CN101011518A - Medicament for treating children's infantile malnutrition symptom - Google Patents
Medicament for treating children's infantile malnutrition symptom Download PDFInfo
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- CN101011518A CN101011518A CNA2007100539604A CN200710053960A CN101011518A CN 101011518 A CN101011518 A CN 101011518A CN A2007100539604 A CNA2007100539604 A CN A2007100539604A CN 200710053960 A CN200710053960 A CN 200710053960A CN 101011518 A CN101011518 A CN 101011518A
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Abstract
The invention discloses a Chinese medicament for treating children's infantile malnutrition which is prepared from the following raw materials (by weight portion): cockroach 10-30 parts, pseudostellaria root 10-25 parts, Chinese yam 10-30 parts, chicken's gizzard-skin 10-30 parts, picrorhiza rhizome 8-15 parts, gentian root 5-15 parts, biond magnolia flower 10-20 parts, finger citron 5-15 parts, licorice 5-10 parts. The medicament can be prepared into granules, oral liquids, pills, tablets and capsules.
Description
Technical field
The present invention relates to the animals and plants Chinese herbal medicine is the medicine that primary raw material is made, and is specifically related to a kind of medicine for the treatment of children's infantile malnutrition symptom.
Background technology
Infantile malnutrition is a kind of children's's common frdquently encountered disease disease.Because father and mother spoil excessively children's, paddy flesh fruit dish wantonly advances, or random absurd throwing has high protein. the nourishing food of high heat, or form the bad habit of monophagia, impairing the spleen and stomach causes anorexia, dyspepsia.Traditional medicine is thought: children's's internal organs are tender and lovely, and weakness of spleen and stomach is injured easily.Also relevant with children's's's " the spleen tending to insufficiency usually " physiological characteristics.Or because of the satiety of breast food, or because of delicious food does not have joint, or infect parasites, and cause spleen injury, transformation failure of spleen, digestion and malabsorption lack nutrition, and hypoevolutism is gradually given birth to long-pending heat, and with the passing of time intenseness of heat becomes infantile malnutrition, then consumes QI and blood, fries in shallow oil bright body fluid.Card is seen: inappetence, and dyspepsia likes to eat foreign body, the happiness drinking cold water, halitosis, it is half congealed or secret to defecate, cacosmia; oliguria with reddish urine or water from washing rice, and the enlarged abdomen muscle reveals, and does; shallow complexion is simple and unadorned wasting, withered skin and hair during stomachache; spirit is not good enough, and is easily irritated exciting, insomnia; or dig nose with rubbing eyebrow, stings to refer to grind one's teeth in sleep remarkable action etc.Doctor trained in Western medicine is diagnosed as " malnutrition " more in treatment, the complementary medicine of only suiting the medicine to the illness, and as replenishing multivitamin, aminoacid and digestant, owing to cure the symptoms, not the disease, curative effect is not too desirable.The Chinese medicine of the treatment commonly used precious electuaries of fertile youngster that adopt, it is to be the granule that raw material is made with Fructus Quisqualis, Radix Codonopsis, Fructus Crataegi, Fructus Oryzae Germinatus, Endothelium corneum, Faeces Vespertilionis, Rhizoma Dioscoreae, Endoconcha Sepiae, Poria, Cacumen Securinegae Suffruticosae, Radix Glycyrrhizae more.This medicine cures mainly and biases toward expelling intestinal worms and removing food stagnancy, the summer-heat diarrhoea of holding concurrently, and relatively poor to the main symptom anorexia curative effect of infantile malnutrition disease.The sweet temperature of its principal agent Fructus Quisqualis, poisonous.Take medicine and avoid the hot tea of drink.Take untoward reaction such as causing singultus, dizzy, vomiting in a large number or for a long time, also have the part infant side effect of constipation to occur.
At the defective of above-mentioned existence, the object of the invention is to provide a kind of reasonable recipe, and is evident in efficacy, and drug safety is suitable for the medicine of the treatment children's infantile malnutrition symptom of children taking.
For achieving the above object, technical scheme of the present invention is: the medicine of this treatment children's infantile malnutrition symptom is formulated by following raw medicaments in portion by weight: Blatta seu periplaneta 10-30 part, Radix Pseudostellariae 10-25 part, Rhizoma Dioscoreae 10-30 part, Endothelium Corneum Gigeriae Galli 10-30 part, Rhizoma Picrorhizae 8-15 part, Radix Gentianae 5-15 part, Fructus Ulmus preparatium 10-20 part, Fructus Citri Sarcodactylis 5-15 part, Radix Glycyrrhizae 5-10 part.
