CN110721143A - Whitening medical biological repair film containing traditional Chinese medicines and preparation method thereof - Google Patents

Whitening medical biological repair film containing traditional Chinese medicines and preparation method thereof Download PDF

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Publication number
CN110721143A
CN110721143A CN201910952972.3A CN201910952972A CN110721143A CN 110721143 A CN110721143 A CN 110721143A CN 201910952972 A CN201910952972 A CN 201910952972A CN 110721143 A CN110721143 A CN 110721143A
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China
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parts
traditional chinese
skin
whitening
chinese medicine
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董莉莉
韩星
练成
吴均福
齐宪臣
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Gansu Jindong Health Technology Co Ltd
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Gansu Jindong Health Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95

Abstract

The invention discloses a medical whitening bioremediation membrane containing traditional Chinese medicines and a preparation method thereof, and the main components of the membrane not only contain nicotinamide, deoxyarbutin and sodium hyaluronate with whitening efficacy, but also contain a traditional Chinese medicine formula which has the effects of skin repair and whitening and is formed by matching pearl powder, white muscardine silkworm, gentian, mulberry leaf, common perilla, ligusticum wallichii, radix angelicae and raw liquorice, and no chemical preparation which is easy to cause skin reaction such as hormone, antibiotic, heavy metal, alcohol, essence, pigment fluorescent agent, preservative and the like is added, so that the membrane is safe when being used by special people with poor skin resistance and no laziness like the hormone. The additive is filtered into five molecular weight grades of large, medium, small, micro and ultramicro, so that the additive can be synergistically acted into a network maintenance membrane, permeate into the muscle bottom, repair damaged elastic fibers, supplement water for a long time, improve water locking capacity, nourish for a long time, increase the thickness of the skin cuticle, improve the immunity of the skin and restore the health state of the skin.

Description

Whitening medical biological repair film containing traditional Chinese medicines and preparation method thereof
Technical Field
The invention belongs to the technical field of medical materials, and particularly relates to a whitening medical biological repair film containing traditional Chinese medicines and a preparation method thereof.
Background
The pursuit of whitening by Asian women never stops just like the pursuit of brightness by human beings, blusher is almost a necessary product of every adult woman, and the blusher is a general powder decoration family of forests such as concealer, foundation, loose powder, makeup powder, pressed powder and the like.
Common whitening methods are: cosmetic whitening, natural whitening, moisturizing whitening, sun screening, freckle removing, toxin expelling, medical whitening, food whitening, fruit whitening, massage whitening and the like.
The process of whitening is also the process of skin renewal and cleansing, and removal of the aged stratum corneum leaves the skin drier, which is very prone to melanin production, and therefore requires timely supplementation of nutrients and water. Moisturizing can also be said to be a basic lesson that any skin needs to do. How to whiten and moisturize the skin is a common topic of concern for women.
Currently, among skin whitening products, the mask is the most effective whitening product, and serves to soak a milk bath on the face's skin, soothe the skin, and allow the skin to better absorb the whitening components in a relaxed state.
At present, most of facial masks have the conventional effects of whitening the face, moisturizing, whitening and the like, and lack the treatment effects of repairing skin wounds, discharging toxins, removing melanin and the like.
In the field of medical repairing masks, enterprises in China take various traditional Chinese medicine extracts as additives, and add the additives into common masks to produce products such as medical masks (or medical repairing masks and medical repairing pastes) and the like as upgrading products of traditional masks. However, the products mainly play a role in moisturizing, and basically have no whitening and skin repairing effects.
Disclosure of Invention
One of the purposes of the invention is to provide a whitening medical biological repairing film containing traditional Chinese medicines;
the invention also aims to provide a preparation method of the whitening medical biological repairing film containing the traditional Chinese medicine.
In order to achieve the purpose, the invention adopts the technical scheme that:
a whitening medical biological repair film containing traditional Chinese medicines is characterized by being prepared from the following raw materials in parts by weight: 3-10 parts of pearl powder, 1-1.5 parts of white muscardine silkworm, 3-6 parts of gentian, 5-10 parts of mulberry leaf, 3-10 parts of common perilla, 3-10 parts of szechuan lovage rhizome, 3-10 parts of angelica dahurica and 2-10 parts of raw liquorice; and (3) other ingredients: 100-150 parts of deionized water, 0.1-0.5 part of sodium hyaluronate, 1-3 parts of vitamin E, 1-3 parts of amino acid, 1-5 parts of hydrolyzed collagen, 1-3 parts of nicotinamide, 1-5 parts of deoxyarbutin and 3-6 parts of glycerol.
In order to further realize the invention, the traditional Chinese medicine is prepared from the following raw materials in parts by weight: 6 parts of pearl powder, 1.2 parts of white muscardine silkworm, 5 parts of gentian, 8 parts of mulberry leaf, 6 parts of common perilla, 6 parts of szechuan lovage rhizome, 6 parts of angelica dahurica, 6 parts of raw liquorice, 120 parts of deionized water, 0.3 part of sodium hyaluronate, 2 parts of vitamin E, 2 parts of amino acid, 3 parts of hydrolyzed collagen, 2 parts of nicotinamide, 4 parts of deoxyarbutin and 5 parts of glycerol.
