CN111012701A

CN111012701A - Traditional Chinese medicine-containing moisturizing medical biological repair film and preparation method thereof

Info

Publication number: CN111012701A
Application number: CN201910951630.XA
Authority: CN
Inventors: 韩星; 练成; 董莉莉; 吴均福; 齐宪臣
Original assignee: Gansu Jindong Health Technology Co Ltd
Current assignee: Gansu Jindong Health Technology Co Ltd
Priority date: 2019-10-08
Filing date: 2019-10-08
Publication date: 2020-04-17

Abstract

The invention discloses a moisturizing medical biological repair film containing traditional Chinese medicines and a preparation method thereof, wherein the main components of the moisturizing medical biological repair film contain sodium hyaluronate with moisturizing efficacy, and also contain a traditional Chinese medicine formula which has skin repairing and skin elasticity enhancing efficacies and is formed by compatibility of Chinese angelica, angelica dahurica, polygonatum odoratum and poria cocos, no chemical preparation which is easy to cause skin reaction such as hormone, antibiotic, heavy metal, alcohol, essence, pigment fluorescent agent, preservative and the like is added, and the moisturizing medical biological repair film is safer for special people with poor skin resistance and no dependence like the hormone. The additive is filtered into five molecular weight grades of large, medium, small, micro and ultramicro, so that the additive can be synergistically acted into a network maintenance membrane, permeate into the muscle bottom, repair damaged elastic fibers, supplement water for a long time, improve water locking capacity, nourish for a long time, increase the thickness of the skin cuticle, improve the immunity of the skin and restore the health state of the skin.

Description

Traditional Chinese medicine-containing moisturizing medical biological repair film and preparation method thereof

Technical Field

The invention belongs to the technical field of medical materials, and particularly relates to a moisturizing medical biological repairing film containing traditional Chinese medicines and a preparation method thereof.

Background

The moisturizing means that skin is covered by skin care products such as repair dressings, facial masks, essence and the like, so that outside air and pollution are temporarily isolated, pores of the skin are expanded, water in the covering is permeated into horny layers of the skin, and thus, the moisture is replenished to the skin, and the skin becomes soft and elastic. Moisturizing is an important concept of beauty because moisture in skin is easily lost, and lack of sufficient moisture content in skin directly causes skin aging due to abnormal metabolism, wrinkles and spots, and other skin problems.

In the field of skin hydration, injection of hyaluronic acid (precisely called hyaluronic acid) is currently the most effective. Hyaluronic acid, the best moisturizing substance found in nature at present, is called the ideal natural moisturizing factor. It is distributed in human skin, synovial fluid of joints, umbilical cord, aqueous humor and vitreous humor, and is an important component for moisturizing skin. However, hyaluronic acid injection is required in professional beauty institutions, is expensive, has postoperative risks, and causes facial expression stiffness due to excessive use.

In order to solve the problem, enterprises add various traditional Chinese medicine extracts as additives into a moisturizing mask containing sodium hyaluronate to produce products such as a medical mask (or a medical repairing mask, a medical repairing paste) and the like as upgrading products of the traditional mask, so that good effects are achieved. But the problem of stiff facial expression still exists after long-term use because the side effect of the sodium hyaluronate is not specifically controlled. The medical moisturizing biological repair film simultaneously contains sodium hyaluronate and a traditional Chinese medicine formula, has three effects of professional biological moisturizing, repairing skin and enhancing skin elasticity, and can solve the side effect of hyaluronic acid contained in a skin care product after long-term use.

Disclosure of Invention

One of the purposes of the invention is to provide a moisturizing medical biological repairing film containing traditional Chinese medicines;

the invention also aims to provide a preparation method of the moisturizing medical biological repairing film containing the traditional Chinese medicine.

In order to achieve the purpose, the invention adopts the technical scheme that:

a moisturizing medical biological repair film containing traditional Chinese medicines is prepared from the following raw materials in parts by weight: 5-15 parts of angelica, 3-10 parts of angelica dahurica, 10-15 parts of polygonatum, 10-15 parts of poria cocos, 100 parts of deionized water, 150 parts of sodium hyaluronate, 0.1-0.5 part of vitamin E1-3 parts of amino acid, 1-5 parts of hydrolyzed collagen and 3-6 parts of glycerol;

in order to further realize the invention, 8 parts of angelica, 6 parts of angelica dahurica, 12 parts of polygonatum odoratum, 12 parts of poria cocos, 120 parts of deionized water, 0.3 part of sodium hyaluronate, 2 parts of vitamin E, 2 parts of amino acid, 3 parts of hydrolyzed collagen and 5 parts of glycerol.