The best proportioning for preparing this medicine is to press the row weight portion:
15 parts of Blatta seu periplanetaes, 15 parts of Radix Pseudostellariaes, 20 parts of Rhizoma Dioscoreaes, 15 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Rhizoma Picrorhizae, 8 parts of Radix Gentianaes, 15 parts of Fructus Ulmus preparatium, 8 parts of Fructus Citri Sarcodactylis, 6 parts in Radix Glycyrrhizae.
Above-mentioned each component is formed medicine of the present invention and be can be made into granule, oral liquid, pill, tablet, capsule by existing common process.
The medicine of above-mentioned component has consumer product dredge stasis, invigorating the spleen and benefiting QI, parasite killing detoxicating functions, cures mainly child's anorexia, malnutrition.Monarch drug is a Blatta seu periplaneta, has dyspepsia and intestinal stasis relieving, detoxicating and resolving stagnation of pathogens.Write in Qing Dynasty's ZHAO Xue-Min supplementary Amplifications of the Compendium of Materia Medica: " Scapipedus is controlled flatulence resulting from deficiency of QI, tympanites, all youngster's infantile malnutritions." cloud again: " all children's suffer from infantile malnutrition, are regardless of how infantile malnutrition, all imitate, and need only eat a secondary and promptly heal, and more the back body is more fertile white and prove successful in every test." and contain multiple digestive enzyme and aminoacid, so anorexia, malnutrition are all had better curative effect.Be used as medicine with Blatta seu periplaneta, break its understanding, turn waste into wealth as insect hundred none usefulness of evil.Ministerial drug is Radix Pseudostellariae, Rhizoma dioscoreae (parched), Endothelium Corneum Gigeriae Galli, Rhizoma Picrorhizae, Radix Gentianae, Fructus Ulmus preparatium, wherein, and Radix Pseudostellariae, Rhizoma dioscoreae (parched): replenishing QI to invigorate the spleen, the anorexia of main weakness of the spleen and stomach; Endothelium Corneum Gigeriae Galli: the grain milling removing food stagnancy, remove full.Can help the precise and tiny picked-up of diet by appetite stimulator; Rhizoma Picrorhizae: press down wooden relieving restlessness, control that children's's infantile malnutrition with fever, tripe expand, hectic fever, night sweat; Radix Gentianae: bitter in the mouth is good for the stomach, and cool in nature removing shied.Liver heat removing gallbladder excess-fire, remove damp-heat in lower-JIAO; Fructus Ulmus preparatium: the removing food stagnancy relieving dyspepsia, control abdominal pain due to worm stagnation, children's's infantile malnutrition with diarrhea, cold-dysentery." book on Chinese herbal medicine converge with speech " kills three worms, the five kinds of child malnutrition that disappears, and the medicine of controlling children's's all kinds of diseases and ailments is also.Adjuvant drug is a Fructus Citri Sarcodactylis, Fructus Citri Sarcodactylis: please stomach raw meat spleen, startup mechanism of qi, warm strong and not dry strong.Messenger drug is Radix Glycyrrhizae and middle emergency, coordinating the actions of various ingredients in a prescription.With Fructus Citri Sarcodactylis compatibility sour and sweet drugs can transforme into YIN, help the gastric qi recovery.
In order to verify therapeutic effect, the present invention has carried out following deep pharmacological testing.
1, acute toxicity test
20 mouse stomach administrations, daily dose 480g/kg observes and did not have any toxic reaction in 7 days, all healthy survival.As calculating with crude drug amount 2.34～2.00 grams by 1～6 years old and 7～12 years old child's average weight per kilogram with body weight for humans, be equivalent to 205～240 times of human metering, prompting body invention medicine, used clinical dosage is safe.
2, long term toxicity test
Medicine rat every day dosage of the present invention is respectively 10,20,40 times of clinical children's's consumption per day, irritated stomach 90 days, carry out hematology and biochemical detection before and after the administration respectively, every index all compares with the blank group, there was no significant difference, the pathological examination of various internal organs does not all have ANOMALOUS VARIATIONS, compares there was no significant difference with the normal control group.
3, clinical verification
Through the clinical practice of outpatient service 200 routine children's infantile malnutrition symptoms, obtained curative effect preferably.Usually taking 3-7 days appetite obviously increases, and wherein to add obvious effective rate be 76.2% to cure rate, and total effective rate reaches 97%, and other establishes matched group, takes " the precious electuary of fertile youngster " 80 examples, and relevant treatment situation is as follows:
(1) method of administration
The oral watered pill of the present invention of test group, every day three times, 1-2 year each 2 grams, 2-3 year each 3 grams, 3-5 year each 4 grams, 6-8 year each 6 grams.Take 1 hour ante cibum.Be 15 days the course of treatment.Matched group oral " the precious electuary of fertile youngster ", three times on the one, be one month the course of treatment.
