CN111038023A - 一种复合型防漏加强片及制备方法 - Google Patents
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Abstract
本发明涉及一种复合型防漏加强片及制备方法，属于医用材料的技术领域。本发明的复合型防漏加强片包括中间层，所述中间层为壳聚糖膜、壳聚糖海绵体或壳聚糖非织造布，并且所述中间层的上表面和下表面通过熔喷法形成聚乳酸‑羟基乙酸聚合物非织造布层，中间层在吸收体液后膨胀形成凝胶，堵塞空隙从而避免液体扩散渗漏。本发明的加强片延长了壳聚糖的作用周期，不仅能持续的加速水分子在产品内扩散渗透，为细胞在材料的空间网络内的生长提供湿润的环境，而且也缓解了因PLGA的不亲水性而导致的降解吸收时间过长的问题。
Description
技术领域
本发明涉及医用材料的技术领域，更具体地说，本发明涉及一种复合型防漏加强片及制备方法。
背景技术
在现有技术中，医疗上用于防止渗漏和组织加强材料尚存在很多问题。使用动物源移植物可能有被非传统感染因子污染的风险，并且这种风险随着物种差异而进一步加剧。后来发展的含氟树脂材料一度成为首选，却又存在因为无法降解而导致感染造成肉芽和皮肤瘘。天然材料如壳聚糖或明胶基产品又存在缝合加固强度不足，迁移和粘连等问题。同时，这类材料普遍缺少组织生长需要的三维空间，因此容易在组织愈合过程中产生压力，因此造成患者不舒适感，延长治疗时间。与此同时也提出一种可降解合成高分子材料，但这类材料普遍存在硬度大，亲水性差，单独使用往往存在柔软度差，与组织贴附能力不强等缺点。也提出一种多层复合型补片，其工艺是各层单独成片后采取胶粘和热压的方式结合，这不仅给机体引入外源异物，而且热压的方法不仅可能破坏材料的物理化学性能，而且严重影响其柔软性，从而导致与皮肤贴合性差，造成脱落。另外，熔喷非织造技术已经有很长的发展历史，其生产原埋是利用高速、高温的空气使熔融聚合物经过模头喷丝孔喷出，直接把丝条吹断成为长短不同的超细短纤维，并经冷空气冷却沉积在取引网上而成。其非织造布产品在农业、工业、卫生领域有成熟、规模化和广泛的应用，特别是作为屏障过滤吸附材料，但在医疗外科植入领域却很少应用。
发明内容
为解决现有技术中存在的上述技术问题，本发明的目的在于提供一种复合型防漏加强片及制备方法。
为了实现上述目的，本发明的第一方面涉及一种复合型防漏加强片。
本发明的复合型防漏加强片，其特征在于：包括中间层，所述中间层为壳聚糖(CS)膜、壳聚糖海绵体或壳聚糖非织造布，并且所述中间层的上表面和下表面通过熔喷法形成聚乳酸-羟基乙酸聚合物(PLGA)非织造布层，所述中间层在吸收体液后膨胀形成凝胶，堵塞空隙从而避免液体扩散渗漏。
其中，所述聚乳酸-羟基乙酸聚合物(PLGA)的重均分子量为50000-200000，优选为120000-200000，并且其中乳酸与羟基乙酸的重量比为50∶50～80∶20。
其中，所述中间层的厚度为0.1mm～1mm，优选为0.2mm～0.6mm，最优选为0.4mm～0.6mm；重量为40g/m2～80g/m2，优选为50g/m2～80g/m2，最优选为50g/m2～70g/m2。
其中，所述非织造布层的厚度为0.1mm～1mm，优选为0.2mm～0.7mm，最优选为0.25mm～0.4mm；重量为20g/m2～80g/m2，优选为30g/m2～60g/m2，最优选为40g/m2～55g/m2。
本发明的第二方面还涉及上述复合型防漏加强片的制备方法。
所述制备方法包括以下步骤：
将干燥的PLGA切片送至螺杆挤压机中加热熔融纺丝，熔体通过喷丝板上的模头喷出，再利用热空气将从模头喷出来的熔体进行牵引拉伸并吹散成更细的纤维，在所述中间层上经冷却空气冷却固化并粘结成非织造布层。