A preparation method of a moisturizing medical biological repairing film containing traditional Chinese medicines comprises the following steps:

(1) preparing radix Angelicae sinensis, radix Angelicae Dahuricae, rhizoma Polygonati Odorati and Poria into nanometer Chinese medicinal powder mixture by nanometer Chinese medicinal powder preparation process;

(2) mixing the nanometer Chinese medicinal powder mixture obtained in step (1) with 7-18L deionized water by static boiling method, decocting for 45-100min, and cooling to 40-60 deg.C to obtain Chinese medicinal mixed concentrated solution;

(3) heating deionized water to 80-85 deg.C, adding sodium hyaluronate and glycerol, homogenizing, and keeping the temperature for 5-10min to obtain sodium hyaluronate mixture;

(4) cooling the sodium hyaluronate mixture obtained in the step (3) to 40-50 ℃, adding the traditional Chinese medicine mixed concentrated solution obtained in the step (2), adding vitamin E, amino acid and hydrolyzed collagen, homogenizing, cooling to 38 ℃, standing until the solution is completely swelled into a transparent solution, and thus obtaining a repairing film additive;

(5) filtering the repairing membrane additives obtained in the step (4) into repairing membrane additives with five molecular weight grades of large, medium, small, micro and ultramicro by adopting a micro-filtration membrane, an ultrafiltration membrane, a nanofiltration membrane and a reverse osmosis membrane respectively;

(6) adopting an artificial intelligence manufacturing full-automatic whole-process cold distribution production line, cooling the repairing film additives of the five molecular weight grades obtained in the step (5) to 0-15 ℃, and accurately coating the repairing film additives on a carrier or mixing the repairing film additives into the carrier according to five molecular weights of large, medium, small, micro and ultramicro from small to large;

(7) and (4) packaging the medical bioprosthetic film obtained in the step (6) according to different carriers.

In order to further realize the invention, the carrier in the step (6) comprises medical bioremediation film paper, mineral mud or jelly glue.

In order to further realize the invention, the amount of the repair film additive coated or mixed in the step (6) is 15-25 mL.

In order to further realize the invention, the medical bioremediation film paper is non-woven fabric or biological fiber.

In order to further realize the invention, the addition amount of the mineral mud or the jelly glue is 100 parts.

Compared with the prior art, the invention has the beneficial effects that:

the main components of the moisturizing medical biological repair film containing the traditional Chinese medicine provided by the invention not only contain sodium hyaluronate with moisturizing efficacy, but also contain a traditional Chinese medicine formula which has skin repairing and skin elasticity enhancing efficacies and is formed by compatibility of angelica, angelica dahurica, polygonatum odoratum and poria cocos, and no chemical preparation which is easy to cause skin reaction, such as hormone, antibiotic, heavy metal, alcohol, essence, pigment fluorescent agent, preservative and the like is added, so that the moisturizing medical biological repair film containing the traditional Chinese medicine is safer when used by special people with poor skin resistance and the dependence of the hormone can not occur.

The angelica sinensis is sweet, pungent and warm in nature and flavor, enters liver, heart and spleen channels, and has the effects of enriching blood, activating blood circulation, and treating skin numbness and traumatic injury.

Radix angelicae: has pungent and warm nature and flavor, enters lung and stomach meridians, and has effects of improving microcirculation, promoting skin metabolism, and delaying skin aging. It has the effects of eliminating dampness and stopping leukorrhagia when combined with Poria, and has the effects of relieving swelling, expelling pus, promoting blood circulation and relieving pain when combined with radix Angelicae sinensis.

Fragrant solomonseal rhizome: sweet and mild in nature and taste, enters lung and stomach channels, and has the effects of nourishing yin, moistening dryness, promoting fluid production, quenching thirst, conditioning internal environment of a body, retaining youthful looks and moistening skin. It can be used with radix Angelicae sinensis to treat xerosis cutis and wrinkle.

Tuckahoe, poria cocos: sweet, light and flat in nature and taste, enters lung, stomach and kidney channels, and has the effects of promoting diuresis, excreting dampness, invigorating spleen and calming heart, thereby moistening skin. The composition is combined with angelica sinensis to achieve the effects of promoting blood circulation, eliminating dampness, beautifying and removing speckles.

Deionized water: can better control the microorganisms and impurities of the product.

Sodium hyaluronate: can form a layer of air-permeable film on the surface of skin to make the skin smooth and moist, promote proliferation and differentiation of epidermal cells, remove oxygen free radicals, and promote regeneration of the skin at the injured part.

Vitamin EE: can provide the skin with the functions of keeping the skin elasticity, supplementing water and improving and enhancing the elasticity of new cells.

Amino acids: has effects of activating cells, improving metabolism and blood circulation, and reviving skin.

Hydrolyzing collagen: has effects in supplementing collagen, restoring skin elasticity, restoring firmness, reducing sagging phenomenon, and smoothing fine lines and wrinkles.

Glycerol: is a moisturizing factor indispensable to cells, has excellent capacity of regulating skin metabolism, promotes the activity of skin aquaporins, and assists in promoting skin metabolism and purification.

Mineral mud: the fine mineral mud is prepared by the phase deposition of sylvite ores in the continental lake, and has the effects of supplementing water, moisturizing and supplementing minerals.

Gel agent of jelly: the jelly prepared by decocting animal protein can be used for preparing products such as capsule, colloid, jelly, etc., and can be used for preparing jelly of skin care products.