(2) efficacy evaluation
1. recovery from illness: weight increase, basic near children's's body weight of the same age, various transference cures, it is normal that every index is recovered.
2. produce effects: body weight obviously increases, and various symptoms are obviously improved, and every index is near normal.
3. effective: body weight increases to some extent, and spirit, appetite and various symptom all have improvement, and every inspection index also has improvement.
4. invalid: clinical symptoms, sign, test check index are not seen improvement.
Efficacy analysis
After medication course of treatment, relatively the situation of change of body weight and other relevant disease before and after the medication by above-mentioned curative effect determinate standard evaluation curative effect, the results are shown in Table 1～4
Table 1. patient's age-sex composition and treatment situation
| Group | Sex | 1～6 year old | 6～12 years old | Recovery from illness | Produce effects | Effectively | Invalid | Effective percentage |
| Test group | The man | 70 | 27 | 104 | 60 | 32 | 4 | 97.0 |
| The woman | 68 | 35 | ||||||
| Matched group | The man | 34 | 10 | 12 | 8 | 46 | 14 | 82.5 |
| The woman | 22 | 14 |
Annotate: X
2=7.11 P＜0.05
Main symptom curative effect comparision before and after table 2 medication
| Disease | Group | Observe routine number | Recovery from illness | Produce effects | Effectively | Invalid | Effective percentage (%) | X 2Value | The P value |
| Appetite | Test group | 192 | 124 | 24 | 42 | 2 | 97.9 | 4.69 | 0.03 |
| Matched group | 76 | 12 | 6 | 48 | 5 | 86.8 | |||
| Complexion | Test group | 198 | 104 | 34 | 55 | 5 | 94.9 | 6.13 | 0.01 |
| Matched group | 78 | 16 | 6 | 47 | 9 | 79.5 | |||
| Stool | Test group | 150 | 100 | 16 | 31 | 3 | 97.3 | 5.42 | 0.019 |
| Matched group | 70 | 12 | 4 | 46 | 8 | 82.8 | |||
| Abdominal distention | Test group | 166 | 118 | 14 | 31 | 3 | 97.6 | 7.86 | 0.005 |
| Matched group | 60 | 14 | 4 | 33 | 9 | 80.0 | |||
| Emotion | Test group | 186 | 116 | 20 | 47 | 3 | 97.8 | 8.15 | 0.004 |
| Matched group | 80 | 20 | 4 | 47 | 9 | 82.5 |
Hematochrome distribution situation contrast before table 3. medication
| Rank | Observe routine number | ＜9g | 9-10.9g | 11-11.9g | ≥12g |
| Test group | 200 | 2 | 126 | 44 | 28 |
| Matched group | 80 | 0 | 44 | 20 | 16 |
Annotate: color compares mutually before two groups of treatments: X
2=1.58 P＞0.05
Hematochrome situation contrast after table 4. medication
| Rank | Observe routine number | ＜9g | 9-10.9g | 11-11.9g | ≥12g |
| Test group | 200 | 1 | 1 | 22 | 176 |
| Matched group | 80 | 0 | 3 | 42 | 35 |
Annotate: two groups of treatment back colors compare mutually: X
2=35.16 P＜0.001
Beneficial effect: pharmacological tests shows that the total effective rate that the present invention treats the weak liver-fire type of infantile consumption spleen reaches 97%, and matched group is 82.5%, learns by statistics and handles the difference significance.Any reaction do not occur, reasonable recipe and simple is a kind of good medicine of department of pediatrics safely and effectively.
Case: 1, opened the XX woman 2 years old
Emaciated physique, the few China of shallow complexion, hair is rare slightly, inappetence, spirit is not good enough, easily flies into a rage the little Huang of tongue fur.This card belongs to the infantile malnutrition gas of infantile malnutrition disease.By taking this medicine, every day 3 times, each 2 grams.Existing appetite after 3 days, spirit takes a turn for the better.Advise to obey again and consolidated curative effect in 10 days.All are normal after one month, absorb well, and long is fair and fat.
2, Liu XX man is 4 years old
Worn to a shadow, shallow complexion is simple and unadorned, and lassitude is easily irritated exciting, bruxism, and serious anorexia, constipation, cacosmia is urinated as water from washing rice yellow fur.This card belongs to the infantile malnutrition of infantile malnutrition disease.By taking this medicine, every day 3 times, each 4 grams.Appetite heightens after 5 days, and spirit is good, and stool every day 1-2 time, urine normally.Advise to obey again and consolidated curative effect in 10 days.All are normal after one month, 1.5 kilograms of weight increase, and height increases by 1 centimetre.
