CN111067098A - Solid preparation with eye health protection effect - Google Patents
Solid preparation with eye health protection effect Download PDFInfo
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- CN111067098A CN111067098A CN201911292426.8A CN201911292426A CN111067098A CN 111067098 A CN111067098 A CN 111067098A CN 201911292426 A CN201911292426 A CN 201911292426A CN 111067098 A CN111067098 A CN 111067098A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of nutrition and health care, and relates to a solid preparation with an eye health protection effect. The solid preparation is prepared from flos Chrysanthemi-Tagetis Erectae-stigma Maydis-Perillae herba composite extract, Aloe-fructus Lycii composite extract, Ginseng radix-radix Panacis Quinquefolii-fructus Ligustri Lucidi composite extract, soybean protein isolate, lactoferrin, and phosphate starch by twice embedding. The solid preparation adopts the way of traditional Chinese medicine health preservation, has reasonable formula, follows the principle of a method for compositely extracting homogeneous functional components, achieves the effect of protecting eye health by multiple ways in a synergistic way, effectively reduces the rate of gastric acid loss by a secondary embedding technology to improve the taking effect, and has the advantage of simple eating.
Description
Technical Field
The invention relates to the field of nutrition and health care, in particular to a solid preparation with the function of protecting eye health.
Background
Due to the heavy use and poor eye use habits of electronic products (especially, the electronic products are used after the lamp is turned off at night), the eye health condition of contemporary people is not optimistic, and the modern people show the situation of low aging development, and the uncomfortable symptoms such as dry eyes, acid swelling and even stabbing pain are often accompanied. Meanwhile, with the increase of age, due to the eye itself or other diseases of the body (hyperlipidemia, hypertension, etc.), ophthalmological diseases such as hyperopia, vitreous opacity, fundus oculi macula, cataract, etc. are inevitably generated.
In terms of eye health management, eye health is protected by oral preparations in addition to the development of good eye habits and the reduction of the degree of use of electronic products.
In the prior art, products for protecting eye health are not many, mainly eye drops are taken as main raw materials, in addition, some people can choose to brew traditional Chinese medicine materials such as chrysanthemum, cassia seeds and the like, and in addition, the eye drops are tablets taking blueberry, vaccinium myrtillus and lutein ester as raw materials. However, these products or processes have certain disadvantages: (1) the eye drops and other products play a role in physically relieving dryness and cooling stimulation, and belong to the field of temporary solution and permanent solution, and are relatively complex to use; (2) many people do not understand the theory of traditional Chinese medicine, do not match with the blending selection, fall into the blind situation, and have improper matching of food therapy materials for conditioning or inconsistent with physique, and only can be counterproductive after long-term use; (3) the tablets taking blueberry, vaccinium myrtillus and lutein ester as raw materials have good effect on improving eyesight, but have relatively long onset time due to the reasons that the raw materials are not embedded (easily damaged in stomach and reduce bioavailability), the action path is single and the like.
Disclosure of Invention
In view of the above, the present invention provides a solid preparation with an effect of protecting eye health, which adopts the way of traditional Chinese medicine health preservation, has a reasonable formula, follows the principle of a method of compound extraction of homogeneous functional components, achieves the effect of protecting eye health through multiple ways of synergy, and simultaneously improves the administration effect by effectively reducing the rate of gastric acid loss through a secondary embedding technology, and has the advantage of simple eating.
In order to achieve the purpose, the invention provides the following technical scheme:
a solid preparation with eye health protecting effect is prepared from flos Chrysanthemi-flos Tagetis Erectae-stigma Maydis-Perillae herba composite extract, Aloe-fructus Lycii composite extract, Ginseng radix-radix Panacis Quinquefolii-fructus Ligustri Lucidi composite extract, soybean protein isolate, lactoferrin, and phosphate starch by secondary embedding technology.
The solid preparation comprises, by weight, 20-40 parts of chrysanthemum morifolium-marigold-corn silk-perilla composite extract, 200 parts of aloe-medlar composite extract, 20-40 parts of ginseng-American ginseng-glossy privet fruit composite extract, 200 parts of soybean protein isolate, 200 parts of lactoferrin and 500 parts of phosphate starch.