The traditional Chinese medicine formula and the additive fully consider six compatibility relations of mutual reinforcement, mutual induction, mutual incompatibility, mutual killing, mutual inhibition and reverse between the traditional Chinese medicine formula and the additive and effect differences generated under different dosage proportions of the traditional Chinese medicines and the additive according to the mechanisms of the traditional Chinese medicine science, the traditional Chinese medicine prescriptions and the traditional Chinese medicine pharmacology, optimize dosage and accurately prepare the traditional Chinese medicine formula and the additive, and carry out combination reaction on effective bioactive components dissolved out of the traditional Chinese medicines by mixing and decocting the traditional Chinese medicines by using deionized water through a static boiling method to form a more complex combination with a specific effect, generate a huge synergistic effect and greatly enhance the treatment effect, wherein the specific action mechanism is as follows:

the angelica is used as a main drug, and can enrich blood, promote blood circulation, treat skin numbness and repair skin injury; the angelica dahurica, the polygonatum and the tuckahoe are used as adjuvant medicines and can nourish yin, moisten dryness, moisten skin and increase skin elasticity; the pungent nature of angelica and angelica dahurica and the sweet nature of polygonatum and tuckahoe are mutually incompatible, so that the product is mild and has no stimulation; the angelica, the polygonatum and the tuckahoe are sweet in nature and taste, and can moisten and enhance the skin elasticity; the skin repairing effect of the traditional Chinese medicine formula is in mutual reinforcement with the moisturizing effect of additives such as sodium hyaluronate and the like, and the effects of repairing skin and increasing skin elasticity can be enhanced; the blood circulation promoting and moisturizing effects of the traditional Chinese medicine formula are matched with the moisturizing and moisturizing effects of additives such as sodium hyaluronate and the like, and the moisturizing and moisturizing effects can be enhanced.

The moisturizing medical biological repair film containing the traditional Chinese medicine is prepared according to the traditional Chinese medicine science, the traditional Chinese medicine prescriptions and the traditional Chinese medicine pharmacology, is simple and effective, has definite component effects and action mechanisms, strong pertinence and specificity and high safety, has the effects of enriching the blood and activating the blood, treating skin numbness and traumatic injury, improving microcirculation, promoting skin metabolism, delaying skin aging, eliminating dampness and stopping leucorrhea, reducing swelling and discharging pus, promoting blood circulation and relieving pain, nourishing yin and moistening dryness, promoting the production of body fluid to quench thirst, conditioning the internal environment of the body, retaining youthful looks, treating dry skin and wrinkles, promoting diuresis and excreting dampness, strengthening the spleen and calming the heart, moistening the skin, activating blood and excreting dampness, nourishing the skin and lightening spots and the like, is synergetic with additives with moisturizing effects such as sodium hyaluronate and the like, and has the advantages of mildness and no stimulation, effectively reducing the water evaporation in the skin and improving the dry state of, The skin moisturizing medical biological repairing film has multiple effects of moisturizing skin, tendering and moisturizing skin, repairing damaged skin epidermal cells, deeply nourishing skin, enhancing skin elasticity, effectively slowing down allergy formation and the like, can effectively treat side effects of long-term use of skin care products and skin care products containing sodium hyaluronate, and fills the blank that the medical biological repairing film has three effects of moisturizing and moisturizing skin and increasing skin elasticity in the current market and is a professional medical moisturizing medical biological repairing film product.

According to the experimental results of the embodiment, the treatment effect of the moisturizing medical biological repairing film containing the traditional Chinese medicine is as follows: 1. compared with the existing product which does not contain traditional Chinese medicines and is the same in sodium hyaluronate content, the moisturizing medical biological repair film containing traditional Chinese medicines has the effect of improving the treatment effect of skin repair; 2. compared with the existing product which does not contain traditional Chinese medicines and is the same in sodium hyaluronate content, the moisturizing medical biological repair film containing traditional Chinese medicines enhances the treatment effect of improving the skin elasticity; 3. compared with the existing product, the moisturizing medical biological repairing film containing traditional Chinese medicines has the advantages that the moisturizing medical biological repairing film containing traditional Chinese medicines enhances the moisturizing and moisturizing treatment effects of skin; 4. compared with two moisturizing medical biological repairing films containing traditional Chinese medicines and used for adjusting the dosage of the mixed concentrated solution of the traditional Chinese medicine formula, the moisturizing medical biological repairing film containing traditional Chinese medicines prepared according to the traditional Chinese medicine formula provided by the invention has the best treatment effects of moisturizing, repairing and increasing skin elasticity; 5. compared with the moisturizing facial mask which contains other traditional Chinese medicines and has the same content of sodium hyaluronate, the moisturizing medical biological repairing film containing the traditional Chinese medicines prepared according to the traditional Chinese medicine formula provided by the invention has the best treatment effects of moisturizing, repairing and increasing skin elasticity.

The invention also provides a preparation method of the medical moisturizing bioremediation membrane containing traditional Chinese medicines, wherein in the production of products, four kinds of filtering membranes, namely a micro-filtering membrane, an ultrafiltration membrane, a nanofiltration membrane and a reverse osmosis membrane, are respectively adopted to filter an additive of the medical moisturizing bioremediation membrane containing traditional Chinese medicines into additives with five molecular weight grades of large, medium, small, micro and ultramicro, wherein the micro-filtering membrane, namely MF, has the molecular weight cutoff of more than 1000 Dalton, the ultrafiltration membrane, namely UF, the molecular weight cutoff of 300 plus materials and 500 Dalton, the nanofiltration membrane, namely NF, the molecular weight cutoff of 200 plus materials and 300 Dalton, the reverse osmosis membrane, namely RO, has the molecular weight cutoff of 100 plus materials and 200 Dalton, an artificial intelligent full-automatic full-process cold distribution production line is adopted, the five-process precise cold distribution of large, medium, small, micro and ultramicro molecules is realized according to the sequential precise coating of the molecular weight from small to large to, the product stimulates the self-repairing ability of the skin and simultaneously protects the skin in all directions. Macromolecule water locking to prevent water loss; the middle molecules are full of water, so that the skin is firmer and full; the small molecules penetrate into the muscle bottom to enhance the microcirculation and metabolic capability of the skin and promote the proliferation and differentiation of epidermal cells; the micro molecules act the additives with different molecular weights synergistically to form a network maintenance film to permeate into the muscle bottom; the original intelligent ultramicro molecules directly send the nutrients in the additives to the muscle bottom, and the nutrients are directly and effectively absorbed and utilized by cells, so that the metabolism of old cells is accelerated, and new cells are generated; five layers of golden compound liquid construct a 'repair-generation-connection' circulation mechanism, repair damaged elastic fibers, supplement water with lasting effect, improve water locking capacity, nourish for a long time, increase the thickness of skin cuticle, improve the immunity of the skin and restore the health state of the skin.