A preparation method of a whitening medical biological repair film containing traditional Chinese medicines comprises the following steps:
(1) preparing pearl powder, white muscardine silkworm, gentian, mulberry leaf, common perilla, szechuan lovage rhizome, dahurian angelica root and raw liquoric root into a nano traditional Chinese medicine powder mixing material by adopting a nano traditional Chinese medicine powder preparation process;
(2) mixing the nanometer Chinese medicinal powder mixture obtained in step (1) with 10-25L distilled water by static boiling method, decocting for 45-100min, cooling to 40-60 deg.C to obtain Chinese medicinal mixed concentrated solution;
(3) heating deionized water to 80-85 deg.C, adding sodium hyaluronate and glycerol, homogenizing, and keeping the temperature for 5-10min to obtain sodium hyaluronate mixture;
(4) cooling the sodium hyaluronate mixture obtained in the step (3) to 40-50 ℃, adding the traditional Chinese medicine mixed concentrated solution obtained in the step (2), adding vitamin E, amino acid, hydrolyzed collagen, nicotinamide and deoxyarbutin, homogenizing, cooling to 38 ℃, and standing until the solution is completely swelled into a transparent solution, thereby obtaining the repairing membrane additive;
(5) filtering the repairing membrane additives obtained in the step (4) into repairing membrane additives with five molecular weight grades of large, medium, small, micro and ultramicro by adopting a micro-filtration membrane, an ultrafiltration membrane, a nanofiltration membrane and a reverse osmosis membrane respectively;
(6) adopting an artificial intelligence manufacturing full-automatic whole-process cold distribution production line, cooling the repairing film additives of the five molecular weight grades obtained in the step (5) to 0-15 ℃, and accurately coating the repairing film additives on a carrier or mixing the repairing film additives into the carrier according to five molecular weights of large, medium, small, micro and ultramicro from small to large;
(7) and (4) packaging the medical bioprosthetic film obtained in the step (6) according to different carriers.
In order to further realize the invention, the carrier in the step (6) comprises medical bioremediation film paper, mineral mud or jelly glue.
In order to further realize the invention, the amount of the repair film additive coated or mixed in the step (6) is 15-25 mL.
In order to further realize the invention, the medical bioremediation film paper is non-woven fabric or biological fiber.
In order to further realize the invention, the addition amount of the mineral mud or the jelly glue is 100 parts.
Compared with the prior art, the invention has the beneficial effects that:
the invention provides a medical whitening bioremediation membrane containing traditional Chinese medicines, which mainly comprises nicotinamide, deoxyarbutin and sodium hyaluronate with whitening effects, and also comprises a traditional Chinese medicine formula which has skin repairing and whitening effects and is formed by compatibility of pearl powder, white muscardine silkworm, gentian, mulberry leaf, common perilla, ligusticum wallichii, radix angelicae and raw liquorice, and does not contain any chemical preparation which is easy to cause skin reaction, such as hormone, antibiotic, heavy metal, alcohol, essence, pigment fluorescent agent, preservative and the like, so that the membrane is safer when being used by special people with low skin resistance and no dependence like the hormone.
Pearl powder: has bitter, cold and salty taste, and has effects of invigorating heart and liver channel, removing pox, treating toxic materials, improving immunity, delaying aging, removing speckle, whitening skin, and supplementing calcium. Is compatible with raw licorice, and has the effects of whitening, moisturizing, tonifying qi and enriching blood.
White muscardine silkworm: salty, pungent and mild in nature and flavor, enters liver and lung meridians, and has the effects of removing chloasma, eliminating senile plaque and sunburn. The product is compatible with folium Mori, and has effects of repairing skin, resolving macula and whitening skin.
Gentian: is bitter and cold in nature, enters liver, gallbladder and stomach channels, and has the effects of clearing heat, eliminating dampness, purging excessive fire of liver and gallbladder, inhibiting tyrosinase active ingredients, and destroying melanin formation environment. It is combined with radix Angelicae Dahuricae to regulate skin metabolism and inhibit melanin formation.
Mulberry leaf: has bitter, sweet and cold property, enters liver and lung channels, has good skin beautifying effect, and particularly has better curative effect on acne and brown spots on the face. The product is combined with radix Angelicae Dahuricae to repair skin and increase skin elasticity.
White perilla: is bitter in nature, sweet and warm in taste, and has the effects of tonifying qi and spleen, eliminating dampness and promoting diuresis, moistening skin and the like, and spleen and stomach meridians entered. The product is combined with rhizoma Ligustici Chuanxiong, and has effects of moistening skin, and replenishing water.
Ligusticum wallichii: has pungent and warm nature and flavor, enters liver, gallbladder and pericardium channels, and has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind, relieving pain, moistening skin, relieving itching and improving facial nutrition. It is combined with radix Glycyrrhizae to achieve the effects of replenishing water and keeping moisture.
Radix angelicae: has pungent and warm nature and flavor, enters lung and stomach meridians, and has effects of improving microcirculation, promoting skin metabolism, and delaying skin aging.
Raw licorice root: has sweet and mild nature and taste, and has effects of invigorating spleen, invigorating qi, whitening skin, and keeping moisture.
Deionized water: can better control the microorganisms and impurities of the product.
Sodium hyaluronate: can form a layer of air-permeable film on the surface of skin to make the skin smooth and moist, promote proliferation and differentiation of epidermal cells, remove oxygen free radicals, and promote regeneration of the skin at the injured part.
Vitamin E: can provide the skin with the functions of keeping the skin elasticity, supplementing water and improving and enhancing the elasticity of new cells.
Amino acids: has effects of activating cells, improving metabolism and blood circulation, and reviving skin.
Hydrolyzing collagen: has effects in supplementing collagen, restoring skin elasticity, restoring firmness, reducing sagging phenomenon, and smoothing fine lines and wrinkles.
Nicotinamide: has the effects of accelerating the metabolism of the skin and the dissolution of melanin at the bottom layer of the skin, thereby achieving the whitening effect of the skin.