The preparation method of the solid preparation comprises the following steps:
step 1, mixing Hangzhou white chrysanthemum, marigold, corn stigma and perilla according to a ratio of 1:1:0.5:0.2, putting the mixture into a ethanol solution with a weight ratio of ten times of 50%, extracting for 150 minutes at 80 ℃ by adopting a microwave-assisted extraction technology, filtering to obtain a supernatant, and preparing the supernatant into the Hangzhou white chrysanthemum-marigold-corn stigma-perilla composite extract by adopting a freeze drying technology;
step 2, mixing aloe and medlar according to the proportion of 0.8:1.2, putting the mixture into ethanol solution with the weight ratio of ten times of 10%, extracting for 120 minutes at the temperature of 80 ℃ by adopting a microwave-assisted extraction technology, filtering to obtain supernatant, and preparing the supernatant into an aloe-medlar composite extract by adopting a freeze drying technology;
step 3, mixing ginseng, American ginseng and glossy privet fruit according to the ratio of 1:1:2, putting the mixture into 80% ethanol solution with the weight ratio of ten times, extracting for 200 minutes at 75 ℃ by adopting a microwave-assisted extraction technology, filtering to obtain supernatant, and preparing the supernatant into the ginseng-American ginseng-glossy privet fruit composite extract by adopting a freeze drying technology;
step 4, weighing the soy protein isolate and the lactoferrin according to the formula ratio, adding the soy protein isolate and the lactoferrin into purified water with the weight ratio of 10 times, and uniformly mixing to obtain an embedding solution 1;
step 5, weighing the chrysanthemum morifolium ramat-marigold-corn stigma-perilla composite extract, the aloe-medlar composite extract and the ginseng-American ginseng-glossy privet fruit composite extract according to the formula amount, sequentially adding the extracts into the embedding liquid 1, uniformly stirring, and preparing the embedding powder 1 by adopting a freeze drying technology;
step 6, weighing phosphate starch with the formula amount, adding the phosphate starch into purified water with the weight proportion of 10 times, and uniformly mixing to obtain embedding liquid 2;
and 7, adding the embedding powder 1 into the embedding liquid 2, and drying by adopting a freeze drying technology to obtain the composite material.
In the technical scheme of the invention:
the flos Chrysanthemi-flos Tagetis Erectae-stigma Maydis-Perillae herba composite extract has effects of removing liver fire, improving eyesight, promoting rhodopsin regeneration, and preventing macular degeneration and retinitis pigmentosa.
The aloe-medlar compound extract has the effects of nourishing liver and kidney, replenishing vital essence, improving eyesight and supplementing eye nutrition.
The Ginseng radix-radix Panacis Quinquefolii-fructus Ligustri Lucidi composite extract has effects of invigorating qi, invigorating middle warmer, and improving cell nutrition and microcirculation.
The soybean protein isolate, the lactoferrin and the phosphate starch are used as wall materials for secondary embedding, so that the three composite extracts can be protected from oxidative deterioration before being taken, are not damaged by gastric acid in the stomach after being taken, and almost do not damage the intestinal tract for absorption.
The invention has the following advantages and beneficial effects:
(1) compared with the prior art, the solid preparation conforms to the health preserving theory of traditional Chinese medicine and the modern nutriology concept from prescription to compound extraction, and comprehensively protects the eye health from four levels of relieving eye discomfort symptoms, supplementing eye nutrient substances, improving cell activity, regulating body functions and the like. By adopting the compound extraction and multi-way effect taking mode, the time for improving the eye discomfort symptom can be effectively shortened, the eye health can be maintained for a long time, and the recurrence probability can be reduced.
(2) Compared with the prior art, the solid preparation effectively improves the stability of the functional components in the preparation in the storage process by a secondary embedding technology. Furthermore, after the preparation enters the stomach, the secondary embedding can effectively resist the damage of gastric acid to the functional components, so that the functional components can smoothly enter the intestinal tract for absorption, and the bioavailability is greatly improved.
