa.s), adding sodium dodecyl sulfate after stirring for 20min, continuously stirring, heating to 60 ℃, and continuously stirring at the stirring speed of 600r/min until the sodium dodecyl sulfate is completely dissolved;
step 2: stearic acid (viscosity 0.0439Pa · s) and trisiloxane (viscosity 8.31073 × 10) were added successively- 4Pa · s), polysorbate (viscosity 8.67384 × 10)-3Pa.s) and fatty alcohol polyoxyethylene ether (viscosity 1.95303X 10)- 3Pa s), heating and stirring until the viscosity of the mixed liquid meets the following conditions:
Figure BDA0002318512780000111
wherein, the heating temperature is controlled to satisfy:
Figure BDA0002318512780000112
the stirring speed satisfies:
Figure BDA0002318512780000113
and step 3: the dibasic ester (viscosity 5.78038X 10) was added-4Pa.s), continuously stirring for 90min, cooling in water bath for 45min to obtain medical sol agentThe water bath temperature is 15 ℃;
controlling the stirring speed to meet the following requirements:
Figure BDA0002318512780000114
comparative example 1
The medical sol of the comparative example comprises the following components in parts by weight: 15-25 parts of dibasic ester (a mixture of dimethyl succinate, dimethyl glutarate and dimethyl adipate in a weight ratio of 1: 1: 1), 20-35 parts of ethanol, 5-10 parts of isopropanol, 10-15 parts of stearic acid, 20-30 parts of trisiloxane, 15-25 parts of polysorbate, 10-15 parts of sodium dodecyl sulfate, 95-150 parts of deionized water and 2 parts of fatty alcohol-polyoxyethylene ether;
the preparation method comprises the following steps:
step 1: adding ethanol and isopropanol into deionized water, stirring for 15min, adding sodium dodecyl sulfate, stirring continuously, heating to 50 deg.C, stirring at 500r/min until the sodium dodecyl sulfate is completely dissolved;
step 2: and continuously and sequentially adding stearic acid, trisiloxane, polysorbate and fatty alcohol-polyoxyethylene ether, heating and stirring until the viscosity of the mixed liquid meets the following requirements:
Figure BDA0002318512780000121
wherein, the heating temperature is controlled to satisfy:
Figure BDA0002318512780000122
the stirring speed satisfies:
Figure BDA0002318512780000123
and step 3: adding dibasic acid ester, stirring for 60min, cooling in water bath for 30min to obtain medical sol agent, wherein the temperature of the water bath is 20 deg.C;
controlling the stirring speed to meet the following requirements:
Figure BDA0002318512780000124
comparative example 2
The medical sol of the comparative example comprises the following components in parts by weight: 15-25 parts of dibasic ester (a mixture of dimethyl succinate, dimethyl glutarate and dimethyl adipate in a weight ratio of 1: 1: 1), 20-35 parts of ethanol, 5-10 parts of isopropanol, 10-15 parts of stearic acid, 20-30 parts of trisiloxane, 15-25 parts of polysorbate, 10-15 parts of sodium dodecyl sulfate, 95-150 parts of deionized water and 2.2 parts of fatty alcohol-polyoxyethylene ether;
the preparation method comprises the following steps:
step 1: adding ethanol and isopropanol into deionized water, stirring for 20min, adding sodium dodecyl sulfate, stirring continuously, heating to 60 deg.C, stirring continuously at a stirring speed of 600r/min until the sodium dodecyl sulfate is completely dissolved;
step 2: and continuously and sequentially adding stearic acid, trisiloxane, polysorbate and fatty alcohol-polyoxyethylene ether, heating and stirring until the viscosity of the mixed liquid meets the following requirements:
Figure BDA0002318512780000131
wherein, the heating temperature is controlled to satisfy:
Figure BDA0002318512780000132
the stirring speed satisfies:
Figure BDA0002318512780000133
and step 3: adding dibasic acid ester, continuously stirring for 90min, cooling in water bath for 45min to obtain medical sol agent, wherein the temperature of the water bath is 15 ℃;
controlling the stirring speed to meet the following requirements:
Figure BDA0002318512780000134
comparative example 3
