CN111018989B - 一种抗pd-l1单克隆抗体以及在制备抗癌药物方面的应用 - Google Patents
一种抗pd-l1单克隆抗体以及在制备抗癌药物方面的应用 Download PDFInfo
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- CN111018989B CN111018989B CN201911288345.0A CN201911288345A CN111018989B CN 111018989 B CN111018989 B CN 111018989B CN 201911288345 A CN201911288345 A CN 201911288345A CN 111018989 B CN111018989 B CN 111018989B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
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- Immunology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- General Chemical & Material Sciences (AREA)
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- Genetics & Genomics (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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Abstract
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201911288345.0A CN111018989B (zh) | 2019-12-16 | 2019-12-16 | 一种抗pd-l1单克隆抗体以及在制备抗癌药物方面的应用 |
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CN201911288345.0A CN111018989B (zh) | 2019-12-16 | 2019-12-16 | 一种抗pd-l1单克隆抗体以及在制备抗癌药物方面的应用 |
Publications (2)
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CN111018989A CN111018989A (zh) | 2020-04-17 |
CN111018989B true CN111018989B (zh) | 2021-03-23 |
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CN201911288345.0A Active CN111018989B (zh) | 2019-12-16 | 2019-12-16 | 一种抗pd-l1单克隆抗体以及在制备抗癌药物方面的应用 |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111995683B (zh) * | 2020-09-02 | 2022-03-11 | 福州迈新生物技术开发有限公司 | 抗pd-l1蛋白单克隆抗体、细胞株及其制备方法和应用 |
CN113336850B (zh) * | 2021-06-02 | 2023-06-23 | 河南中医药大学 | 一种抗人pd-l1单克隆抗体及其应用 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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PT3489254T (pt) * | 2012-04-30 | 2022-12-30 | Biocon Ltd | Proteínas de fusão direcionadas/imunomoduladoras e seus métodos de fabrico |
CN103242448B (zh) * | 2013-05-27 | 2015-01-14 | 郑州大学 | 一种全人源化抗pd-1单克隆抗体及其制备方法和应用 |
CN105061597B (zh) * | 2015-06-09 | 2016-04-27 | 北京东方百泰生物科技有限公司 | 一种抗pd-1的单克隆抗体及其获得方法 |
CA3033896A1 (en) * | 2016-08-15 | 2018-02-22 | National University Corporation Hokkaido University | Anti-pd-l1 antibody |
CN106967658B (zh) * | 2017-02-23 | 2020-09-15 | 郑州大学 | 一种提高Fab抗体表达量的方法 |
WO2019126257A1 (en) * | 2017-12-21 | 2019-06-27 | Merck Patent Gmbh | Combination of an anti-pd-l1 antibody and ido1 inhibitor for the treatment of cancer |
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Effective date of registration: 20210628 Address after: 423000 Caotang Road, Tujiang Town, Guidong County, Chenzhou City, Hunan Province Patentee after: Chenzhou Zhicun Intellectual Property Service Co.,Ltd. Address before: 450000 100 science Avenue, Zhengzhou high tech Zone, Henan Patentee before: Zhengzhou University Effective date of registration: 20210628 Address after: 528400 No.1 Workshop, Lipson Science Park, No.1 Yangfan street, Cuiheng New District, Zhongshan City, Guangdong Province Patentee after: Guanke Biotechnology (Zhongshan) Co.,Ltd. Address before: 423000 Caotang Road, Tujiang Town, Guidong County, Chenzhou City, Hunan Province Patentee before: Chenzhou Zhicun Intellectual Property Service Co.,Ltd. |