CN111067988A - Traditional Chinese medicine preparation for preventing avian influenza and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for preventing avian influenza and preparation method thereof Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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Abstract
The invention belongs to the technical field of poultry breeding and discloses a traditional Chinese medicine preparation for preventing avian influenza, which is prepared from the following raw materials in parts by weight: 0.1-1 part of industrial hemp extract, 5-10 parts of wrinkled gianthyssop herb, 5-10 parts of aloe leaf, 3-10 parts of rhizoma atractylodis and 3-8 parts of dyers woad leaf; the preparation method comprises the following steps: cleaning herba Agastaches, folium Aloe, rhizoma Atractylodis, and folium Isatidis, cutting into small pieces, adding into a fermenter, adding lactobacillus fermentation liquid, and fermenting to obtain fermentation liquid; mixing with industrial hemp extract, concentrating to obtain extract, and drying to obtain powder. The traditional Chinese medicine preparation for preventing avian influenza can prevent poultry from being infected with avian influenza, effectively control the propagation and spread of avian influenza and cut off the source of human avian influenza; meanwhile, the economic loss of poultry farmers is reduced, the market supply is guaranteed, and the masses eat the reassuring chicken, duck and goose meat.
Description
Technical Field
The invention belongs to the technical field of poultry breeding, and relates to a traditional Chinese medicine preparation for preventing avian influenza and a preparation method thereof.
Background
Avian influenza is an infection or disease syndrome caused by avian influenza virus, mild respiratory symptoms can appear after poultry are infected with the avian influenza virus, the food consumption is reduced, the egg production is reduced, even systemic diseases are caused, and the death rate can reach 100%. The disease has high morbidity and recessive infection rate in domestic and international poultry, and directly influences the healthy development of poultry breeding industry in China.
At present, the prevention and treatment of avian influenza mainly adopts a method combining vaccine prevention and drug treatment. The vaccine is a main means for preventing influenza, and because the avian influenza virus antigenic variation can obviously reduce the effectiveness of the vaccine, the research on the anti-avian influenza virus medicament is more and more focused. The currently commonly used antiviral therapeutic drugs comprise amantadine, ribavirin and neuraminidase inhibitors, although the drugs have certain effects, the overall effect is not great, even the egg yield of chickens is affected, and the clinical application effect is not obvious due to more avian influenza virus serotypes.
At present, when most of farms raise chickens, in order to reduce the risk of avian influenza outbreak, enhance the resistance of the chickens and reduce the risk of illness of people, part of western medicines for resisting avian influenza are required to be mixed in the feed of the chickens generally, and the medicines and the feed are mixed together to feed, so that the healthy growth of chicken flocks is ensured, and the probability of avian influenza is reduced. Therefore, the research and the development of the traditional Chinese medicine preparation for preventing and treating the avian influenza have important significance.
Disclosure of Invention
The technical problem to be solved by the invention is to overcome the defects and provide a Chinese medicinal preparation for preventing avian influenza, which can prevent poultry from being infected with avian influenza, effectively control the propagation and spread of avian influenza and cut off the source of human avian influenza; meanwhile, the economic loss of poultry farmers is reduced, the market supply is guaranteed, and the masses eat the reassuring chicken, duck and goose meat.
In order to solve the technical problems, the technical scheme of the invention is as follows:
a traditional Chinese medicine preparation for preventing avian influenza is prepared from the following raw materials in parts by weight: 0.1-1 part of industrial hemp extract, 5-10 parts of wrinkled gianthyssop herb, 5-10 parts of aloe leaf, 3-10 parts of rhizoma atractylodis and 3-8 parts of dyers woad leaf.
Preferably, the traditional Chinese medicine preparation for preventing avian influenza is prepared from the following raw materials in parts by weight: 0.5 part of industrial hemp extract, 8 parts of wrinkled gianthyssop herb, 6 parts of aloe leaf, 5 parts of rhizoma atractylodis and 4 parts of dyers woad leaf.
