CN110483821A - A kind of latex balloon and its preparation method and application of siliconized processing - Google Patents
A kind of latex balloon and its preparation method and application of siliconized processing Download PDFInfo
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- CN110483821A CN110483821A CN201910686818.6A CN201910686818A CN110483821A CN 110483821 A CN110483821 A CN 110483821A CN 201910686818 A CN201910686818 A CN 201910686818A CN 110483821 A CN110483821 A CN 110483821A
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- siliconized
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- latex balloon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
- B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
- B29C41/14—Dipping a core
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08C—TREATMENT OR CHEMICAL MODIFICATION OF RUBBERS
- C08C1/00—Treatment of rubber latex
- C08C1/14—Coagulation
- C08C1/15—Coagulation characterised by the coagulants used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2022/00—Hollow articles
- B29L2022/02—Inflatable articles
- B29L2022/027—Air bags
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2313/00—Characterised by the use of rubbers containing carboxyl groups
- C08J2313/02—Latex
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2483/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon only; Derivatives of such polymers
- C08J2483/04—Polysiloxanes
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention belongs to medical instrument preparation technical fields, disclose a kind of latex balloon and preparation method thereof of siliconized processing, the preparation method comprises the following steps: (1) sacculus mould being impregnated in mixing coagulator；(2) sacculus mould is impregnated in prevulcanized latex；(3) sacculus mould is impregnated into coagulant solution again, obtains molding sacculus glue film；(4) sacculus glue film is impregnated in water, takes out drying；(5) the sacculus glue film after drying is demoulded, then latex balloon is immersed in organic silicon emulsion, taken out latex balloon, solidify at 100 DEG C -130 DEG C, obtain the latex balloon of siliconized processing.The latex balloon of the siliconized processing of the application provides the selection of bigger sacculus capacity, the good tensile strength of latex imparts the filling volume of catheter sacculus enough capacity, its maximum filling volume reaches 200ml, preferably solves the problems, such as to carry out hemostasis by compression using sacculus.
Description
Technical field
The present invention relates to medical instrument preparation technical field more particularly to a kind of latex balloons and its system of siliconized processing
Preparation Method and application.
Background technique
In the prior art, the balloon material of silicone catheter is also that silica gel material is made, because of the feature that silicone elastomer is poor,
Maximum sacculus capacity can only fill 30-50 milliliters, and sacculus is easier to burst because pressure is excessive, and part is needed sufficiently by ball
Capsule is filled to when the larger operation for carrying out hemostasis by compression, is easy the smaller enough oppressive forces of shortage because sacculus fills to increase out
Washing time in blood volume or extension surgical procedure.
In addition, silica gel balloon urinary material molecules are more loose, silicone catheter during indwelling need to every 2-3 days to sacculus into
Row supplement sterile water or physiological saline give medical staff's tourniquet to needing patient's use of Preserving time catheter to make troubles
To bear.
The method that domestic enterprise or scientific research institutions can effectively solve this problem not yet at present, and European and American developed countries are few
Number manufacturer has developed Large strain, elastomeric silica gel balloon urinary material, but technology holds in close confidence, and raw material are never to outgoing
It sells.Therefore, the balloon material and its preparation process that good biocompatibility, tearing strength are high, elasticity is good are developed, external ridge is broken
It is disconnected, it is Medical urethral catheter industry development critical issue urgently to be resolved.
Therefore, the small silicidation latex balloon of a kind of it is urgent to provide sacculus capacity big, good biocompatibility, frictional force
Preparation method.
Summary of the invention
The small latex balloon of a kind of the purpose of the present invention is to provide sacculus capacity big, good biocompatibility, frictional force
And its preparation method and application.
To achieve the goals above, the technical solution adopted by the present invention is that:
A kind of preparation method of the latex balloon of siliconized processing, comprising the following steps:
(1) sacculus mould is impregnated in mixing coagulator；
(2) sacculus mould is impregnated in prevulcanized latex；
(3) sacculus mould is impregnated into coagulant solution again, obtains molding sacculus glue film；
(4) sacculus glue film is impregnated in water, takes out drying；
(5) the sacculus glue film after drying is demoulded, then latex balloon is immersed in organic silicon emulsion, take out latex balloon
Capsule solidifies at 100 DEG C -130 DEG C, obtains the latex balloon of siliconized processing.