The medical sol of the comparative example comprises the following components in parts by weight: 15-25 parts of dibasic ester (a mixture of dimethyl succinate, dimethyl glutarate and dimethyl adipate in a weight ratio of 1: 1: 1), 20-35 parts of ethanol, 5-10 parts of isopropanol, 10-15 parts of stearic acid, 20-30 parts of trisiloxane, 15-25 parts of polysorbate, 10-15 parts of sodium dodecyl sulfate, 95-150 parts of deionized water and 2.5 parts of fatty alcohol-polyoxyethylene ether;
step 1: adding ethanol and isopropanol into deionized water, stirring for 15min, adding sodium dodecyl sulfate, stirring continuously, heating to 60 deg.C, stirring continuously at a rotation speed of 550r/min until the sodium dodecyl sulfate is completely dissolved;
step 2: and continuously and sequentially adding stearic acid, trisiloxane, polysorbate and fatty alcohol-polyoxyethylene ether, heating and stirring until the viscosity of the mixed liquid meets the following requirements:
Figure BDA0002318512780000141
wherein the heating temperature is controlled to be 85 ℃;
the stirring speed is 620 r/min;
and step 3: adding dibasic acid ester, continuously stirring for 75min, cooling in water bath for 40min to obtain medical sol agent, wherein the temperature of the water bath is 18 ℃;
the stirring speed was controlled at 650 r/min.
The temperature and the rotation speed in comparative example 3 were both randomly set and were not determined according to empirical formulas.
The medical sol obtained in examples 1 to 4 and comparative examples 1 to 3 had no pungent odor, the medical sol obtained in examples 1 to 4 and comparative examples 1 to 3 was subjected to a sol test, 28 catheters of the same kind were taken, transparent dressings of the same material and the same size were respectively adhered, a circle of PICC tubes were applied, after 3 hours of application, the medical sol obtained in examples 1 to 4 and comparative examples 1 to 3 was applied, the same sol was applied every 4 tubes, wiping was performed every 2 seconds until the dressings were completely removed, and the time taken for the same sol was averaged, and the specific results are shown in table 1.
TABLE 1 results of the experiment
Serial number Time taken to remove dressing(s)
Example 1 40
Example 2 42
Example 3 36
Example 4 38
Comparative example 1 205
Comparative example 2 240
Comparative example 3 Can not be completely removed
As can be seen from table 1, the medical sol prepared in examples 1 to 4 can quickly remove the dressing on the PICC tube and the viscose thereon, while the medical sol prepared in comparative examples 1 to 2 does not determine the weight part of the fatty alcohol-polyoxyethylene ether by an empirical formula, and the medical sol obtained by determining the reaction temperature and the stirring speed by using the temperature and rotation speed formula provided by the invention can completely remove the dressing on the PICC tube and the viscose thereon, but the medical sol is long in use, and the weight part of the fatty alcohol-polyoxyethylene ether, the reaction temperature and the stirring speed in comparative example 3 are randomly determined, and it is found that the dressing on the PICC tube and the viscose thereon cannot be completely removed.
The preparation method of the medical sol designed and developed by the invention can be used for efficiently preparing the medical sol by optimally controlling the weight parts of the fatty alcohol-polyoxyethylene ether and accurately controlling the reaction degree, the reaction temperature and the stirring speed.
While embodiments of the invention have been disclosed above, it is not limited to the applications listed in the description and the embodiments, which are fully applicable in all kinds of fields of application of the invention, and further modifications may readily be effected by those skilled in the art, so that the invention is not limited to the specific details without departing from the general concept defined by the claims and the scope of equivalents.