Preferably, the content of cannabidiol in the industrial cannabis extract is more than 50%, and the content of tetrahydroindustrial cannabinol is less than 0.3%.
The pharmacological effects of the traditional Chinese medicine components of the invention are as follows:
hemp: sweet, pungent and mild in nature, has the effects of relieving swelling, drawing out pus, relieving itching, purging and removing stagnation. It is indicated for abscess, deep rooted carbuncle, swelling and toxin, scrofula, sore throat, scabies, tinea, edema, abdominal distention, dry stool.
Agastache rugosus: pungent in flavor and slightly warm in nature. It enters spleen, stomach and lung meridians. Aromatic dampness eliminating, stomach regulating, antiemetic, summer-heat dispelling, and exterior syndrome relieving; epigastric-abdominal distention and fullness, anorexia and vomiting due to damp obstructing the middle energizer; diarrhea, headache due to cold and heat caused by exogenous summer-heat and dampness, fever at the beginning of damp-warm disease, and physical distress.
Aloe leaves: bitter and cold; it enters liver, stomach and large intestine meridians; has effects of relaxing bowels with purgative, removing liver heat, killing parasite, resisting virus, resisting bacteria, clearing heat, removing toxic substance, clearing liver heat, resisting bacteria, killing bacteria, improving disease resistance, preventing virus from invading host cell, inhibiting DNA and RNA synthesis, inhibiting virus growth and reproduction, resisting virus, removing toxic substance, and improving immunity.
Rhizoma atractylodis: invigorating spleen, eliminating dampness, resolving stagnation, removing filth, treating spleen due to excessive dampness, listlessness, lethargy, abdominal distention, anorexia, emesis, diarrhea, dysentery, malaria, phlegm retention, edema, common cold, anemofrigid-damp arthralgia, foot flaccidity, and night blindness; notopterygii rhizoma, dispelling exterior cold, dispelling pathogenic wind and removing dampness, benefiting articulation, treating common cold wind cold, headache without sweat, wind-cold-dampness arthralgia, neck rigidity, tendon and spasm, bone joint soreness and pain, edema due to wind-cold, superficial infection and skin sore.
Folium isatidis: bitter taste, cold and non-toxic, entering liver, heart and stomach meridians; the main functions are as follows: clearing away heat, removing toxic substances, cooling blood, stopping bleeding, and treating epidemic febrile disease, excessive heat, polydipsia, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, hematemesis, epistaxis, jaundice, dysentery, pharyngitis, aphtha, carbuncle, cellulitis, and toxic swelling. Modern researches prove that the dyers woad leaf has the effects of resisting pathogenic microorganisms, expanding the cardiovascular system, resisting inflammation, relieving fever, improving the immunologic function, stimulating smooth muscles and protecting liver injury to a certain extent.
The invention also aims to provide a preparation method of the traditional Chinese medicine preparation for preventing avian influenza, which comprises the following steps:
(1) weighing agastache rugosus, aloe leaves, rhizoma atractylodis and folium isatidis according to parts by weight, cleaning, drying, and cutting into small pieces for later use;
(2) putting the Chinese medicinal blocks obtained in the step (1) into a fermentation barrel, adding lactobacillus fermentation liquor, fermenting at 26-30 ℃ for 60-100 days, and stirring for 2 times every day to obtain fermentation liquor;
(3) and (3) adding the industrial hemp extract into the fermentation liquor obtained in the step (2) according to the weight part, uniformly mixing, concentrating to obtain an extract, and drying to obtain powder, thus obtaining the traditional Chinese medicine preparation for preventing avian influenza.
Preferably, the lactobacillus fermentation liquor is prepared by mixing lactobacillus bacteria liquid and brown sugar, and adding water to dissolve the mixture.
Preferably, the mass ratio of the lactobacillus bacterial liquid to the brown sugar to the water is 1:1: 10.