Preferably, in step (1), the mixing coagulator is made of calcium carbonate, calcium nitrate and ethyl alcohol.
Preferably, in step (1), the mixing coagulator is included the following components'mass percentage: calcium carbonate 3-12%,
Calcium nitrate 2-5% and ethyl alcohol 83-95%.
Preferably, in step (2), the time of the dipping is 5-60 seconds.
Preferably, in step (2), the prevulcanized latex is selected from presulfurization carboxylic acrylonitrile butadiene rubber latex and the poly- isoamyl two of presulfurization
One or both of alkene latex.
Preferably, in step (3), the coagulant solution is to be dissolved in ethyl alcohol by calcium nitrate to obtain, calcium nitrate and ethyl alcohol
Mass percent is 2-5%:95-98%.
Preferably, in step (4), the temperature of the water is in 40 DEG C -60 DEG C；The temperature of the drying is 40 DEG C -60 DEG C,
Time is 10-30min.
Preferably, in step (5), it is by coating emulsion that the organic silicon emulsion, which is by the organic silicon emulsion, promotes cream
Liquid and catalyst composition.It is highly preferred that the mass ratio of the coating emulsion, promotion lotion and catalyst is 14-18:2-3:1-2；
The coating emulsion be neopelex, fatty alcohol polyoxyethylene ether and water mix,；The promotion lotion be by
Octyl phenol polyalkenylethers, promotor and water mix；The catalyst sodium hydroxide, chloroplatinic acid, tetramethylammonium hydroxide and two
One or more of butyl tin dilaurate tin.
It is highly preferred that in step (5), another process of the silicidation are as follows: by SiO2Colloid substance is hydrolyzed to,
Catalyst is added and forms mixture, then mixture is sprayed into latex balloon surface, solidifies 1-3 seconds at 100 DEG C -130 DEG C, cream
Glue balloon surface obtains with a thickness of 3-5 microns of fine and close silication film layers.
A kind of latex balloon of siliconized processing, the latex balloon of the siliconized processing is by the preparation method system
.
A kind of catheter, including the latex balloon.
The method have the benefit that:
(1) for clinical operation it is needed when simultaneously for the patient that bladder and prostate carry out hemostasis by compression and flushing, this
The latex balloon of the siliconized processing of application provides the selection of bigger sacculus capacity, since the good tensile strength of latex assigns
The filling volume of catheter sacculus enough capacity, the superperformance that maximum filling volume reaches 80ml, and is not easily broken, preferably
It solves the problems, such as to carry out hemostasis by compression using sacculus.
(2) the latex balloon surface of the application is after impregnation technology, then carries out silicidation, is coated with one in balloon surface
Layer silica-gel coating, so that the surfacing with human contact is still silica gel material, the good biological compatibility of silica gel is effectively
It ensure that and the specific preferable biocompatibility of the product surface of human contact.
Specific embodiment
In order to make the objectives, technical solutions and advantages of the present invention clearer, below by embodiment, to the present invention into
Row is further described.However, it should be understood that the specific embodiments described herein are merely illustrative of the present invention, and do not have to
In limiting the scope of the invention.
Embodiment 1
A kind of preparation method of the latex balloon of siliconized processing, comprising the following steps:
(1) 10% calcium carbonate, 3% calcium nitrate and 87% ethyl alcohol are mixed, obtains mixing coagulator, then sacculus mould is soaked
Stain is in mixing coagulator；
(2) sacculus mould is impregnated in presulfurization carboxylic acrylonitrile butadiene rubber latex 30 seconds；
(3) 5% calcium nitrate is dissolved in 95% ethyl alcohol and obtains coagulant solution, then sacculus mould is impregnated in coagulant solution
In, obtain molding glue film；
(4) molding glue film is immersed in 50 DEG C of water, takes out the dry 20min at 45 DEG C；
(5) glue film after drying is demoulded, the latex balloon after demoulding is immersed in organic silicon emulsion 5 seconds, take out cream
Glueballs capsule solidifies 3 seconds at 120 DEG C, obtains the latex balloon of siliconized processing.