Detailed Description

The present invention will be further described with reference to the following embodiments.

Example 1:

(1) preparing 15g of angelica, 10g of angelica dahurica, 15g of polygonatum odoratum and 15g of poria cocos into a nano traditional Chinese medicine powder mixing material by adopting a nano traditional Chinese medicine powder preparation process;

(2) mixing the nanometer Chinese medicine powder mixed material in the step (1) with 18L deionized water by adopting a static boiling method, decocting for 100min, and cooling to 60 ℃ to obtain a Chinese medicine mixed concentrated solution;

(3) heating 150g of deionized water to 85 ℃, adding 0.5g of sodium hyaluronate and 6g of glycerol, homogenizing uniformly, and keeping the temperature for 10min to obtain a sodium hyaluronate mixture;

(4) and (3) cooling the sodium hyaluronate mixture obtained in the step (3) to 50 ℃, adding the traditional Chinese medicine mixed concentrated solution obtained in the step (2), adding vitamin E3g, 3g of amino acid and 5g of hydrolyzed collagen, homogenizing, cooling to 38 ℃, standing until the solution is completely swelled into a transparent solution, and thus obtaining the additive of the moisturizing medical biological repair membrane containing traditional Chinese medicines.

Example 2:

(1) preparing 8g of angelica, 6g of angelica dahurica, 12g of polygonatum odoratum and 12g of poria cocos into a nano traditional Chinese medicine powder mixing material by adopting a nano traditional Chinese medicine powder preparation process;

(2) mixing the nanometer traditional Chinese medicine powder mixed material in the step (1) with 12L deionized water by adopting a static boiling method, decocting for 60min, and cooling to 45 ℃ to obtain a traditional Chinese medicine mixed concentrated solution;

(3) heating 120g of deionized water to 82 ℃, adding 0.3g of sodium hyaluronate and 5g of glycerol, homogenizing uniformly, and keeping the temperature for 8min to obtain a sodium hyaluronate mixture;

(4) and (3) cooling the sodium hyaluronate mixture obtained in the step (3) to 45 ℃, adding the traditional Chinese medicine mixed concentrated solution obtained in the step (2), adding vitamin E2g, 2g of amino acid and 3g of hydrolyzed collagen, homogenizing, cooling to 38 ℃, standing until the solution is completely swelled into a transparent solution, and thus obtaining the additive of the moisturizing medical biological repair membrane containing traditional Chinese medicines.

Example 3:

(1) preparing 5g of angelica, 3g of angelica dahurica, 10g of polygonatum odoratum and 10g of poria cocos into a nano traditional Chinese medicine powder mixing material by adopting a nano traditional Chinese medicine powder preparation process;

(2) mixing and decocting the nanometer traditional Chinese medicine powder mixed material in the step (1) with 7L of deionized water for 45min by adopting a static boiling method, and cooling to 40 ℃ to obtain a traditional Chinese medicine mixed concentrated solution;

(3) heating 100g of deionized water to 80 ℃, adding 0.1g of sodium hyaluronate and 3g of glycerol, homogenizing uniformly, and keeping the temperature for 5min to obtain a sodium hyaluronate mixture;

(4) and (3) cooling the sodium hyaluronate mixture obtained in the step (3) to 40 ℃, adding the traditional Chinese medicine mixed concentrated solution obtained in the step (2), adding vitamin E1g, 1g of amino acid and 1g of hydrolyzed collagen, homogenizing, cooling to 38 ℃, standing until the solution is completely swelled into a transparent solution, and thus obtaining the additive of the moisturizing medical biological repair membrane containing traditional Chinese medicines.

After the additives of the moisturizing medical biological repairing membrane containing traditional Chinese medicines in the embodiments 1 to 3 are prepared, four kinds of filtering membranes, namely a micro-filtering membrane, an ultrafiltration membrane, a nano-filtration membrane and a reverse osmosis membrane, are respectively adopted to filter the additives into five kinds of repairing membrane additives with molecular weight grades, namely large, medium, small, micro and ultramicro; adopting an artificial intelligence manufacturing full-automatic whole-process cold distribution production line, cooling the repair film additives of the five molecular weight grades to 0-15 ℃, and accurately coating the repair film additives on a carrier or mixing the repair film additives into the carrier from small to large according to five molecular weights of large, medium, small, micro and ultramicro; and packaging the medical bioprosthetic film according to different carriers.