(3) For a user, the solid preparation is convenient to eat and can be drunk and exert the effect only by being brewed with water. For related production enterprises, the solid preparation can be further prepared into various dosage forms such as tablets, capsules, soft sweets and the like, and is widely applied.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The invention discloses a solid preparation with the effect of protecting eye health, and the technical personnel in the field can use the content for reference and appropriately improve the parameters for realization. It is expressly intended that all such similar substitutes and modifications which would be obvious to one skilled in the art are deemed to be included in the invention. While the detection methods of the present invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the methods and applications described herein, as well as other suitable variations and combinations, may be made to implement and use the invention without departing from the spirit and scope of the invention.
In order to better illustrate the invention, reference will now be made to specific examples.
Example 1:
1. mixing flos Chrysanthemi, flos Tagetis Erectae, stigma Maydis and Perillae herba at a ratio of 1:1:0.5:0.2, adding into 50% ethanol solution, extracting at 80 deg.C for 150 min with microwave-assisted extraction technology, filtering to obtain supernatant, and lyophilizing the supernatant to obtain flos Chrysanthemi-flos Tagetis Erectae-stigma Maydis-Perillae composite extract;
2. mixing aloe and fructus Lycii at a ratio of 0.8:1.2, adding into 10% ethanol solution ten times the weight ratio, extracting at 80 deg.C for 120 min by microwave-assisted extraction technology, filtering to obtain supernatant, and lyophilizing the supernatant to obtain aloe-fructus Lycii composite extract;
3. mixing Ginseng radix, radix Panacis Quinquefolii and fructus Ligustri Lucidi at a ratio of 1:1:2, adding into 80% ethanol solution ten times the weight ratio, extracting at 75 deg.C for 200 min by microwave-assisted extraction technology, filtering to obtain supernatant, and lyophilizing the supernatant to obtain Ginseng radix-radix Panacis Quinquefolii-fructus Ligustri Lucidi composite extract;
4. weighing 1000g of soybean protein isolate and 1000g of lactoferrin, adding 20000g of purified water, and uniformly mixing to obtain an embedding solution 1;
5. weighing 200g of chrysanthemum morifolium-marigold-corn stigma-purple perilla composite extract, 1000g of aloe-medlar composite extract and 200g of ginseng-American ginseng-glossy privet fruit composite extract, sequentially adding the extracts into the embedding liquid 1, uniformly stirring, and preparing the embedding powder 1 by adopting a freeze drying technology;
6. weighing 5000g of phosphate starch, adding 50000g of purified water, and uniformly mixing to obtain embedding liquid 2;
7. and adding the embedding powder 1 into the embedding liquid 2, and drying by adopting a freeze drying technology to obtain the composite material.
Example 2:
1. mixing flos Chrysanthemi, flos Tagetis Erectae, stigma Maydis and Perillae herba at a ratio of 1:1:0.5:0.2, adding into 50% ethanol solution, extracting at 80 deg.C for 150 min with microwave-assisted extraction technology, filtering to obtain supernatant, and lyophilizing the supernatant to obtain flos Chrysanthemi-flos Tagetis Erectae-stigma Maydis-Perillae composite extract;
2. mixing aloe and fructus Lycii at a ratio of 0.8:1.2, adding into 10% ethanol solution ten times the weight ratio, extracting at 80 deg.C for 120 min by microwave-assisted extraction technology, filtering to obtain supernatant, and lyophilizing the supernatant to obtain aloe-fructus Lycii composite extract;
3. mixing Ginseng radix, radix Panacis Quinquefolii and fructus Ligustri Lucidi at a ratio of 1:1:2, adding into 80% ethanol solution ten times the weight ratio, extracting at 75 deg.C for 200 min by microwave-assisted extraction technology, filtering to obtain supernatant, and lyophilizing the supernatant to obtain Ginseng radix-radix Panacis Quinquefolii-fructus Ligustri Lucidi composite extract;
4. weighing 2000g of soybean protein isolate and 2000g of lactoferrin, adding 40000g of purified water, and uniformly mixing to obtain an embedding solution 1;
5. weighing 400g of chrysanthemum morifolium-marigold-corn stigma-purple perilla composite extract, 2000g of aloe-medlar composite extract and 400g of ginseng-American ginseng-glossy privet fruit composite extract, sequentially adding the extracts into the embedding liquid 1, uniformly stirring, and preparing the embedding powder 1 by adopting a freeze drying technology;
6. weighing 10000g of phosphate starch, adding 100000g of purified water, and uniformly mixing to obtain embedding liquid 2;
7. and adding the embedding powder 1 into the embedding liquid 2, and drying by adopting a freeze drying technology to obtain the composite material.