Embodiment 2
A kind of preparation method of the latex balloon of siliconized processing, comprising the following steps:
(1) 8% calcium carbonate, 4% calcium nitrate and 88% ethyl alcohol are mixed, obtains mixing coagulator, then sacculus mould is soaked
Stain is in mixing coagulator；
(2) sacculus mould is impregnated in presulfurization carboxylic acrylonitrile butadiene rubber latex 30 seconds；
(3) 5% calcium nitrate is dissolved in 95% ethyl alcohol and obtains coagulant solution, then sacculus mould is impregnated in coagulant solution
In, obtain molding glue film；
(4) molding glue film is immersed in 50 DEG C of water, takes out the dry 20min at 45 DEG C；
(5) glue film after drying is demoulded, the latex balloon after demoulding is immersed in organic silicon emulsion 5 seconds, take out cream
Glueballs capsule solidifies 3 seconds at 120 DEG C, obtains the latex balloon of siliconized processing.
Embodiment 3
A kind of preparation method of the latex balloon of siliconized processing, comprising the following steps:
(1) 5% calcium carbonate, 3% calcium nitrate and 92% ethyl alcohol are mixed, obtains mixing coagulator, then sacculus mould is soaked
Stain is in mixing coagulator；
(2) sacculus mould is impregnated in presulfurization carboxylic acrylonitrile butadiene rubber latex 30 seconds；
(3) 5% calcium nitrate is dissolved in 95% ethyl alcohol and obtains coagulant solution, then sacculus mould is impregnated in coagulant solution
In, obtain molding glue film；
(4) molding glue film is immersed in 50 DEG C of water, takes out the dry 20min at 45 DEG C；
(5) glue film after drying is demoulded, the latex balloon after demoulding is immersed in organic silicon emulsion 5 seconds, take out cream
Glueballs capsule solidifies 3 seconds at 120 DEG C, obtains the latex balloon of siliconized processing.
Comparative example 1
A kind of preparation method of catheter latex balloon, comprising the following steps:
(1) sacculus mould is impregnated in the mixing coagulator being made of 10% calcium carbonate, 3% calcium nitrate and 87% ethyl alcohol
In；
(2) sacculus mould is impregnated in pre-vulcanized natural latex 30 seconds；
(3) sacculus mould is impregnated again and is dissolved in the coagulant solution that 95% ethyl alcohol obtains by 5% calcium nitrate, formed
Glue film；
(4) molding glue film is immersed in 50 DEG C of water, takes out the dry 20min at 45 DEG C；
(5) glue film after drying is demoulded, then carries out recontour, sterilized, obtain latex balloon.
Comparative example 2
A kind of preparation method of silica gel balloon urinary, comprising the following steps:
(1) sacculus mould is impregnated in the mixing coagulator being made of 10% calcium carbonate, 3% calcium nitrate and 87% ethyl alcohol
In；
(2) sacculus mould is impregnated in silica gel 30 seconds；
(3) sacculus mould is impregnated again and is dissolved in the coagulant solution that 95% ethyl alcohol obtains by 5% calcium nitrate, formed
Glue film；
(4) molding glue film is immersed in 50 DEG C of water, takes out the dry 20min at 45 DEG C；
(5) glue film after drying is demoulded, then carries out recontour, sterilized, obtain silicone catheter sacculus.
Silica gel balloon urinary prepared by latex balloon obtained by embodiment 1-3 and comparative example 1 and comparative example 2 carries out performance
Test, the results are shown in Table 1:
Table 1
The latex balloon of the application is after silicidation, and percolation ratio reduces, good biocompatibility, anuria mineralization,
And it is nonirritant to mucous membrane, the blasting capacity of latex balloon has reached 200ml.
Claims (10)
1. a kind of preparation method of the latex balloon of siliconized processing, which comprises the following steps:
(1) sacculus mould is impregnated in mixing coagulator；
(2) sacculus mould is impregnated in prevulcanized latex；
(3) sacculus mould is impregnated into coagulant solution again, obtains molding sacculus glue film；
(4) sacculus glue film is impregnated in water, takes out drying；
(5) the sacculus glue film after drying is demoulded, then latex balloon is immersed in organic silicon emulsion, take out latex balloon, In
Solidify at 100 DEG C -130 DEG C, obtains the latex balloon of siliconized processing.