其中，所述熔喷模头温度在140～175℃，模头宽度在200～500mm，孔径在0.1～0.6mm，熔体挤出量在0.01～0.060g/(孔·min)，所述热空气温度为175～200℃，热空气流速为100～800m/s，压强在0.3～0.5MPa；所述冷却空气温度为10～35℃，风速为0.2～0.6m/s。
其中，所述壳聚糖膜的制备工艺如下：将壳聚糖溶解在醋酸溶液中制成壳聚糖溶液，醋酸浓度为1wt％～5wt％，壳聚糖浓度为1wt％～3wt％，壳聚糖溶液经过过滤、真空脱泡后在聚四氟乙烯板上流延成膜，于50℃烘箱内干燥后揭膜；然后置入碱液中中和，取出后用去离子水反复冲洗到中性后自然干燥即可。
其中，所述壳聚糖海绵的制备工艺如下：将壳聚糖溶解在醋酸溶液中制成壳聚糖溶液，醋酸浓度为1wt％～5wt％，壳聚糖浓度为1wt％～3wt％，将所述壳聚糖溶液置于模具中冷冻干燥，然后置入碱液中中和，取出后用去离子水反复冲洗到中性后自然干燥即可。
其中，所述壳聚糖非织造布的工艺如下：采用壳聚糖原料制成短纤维，梳理后针刺或水刺固结制成。
与现有技术相比，本发明的复合型防漏加强片及制备方法具有以下有益效果：
(1)壳聚糖材料经过交联改性，有较强的吸水能力且遇水能形成凝胶状，不仅具有粘性而且可以更好的贴附于组织上；具有膜的封闭性能，能起到密封的作用，防止漏气漏液；同时交联的壳聚糖凝胶具有了网络空间结构，从而给细胞在内部增殖提供生长环境。
(2)非织造布是采用熔喷技术直接在壳聚糖上成网，非织造布的纤维之间以及与壳聚糖层之间通过余热粘结，避免使用粘合剂而导致组织感染，同时也缩短了工艺流程，节约成本，可以实现规模化生产。
(3)内含有壳聚糖层与双层非织造布层构成三维网络结构，与天然细胞外基质(ECM)结构相似，不仅可以作为细胞骨架，而且能为细胞提供一定的生物信号，提高细胞的响应性和相容性，同时壳聚糖凝胶以及与网络的复合结构也为细胞提供了持续湿润、无菌和无压的生长环境，加快组织愈合。
(4)以CS和PLGA作为原料，两者均可完全降解，产物无毒副作用并最终随人体代谢排出体外，降低了机体负担。同时，PLGA非织造布会后于壳聚糖层降解，因此材料的结构设计也保证了补片不会因为壳聚糖层的降解而突然坍塌失去强度，这种机制对于创口的修补是必要的。
(5)壳聚糖分子中含有大量的活性基团一羟基和氨基，可与PLGA中的羟基、羰基通过氢键形式结合，增强复合物的机械强度。
(6)通过壳聚糖层的复合弥补PLGA材料憎水的属性，能让产品通过吸水而变得亲水，从而增加了产品的渗透性。这对于控制营养物质和其他代谢物运输到周围愈合组织非常重要。
附图说明
图1为本发明的复合型防漏加强片的工艺流程图。
图2为本发明的复合型防漏加强片的结构示意图。
具体实施方式
以下将结合具体实施例对本发明的复合型防漏加强片及制备方法做进一步的阐述，以帮助本领域的技术人员对本发明的发明构思、技术方案有更完整、准确和深入的理解。
本发明的复合型防漏加强片能在伤口愈合后完全降解，具体来说其具有三层结构：中间层为壳聚糖(CS)膜、壳聚糖海绵体或壳聚糖非织造布，所述中间层的上表面和下表面通过熔喷法形成聚乳酸-羟基乙酸聚合物(PLGA)非织造布层，所述中间层在吸收体液后膨胀形成凝胶，堵塞空隙从而避免液体扩散渗漏。在本发明中，所述聚乳酸-羟基乙酸聚合物(PLGA)的重均分子量为50000-200000，优选为120000-200000，并且其中乳酸与羟基乙酸的重量比为50∶50～80∶20。所述中间层的厚度为0.1mm～1mm，优选为0.2mm～0.6mm，最优选为0.4mm～0.6mm；重量为40g/m2～80g/m2，优选为50g/m2～80g/m2，最优选为50g/m2～70g/m2。所述非织造布层的厚度为0.1mm～1mm，优选为0.2mm～0.7mm，最优选为0.25mm～0.4mm；重量为20g/m2～80g/m2，优选为30g/m2～60g/m2，最优选为40g/m2～55g/m2。同时为创口提供湿润的环境，加快组织长入，促进伤口在湿性条件下愈合。另外壳聚糖降解时释放的氨基葡萄糖等碱性小分子物质能中和两侧聚乳酸材料在降解时释放的乳酸等酸性产物，防止因聚乳酸降解导致局部酸浓度过大，抑制迟发性异物炎症反应，其典型结构如图2所示。