3, high XX man is 5 years old
Body skeletonize, face are old man's looks, and skin is shrivelled, and be skinny, lethargy, hair is withered, anorexia, the loose stool, the time low grade fever, pale and tender tongue arranged.This disease belongs to the chronic infantile malnutrition of infantile malnutrition disease.All empty for QI and blood, taste void loses, and then becomes this disease.By taking this medicine, every day 3 times, each 4 grams.Appetite heightened in 7 days, and spirit takes a turn for the better, and stool every day 1 time, urine is normal.Advise to obey again and consolidated curative effect in 10 days.Follow-uply be taken after mixing with liquid recovery from illness after month with BAZHEN TANG.
The specific embodiment
Embodiment 1
Take by weighing raw material by following parts by weight: 10 parts of Blatta seu periplanetaes, 10 parts of Radix Pseudostellariaes, 10 parts of Rhizoma Dioscoreaes, 10 parts of Endothelium Corneum Gigeriae Galli, 8 parts of Rhizoma Picrorhizae, 5 parts of Radix Gentianaes, 10 parts of Fructus Ulmus preparatium, 5 parts of Fructus Citri Sarcodactylis, 5 parts in Radix Glycyrrhizae.Blatta seu periplaneta catches and kills in the rearmounted ethanol and sterilize, and uses behind the foreign material in the foot of decaptitating after the sterilization, wing and the tripe.Above-mentioned all medicine oven dry are pulverized, cross 110 mesh sieves, incapsulate every 400mg/ grain.Or its add amylum pregelatinisatum, hard magnesium is made tablet or pill according to a conventional method, every/or ball be the 100mg/ sheet.Be used for the treatment of by every medicated powder content 0.4 gram and calculate, obey every day three times, 1-2 year each 2 grams, 2-3 year each 3 grams, 3-5 year each 4 grams, 6-8 year each 6 grams.Take 1 hour ante cibum.Tablet calculates by matched doses and takes.
Embodiment 2
Take by weighing raw material by following parts by weight: 30 parts of Blatta seu periplanetaes, 25 parts of Radix Pseudostellariaes, 30 parts of Rhizoma Dioscoreaes, 30 parts of Endothelium Corneum Gigeriae Galli, 15 parts of Rhizoma Picrorhizae, 15 parts of Radix Gentianaes, 20 parts of Fructus Ulmus preparatium, 15 parts of Fructus Citri Sarcodactylis, 10 parts in Radix Glycyrrhizae.Blatta seu periplaneta catches and kills in the rearmounted ethanol and sterilize, and uses behind the foreign material in the foot of decaptitating after the sterilization, wing and the tripe.Above-mentioned all liquid medicine is decocted 2 times, and 1～2 hour for the first time, the 2nd time 0.5～1.5 hour, merging filtrate left standstill.Proportion is 1.15～1.21 when getting supernatant concentration to the heat survey, is cooled to room temperature.Add right amount of auxiliary materials, granulate, add volatile oil, promptly make the granule finished product, adopt In Aluminium Foil Packing, the 5g/ bag.
Embodiment 3
Take by weighing raw material by following parts by weight: 15 parts of Blatta seu periplanetaes, 15 parts of Radix Pseudostellariaes, 20 parts of Rhizoma Dioscoreaes, 15 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Rhizoma Picrorhizae, 8 parts of Radix Gentianaes, 15 parts of Fructus Ulmus preparatium, 8 parts of Fructus Citri Sarcodactylis, 7 parts in Radix Glycyrrhizae.Blatta seu periplaneta catches and kills in the rearmounted ethanol and sterilize, and uses behind the foreign material in the foot of decaptitating after the sterilization, wing and the tripe.Above-mentioned all medicines are added in the multipotency extraction pot, with water boiling and extraction 2～4 times, each extraction time is 1～3 hour, the addition of water is 5～10 times, extracting liquid filtering, be concentrated into runny plaste, add tween in the volatile oil, add Mel again, an amount of distilled water stirs evenly, pack into and make the oral liquid of 10ml specification in the bottle, sterilization promptly gets required finished product.