Preferably, the number of strains in the lactobacillus liquid is more than or equal to 1010。
Compared with the prior art, the invention has the beneficial effects that:
(1) the traditional Chinese medicine preparation for preventing avian influenza is prepared from industrial hemp extract and lactobacillus fermentation extracts of agastache rugosus, aloe leaf, rhizoma atractylodis and folium isatidis, supplements each other, has strong antibacterial and bacteriostatic effects, enhances the disease resistance of poultry and reduces the occurrence of avian influenza.
(2) The traditional Chinese medicine preparation for preventing avian influenza can prevent poultry from being infected with avian influenza, effectively control the propagation and spread of avian influenza and cut off the source of human avian influenza; meanwhile, the economic loss of poultry farmers is reduced, the market supply is guaranteed, and the masses eat the reassuring chicken, duck and goose meat.
Detailed Description
The following description is made for the purpose of illustrating the principles and features of the present invention and is not intended to limit the scope of the invention.
Example 1
A traditional Chinese medicine preparation for preventing avian influenza is prepared from the following raw materials in parts by weight: 0.1 part of industrial hemp extract, 5 parts of wrinkled gianthyssop herb, 5 parts of aloe leaf, 3 parts of rhizoma atractylodis and 3 parts of dyers woad leaf.
A preparation method of a traditional Chinese medicine preparation for preventing avian influenza comprises the following steps:
(1) weighing agastache rugosus, aloe leaves, rhizoma atractylodis and folium isatidis according to parts by weight, cleaning, drying, and cutting into small pieces for later use;
(2) putting the Chinese medicinal blocks obtained in the step (1) into a fermentation barrel, adding lactobacillus fermentation liquor, fermenting for 100 days at 26 ℃, and stirring for 2 times every day to obtain fermentation liquor;
(3) and (3) adding the industrial hemp extract into the fermentation liquor obtained in the step (2) according to the weight part, uniformly mixing, concentrating to obtain an extract, and drying to obtain powder, thus obtaining the traditional Chinese medicine preparation for preventing avian influenza.
Example 2
A traditional Chinese medicine preparation for preventing avian influenza is prepared from the following raw materials in parts by weight: 0.3 part of industrial hemp extract, 10 parts of wrinkled gianthyssop herb, 8 parts of aloe leaf, 5 parts of rhizoma atractylodis and 4 parts of dyers woad leaf.
A preparation method of a traditional Chinese medicine preparation for preventing avian influenza comprises the following steps:
(1) weighing agastache rugosus, aloe leaves, rhizoma atractylodis and folium isatidis according to parts by weight, cleaning, drying, and cutting into small pieces for later use;
(2) putting the Chinese medicinal blocks obtained in the step (1) into a fermentation barrel, adding lactobacillus fermentation liquor, fermenting for 90 days at 28 ℃, and stirring for 2 times every day to obtain fermentation liquor;
(3) and (3) adding the industrial hemp extract into the fermentation liquor obtained in the step (2) according to the weight part, uniformly mixing to obtain mixed fermentation liquor, concentrating to obtain an extract, and drying to obtain powder to obtain the traditional Chinese medicine preparation for preventing avian influenza.
Example 3
A traditional Chinese medicine preparation for preventing avian influenza is prepared from the following raw materials in parts by weight: 0.5 part of industrial hemp extract, 8 parts of wrinkled gianthyssop herb, 8 parts of aloe leaf, 6 parts of rhizoma atractylodis and 5 parts of dyers woad leaf.
A preparation method of a traditional Chinese medicine preparation for preventing avian influenza comprises the following steps:
(1) weighing agastache rugosus, aloe leaves, rhizoma atractylodis and folium isatidis according to parts by weight, cleaning, drying, and cutting into small pieces for later use;
(2) putting the Chinese medicinal blocks obtained in the step (1) into a fermentation barrel, adding lactobacillus fermentation liquor, fermenting at 28 ℃ for 80 days, and stirring for 2 times every day to obtain fermentation liquor;
(3) and (3) adding the industrial hemp extract into the fermentation liquor obtained in the step (2) according to the weight part, uniformly mixing, concentrating to obtain an extract, and drying to obtain powder, thus obtaining the traditional Chinese medicine preparation for preventing avian influenza.