Experimental example 1:

(1) comparative experiment for repairing scald skin of white rat: taking 25 white rats with the weight of about 110g, carrying out back unhairing treatment by using 6.5% sodium sulfide solution, wherein the unhairing area is 2.5cm multiplied by 2.0cm, and normally feeding the white rats for 12h after being washed clean by deionized water. The wounds were cut along the depilated site with a laser beam after anaesthesia with ether at a cutting rate of 0.5m/min, resulting in post-operative wounds which were then randomly divided into five groups of 5 per group. Then, five groups of rats were subjected to comparative experiment for repairing the scalded skin by using the moisturizing medical bioprosthetic film containing the traditional Chinese medicine prepared in example 1, and the skin was replaced every 2 hours for 10 times at most, with scab as a healing judgment condition and scab time as a comparative index, and the experimental results are shown in table 1.

(2) Skin elasticity increasing and water replenishing treatment contrast experiment: 25 female volunteers with history of hyaluronic acid injection and facial rigidity symptoms are collected, the female volunteers are aged 30-40 years, have the weight of 45-55kg, have no other facial skin diseases, have similar skin elasticity values and skin water content, and are randomly divided into five groups of 5 persons in each group. Then, the moisturizing medical biological repairing film containing the traditional Chinese medicine prepared in example 1 is used for carrying out comparison experiments of skin elasticity increasing and moisturizing treatment on five groups of volunteers, the film is replaced 2 times a day for 5 days in total, the elasticity and moisture indexes of the facial skin before and after the experiment are detected and recorded by a skin detector, and the average value of each group in the day is calculated as a comparison index. The tested volunteers apply the moisturizing medical bioprosthetic film containing the traditional Chinese medicine for 1 hour every day, then face cleaning is carried out, and the facial muscles are relaxed for 30min in the environment with the room temperature of 22-25 ℃ and the relative humidity of 55 +/-5%. An Ina high-precision skin detector is used for detecting the elasticity index and the moisture index of the facial skin, the probe repeatedly measures the facial skin in the same detected area for 3 times during measurement, the average value is obtained, and the experimental result is shown in tables 2-3.

TABLE 1 comparative experimental results for scald skin repair

Test object	Scab formation time (h)
		White rat 1	9
White rat 2	10
		White rat 3	8
White rat 4	9
		White rat 5	9
Average	9

TABLE 2 comparative experiment results for increasing skin elasticity

TABLE 3 comparison of the results of the Water supplement treatment

Test object	Before the experiment	Day 1	Day 2	Day 3	Day 4	Day 5
							Volunteer 1	36.10	37.23	38.04	38.90	39.37	39.81
Volunteer 2	36.01	38.10	38.75	39.65	39.58	39.93
							Volunteer 3	36.55	37.25	38.01	38.54	39.81	41.43
Volunteer 4	35.59	36.73	37.55	37.94	37.98	38.81
							Volunteer 5	36.22	36.45	37.21	37.65	38.27	39.41
Average water content	36.09	37.15	37.91	38.54	39.00	39.88
							Cumulative increment	0.00	1.06	1.82	2.44	2.91	3.79

Experimental example 2:

(1) comparative experiment for repairing scald skin of white rat: taking 25 white rats with the weight of about 110g, carrying out back unhairing treatment by using 6.5% sodium sulfide solution, wherein the unhairing area is 2.5cm multiplied by 2.0cm, and normally feeding the white rats for 12h after being washed clean by deionized water. The wounds were cut along the depilated site with a laser beam after anaesthesia with ether at a cutting rate of 0.5m/min, resulting in post-operative wounds which were then randomly divided into five groups of 5 per group. Then, the moisturizing medical biological repair film containing the traditional Chinese medicines prepared in example 2 is used for performing a scald skin repair comparison experiment on five groups of white rats, the white rats are replaced once every 2 hours and 10 times at most, scab is taken as a healing judgment condition, scab forming time is taken as a comparison index, and the experiment results are shown in table 4.

(2) Skin elasticity increasing and water replenishing treatment contrast experiment: 25 female volunteers with history of hyaluronic acid injection and facial rigidity symptoms are collected, the female volunteers are aged 30-40 years, have the weight of 45-55kg, have no other facial skin diseases, have similar skin elasticity values and skin water content, and are randomly divided into five groups of 5 persons in each group. Then, the moisturizing medical biological repairing film containing the traditional Chinese medicine prepared in example 2 is adopted to carry out comparison experiments of skin elasticity increasing and moisturizing treatment on five groups of volunteers, the experiment is carried out 2 times a day for 5 days in total, the elasticity and moisture indexes of the facial skin before and after the experiment are detected and recorded by a skin detector, and the average value of each group in the day is calculated as the comparison index. The tested volunteers apply the moisturizing medical bioprosthetic film containing the traditional Chinese medicine for 1 hour every day, then face cleaning is carried out, and the facial muscles are relaxed for 30min in the environment with the room temperature of 22-25 ℃ and the relative humidity of 55 +/-5%. An Ina high-precision skin detector is used for detecting the elasticity index and the moisture index of the facial skin, the probe repeatedly measures the facial skin in the same detected area for 3 times during measurement, the average value is obtained, and the experimental result is shown in tables 5-6.