本发明的复合型防漏加强片的制备工艺流程图如图1所示，具体包括以下步骤：
1.壳聚糖层的制备
A.壳聚糖膜的制备：适量壳聚糖溶解醋酸溶液中制成壳聚糖溶液，醋酸浓度为1wt％～5wt％，优选为2wt％～4wt％，最优选为3wt％；壳聚糖浓度为1wt％～3wt％，优选为1.5wt％～2.5wt％，最优选为2wt％。当壳聚糖的浓度大于3wt％时，则壳聚糖过于黏稠，成膜不均匀；当壳聚糖的浓度小于1wt％时，不易成膜和揭膜且成膜强度太低。将壳聚糖溶液用2号砂芯漏斗过滤，压力在0.8～1MPa，真空脱泡后在聚四氟乙烯板上流延成膜，于50℃烘箱内干燥后揭膜。然后置入1mol/L的NaOH溶液中浸泡24h以中和过量醋酸，取出后用去离子水反复冲洗到中性后自然干燥即得。
B.壳聚糖海绵的制备：适量壳聚糖溶解醋酸溶液中制成壳聚糖溶液，醋酸浓度为1wt％～5wt％，优选为2wt％～4wt％，最优选为3wt％；壳聚糖浓度为1wt％～3wt％，优选为1.5wt％～2.5wt％，最优选为2wt％。溶液置于模具中进行冷冻干燥12h，然后置入1mol/L的NaOH溶液中浸泡24h以中和过量醋酸，取出后用去离子水反复冲洗到中性后自然干燥备用。
C.壳聚糖非织造布的制备：壳聚糖非织造布直接采用壳聚糖原料制成的短纤维通过梳理后针刺或水刺固结的方法制成。
在上述工艺A、B、C中，所述壳聚糖原料的脱乙酰度为95％以上，灰分小于0.5％，粘度＞800CPS。
2.熔喷非织造层的制备
将PLGA切片干燥至含水量在50ppm以下，然后将干燥的切片送至螺杆挤压机中加热熔融纺丝，纺丝条件如下：螺杆挤压机长径比30～40，螺杆挤出机内部温度在140～300℃，箱体温度在150～200℃，进料段在100～140℃，压缩段在110～170℃，计量段在170～220℃，螺杆转速在10～50rpm，纺丝速度在200～2000m/min。熔体通过喷丝板上的模头喷出，再利用高温、高速的热空气将从模头喷出来的熔体细流进行牵引拉伸并吹散成更细的纤维，经冷却空气冷却固化最终在接收装置上聚集成网，并利用自身余热互相粘结成非织造布，其条件如下：熔喷模头温度在140～175℃，模头宽度在200～500mm，孔径在0.1～0.6mm，熔体挤出量在0.01～0.060g/(孔·min)，高温热空气温度为175～200℃，热空气流速为100～800m/s，压强在0.3～0.5MPa；两侧冷却空气温度在10～35℃，风速在0.2～0.6m/s。
3.复合
对于可吸收的植入医用耗材，层与层之间的复合通常采用层叠然后热压加固成型。在本发明中，是把熔喷法形成的纤维直接沉积在壳聚糖层上来形成熔喷非织造布层，即在2步骤进行之前先将1步骤中三种方式得到的壳聚糖材料层分别作为背衬基材置于熔喷机接收板上，直接在壳聚糖基材上进行熔喷。另一面也以同样的方式进行即最终形成PLGA-CS-PLGA的三层结构，目的是使最终产品有更好的柔软度；同时也防止壳聚糖层在体内脱落，而且也通过多层复合的方式进一步使产品能更好的发挥防止体液渗漏和漏气的作用。
采用步骤3中一步成型法的目的一是因为考虑到产品作为体内植入使用，采用热压的方式会降低最终产品的柔软度。在本发明中，对常规的熔喷工艺进行了以下改进：
(1)增加冷却空气压强和接收板下的抽吸力。冷却空气与喷出纤维成一定角度把纤维向下吹制在接受网上，同时接收板下形成负压以使纤维沉积在接受板上，从而可以增强熔喷层与壳聚糖层的粘结强度，可以提高抗剥离能力。