Example 4
A traditional Chinese medicine preparation for preventing avian influenza is prepared from the following raw materials in parts by weight: 1 part of industrial hemp extract, 10 parts of wrinkled gianthyssop herb, 10 parts of aloe leaf, 10 parts of rhizoma atractylodis and 8 parts of dyers woad leaf.
A preparation method of a traditional Chinese medicine preparation for preventing avian influenza comprises the following steps:
(1) weighing agastache rugosus, aloe leaves, rhizoma atractylodis and folium isatidis according to parts by weight, cleaning, drying, and cutting into small pieces for later use;
(2) putting the Chinese medicinal blocks obtained in the step (1) into a fermentation barrel, adding lactobacillus fermentation liquor, fermenting at 30 ℃ for 60 days, and stirring for 2 times every day to obtain fermentation liquor;
(3) and (3) adding the industrial hemp extract into the fermentation liquor obtained in the step (2) according to the weight part, uniformly mixing, concentrating to obtain an extract, and drying to obtain powder, thus obtaining the traditional Chinese medicine preparation for preventing avian influenza.
Comparative example 1
The industrial hemp extract was removed and the preparation method was the same as in example 4.
Comparative example 2
Agastache rugosa was removed and the rest of the preparation was the same as in example 4.
Comparative example 3
The aloe leaves were removed and the remaining preparation method was the same as in example 4.
Comparative example 4
The preparation method is the same as that of example 4 except that the rhizoma atractylodis is removed.
Comparative example 5
The isatis leaf was removed and the preparation was carried out in the same manner as in example 4.
Examples of effects
The cultivation effects of the traditional Chinese medicine preparation for preventing avian influenza in the examples and the comparative examples are compared:
in Kunming area of Yunnan province, 10000 chicks of 1 day old are selected and randomly divided into 10 groups, each group comprises 1000 chicks which are respectively an example group, a comparison group and a comparison group, the chicks of the comparison group are not added with a traditional Chinese medicine for preventing avian influenza, the chicks of the example group and the comparison group are respectively added with a traditional Chinese medicine for preventing avian influenza for feeding for 6 times each day, the addition amount is 0.1 percent of the weight of the chicks, the chicks are fed to 21 days old, the weight gain rate, the avian influenza infection rate and the survival rate of the chicks are calculated, and the breeding effects of the traditional Chinese medicine for preventing avian influenza of the example and the comparison are shown in Table 2.
Table 2 comparison of the culture effects of the Chinese medicinal preparations for preventing avian influenza in examples and comparative examples
The results in table 1 show that the traditional Chinese medicine preparation for preventing avian influenza prepared by the invention has a lower avian influenza infection rate, a higher weight gain rate and a higher survival rate than those of the comparative example and the control group, and the traditional Chinese medicine preparation for preventing avian influenza has a good breeding effect.
The foregoing is considered as illustrative of the preferred embodiments of the invention, but is made merely for the purpose of providing an understanding of the principles of the embodiments; meanwhile, for a person skilled in the art, according to the present embodiment, there may be a change in the specific implementation and application scope, and in summary, the present disclosure should not be construed as a limitation to the present invention.
Claims (7)
1. A traditional Chinese medicine preparation for preventing avian influenza is characterized in that: the compound is prepared from the following raw materials in parts by weight: 0.1-1 part of industrial hemp extract, 5-10 parts of wrinkled gianthyssop herb, 5-10 parts of aloe leaf, 3-10 parts of rhizoma atractylodis and 3-8 parts of dyers woad leaf.