And (3) deoxyarbutin: has the effect of reducing melanin synthesis by inhibiting the activity of tyrosinase.
Glycerol: is a moisturizing factor indispensable to cells, has excellent capacity of regulating skin metabolism, promotes the activity of skin aquaporins, and assists in promoting skin metabolism and purification.
Mineral mud: the fine mineral mud is prepared by the phase deposition of sylvite ores in the continental lake, and has the effects of supplementing water, moisturizing and supplementing minerals.
Gel agent of jelly: the jelly prepared by decocting animal protein can be used for preparing products such as capsule, colloid, jelly, etc., and can be used for preparing jelly of skin care products.
The traditional Chinese medicine formula and the additive fully consider six compatibility relations of mutual reinforcement, mutual induction, mutual incompatibility, mutual killing, mutual inhibition and reverse between the traditional Chinese medicine formula and the additive and effect differences generated under different dosage proportions of the traditional Chinese medicines and the additive according to the mechanisms of the traditional Chinese medicine science, the traditional Chinese medicine prescriptions and the traditional Chinese medicine pharmacology, optimize dosage and accurately prepare the traditional Chinese medicine formula and the additive, and carry out combination reaction on effective bioactive components dissolved out of the traditional Chinese medicines by using a static boiling method and mixing and decocting the traditional Chinese medicines by using distilled water to form a more complex combination with specific effects, generate huge synergistic effect and greatly enhance the treatment effect, wherein the specific action mechanism is as follows:
the silkworm, the gentian, the mulberry leaf and the angelica dahurica are used as main medicines, and can remove freckles and regulate skin metabolism; the pearl powder, the common perilla, the szechuan lovage rhizome and the raw liquoric root are taken as auxiliary medicines, and have the effects of tonifying qi and enriching blood, repairing skin, whitening and moisturizing, moistening skin and relieving itching and the like; the main drug property is bitter, salty, pungent and cold, the auxiliary drug property is sweet and mild, and the main drug property and the auxiliary drug property are mutually incompatible, so that the product is mild and has no stimulation; silkworm, gentian and mulberry leaf are mutually matched to enhance the freckle removing effect; radix Gentianae and radix Angelicae Dahuricae are mutually reinforced, and can regulate skin metabolism and inhibit melanin formation; the pearl powder and the angelica dahurica are matched, so that the skin can be repaired, and the effects of moisturizing and wrinkle resisting are achieved; the rhizoma ligustici wallichii and the raw liquorice are mutually matched, so that the effects of moisturizing can be enhanced; the efficacies of replenishing qi and blood and repairing skin of the traditional Chinese medicine formula are in mutual reinforcement with the moisturizing efficacy of additives such as sodium hyaluronate and the like, and the efficacies of repairing skin and increasing skin elasticity can be enhanced; the traditional Chinese medicine formula has the effects of removing freckles, whitening, moisturizing, resisting wrinkles and inhibiting melanin, is matched with the whitening effect of additives such as nicotinamide, deoxyarbutin and the like, and can strengthen the effects of expelling toxin, removing freckles and whitening.
The traditional Chinese medicine formula adopted by the whitening medical biological repair film containing traditional Chinese medicines is prepared according to the traditional Chinese medicine science, the traditional Chinese medicine prescriptions and the traditional Chinese medicine pharmacology, is simple and effective, has definite component efficacy and action mechanism, strong pertinence and speciality and high safety, has the effects of improving human immunity, delaying senility, removing freckles, whitening, tonifying qi, enriching blood, repairing skin, clearing heat, drying dampness, purging liver and gallbladder excess fire, inhibiting the active ingredients of tyrosinase, destroying the environment for forming melanin, regulating skin metabolism, inhibiting melanin formation, treating acne, increasing skin elasticity, tonifying qi, strengthening spleen, drying dampness, promoting diuresis, moistening skin, relieving itching, improving facial nutrition, moisturizing, improving microcirculation, whitening, moisturizing and the like, and is cooperated with the additives with the whitening effect such as nicotinamide, deoxyarbutin, sodium hyaluronate and the like, the whitening skin-care mask is mild and non-irritant, can relieve skin, discharge toxin, remove melanin, open inherent luster of skin, repair damaged skin epidermal cells, deeply nourish skin, enhance skin elasticity, effectively slow down allergy, improve dry skin state, supplement skin moisture, make skin tender and moisturized and the like, and fills the blank that the current market has three effects of professional biological whitening, skin repairing and water supplementing and moisturizing and a professional medical grade whitening medical biological repairing film product.
According to the experimental results of the examples, the therapeutic effects of the whitening medical biological repair film containing the traditional Chinese medicines provided by the invention are as follows: 1. the whitening medical biological repairing film containing the traditional Chinese medicine provided by the invention has the whitening treatment effect compared with the existing common facial mask without the traditional Chinese medicine; 2. the whitening medical biological repair film containing the traditional Chinese medicine provided by the invention has the treatment effect of skin repair compared with the existing common mask without the traditional Chinese medicine; 3. compared with the existing common facial mask without traditional Chinese medicines, the whitening medical biological repair membrane containing traditional Chinese medicines enhances the effects of moisturizing and treating skin; 4. compared with the traditional Chinese medicine-containing whitening old medical biological repair film prepared by adjusting the dosage of the mixed concentrated solution of the traditional Chinese medicine formula, the traditional Chinese medicine-containing whitening medical biological repair film prepared according to the traditional Chinese medicine formula provided by the invention has the best treatment effects of whitening, repairing skin and moisturizing; 5. compared with the common facial mask containing other traditional Chinese medicines in the existing product, the traditional Chinese medicine-containing whitening medical biological repair film prepared according to the traditional Chinese medicine formula provided by the invention has the best treatment effects of whitening, repairing skin and moisturizing.