(2)通过调节和控制熔喷模头温度、挤出量、热空气的温度等使得壳聚糖中间层的温度控制在50～105℃之间(软化温度)。熔喷纤维到达网布时由于余热还有很高的温度，加热壳聚糖层使壳聚糖层部分熔融，从而不仅使熔喷纤维之间通过余热进行粘合，也使熔喷层与壳聚糖层之间面对面的热粘合在一起，从而达到了零粘结剂添加。复合时接收板下的抽力要大于单独熔喷时的抽力，而且适当加大冷却空气的压强，上压下抽，从而使熔喷层与壳聚糖层紧密的粘合在一起。
实施例1
本实施例的复合型防漏加强片的制备工艺如下：
(1)取2g壳聚糖溶解在醋酸溶液中制成壳聚糖水溶液，壳聚糖水溶液中醋酸的浓度为3wt％；壳聚糖的浓度为2wt％。将上述壳聚糖溶液用2号砂芯漏斗过滤，压力为1MPa，真空脱泡后在聚四氟乙烯板上流延成膜，于50℃烘箱内干燥后揭膜。然后置入1mol/L的NaOH溶液中浸泡24h以中和过量醋酸，取出后用去离子水反复冲洗到中性后自然干燥备用，所得到的壳聚糖膜质量为90g/m2，厚度为0.47mm。
(2)将3g PLGA切片(PL∶PG＝75∶25)彻底干燥后送至螺杆挤压机中加热熔融纺丝，纺丝条件如下：螺杆挤压机长径比为40，螺杆挤出机内部温度为270℃，箱体温度为160℃，进料段为120℃，压缩段为170℃，计量段为200℃，螺杆转速为30rpm，纺丝速度为200m/min。熔体通过喷丝板上的模头喷出，再利用高温、高速的热空气将从模头喷出来的熔体细流进行牵引拉伸并吹散成更细的纤维，经冷却空气冷却固化最终在壳聚糖膜上聚集成网，并利用自身余热互相粘结，其条件如下：熔喷模头温度为175℃，模头宽度为300mm，孔径为0.5mm，熔体挤出量为0.05g/(孔·min)，高温热空气温度为180℃，热空气流速为400m/s，其压强为0.3MPa，两侧冷却空气温度为25℃，风速为0.4m/s。然后以同样的方法在壳聚糖膜的另一面也形成一层同样的PLGA非织造布材料最终形成本实施例的复合型防漏加强片，其厚度为1.2mm，质量为141g/m2。
实施例2
本实施例的复合型防漏加强片的制备工艺如下：
(1)取2g壳聚糖溶解醋酸溶液中制成壳聚糖水溶液，壳聚糖水溶液中醋酸浓度为1wt％，壳聚糖的浓度为1wt％。溶液置于模具中进行冷冻干燥12h，然后置入1mol/L的NaOH溶液中浸泡24h以中和过量醋酸，取出后用去离子水反复冲洗到中性后自然干燥备用，所得到的壳聚糖海绵质量为21g/m2，厚度为1.0mm。
(2)将3g PLGA切片(PL∶PG＝75∶25)彻底干燥后送至螺杆挤压机中加热熔融纺丝，纺丝条件如下：螺杆挤压机长径比为40，螺杆挤出机内部温度为270℃，箱体温度为160℃，进料段为120℃，压缩段为170℃，计量段为200℃，螺杆转速为30rpm，纺丝速度为200m/min。熔体通过喷丝板上的模头喷出，再利用高温、高速的热空气将从模头喷出来的熔体细流进行牵引拉伸并吹散成更细的纤维，经冷却空气冷却固化最终在壳聚糖海绵上聚集成网，并利用自身余热互相粘结，其条件如下：熔喷模头温度为175℃，模头宽度为300mm，孔径为0.5mm，熔体挤出量为0.05g/(孔·min)，高温热空气温度为180℃，热空气流速为400m/s，其压强为0.3MPa，两侧冷却空气温度为25℃，风速为0.4m/s。然后以同样的方法在壳聚糖海绵的另一面也形成一层同样的PLGA非织造布材料最终形成本实施例的复合型防漏加强片，其厚度为1.6mm，质量为69g/m2。
实施例3