Example 3:
1. mixing flos Chrysanthemi, flos Tagetis Erectae, stigma Maydis and Perillae herba at a ratio of 1:1:0.5:0.2, adding into 50% ethanol solution, extracting at 80 deg.C for 150 min with microwave-assisted extraction technology, filtering to obtain supernatant, and lyophilizing the supernatant to obtain flos Chrysanthemi-flos Tagetis Erectae-stigma Maydis-Perillae composite extract;
2. mixing aloe and fructus Lycii at a ratio of 0.8:1.2, adding into 10% ethanol solution ten times the weight ratio, extracting at 80 deg.C for 120 min by microwave-assisted extraction technology, filtering to obtain supernatant, and lyophilizing the supernatant to obtain aloe-fructus Lycii composite extract;
3. mixing Ginseng radix, radix Panacis Quinquefolii and fructus Ligustri Lucidi at a ratio of 1:1:2, adding into 80% ethanol solution ten times the weight ratio, extracting at 75 deg.C for 200 min by microwave-assisted extraction technology, filtering to obtain supernatant, and lyophilizing the supernatant to obtain Ginseng radix-radix Panacis Quinquefolii-fructus Ligustri Lucidi composite extract;
4. weighing 1500g of soybean protein isolate and 1500g of lactoferrin, adding the soybean protein isolate and the lactoferrin into 30000g of purified water, and uniformly mixing to obtain an embedding solution 1;
5. weighing 300g of chrysanthemum morifolium-marigold-corn stigma-purple perilla composite extract, 1500g of aloe-medlar composite extract and 300g of ginseng-American ginseng-glossy privet fruit composite extract, sequentially adding the extracts into the embedding liquid 1, uniformly stirring, and preparing the embedding powder 1 by adopting a freeze drying technology;
6. weighing 7500g of phosphate starch, adding 75000g of purified water, and mixing uniformly to obtain embedding solution 2;
7. and adding the embedding powder 1 into the embedding liquid 2, and drying by adopting a freeze drying technology to obtain the composite material.
Example 4:
in this example, lycium barbarum polysaccharide is used as a marker active ingredient to illustrate the protective effect of the secondary encapsulation on the active ingredient.
1. Taking 6g of the solid preparation prepared in the embodiment 1, and detecting the content of the lycium barbarum polysaccharides in the solid preparation; taking 6g of the solid preparation prepared in the embodiment 1, soaking the solid preparation in 200mL of artificial gastric acid solution for 30 minutes, then soaking the solid preparation in 200mL of artificial intestinal juice for 30 minutes, detecting the content of the lycium barbarum polysaccharide in the artificial intestinal juice, and calculating the loss rate of the lycium barbarum polysaccharide, wherein the results are shown in Table 1;
2. taking 6g of non-embedded aloe-medlar composite extract, and detecting the content of medlar polysaccharide in the aloe-medlar composite extract; taking 6g of the solid preparation prepared in the embodiment 1, soaking the solid preparation in 200mL of artificial gastric acid solution for 30 minutes, then soaking the solid preparation in 200mL of artificial intestinal juice for 30 minutes, detecting the content of the lycium barbarum polysaccharide in the artificial intestinal juice, and calculating the loss rate of the lycium barbarum polysaccharide, wherein the results are shown in Table 1;
TABLE 1 loss of Lycium barbarum polysaccharides
| Sample name | Wolfberry polysaccharide loss (%) |
| EXAMPLE 1 solid preparation | 3.4 |
| Non-embedded aloe-wolfberry composite extract | 29.7 |
As can be seen from Table 1, compared with the 29.7% loss rate of the non-embedded aloe-medlar composite extract, the loss rate of medlar polysaccharide in the solid preparation subjected to secondary embedding is only 3.4%, and the effective components are greatly protected.