The invention also provides a preparation method of the whitening medical biological repair membrane containing the traditional Chinese medicines, wherein four kinds of filtering membranes, namely a microfiltration membrane, an ultrafiltration membrane, a nanofiltration membrane and a reverse osmosis membrane, are respectively adopted in the production of the product to filter an additive of the whitening medical biological repair membrane containing the traditional Chinese medicines into five kinds of additives with molecular weight grades of large, medium, small, micro and ultramicro, and an artificial intelligent manufacturing full-process cold distribution production line is adopted to realize full-process accurate cold distribution of five layers of large, medium, small, micro and ultramicro molecules, so that the product can stimulate the self-repairing capability of the skin and simultaneously protect the skin in all directions. Macromolecule water locking to prevent water loss; the middle molecules are full of water, so that the skin is firmer and full; the small molecules penetrate into the muscle bottom to enhance the microcirculation and metabolic capability of the skin and promote the proliferation and differentiation of epidermal cells; the micro molecules act the additives with different molecular weights synergistically to form a network maintenance film to permeate into the muscle bottom; the original intelligent ultramicro molecules directly send the nutrients in the additives to the muscle bottom, and the nutrients are directly and effectively absorbed and utilized by cells, so that the metabolism of old cells is accelerated, and new cells are generated; five layers of golden compound liquid construct a 'repair-generation-connection' circulation mechanism, repair damaged elastic fibers, supplement water with lasting effect, improve water locking capacity, nourish for a long time, increase the thickness of skin cuticle, improve the immunity of the skin and restore the health state of the skin.
Detailed Description
The present invention will be further described with reference to the following embodiments.
Example 1:
(1) preparing 10g of pearl powder, 1.5g of white muscardine silkworm, 6g of gentian, 5-10g of mulberry leaf, 10g of common perilla, 10g of szechuan lovage rhizome, 10g of angelica root and 10g of raw liquorice into a nano traditional Chinese medicine powder mixing material by adopting a nano traditional Chinese medicine powder preparation process;
(2) mixing the nanometer Chinese medicinal powder mixture obtained in step (1) with 25L distilled water by static boiling method, decocting for 100min, and cooling to 60 deg.C to obtain Chinese medicinal mixed concentrated solution;
(3) heating 150g of deionized water to 85 ℃, adding 0.5g of sodium hyaluronate and 6g of glycerol, homogenizing uniformly, and keeping the temperature for 10min to obtain a sodium hyaluronate mixture;
(4) cooling the sodium hyaluronate mixture obtained in the step (3) to 50 ℃, adding the traditional Chinese medicine mixed concentrated solution obtained in the step (2), adding vitamin E3g, amino acid 3g, hydrolyzed collagen 5g, nicotinamide 3g and deoxyarbutin 5g, homogenizing, cooling to 38 ℃, and standing until the solution is completely swelled into a transparent solution, thereby obtaining the additive of the whitening medical bioprosthetic membrane containing traditional Chinese medicines;
example 2:
(1) preparing 6g of pearl powder, 1.2g of white muscardine silkworm, 5g of gentian, 8g of mulberry leaf, 6g of common perilla, 6g of szechuan lovage rhizome, 6g of angelica root and 6g of raw liquorice into a nano traditional Chinese medicine powder mixing material by adopting a nano traditional Chinese medicine powder preparation process;
(2) mixing the nanometer Chinese medicinal powder mixture obtained in step (1) with 18L distilled water by static boiling method, decocting for 60min, and cooling to 45 deg.C to obtain Chinese medicinal mixed concentrated solution;
(3) heating 120g of deionized water to 82 ℃, adding 0.3g of sodium hyaluronate and 5g of glycerol, homogenizing uniformly, and keeping the temperature for 8min to obtain a sodium hyaluronate mixture;
(4) cooling the sodium hyaluronate mixture obtained in the step (3) to 45 ℃, adding the traditional Chinese medicine mixed concentrated solution obtained in the step (2), adding vitamin E2g, amino acid 2g, hydrolyzed collagen 3g, nicotinamide 2g and deoxyarbutin 4g, homogenizing, cooling to 38 ℃, standing until the solution is completely swelled into a transparent solution, and thus obtaining the additive of the whitening medical bioprosthetic membrane containing traditional Chinese medicines;
example 3:
(1) preparing 3g of pearl powder, 1g of white muscardine silkworm, 3g of gentian, 5g of mulberry leaf, 3g of common perilla, 3g of szechuan lovage rhizome, 3g of angelica root and 2g of raw liquorice into a nano traditional Chinese medicine powder mixing material by adopting a nano traditional Chinese medicine powder preparation process;
(2) mixing the nanometer Chinese medicinal powder mixture obtained in step (1) with 10L distilled water by static boiling method, decocting for 45min, and cooling to 40 deg.C to obtain Chinese medicinal mixed concentrated solution;
(3) heating 100g of deionized water to 80 ℃, adding 0.1g of sodium hyaluronate and 3g of glycerol, homogenizing uniformly, and keeping the temperature for 5min to obtain a sodium hyaluronate mixture;
(4) cooling the sodium hyaluronate mixture obtained in the step (3) to 40 ℃, adding the traditional Chinese medicine mixed concentrated solution obtained in the step (2), adding vitamin E1g, amino acid 1g, hydrolyzed collagen 1g, nicotinamide 1g and deoxyarbutin 1g, homogenizing, cooling to 38 ℃, and standing until the solution is completely swelled into a transparent solution, thereby obtaining the additive of the whitening medical biological repair membrane containing traditional Chinese medicines;
after the additives of the whitening medical biological repair membrane containing the traditional Chinese medicines in the embodiments 1 to 3 are prepared, four kinds of filter membranes, namely a micro-filter membrane, an ultrafiltration membrane, a nano-filter membrane and a reverse osmosis membrane, are respectively adopted to filter the mixture into five kinds of repair membrane additives with molecular weight grades, namely large, medium, small, micro and ultramicro; adopting an artificial intelligence manufacturing full-automatic whole-process cold distribution production line, cooling the repair film additives of the five molecular weight grades to 0-15 ℃, and accurately coating the repair film additives on a carrier or mixing the repair film additives into the carrier from small to large according to five molecular weights of large, medium, small, micro and ultramicro; and packaging the medical bioprosthetic film according to different carriers.