Claims (3)
1, a kind of medicine for the treatment of children's infantile malnutrition symptom is characterized in that being made by following materials based on weight: Blatta seu periplaneta 10-30 part, Radix Pseudostellariae 10-25 part, Rhizoma Dioscoreae 10-30 part, Endothelium Corneum Gigeriae Galli 10-30 part, Rhizoma Picrorhizae 8-15 part, Radix Gentianae 5-15 part, Fructus Ulmus preparatium 10-20 part, Fructus Citri Sarcodactylis 5-15 part, Radix Glycyrrhizae 5-10 part.
2, the medicine of treatment children's infantile malnutrition symptom according to claim 1 is characterized in that being made by following materials based on weight: 15 parts of Blatta seu periplanetaes, 15 parts of Radix Pseudostellariaes, 20 parts of Rhizoma Dioscoreaes, 15 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Rhizoma Picrorhizae, 8 parts of Radix Gentianaes, 15 parts of Fructus Ulmus preparatium, 8 parts of Fructus Citri Sarcodactylis, 6 parts in Radix Glycyrrhizae.
3, the medicine of treatment children's infantile malnutrition symptom according to claim 1 and 2 is characterized in that described medicine can be made into granule, oral liquid, pill, tablet, capsule.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007100539604A CN100528204C (en) | 2007-02-03 | 2007-02-03 | Medicament for treating children's infantile malnutrition symptom |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007100539604A CN100528204C (en) | 2007-02-03 | 2007-02-03 | Medicament for treating children's infantile malnutrition symptom |
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| Publication Number | Publication Date |
|---|---|
| CN101011518A true CN101011518A (en) | 2007-08-08 |
| CN100528204C CN100528204C (en) | 2009-08-19 |
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|---|---|---|---|
| CNB2007100539604A Expired - Fee Related CN100528204C (en) | 2007-02-03 | 2007-02-03 | Medicament for treating children's infantile malnutrition symptom |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104138451A (en) * | 2013-10-21 | 2014-11-12 | 金秀瑶族自治县瑶医医院 | Yao medicine infantile malnutrition powder and preparation method thereof |
| CN104800515A (en) * | 2015-05-21 | 2015-07-29 | 霍玉莲 | Chinese medicinal formula for treating infantile malnutrition |
| CN104800711A (en) * | 2015-05-21 | 2015-07-29 | 霍玉莲 | Traditional Chinese medicine composition for treating infantile malnutrition and preparation method thereof |
| CN104857242A (en) * | 2015-05-21 | 2015-08-26 | 霍玉莲 | Spleen-invigorating and digestion-promoting preparation for treating infantile malnutrition and preparation method |
| CN105148165A (en) * | 2015-09-28 | 2015-12-16 | 潘尧 | Traditional Chinese medicine composition for treating infantile malnutrition and preparation method thereof |
| CN116763880A (en) * | 2023-07-31 | 2023-09-19 | 浙江省立同德医院(浙江省精神卫生研究院) | Traditional Chinese medicine composition and preparation for treating functional dyspepsia accompanied with emaciation and application of traditional Chinese medicine composition and preparation |
-
2007
- 2007-02-03 CN CNB2007100539604A patent/CN100528204C/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104138451A (en) * | 2013-10-21 | 2014-11-12 | 金秀瑶族自治县瑶医医院 | Yao medicine infantile malnutrition powder and preparation method thereof |
| CN104138451B (en) * | 2013-10-21 | 2017-01-04 | 金秀瑶族自治县瑶医医院 | Precious jade medicine GANJI SAN and preparation method thereof |
| CN104800515A (en) * | 2015-05-21 | 2015-07-29 | 霍玉莲 | Chinese medicinal formula for treating infantile malnutrition |
| CN104800711A (en) * | 2015-05-21 | 2015-07-29 | 霍玉莲 | Traditional Chinese medicine composition for treating infantile malnutrition and preparation method thereof |
| CN104857242A (en) * | 2015-05-21 | 2015-08-26 | 霍玉莲 | Spleen-invigorating and digestion-promoting preparation for treating infantile malnutrition and preparation method |
| CN105148165A (en) * | 2015-09-28 | 2015-12-16 | 潘尧 | Traditional Chinese medicine composition for treating infantile malnutrition and preparation method thereof |
| CN116763880A (en) * | 2023-07-31 | 2023-09-19 | 浙江省立同德医院(浙江省精神卫生研究院) | Traditional Chinese medicine composition and preparation for treating functional dyspepsia accompanied with emaciation and application of traditional Chinese medicine composition and preparation |
| CN116763880B (en) * | 2023-07-31 | 2024-01-30 | 浙江省立同德医院(浙江省精神卫生研究院) | Traditional Chinese medicine composition and preparation for treating functional dyspepsia accompanied with emaciation and application of traditional Chinese medicine composition and preparation |
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