2. The traditional Chinese medicine preparation for preventing avian influenza according to claim 1, which is characterized in that: the compound is prepared from the following raw materials in parts by weight: 0.5 part of industrial hemp extract, 8 parts of wrinkled gianthyssop herb, 6 parts of aloe leaf, 5 parts of rhizoma atractylodis and 4 parts of dyers woad leaf.
3. The traditional Chinese medicine preparation for preventing avian influenza according to any one of claims 1 to 2, characterized in that: the content of cannabidiol in the industrial hemp extract is more than 50 percent, and the content of tetrahydroindustrial cannabinol is less than 0.3 percent.
4. A method for preparing a Chinese medicinal preparation for preventing avian influenza as claimed in any one of claims 1 to 2, which is characterized in that: the method comprises the following steps:
(1) weighing agastache rugosus, aloe leaves, rhizoma atractylodis and folium isatidis according to parts by weight, cleaning, drying, and cutting into small pieces for later use;
(2) putting the Chinese medicinal blocks obtained in the step (1) into a fermentation barrel, adding lactobacillus fermentation liquor, fermenting at 26-30 ℃ for 60-100 days, and stirring for 2 times every day to obtain fermentation liquor;
(3) and (3) adding the industrial hemp extract into the fermentation liquor obtained in the step (2) according to the weight part, uniformly mixing, concentrating to obtain an extract, and drying to obtain powder, thus obtaining the traditional Chinese medicine preparation for preventing avian influenza.
5. The method for preparing a Chinese medicinal preparation for preventing avian influenza according to claim 4, wherein the method comprises the following steps: the lactobacillus fermentation liquor is prepared by mixing lactobacillus liquid and brown sugar, and adding water to dissolve.
6. The method for preparing a Chinese medicinal preparation for preventing avian influenza according to claim 5, wherein the method comprises the following steps: the mass ratio of the lactobacillus bacterial liquid to the brown sugar to the water is 1:2: 12.
7. The prevention of avian influenza as claimed in claim 5The preparation method of the traditional Chinese medicine preparation is characterized by comprising the following steps: the number of strains in the lactobacillus liquid is more than or equal to 1010。
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857698A (en) * | 2006-03-31 | 2006-11-08 | 陈培生 | Production process of biopreparation for treating bird flu |
| CN102526354A (en) * | 2012-01-11 | 2012-07-04 | 河南天纳图生物科技有限公司 | Chinese medicament for viral diseases |
| CN107594127A (en) * | 2017-11-01 | 2018-01-19 | 黄业钧 | It is a kind of to be used to prevent Chinese herbal feed additive of avian influenza virus and preparation method thereof |
| CN109453247A (en) * | 2018-12-06 | 2019-03-12 | 梁金星 | A kind of prevention and treatment four seasons common cold, influenza, the Chinese medicine composition of bird flu, Chinese medical extract and preparation method thereof and dosage form |
-
2020
- 2020-01-14 CN CN202010036650.7A patent/CN111067988A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857698A (en) * | 2006-03-31 | 2006-11-08 | 陈培生 | Production process of biopreparation for treating bird flu |
| CN102526354A (en) * | 2012-01-11 | 2012-07-04 | 河南天纳图生物科技有限公司 | Chinese medicament for viral diseases |
| CN107594127A (en) * | 2017-11-01 | 2018-01-19 | 黄业钧 | It is a kind of to be used to prevent Chinese herbal feed additive of avian influenza virus and preparation method thereof |
| CN109453247A (en) * | 2018-12-06 | 2019-03-12 | 梁金星 | A kind of prevention and treatment four seasons common cold, influenza, the Chinese medicine composition of bird flu, Chinese medical extract and preparation method thereof and dosage form |
Non-Patent Citations (2)
| Title |
|---|
| 侯政平等: "浅谈禽流感的中医药防治", 《甘肃中医》 * |
| 刘福堃等: "《微生物酵素及其应用》", 31 January 2014, 辽宁科学技术出版社 * |
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