TABLE 4 comparative experimental results for skin repair of scald

Test object	Scab formation time (h)
		White rat 1	8
White rat 2	9
		White rat 3	7
White rat 4	10
		White rat 5	9
Average	8.6

TABLE 5 comparative experiment results for increasing skin elasticity

Test object	Before the experiment	Day 1	Day 2	Day 3	Day 4	Day 5
							Volunteer 1	0.8125	0.8288	0.8453	0.8622	0.8834	0.9011
Volunteer 2	0.8234	0.8401	0.8569	0.8740	0.8967	0.9146
							Volunteer 3	0.8075	0.8237	0.8425	0.8584	0.8756	0.9014
Volunteer 4	0.7861	0.8024	0.8184	0.8348	0.8624	0.8975
							Volunteer 5	0.7913	0.8082	0.8244	0.8419	0.8678	0.8921
Mean elasticity	0.8042	0.8206	0.8375	0.8543	0.8772	0.9105
							Cumulative increment	0.0000	0.0165	0.0333	0.0501	0.0730	0.1063

TABLE 6 comparative Experimental results of Water supplement treatment

Test object	Before the experiment	Day 1	Day 2	Day 3	Day 4	Day 5
							Volunteer 1	36.56	37.29	38.21	38.90	39.84	40.37
Volunteer 2	36.23	38.10	38.75	39.65	40.26	40.70
							Volunteer 3	35.93	37.25	38.01	38.54	39.40	41.46
Volunteer 4	35.53	36.35	37.16	37.73	38.64	40.48
							Volunteer 5	36.00	36.45	37.10	37.89	39.22	41.04
Average water content	36.05	37.09	37.84	38.54	39.47	40.81
							Cumulative increment	0.00	1.04	1.79	2.49	3.42	4.76

Experimental example 3:

(1) comparative experiment for repairing scald skin of white rat: taking 25 white rats with the weight of about 110g, carrying out back unhairing treatment by using 6.5% sodium sulfide solution, wherein the unhairing area is 2.5cm multiplied by 2.0cm, and normally feeding the white rats for 12h after being washed clean by deionized water. The wounds were cut along the depilated site with a laser beam after anaesthesia with ether at a cutting rate of 0.5m/min, resulting in post-operative wounds which were then randomly divided into five groups of 5 per group. Then, five groups of rats were subjected to comparative experiment for repairing the scalded skin by using the moisturizing medical bioprosthetic film containing the traditional Chinese medicine prepared in example 3, and the skin was replaced every 2 hours for 10 times at most, with scabs as healing judgment conditions and scab formation time as comparative index, and the experimental results are shown in table 7.

(2) Skin elasticity increasing and water replenishing treatment contrast experiment: 25 female volunteers with history of hyaluronic acid injection and facial rigidity symptoms are collected, the female volunteers are aged 30-40 years, have the weight of 45-55kg, have no other facial skin diseases, have similar skin elasticity values and skin water content, and are randomly divided into five groups of 5 persons in each group. Then, the moisturizing medical biological repairing film containing the traditional Chinese medicine prepared in example 3 is used for carrying out comparison experiments of skin elasticity increasing and moisturizing treatment on five groups of volunteers, the film is replaced 2 times a day for 5 days in total, the elasticity and moisture indexes of the facial skin before and after the experiment are detected and recorded by a skin detector, and the average value of each group in the day is calculated as a comparison index. The tested volunteers apply the moisturizing medical bioprosthetic film containing the traditional Chinese medicine for 1 hour every day, then face cleaning is carried out, and the facial muscles are relaxed for 30min in the environment with the room temperature of 22-25 ℃ and the relative humidity of 55 +/-5%. The elasticity index and the moisture index of the facial skin are detected by using an Ina high-precision skin detector, the probe repeatedly measures the facial skin in the same detected area for 3 times during measurement, the average value is obtained, and the experimental result is shown in tables 8-9.

Table 7 comparative experiment results for repairing scalded skin

Test object	Scab formation time (h)
		White rat 1	11
White rat 2	10
		White rat 3	12
White rat 4	13
		White rat 5	11
Average	11.4

TABLE 8 comparative experiment results for increasing skin elasticity

Test object	Before the experiment	Day 1	Day 2	Day 3	Day 4	Day 5
							Volunteer 1	0.8027	0.8107	0.8127	0.8208	0.8290	0.8373
Volunteer 2	0.8184	0.8266	0.8340	0.8424	0.8508	0.8593
							Volunteer 3	0.8185	0.8254	0.8320	0.8412	0.8496	0.8581
Volunteer 4	0.8083	0.8164	0.8245	0.8328	0.8411	0.8495
							Volunteer 5	0.8112	0.8105	0.8186	0.8268	0.8392	0.8476
Mean elasticity	0.8118	0.8199	0.8281	0.8346	0.8446	0.8531
							Cumulative increment	0.0000	0.0081	0.0163	0.0228	0.0328	0.0412

TABLE 9 comparative Experimental results of Water supplement treatment

Test object	Before the experiment	Day 1	Day 2	Day 3	Day 4	Day 5
							Volunteer 1	35.83	36.55	36.91	37.65	38.40	38.79
Volunteer 2	38.04	38.50	39.27	39.46	40.06	40.26
							Volunteer 3	35.93	36.65	37.02	37.46	37.84	38.59
Volunteer 4	33.76	34.09	34.77	35.12	35.82	36.54
							Volunteer 5	36.72	37.46	37.83	38.40	38.86	39.25
Average water content	36.06	36.65	37.16	37.62	38.20	38.69
							Cumulative increment	0.00	0.59	1.10	1.56	2.14	2.63

Experimental example 4:

a common moisturizing mask which does not contain traditional Chinese medicines and has the same sodium hyaluronate content is selected to carry out a comparison experiment of scald skin repair and a comparison experiment of skin elasticity increase and moisturizing treatment, and the results are shown in tables 10-12.