Experimental example 1:
(1) comparative experiment for repairing scald skin of white rat: taking 25 big white rats with weight of about 110g, carrying out back depilation treatment with 6.5% sodium sulfide solution, wherein the depilation area is 2.5cm × 2.0cm, and feeding for 12h normally after being washed clean with distilled water. The wounds were cut along the depilated site with a laser beam after anaesthesia with ether at a cutting rate of 0.5m/min, resulting in post-operative wounds which were then randomly divided into five groups of 5 per group. Then, the whitening medical biological repair film containing the traditional Chinese medicine prepared in example 1 was used for performing a comparative experiment on the scalded skin of five groups of rats, the skin was replaced every 2 hours for at most 10 times, scabbing was used as a healing judgment condition, scabbing time was used as a comparative index, and the experimental results are shown in table 1.
(2) Comparative experiment of face whitening and moisturizing treatment: 25 female volunteers aged 30-40 years and weighed 45-55kg, had no other facial skin diseases, similar skin color brightness values and skin moisture contents, and were randomly divided into five groups of 10 persons each. Then, the whitening medical biological repair film containing the traditional Chinese medicine prepared in example 1 is used for carrying out comparison experiments of skin elasticity increasing and water replenishing treatment on five groups of volunteers, the film is replaced 2 times a day for 5 days in total, a skin detector is used for detecting and recording the moisture index contained in the facial skin and the index reflecting the skin age before and after the experiment every day, and the average value of each group on the day is calculated as the comparison index. The tested volunteers apply the whitening medical biological repair film containing the traditional Chinese medicine for 1 hour every day, then face cleaning is carried out, and the facial muscle groups are relaxed for 30min in the environment with the room temperature of 22-25 ℃ and the relative humidity of 55 +/-5%. An Ina high-precision skin detector is used for detecting the moisture index of the facial skin, the probe repeatedly measures the moisture index in the same measured area for 3 times during measurement, the average value is taken, and the experimental result is shown in tables 2-3. Skin brightness index was measured using a multifunctional skin tester MPA9, Courage Khazaka electronics, germany.
TABLE 1 comparative experimental results for scald skin repair
Test object Scab formation time (h)
White rat 1 9
White rat 2 10
White rat 3 8
White rat 4 9
White rat 5 9
Average 9
Table 2 results of the comparative experiment for whitening the face
Test object Before the experiment Day 1 Day 2 Day 3 Day 4 Day 5
Volunteer 1 64.72 66.79 68.13 69.49 71.57 73.29
Volunteer 2 65.18 66.74 67.75 69.10 71.86 73.30
Volunteer 3 64.54 66.61 67.94 69.98 71.38 73.52
Volunteer 4 64.16 65.76 67.08 68.42 70.47 71.88
Volunteer 5 65.87 67.65 70.35 71.76 73.56 75.03
Average L value 64.89 66.71 68.25 69.75 71.77 73.40
Cumulative increment 0.00 1.82 3.35 4.86 6.87 8.51
TABLE 3 comparison of the results of the Water supplement treatment
Test object Before the experiment Day 1 Day 2 Day 3 Day 4 Day 5
Volunteer 1 36.72 37.34 37.98 38.62 39.32 39.91
Volunteer 2 37.15 37.75 38.50 39.27 40.06 40.74
Volunteer 3 36.35 37.04 37.71 38.39 39.15 39.78
Volunteer 4 35.87 36.59 37.17 37.92 38.56 39.22
Volunteer 5 35.96 36.50 37.15 37.90 38.66 39.24
Average water content 36.41 37.04 37.70 38.42 39.15 39.78
Cumulative increment 0.00 0.63 1.29 2.01 2.74 3.37
Experimental example 2:
(1) comparative experiment for repairing scald skin of white rat: taking 25 big white rats with weight of about 110g, carrying out back depilation treatment with 6.5% sodium sulfide solution, wherein the depilation area is 2.5cm × 2.0cm, and feeding for 12h normally after being washed clean with distilled water. The wounds were cut along the depilated site with a laser beam after anaesthesia with ether at a cutting rate of 0.5m/min, resulting in post-operative wounds which were then randomly divided into five groups of 5 per group. Then, the whitening medical biological repair film containing the traditional Chinese medicine prepared in example 2 was used to perform a comparative experiment on the scald skin repair of five groups of rats, the film was replaced every 2 hours for at most 10 times, scab was used as a healing determination condition, scab formation time was used as a comparative index, and the experimental results are shown in table 4.