2. the preparation method of the latex balloon of siliconized processing according to claim 1, which is characterized in that in step (1),
The mixing coagulator is made of calcium carbonate, calcium nitrate and ethyl alcohol.
3. the preparation method of the latex balloon of siliconized processing according to claim 1, which is characterized in that in step (1),
The mixing coagulator includes the following components'mass percentage: calcium carbonate 3-12%, calcium nitrate 2-5% and ethyl alcohol 83-95%.
4. the preparation method of the latex balloon of siliconized processing according to claim 1, which is characterized in that in step (2),
The time of the dipping is 5-60 seconds.
5. the preparation method of the latex balloon of siliconized processing according to claim 1, which is characterized in that in step (2),
The prevulcanized latex is selected from one or both of presulfurization carboxylic acrylonitrile butadiene rubber latex and presulfurization polyisoprene latex.
6. the preparation method of the latex balloon of siliconized processing according to claim 1, which is characterized in that in step (3),
The coagulant solution is to be dissolved in ethyl alcohol by calcium nitrate to obtain, and the mass percent of calcium nitrate and ethyl alcohol is 2-5%:95-98%.
7. the preparation method of the latex balloon of siliconized processing according to claim 1, which is characterized in that in step (4),
The temperature of the water is in 40 DEG C -60 DEG C；The temperature of the drying is 40 DEG C -60 DEG C, time 10-30min.
8. the preparation method of the latex balloon of siliconized processing according to claim 1, which is characterized in that in step (5),
The organic silicon emulsion is made of coating emulsion, promotion lotion and catalyst.
9. a kind of latex balloon of siliconized processing, which is characterized in that the latex balloon of the siliconized processing is by claim 1
It is made to 8 described in any item preparation methods.
10. a kind of catheter, which is characterized in that the catheter includes latex balloon as claimed in claim 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910686818.6A CN110483821A (en) | 2019-07-29 | 2019-07-29 | A kind of latex balloon and its preparation method and application of siliconized processing |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910686818.6A CN110483821A (en) | 2019-07-29 | 2019-07-29 | A kind of latex balloon and its preparation method and application of siliconized processing |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111803719A (en) * | 2020-05-28 | 2020-10-23 | 广州新诚生物科技有限公司 | Preparation method of degradable balloon and balloon prepared by using preparation method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004189917A (en) * | 2002-12-12 | 2004-07-08 | Denki Kagaku Kogyo Kk | Silica-composite latex composition, silica-composite polychloroprene composition and method for producing the same |
| CN101357249A (en) * | 2008-09-02 | 2009-02-04 | 扬中金祥乳胶制品有限公司 | Silica-gel coating catheters and production technique thereof |
| CN107050626A (en) * | 2017-03-18 | 2017-08-18 | 湛江市事达实业有限公司 | A kind of sacculus self retaining catheter and its production technology |
| CN108245222A (en) * | 2018-01-23 | 2018-07-06 | 青岛星创医疗科技有限公司 | The medical preparation method for taking stone sacculus |
-
2019
- 2019-07-29 CN CN201910686818.6A patent/CN110483821A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004189917A (en) * | 2002-12-12 | 2004-07-08 | Denki Kagaku Kogyo Kk | Silica-composite latex composition, silica-composite polychloroprene composition and method for producing the same |
| CN101357249A (en) * | 2008-09-02 | 2009-02-04 | 扬中金祥乳胶制品有限公司 | Silica-gel coating catheters and production technique thereof |
| CN107050626A (en) * | 2017-03-18 | 2017-08-18 | 湛江市事达实业有限公司 | A kind of sacculus self retaining catheter and its production technology |
| CN108245222A (en) * | 2018-01-23 | 2018-07-06 | 青岛星创医疗科技有限公司 | The medical preparation method for taking stone sacculus |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111803719A (en) * | 2020-05-28 | 2020-10-23 | 广州新诚生物科技有限公司 | Preparation method of degradable balloon and balloon prepared by using preparation method |
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Application publication date: 20191122 |