Comparative experiment result for repairing skin of scald in table 10

Test object	Scab formation time (h)
		White rat 1	13
White rat 2	12
		White rat 3	15
White rat 4	14
		White rat 5	16
Average	14

TABLE 11 comparative experiment results for increasing skin elasticity

Test object	Before the experiment	Day 1	Day 2	Day 3	Day 4	Day 5
							Volunteer 1	0.8102	0.8118	0.8159	0.8191	0.8232	0.8265
Volunteer 2	0.8151	0.8192	0.8216	0.8257	0.8299	0.8340
							Volunteer 3	0.8085	0.8109	0.8150	0.8174	0.8215	0.8240
Volunteer 4	0.7985	0.8025	0.8065	0.8105	0.8130	0.8146
							Volunteer 5	0.8124	0.8148	0.8189	0.8230	0.8263	0.8288
Mean elasticity	0.8089	0.8119	0.8156	0.8192	0.8228	0.8256
							Cumulative increment	0.0000	0.0029	0.0066	0.0102	0.0138	0.0166

TABLE 12 comparative Experimental results of Water supplement treatment

Test object	Before the experiment	Day 1	Day 2	Day 3	Day 4	Day 5
							Volunteer 1	36.21	36.32	36.39	36.46	36.57	36.65
Volunteer 2	36.14	36.25	36.36	36.43	36.54	36.59
							Volunteer 3	35.93	36.04	36.15	36.26	36.35	36.46
Volunteer 4	35.74	35.81	35.92	36.03	36.13	36.24
							Volunteer 5	36.35	36.46	36.57	36.64	36.75	36.79
Average water content	36.07	36.18	36.28	36.36	36.47	36.55
							Cumulative increment	0.00	0.10	0.20	0.29	0.39	0.47

Experimental example 5:

the moisturizing facial mask containing other traditional Chinese medicines and the same sodium hyaluronate content in the existing product is selected to carry out comparison experiments on the skin repair of the scald and the skin elasticity increase and moisturizing treatment, and the results are shown in tables 13-15.

Comparative experiment result for repairing skin of scald in table 13

Test object	Scab formation time (h)
		White rat 1	12
White rat 2	13
		White rat 3	11
White rat 4	14
		White rat 5	12
Average	12.4

TABLE 14 comparative experimental results for increasing skin elasticity

Test object	Before the experiment	Day 1	Day 2	Day 3	Day 4	Day 5
							Volunteer 1	0.8115	0.8156	0.8205	0.8237	0.8279	0.8312
Volunteer 2	0.8144	0.8201	0.8234	0.8275	0.8316	0.8358
							Volunteer 3	0.8106	0.8130	0.8171	0.8195	0.8245	0.8269
Volunteer 4	0.8092	0.8141	0.8181	0.8222	0.8247	0.8263
							Volunteer 5	0.8071	0.8103	0.8144	0.8185	0.8225	0.8250
Mean elasticity	0.8106	0.8146	0.8187	0.8223	0.8262	0.8290
							Cumulative increment	0.0000	0.0041	0.0081	0.0117	0.0157	0.0185

TABLE 15 comparative Experimental results of Water supplement treatment

Test object	Before the experiment	Day 1	Day 2	Day 3	Day 4	Day 5
							Volunteer 1	36.24	36.38	36.53	36.68	36.86	36.97
Volunteer 2	36.27	36.38	36.49	36.56	36.71	36.84
							Volunteer 3	35.80	35.91	36.02	36.16	36.25	36.36
Volunteer 4	35.74	35.81	36.03	36.13	36.28	36.42
							Volunteer 5	36.38	36.49	36.64	36.75	36.93	37.00
Average water content	36.09	36.19	36.34	36.46	36.60	36.72
							Cumulative increment	0.00	0.11	0.25	0.37	0.52	0.63

Experimental examples 1-5 comprehensive comparative analysis comparison experiments on scald skin repair and skin elasticity increase and moisturizing treatment, the results are shown in tables 16-18:

comparative experiment result for repairing scald skin on surface 16

TABLE 17 comparative experiment results for increasing skin elasticity

TABLE 18 comparative Experimental results of Water supplement treatment

As can be seen from tables 16-18, the comparative results of the experimental examples of examples 1-5 show:

(1) the data in Table 16 show that the moisturizing medical biological repair film containing traditional Chinese medicines (example 2) provided by the invention has the best scabbing effect on the scald part, and is 8.6 h; when the moisturizing medical biological repair film containing traditional Chinese medicines provided by the invention is used (example 1), the scabbing effect of the scalded part is the second, and is 9.0 h; when the moisturizing medical biological repair film containing traditional Chinese medicines provided by the invention is used (example 3), the scabbing effect of the scalded part is the third, namely 11.4 hours; when the moisturizing mask containing other traditional Chinese medicines and the same sodium hyaluronate content is used in the existing product, the scabbing effect of the scalded part is fourth and is 12.4 hours; the common moisturizing mask which does not contain traditional Chinese medicines and has the same content of sodium hyaluronate is used, the scabbing time of the scalded part is the longest, and is 14 hours. Experimental data show that compared with the existing product which does not contain traditional Chinese medicines and is a common moisturizing facial mask with the same content of sodium hyaluronate, the moisturizing medical biological repairing film containing traditional Chinese medicines increases the treatment effect of skin repairing.