(2) Comparative experiment of face whitening and moisturizing treatment: 25 female volunteers aged 30-40 years and weighed 45-55kg, had no other facial skin diseases, similar skin color brightness values and skin moisture contents, and were randomly divided into five groups of 10 persons each. Then, the whitening medical biological repair film containing the traditional Chinese medicine prepared in example 1 is used for carrying out comparison experiments of skin elasticity increasing and water replenishing treatment on five groups of volunteers, the film is replaced 2 times a day for 5 days in total, a skin detector is used for detecting and recording the moisture index contained in the facial skin and the index reflecting the skin age before and after the experiment every day, and the average value of each group on the day is calculated as the comparison index. The tested volunteers apply the whitening medical biological repair film containing the traditional Chinese medicine for 1 hour every day, then face cleaning is carried out, and the facial muscle groups are relaxed for 30min in the environment with the room temperature of 22-25 ℃ and the relative humidity of 55 +/-5%. An Ina high-precision skin detector is used for detecting the moisture index of the facial skin, the probe repeatedly measures the moisture index in the same measured area for 3 times during measurement, the average value is taken, and the experimental result is shown in tables 5-6. Skin brightness index was measured using a multifunctional skin tester MPA9, Courage Khazaka electronics, germany.
TABLE 4 comparative experimental results for skin repair of scald
Test object Scab formation time (h)
White rat 1 9
White rat 2 9
White rat 3 8
White rat 4 8
White rat 5 10
Average 8.8
Table 5 comparative test results for facial whitening
Figure BDA0002225723980000091
Figure BDA0002225723980000101
TABLE 6 comparative Experimental results of Water supplement treatment
Test object Before the experiment Day 1 Day 2 Day 3 Day 4 Day 5
Volunteer 1 36.56 37.48 38.41 39.37 40.28 41.29
Volunteer 2 37.05 37.94 38.81 39.79 40.78 41.84
Volunteer 3 36.34 37.25 38.14 39.06 40.03 41.03
Volunteer 4 35.37 36.15 37.06 37.98 38.89 39.94
Volunteer 5 35.61 36.50 37.41 38.35 39.23 40.21
Average water content 36.19 37.06 37.97 38.91 39.84 40.86
Cumulative increment 0.00 0.88 1.78 2.72 3.66 4.68
Experimental example 3:
(1) comparative experiment for repairing scald skin of white rat: taking 25 big white rats with weight of about 110g, carrying out back depilation treatment with 6.5% sodium sulfide solution, wherein the depilation area is 2.5cm × 2.0cm, and feeding for 12h normally after being washed clean with distilled water. The wounds were cut along the depilated site with a laser beam after anaesthesia with ether at a cutting rate of 0.5m/min, resulting in post-operative wounds which were then randomly divided into five groups of 5 per group. Then, the whitening medical bioprosthetic film containing the traditional Chinese medicine prepared in example 3 was used to perform a comparative experiment on the scalded skin of five groups of rats, the skin was replaced every 2 hours for at most 10 times, scabbing was used as a healing judgment condition, scabbing time was used as a comparative index, and the experimental results are shown in table 7.
(2) Comparative experiment of face whitening and moisturizing treatment: 25 female volunteers aged 30-40 years and weighed 45-55kg, had no other facial skin diseases, similar skin color brightness values and skin moisture contents, and were randomly divided into five groups of 10 persons each. Then, the whitening medical biological repair film containing the traditional Chinese medicine prepared in example 1 is used for carrying out comparison experiments of skin elasticity increasing and water replenishing treatment on five groups of volunteers, the film is replaced 2 times a day for 5 days in total, a skin detector is used for detecting and recording the moisture index contained in the facial skin and the index reflecting the skin age before and after the experiment every day, and the average value of each group on the day is calculated as the comparison index. The tested volunteers apply the whitening medical biological repair film containing the traditional Chinese medicine for 1 hour every day, then face cleaning is carried out, and the facial muscle groups are relaxed for 30min in the environment with the room temperature of 22-25 ℃ and the relative humidity of 55 +/-5%. An Ina high-precision skin detector is used for detecting the moisture index of the facial skin, the probe repeatedly measures the moisture index in the same measured area for 3 times during measurement, the average value is taken, and the experimental result is shown in tables 8-9. Skin brightness index was measured using a multifunctional skin tester MPA9, Courage Khazaka electronics, germany.
Table 7 comparative experiment results for repairing scalded skin
Figure BDA0002225723980000102
Figure BDA0002225723980000111
Table 8 comparative test results for whitening of face
Test object Before the experiment Day 1 Day 2 Day 3 Day 4 Day 5
Volunteer 1 65.62 67.26 67.87 68.55 69.23 69.93
Volunteer 2 64.87 67.14 67.75 68.42 69.11 69.80
Volunteer 3 65.25 67.53 68.07 68.82 69.51 70.21
Volunteer 4 64.15 67.36 68.03 68.71 69.40 70.09
Volunteer 5 65.47 66.78 67.45 68.12 69.14 69.83
Average L value 65.07 67.22 67.83 68.53 69.28 69.97
Cumulative increment 0.00 2.14 2.76 3.45 4.21 4.90
TABLE 9 comparative Experimental results of Water supplement treatment
Test object Before the experiment Day 1 Day 2 Day 3 Day 4 Day 5
Volunteer 1 36.01 36.73 37.10 37.84 38.60 38.99
Volunteer 2 38.16 38.62 39.40 39.59 40.19 40.39
Volunteer 3 37.06 37.81 38.18 38.64 39.03 39.81
Volunteer 4 33.25 33.58 34.26 34.60 35.29 36.00
Volunteer 5 35.96 36.68 37.05 37.61 38.06 38.44
Average water content 36.09 36.69 37.20 37.66 38.23 38.72
Cumulative increment 0.00 0.59 1.11 1.56 2.14 2.63
Experimental example 4:
a common moisturizing mask without traditional Chinese medicines in the existing product is selected to carry out a scald skin repair comparison experiment and a face whitening and moisturizing treatment comparison experiment, and the results are shown in tables 10-12.