与以上实施例不同的是，本实施例直接裁取了一块100×100mm大小，厚度为0.1mm，质量为50g/m2的壳聚糖短纤维铺网后经水刺加固形成的壳聚糖非织造布作为基材并在其上进行PLGA的熔融纺丝。将3g PLGA切片(PL∶PG＝82∶18)彻底干燥后送至螺杆挤压机中加热熔融纺丝，纺丝条件如下：螺杆挤压机长径比为40，螺杆挤出机内部温度为270℃，箱体温度为160℃，进料段为120℃，压缩段为170℃，计量段为200℃，螺杆转速为30rpm，纺丝速度为200m/min。熔体通过喷丝板上的模头喷出，再利用高温、高速的热空气将从模头喷出来的熔体细流进行牵引拉伸并吹散成更细的纤维，经冷却空气冷却固化最终在壳聚糖非织造布上聚集成网，并利用自身余热互相粘结，其条件如下：熔喷模头温度为175℃，模头宽度为300mm，孔径为0.5mm，熔体挤出量为0.05g/(孔·min)，高温热空气温度为180℃，热空气流速为400m/s，其压强为0.3MPa，两侧冷却空气温度为25℃，风速为0.4m/s。然后以同样的方法在非织造布的另一面也形成一层同样的PLGA非织造布材料最终形成复合型非织造布材料，其厚度为1.0mm，重量为110g/m2。
对比例1
以实施例1中的壳聚糖膜为基材并以同样的条件在壳聚糖膜的一面形成一层PLGA非织造布材料得到双层材料，厚度为0.9mm，质量为119g/m2。
对比例2
以实施例3中的壳聚糖非织造布为基材并以同样的条件在壳聚糖非织造布的两各面形成一层PLGA非织造布材料，然后再进行热压加固，温度为70℃，最终得到复合型非织造材料，其厚度为0.6mm，质量为121g/m2。
性能测试
柔软度：将以上各实施例和对比例产品分别裁取50mm×100mm的样片，将其置于硬度测试夹具上(狭缝宽度10mm)，启动电子万能试验机(CMT2503)，测得将样片压至夹具底部的力，力越大说明样品柔软度越低。
拉伸强度：将以上各实施例和对比例产品分别裁取50mm×100mm的样片，浸泡于37℃的生理盐水中适当时间后取出。用拉伸试验机进行拉伸试验并记录强度变化，条件如下：隔距50mm，拉伸速度100mm/min。
缝合强度：将以上各实施例和对比例产品分别裁取50mm×100mm的样片，浸泡于37℃的生理盐水中适当时间后取出。然后在边沿30mm处用单丝环形针缝合之后用拉伸试验机进行缝合强度测试，条件如下：隔距50mm，拉伸速度100mm/min。
剥离情况：剥离情况用来说明PLGA非织造布层与壳聚糖层黏合能力。将以上各实施例和对比例1分别裁取50mm×50mm的样片各若干，浸泡于37℃的生理盐水中10天，每隔一天观察层间剥离情况。
透气性能：使用型号为YG461H全自动透气仪进行对样品进行测试，测试的面积为20cm2，压力差为200Pa，分别取10个测试点进行测试，求其平均值为最后的透气率。
性能测试结果如表1所示：
表1 性能指标测试结果
结果分析
柔软度方面实施例3中由壳聚糖非织造布作为中间层且采用自粘合的复合材料柔软度最高；拉伸强度方面，虽然对比例2中采用热压加固的复合材料有最大的拉伸强度，但由于干态下其柔软度确是最小的，手术操作的时候容易损伤组织且缝合难度较大，因此不适合做体内植入使用，这主要是因为壳聚糖膜属性本身刚性太大，而将壳聚糖加工成纤维或非织造布则很大程度上规避了这个缺点。
实施例1-3的耐缝合强度均比对比例的双层材料要强，这不仅是因为三层膜结构在物理上又多了一层加强层，从而具有了更加复杂的内部结构，与细胞外基质(ECM)也更加相似；另外，缺少外侧加强层，双层材料容易导致壳聚糖凝胶在体内短时间内脱落，这个结论也能从剥离实验现象中得出：
我们分别把所有样品裁取50×50mm的样片置于生理盐水中10天，每隔1天观察样品分层情况，实验结果实施例1-3的复合材料在生理盐水里10天未发现脱落分层现象；而对比例1中双层材料由于缺少加强层，在第4出现了端部层间开口现象，在第十天层间脱落过半，因此起不到良好的止血与防漏功能；透气度方面可以看出所有样品都为0，因此说明具有较好的封闭特性。这是因为所采用的壳聚糖已经过交联处理，都有良好的吸水能力且遇水均能呈现出凝胶特质，从而起到防止漏气的作用。