Example 5:
the preparation prepared in examples 2 and 3 and a product of a commercially available blueberry lutein ester tablet are respectively administered to 30 people who have eye discomfort clinically, and the effect is counted after each person takes the preparation for 30 days.
The following table shows the results of the human test:
as can be seen from the above-mentioned results,
(1) according to the standard judgment of health food inspection and evaluation technical specification (2003), revised edition of standards for relieving asthenopia, the preparation obtained in example 2-3 is proved to have the function of protecting eye health.
(2) Compared with the products sold in the market, the technical scheme provided by the invention can improve the effective rate by more than 10%, and the effect is more obvious.
The foregoing is directed to embodiments of the present invention and it is understood that various modifications and enhancements may be made by those skilled in the art without departing from the principles of the invention, which should be considered as within the scope of the invention.
Claims (3)
1. A solid preparation with the effect of protecting eye health is characterized by comprising a chrysanthemum morifolium ramat-marigold-corn stigma-perilla composite extract, an aloe-medlar composite extract, a ginseng-American ginseng-glossy privet fruit composite extract, a soybean protein isolate, lactoferrin and phosphate starch through a secondary embedding technology.
2. The solid preparation as claimed in claim 1, wherein the solid preparation comprises 20-40 parts by weight of chrysanthemum morifolium-marigold-corn silk-perilla composite extract, 100-200 parts by weight of aloe-medlar composite extract, 20-40 parts by weight of ginseng-American ginseng-glossy privet fruit composite extract, 100-200 parts by weight of isolated soy protein, 100-200 parts by weight of lactoferrin and 500-1000 parts by weight of phosphate starch.
3. The solid preparation according to claim 1, wherein the preparation method of the solid preparation comprises the steps of:
step 1, mixing Hangzhou white chrysanthemum, marigold, corn stigma and perilla according to a ratio of 1:1:0.5:0.2, putting the mixture into a ethanol solution with a weight ratio of ten times of 50%, extracting for 150 minutes at 80 ℃ by adopting a microwave-assisted extraction technology, filtering to obtain a supernatant, and preparing the supernatant into the Hangzhou white chrysanthemum-marigold-corn stigma-perilla composite extract by adopting a freeze drying technology;
step 2, mixing aloe and medlar according to the proportion of 0.8:1.2, putting the mixture into ethanol solution with the weight ratio of ten times of 10%, extracting for 120 minutes at the temperature of 80 ℃ by adopting a microwave-assisted extraction technology, filtering to obtain supernatant, and preparing the supernatant into an aloe-medlar composite extract by adopting a freeze drying technology;
step 3, mixing ginseng, American ginseng and glossy privet fruit according to the ratio of 1:1:2, putting the mixture into 80% ethanol solution with the weight ratio of ten times, extracting for 200 minutes at 75 ℃ by adopting a microwave-assisted extraction technology, filtering to obtain supernatant, and preparing the supernatant into the ginseng-American ginseng-glossy privet fruit composite extract by adopting a freeze drying technology;
step 4, weighing the soy protein isolate and the lactoferrin according to the formula ratio, adding the soy protein isolate and the lactoferrin into purified water with the weight ratio of 10 times, and uniformly mixing to obtain an embedding solution 1;
step 5, weighing the chrysanthemum morifolium ramat-marigold-corn stigma-perilla composite extract, the aloe-medlar composite extract and the ginseng-American ginseng-glossy privet fruit composite extract according to the formula amount, sequentially adding the extracts into the embedding liquid 1, uniformly stirring, and preparing the embedding powder 1 by adopting a freeze drying technology;
step 6, weighing phosphate starch with the formula amount, adding the phosphate starch into purified water with the weight proportion of 10 times, and uniformly mixing to obtain embedding liquid 2;
and 7, adding the embedding powder 1 into the embedding liquid 2, and drying by adopting a freeze drying technology to obtain the composite material.
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