Comparative experiment result for repairing skin of scald in table 10
Test object Scab formation time (h)
White rat 1 13
White rat 2 12
White rat 3 13
White rat 4 14
White rat 5 12
Average 12.8
Table 11 comparative results of skin whitening
Figure BDA0002225723980000112
Figure BDA0002225723980000121
TABLE 12 comparative Experimental results of Water supplement treatment
Test object Before the experiment Day 1 Day 2 Day 3 Day 4 Day 5
Volunteer 1 36.15 36.26 36.33 36.40 36.51 36.59
Volunteer 2 36.04 36.15 36.26 36.33 36.44 36.49
Volunteer 3 36.45 36.56 36.67 36.78 36.87 36.98
Volunteer 4 35.98 36.05 36.16 36.27 36.38 36.49
Volunteer 5 35.89 36.00 36.11 36.18 36.29 36.32
Average water content 36.10 36.20 36.30 36.39 36.50 36.57
Cumulative increment 0.00 0.10 0.20 0.29 0.40 0.47
Experimental example 5:
a moisturizing mask containing other traditional Chinese medicines in the existing product is selected to carry out a scald skin repair comparison experiment and a face whitening and moisturizing treatment comparison experiment, and the results are shown in tables 13-15.
Comparative experiment result for repairing skin of scald in table 13
Test object Scab formation time (h)
White rat 1 12
White rat 2 13
White rat 3 13
White rat 4 12
White rat 5 11
Average 12.2
Table 14 comparative test results for facial whitening
Test object Before the experiment Day 1 Day 2 Day 3 Day 4 Day 5
Volunteer 1 65.24 65.70 66.03 66.36 66.69 67.02
Volunteer 2 64.56 68.76 69.00 69.34 69.69 70.04
Volunteer 3 65.12 65.45 65.77 66.04 66.37 66.76
Volunteer 4 65.36 65.74 66.07 66.40 66.60 66.93
Volunteer 5 64.58 64.93 65.25 65.58 65.84 66.11
Average L value 64.97 66.11 66.42 66.74 67.04 67.37
Cumulative increment 0.00 1.14 1.45 1.77 2.06 2.40
TABLE 15 comparative Experimental results of Water supplement treatment
Figure BDA0002225723980000122
Figure BDA0002225723980000131
Experimental examples 1-5 comprehensive comparative analysis comparison experiments on scald skin repair and comparison experiments on facial whitening and moisturizing treatment, the results are shown in tables 16-18:
comparative experiment result for repairing scald skin on surface 16
Figure BDA0002225723980000132
Table 17 comparative test results for facial whitening
Figure BDA0002225723980000133
TABLE 18 comparative Experimental results of Water supplement treatment
Figure BDA0002225723980000134
Figure BDA0002225723980000141
As can be seen from tables 16-18, the comparative results of the experimental examples of examples 1-5 show:
the experimental data comparison results of examples 1 to 5 show that the therapeutic effects of the whitening medical biological repair film containing the traditional Chinese medicines are as follows:
(1) the data in table 16 show that the whitening medical bioprosthetic film containing traditional Chinese medicines (example 2) provided by the invention has the best scabbing effect on the scalded part, and is 8.8 h; when the whitening medical biological repair film containing the traditional Chinese medicine provided by the invention is used (example 1), the scabbing effect of the scalded part is the second, and is 9.0 h; when the whitening medical biological repair film containing the traditional Chinese medicines provided by the invention is used (example 3), the scabbing effect of the scalded part is the third, and is 10.6 h; when the common facial mask containing other traditional Chinese medicines in the existing product is used, the scabbing effect of the scalded part is the fourth, and is 12.2 hours; when the common facial mask without traditional Chinese medicines in the existing products is used, the scabbing time of the scalded part is the longest and is 12.8 hours. Experimental data show that the whitening medical biological repair film containing the traditional Chinese medicine provided by the invention has the treatment effect of skin repair compared with the existing common facial mask without the traditional Chinese medicine.
(2) The data in table 17 show that the whitening medical bioprosthetic film containing traditional Chinese medicines (example 2) provided by the invention has the best whitening effect, and the skin brightness index is 74.90; when the whitening medical biological repairing film containing the traditional Chinese medicine provided by the invention is used (example 1), the whitening effect is the second, and the skin brightness index is 73.40; when the whitening medical biological repair film containing the traditional Chinese medicines provided by the invention is used (example 3), the whitening effect is the third, and the skin brightness index is 69.97; the common facial mask containing other traditional Chinese medicines in the existing product is used, the whitening effect is fourth, and the skin brightness index is 67.37; the common facial mask containing no traditional Chinese medicines in the existing products is used, the whitening effect is the worst, and the skin brightness index is 66.47. Experimental data show that the whitening medical biological repair film containing the traditional Chinese medicine has the whitening treatment effect compared with the existing common facial mask without the traditional Chinese medicine.
(3) The data in table 18 show that the whitening medical biological repair film containing traditional Chinese medicines (example 2) provided by the invention has the best moisturizing effect, and the moisture index of the skin is 39.84; when the whitening medical biological repair film containing the traditional Chinese medicines provided by the invention is used (example 1), the moisturizing effect is second, and the moisture index of the skin is 39.15; when the whitening medical biological repair film containing the traditional Chinese medicines provided by the invention is used (example 3), the moisturizing effect is the third, and the moisture index of the skin is 38.23; the existing product contains other traditional Chinese medicines, the moisturizing effect is fourth, and the skin moisture index is 36.83; the common facial mask containing no traditional Chinese medicines in the existing products is used, the moisturizing effect is the worst, and the moisture index of skin is 36.50. Experimental data show that compared with the existing common facial mask without traditional Chinese medicines, the whitening medical biological repair film containing traditional Chinese medicines provided by the invention enhances the skin moisturizing and treating effects.