(2) The data in table 17 show that the moisturizing medical biological repair film containing traditional Chinese medicines (example 2) provided by the invention has the best effect of increasing the skin elasticity, and the skin elasticity index is 0.9105; the moisturizing medical biological repairing film containing traditional Chinese medicines (example 1) provided by the invention has the second effect of increasing the skin elasticity, and the skin elasticity index is 0.8808; the moisturizing medical biological repairing film containing traditional Chinese medicines (example 3) provided by the invention has the third effect of increasing the skin elasticity, and the skin elasticity index is 0.8531; the moisturizing mask containing other traditional Chinese medicines and the same sodium hyaluronate content is used in the existing product, the skin elasticity is improved, and the skin elasticity index is 0.8290; the common moisturizing mask which does not contain traditional Chinese medicines and has the same content of sodium hyaluronate is used in the existing product, so that the skin elasticity increasing effect is the worst, and the skin elasticity index is 0.8256. Experimental data show that compared with the existing common moisturizing facial mask which does not contain traditional Chinese medicines and has the same content of sodium hyaluronate, the moisturizing medical biological repairing film containing traditional Chinese medicines enhances the treatment effect of improving the skin elasticity.

(3) The data in table 18 show that the moisturizing medical biological repair film containing traditional Chinese medicines (example 2) provided by the invention has the best moisturizing effect, and the skin moisture index is 40.81; when the moisturizing medical biological repairing film containing the traditional Chinese medicines provided by the invention is used (example 1), the moisturizing effect is second, and the moisture index of skin is 39.88; by using the moisturizing medical biological repairing film containing the traditional Chinese medicines (example 3), the moisturizing effect is the third, and the skin moisture index is 38.69; the moisturizing mask containing other traditional Chinese medicines and the same sodium hyaluronate content is used in the existing product, the moisturizing effect is fourth, and the skin hydration index is 36.72; the common moisturizing mask which does not contain traditional Chinese medicines and has the same content of sodium hyaluronate is used in the existing products, the moisturizing effect is the worst, and the moisture index of skin is 36.55. Experimental data show that compared with the existing common moisturizing facial mask which does not contain traditional Chinese medicines and has the same sodium hyaluronate content, the moisturizing medical biological repairing film containing traditional Chinese medicines enhances the moisturizing and moisturizing treatment effects of skin.

(4) The effect rankings in tables 16-18 show that the moisturizing medical bioprosthetic film containing traditional Chinese medicines prepared according to the traditional Chinese medicine formula provided by the invention has the best therapeutic effects of moisturizing, skin repairing and skin elasticity increasing compared with the moisturizing medical bioprosthetic film containing traditional Chinese medicines provided by the invention, which adjusts the dosage of the mixed concentrated solution of the traditional Chinese medicine formula.

(5) The effect rankings in tables 16-18 show that compared with the moisturizing facial mask containing other traditional Chinese medicines and the same content of sodium hyaluronate in the existing product, the moisturizing medical biological repairing mask containing the traditional Chinese medicines prepared according to the traditional Chinese medicine formula provided by the invention has the best treatment effects of moisturizing, repairing and increasing skin elasticity.

Claims

1. A moisturizing medical biological repair film containing traditional Chinese medicines is characterized by being prepared from the following raw materials in parts by weight: 5-15 parts of angelica, 3-10 parts of angelica dahurica, 10-15 parts of polygonatum, 10-15 parts of poria cocos, 100-150 parts of deionized water, 0.1-0.5 part of sodium hyaluronate, 1-3 parts of vitamin E, 1-3 parts of amino acid, 1-5 parts of hydrolyzed collagen and 3-6 parts of glycerol.

2. The traditional Chinese medicine-containing moisturizing medical bioprosthetic film of claim 1, which is prepared from the following raw materials in parts by weight: 8 parts of angelica sinensis, 6 parts of angelica dahurica, 12 parts of polygonatum odoratum, 12 parts of poria cocos, 120 parts of deionized water, 0.3 part of sodium hyaluronate, 2 parts of vitamin E, 2 parts of amino acid, 3 parts of hydrolyzed collagen and 5 parts of glycerol.

3. The preparation method of the traditional Chinese medicine-containing moisturizing medical bioprosthetic film of claim 1 or 2, which is characterized by comprising the following steps:

4. The preparation method of the traditional Chinese medicine-containing water-replenishing medical bioprosthetic film of claim 3, which is characterized by comprising the following steps: and (6) the carrier comprises medical biological repair membrane paper, mineral mud or jelly glue.

5. The preparation method of the traditional Chinese medicine-containing water-replenishing medical bioprosthetic film of claim 4, which is characterized by comprising the following steps: the amount of the repair film additive coated or mixed in the step (6) is 15-25 mL.

6. The preparation method of the traditional Chinese medicine-containing water-replenishing medical bioprosthetic film of claim 4, which is characterized by comprising the following steps: the medical bioremediation film paper is non-woven fabric or biological fiber.

7. The preparation method of the traditional Chinese medicine-containing water-replenishing medical bioprosthetic film of claim 4, which is characterized by comprising the following steps: the addition amount of the mineral mud or the jelly glue agent is 100 parts.