实施例1的产品由于壳聚糖在中间层也减缓了壳聚糖在体内的降解速度，从而延长了壳聚糖的作用周期，再加之壳聚糖的亲水性，不仅能持续的加速水分子在产品内扩散渗透，为细胞在在材料的空间网络内的生长提供湿润的环境，而且也缓解了因PLGA的不亲水性而导致的降解吸收时间过长的问题。
对于本领域的普通技术人员而言，具体实施例只是对本发明进行了示例性描述，显然本发明具体实现并不受上述方式的限制，只要采用了本发明的技术方案进行的各种非实质性的改进，均在本发明的保护范围之内。
Claims (10)
1.一种复合型防漏加强片及制备方法，其特征在于：包括中间层，所述中间层为壳聚糖膜、壳聚糖海绵体或壳聚糖非织造布，并且所述中间层的上表面和下表面通过熔喷法形成聚乳酸-羟基乙酸聚合物非织造布层，所述中间层在吸收体液后膨胀形成凝胶，堵塞空隙从而避免液体扩散渗漏。
2.根据权利要求1所述的复合型防漏加强片及制备方法，其特征在于：所述聚乳酸-羟基乙酸聚合物的重均分子量为50000-200000，并且所述聚合物中乳酸与羟基乙酸的重量比为50∶50～80∶20。
3.根据权利要求1所述的复合型防漏加强片及制备方法，其特征在于：所述中间层的厚度为0.1mm～1mm，重量为40g/m2～80g/m2。
4.根据权利要求1所述的复合型防漏加强片及制备方法，其特征在于：所述非织造布层的厚度为0.1mm～1mm，重量为20g/m2～80g/m2。
5.根据权利要求1所述的复合型防漏加强片及制备方法，其特征在于：所述中间层上表面和下表面上的非织造布层的厚度相等或不相等。
6.权利要求1-5任一项所述的复合型防漏加强片的制备方法，其特征在于包括以下步骤：
将干燥的PLGA切片送至螺杆挤压机中加热熔融纺丝，熔体通过喷丝板上的模头喷出，再利用热空气将从模头喷出来的熔体进行牵引拉伸并吹散成更细的纤维，在所述中间层上经冷却空气冷却固化并粘结成非织造布层。
7.根据权利要求6所述的复合型防漏加强片的制备方法，其特征在于：所述熔喷模头温度为140～175℃，模头宽度为200～500mm，孔径为0.1～0.6mm，熔体挤出量为0.01～0.060g/(孔·min)，所述热空气温度为175～200℃，热空气流速为100～800m/s，压强为0.3～0.5MPa；所述冷却空气温度为10～35℃，风速为0.2～0.6m/s。
8.根据权利要求6所述的复合型防漏加强片的制备方法，其特征在于：所述壳聚糖膜的制备工艺如下：将壳聚糖溶解在醋酸溶液中制成壳聚糖溶液，醋酸浓度为1wt％～5wt％，壳聚糖浓度为1wt％～3wt％，壳聚糖溶液经过过滤、真空脱泡后在聚四氟乙烯板上流延成膜，于50℃烘箱内干燥后揭膜；然后置入碱液中中和，取出后用去离子水反复冲洗到中性后自然干燥即可。
9.根据权利要求6所述的复合型防漏加强片的制备方法，其特征在于：所述壳聚糖海绵的制备工艺如下：将壳聚糖溶解在醋酸溶液中制成壳聚糖溶液，醋酸浓度为1wt％～5wt％，壳聚糖浓度为1wt％～3wt％，将所述壳聚糖溶液置于模具中冷冻干燥，然后置入碱液中中和，取出后用去离子水反复冲洗到中性后自然干燥即可。
10.根据权利要求6所述的复合型防漏加强片的制备方法，其特征在于：所述壳聚糖非织造布的工艺如下：采用壳聚糖原料制成短纤维，梳理后针刺或水刺固结制成。
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| CN116752285A (zh) * | 2023-08-18 | 2023-09-15 | 山东希瑞新材料有限公司 | 一种复合非织造布及其制备方法和应用 |
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