(4) The effect rankings in tables 16-18 show that the whitening medical bioremediation film containing traditional Chinese medicines prepared according to the traditional Chinese medicine formula provided by the invention has the best treatment effects of whitening, skin repair and moisturizing compared with the two whitening medical bioremediation films containing traditional Chinese medicines for adjusting the dosage of the mixed concentrated solution of the traditional Chinese medicine formula provided by the invention.
(5) The effect rankings in tables 16-18 show that, compared with the common facial mask containing other traditional Chinese medicines in the existing product at present, the medical whitening biological repair film containing traditional Chinese medicines prepared according to the traditional Chinese medicine formula provided by the invention has the best treatment effects of whitening, skin repair and moisturizing.

Claims (7)

1. A whitening medical biological repair film containing traditional Chinese medicines is characterized by being prepared from the following raw materials in parts by weight: 3-10 parts of pearl powder, 1-1.5 parts of white muscardine silkworm, 3-6 parts of gentian, 5-10 parts of mulberry leaf, 3-10 parts of common perilla, 3-10 parts of szechuan lovage rhizome, 3-10 parts of angelica dahurica and 2-10 parts of raw liquorice; and (3) other ingredients: 100-150 parts of deionized water, 0.1-0.5 part of sodium hyaluronate, 1-3 parts of vitamin E, 1-3 parts of amino acid, 1-5 parts of hydrolyzed collagen, 1-3 parts of nicotinamide, 1-5 parts of deoxyarbutin and 3-6 parts of glycerol.
2. The traditional Chinese medicine-containing whitening medical bioprosthetic film of claim 1 is prepared from the following raw materials in parts by weight: 6 parts of pearl powder, 1.2 parts of white muscardine silkworm, 5 parts of gentian, 8 parts of mulberry leaf, 6 parts of common perilla, 6 parts of szechuan lovage rhizome, 6 parts of angelica dahurica, 6 parts of raw liquorice, 120 parts of deionized water, 0.3 part of sodium hyaluronate, 2 parts of vitamin E, 2 parts of amino acid, 3 parts of hydrolyzed collagen, 2 parts of nicotinamide, 4 parts of deoxyarbutin and 5 parts of glycerol.
3. The preparation method of the traditional Chinese medicine-containing whitening medical bioprosthetic film as claimed in claim 1 or 2, characterized by comprising the following steps:
(1) preparing pearl powder, white muscardine silkworm, gentian, mulberry leaf, common perilla, szechuan lovage rhizome, dahurian angelica root and raw liquoric root into a nano traditional Chinese medicine powder mixing material by adopting a nano traditional Chinese medicine powder preparation process;
(2) mixing the nanometer Chinese medicinal powder mixture obtained in step (1) with 10-25L distilled water by static boiling method, decocting for 45-100min, cooling to 40-60 deg.C to obtain Chinese medicinal mixed concentrated solution;
(3) heating deionized water to 80-85 deg.C, adding sodium hyaluronate and glycerol, homogenizing, and keeping the temperature for 5-10min to obtain sodium hyaluronate mixture;
(4) cooling the sodium hyaluronate mixture obtained in the step (3) to 40-50 ℃, adding the traditional Chinese medicine mixed concentrated solution obtained in the step (2), adding vitamin E, amino acid, hydrolyzed collagen, nicotinamide and deoxyarbutin, homogenizing, cooling to 38 ℃, and standing until the solution is completely swelled into a transparent solution, thereby obtaining the repairing membrane additive;
(5) filtering the repairing membrane additives obtained in the step (4) into repairing membrane additives with five molecular weight grades of large, medium, small, micro and ultramicro by adopting a micro-filtration membrane, an ultrafiltration membrane, a nanofiltration membrane and a reverse osmosis membrane respectively;
(6) adopting an artificial intelligence manufacturing full-automatic whole-process cold distribution production line, cooling the repairing film additives of the five molecular weight grades obtained in the step (5) to 0-15 ℃, and accurately coating the repairing film additives on a carrier or mixing the repairing film additives into the carrier according to five molecular weights of large, medium, small, micro and ultramicro from small to large;
(7) and (4) packaging the medical bioprosthetic film obtained in the step (6) according to different carriers.
4. The preparation method of the traditional Chinese medicine-containing whitening medical bioprosthetic film of claim 3, which is characterized by comprising the following steps of:
and (6) the carrier comprises medical biological repair membrane paper, mineral mud or jelly glue.
5. The preparation method of the traditional Chinese medicine-containing whitening medical bioprosthetic film of claim 4, which is characterized by comprising the following steps:
the amount of the repair film additive coated or mixed in the step (6) is 15-25 mL.
6. The preparation method of the traditional Chinese medicine-containing whitening medical bioprosthetic film of claim 4, which is characterized by comprising the following steps: the medical bioremediation film paper is non-woven fabric or biological fiber.
7. The preparation method of the traditional Chinese medicine-containing whitening medical bioprosthetic film of claim 4, which is characterized by comprising the following steps: the addition amount of the mineral mud or the jelly glue agent is 100 parts.
CN201910952972.3A 2019-10-08 2019-10-08 Whitening medical biological repair film containing traditional Chinese medicines and preparation method thereof Pending CN110721143A (en)

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