Claims (10)

1. The medical sol agent is characterized by comprising the following components in parts by weight: 15-25 parts of dibasic ester, 20-35 parts of ethanol, 5-10 parts of isopropanol, 10-15 parts of stearic acid, 20-30 parts of trisiloxane, 15-25 parts of polysorbate, 10-15 parts of sodium dodecyl sulfate, 95-150 parts of deionized water and fatty alcohol-polyoxyethylene ether;
wherein the fatty alcohol-polyoxyethylene ether satisfies the following requirements in parts by weight:
Figure FDA0002318512770000011
in the formula, afIs the portion of fatty alcohol-polyoxyethylene ether, atIs the fraction of sodium dodecyl sulfate, aoIs the fraction of stearic acid, apIs polysorbatePart number of (a)wIs the fraction of deionized water, aeIs the fraction of ethanol, agIs a large fraction of isopropanol, asIs the fraction of trisiloxane ajIn parts of dibasic ester.
2. The medical sol of claim 1, wherein the weight ratio of polysorbate to sodium dodecyl sulfate is: 1.5 to 2.5.
3. The medical sol of claim 1, wherein the weight ratio of the polysorbate to the total parts of ethanol and isopropanol is: 0.3 to 0.8.
4. The medical sol of claim 1, wherein the weight ratio of the sodium dodecyl sulfate to the stearic acid is: 0.6 to 1.5.
5. The medical sol of claim 1, wherein the dibasic ester is one or more of dimethyl succinate, dimethyl glutarate and dimethyl adipate.
6. The medical sol of claim 5, wherein the dibasic ester is a mixture of dimethyl succinate, dimethyl glutarate and dimethyl adipate in a weight ratio of 1: 1: 1.
7. the preparation method of the medical sol is characterized by comprising the following steps:
step 1: adding ethanol and isopropanol into deionized water, stirring for 15-20 min, adding sodium dodecyl sulfate, continuously stirring, heating to 50-60 ℃, and continuously stirring until the sodium dodecyl sulfate is completely dissolved;
wherein the ethanol comprises 20-35 parts of isopropanol, 5-10 parts of sodium dodecyl sulfate and 95-150 parts of deionized water;
step 2: and continuously and sequentially adding stearic acid, trisiloxane, polysorbate and fatty alcohol-polyoxyethylene ether, heating and stirring until the viscosity of the mixed liquid meets the following requirements:
Figure FDA0002318512770000021
wherein, the heating temperature is controlled to satisfy:
Figure FDA0002318512770000022
the stirring speed satisfies:
Figure FDA0002318512770000023
and
10-15 parts of stearic acid, 20-30 parts of trisiloxane and 15-25 parts of polysorbate, wherein the fatty alcohol-polyoxyethylene ether is prepared by the following raw materials in parts by weight:
Figure FDA0002318512770000024
in the formula, ηmFor the viscosity of the mixed liquid, T is the heating temperature of step 2, T0At normal temperature of 25 ℃, ηoViscosity of stearic acid at ordinary temperature, ηsViscosity of trisiloxane at ambient temperature, ηpIs viscosity of polysorbate at room temperature, ηwIs the viscosity of deionized water at normal temperature, T1Is the heating temperature of step 1, n2The stirring speed of step 2, n1The stirring speed in the step 1 is shown, and e is the base number of the natural logarithm; a isfIs the portion of fatty alcohol-polyoxyethylene ether, atIs the fraction of sodium dodecyl sulfate, aoIs the fraction of stearic acid, apIs the number of polysorbate portions, awIs the fraction of deionized water, aeIs the fraction of ethanol, agIs a large fraction of isopropanol, asIs the fraction of trisiloxane ajAs part of the dibasic ester, atotalIs the total parts;
and step 3: adding dibasic ester, continuously stirring for 60-90 min, and cooling in a water bath for 30-45 min to obtain the medical sol;
wherein the dibasic acid ester accounts for 15-25 parts.
8. The method for preparing the medical sol according to claim 7, wherein in the step 3, the stirring speed is controlled so as to satisfy:
Figure FDA0002318512770000031
in the formula, n3The stirring speed in step 3, ηjIs the viscosity of the dibasic ester at normal temperature.
9. The method for preparing the medical sol agent as claimed in claim 7 or 8, wherein the temperature of the water bath is 15-20 ℃.
10. The method of preparing the medical sol of claim 9, wherein the dibasic ester is a mixture of dimethyl succinate, dimethyl glutarate and dimethyl adipate in a weight ratio of 1: 1: 1.
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