CN110755273A - Chinese medicine-containing microcapsule powder whitening medical biological repair dressing and preparation method thereof - Google Patents

Chinese medicine-containing microcapsule powder whitening medical biological repair dressing and preparation method thereof Download PDF

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Publication number
CN110755273A
CN110755273A CN201910952925.9A CN201910952925A CN110755273A CN 110755273 A CN110755273 A CN 110755273A CN 201910952925 A CN201910952925 A CN 201910952925A CN 110755273 A CN110755273 A CN 110755273A
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microcapsule powder
parts
traditional chinese
whitening
chinese medicine
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Inventor
董莉莉
韩星
练成
郭晓青
吴均福
齐宪臣
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Gansu Jindong Health Technology Co Ltd
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Gansu Jindong Health Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95

Abstract

The dressing comprises pearl powder, white muscardine silkworm, gentian, mulberry leaf, common perilla, szechuan lovage rhizome, dahurian angelica root and raw liquorice, the traditional Chinese medicines are prepared into a traditional Chinese medicine mixed concentrated solution, the traditional Chinese medicine mixed concentrated solution and other auxiliary materials are added into a sodium hyaluronate mixed material to prepare a transparent solution, the transparent solution is used as a core material to be uniformly mixed with a capsule wall material, and the transparent solution is prepared into microcapsule powder through spray drying equipment, so that the traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressing is obtained. The traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressing provided by the invention has three effects of professional biological whitening, skin repair and moisturizing, is simple and effective in formula, clear in component effect and action mechanism, strong in pertinence and specificity and high in safety, and fills the blank of a professional medical microcapsule powder whitening medical biological repair dressing product.

Description

Chinese medicine-containing microcapsule powder whitening medical biological repair dressing and preparation method thereof
Technical Field
The invention belongs to the technical field of medical materials, and particularly relates to a traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressing and a preparation method thereof.
Background
The pursuit of whitening by Asian women never stops just like the pursuit of brightness by human beings, blusher is almost a necessary product of every adult woman, and the blusher is a general powder decoration family of forests such as concealer, foundation, loose powder, makeup powder, pressed powder and the like.
Common whitening methods are: cosmetic whitening, natural whitening, moisturizing whitening, sun screening, freckle removing, toxin expelling, medical whitening, food whitening, fruit whitening, massage whitening and the like.
The process of whitening is also the process of skin renewal and cleansing, and removal of the aged stratum corneum leaves the skin drier, which is very prone to melanin production, and therefore requires timely supplementation of nutrients and water. Moisturizing can also be said to be a basic lesson that any skin needs to do. How to whiten and moisturize the skin is a common topic of concern for women.
At present, most of whitening facial cleansers, skin fresheners, essence, skin care creams and face creams belong to skin care products and cosmetics, the effects of the whitening facial cleansers and the face cleansers are limited to conventional effects of whitening, moisturizing and the like, and the treatment effects of repairing skin wounds, discharging toxins, removing melanin and the like are lacked.
In the field of medical dressings, enterprises in China produce medical skin care products as upgrading products of traditional skin care products by taking various traditional Chinese medicine extracts as additives. However, the products only have the conventional skin care effects of moisturizing, whitening, resisting aging and the like, and basically have no whitening treatment and skin repair effects on pigment skin.
Therefore, in the market, medical-grade skin care products with whitening and repairing effects are blank, and high-end medical-grade microcapsule powder whitening medical biological repair dressing products with three effects of professional biological whitening, skin repairing and moisturizing are not available.
The microcapsule technology is a technology of embedding and sealing solid, liquid or gas substances in a micro polymer film to form a solid particle product, so that the coated materials can be protected and isolated from the external environment, the original color, flavor, performance and biological activity are maintained to the maximum extent, and the damage and loss of nutrient substances are prevented.
China is in a rapid development stage in the application field of microcapsule technology, and has been successfully applied in many fields such as food, chemical engineering, medicine, biotechnology and the like. In the field of medical dressings, the medicinal components of the traditional dressings can be packaged and stored by a microcapsule technology, so that the biological activity of the medicinal components is maintained to the maximum extent, the medicinal components are prevented from being oxidized, sensitive components are protected, the release speed and time are controlled, meanwhile, the damage and loss of nutrient substances are prevented, and the treatment effect of the medical dressings can be obviously enhanced.
Disclosure of Invention
One of the purposes of the invention is to provide a medical biological repair dressing containing traditional Chinese medicine microcapsule powder for whitening skin;
the invention also aims to provide a preparation method of the Chinese medicinal microcapsule powder whitening medical biological repair dressing.
In order to achieve the purpose, the invention adopts the technical scheme that:
a microcapsule powder whitening medical biological repair dressing containing traditional Chinese medicines comprises the following raw materials in parts by weight: 3-10 parts of pearl powder, 1-1.5 parts of white muscardine silkworm, 3-6 parts of gentian, 5-10 parts of mulberry leaf, 3-10 parts of common perilla, 3-10 parts of szechuan lovage rhizome, 3-10 parts of angelica dahurica, 2-10 parts of raw liquoric root, 0.1-0.5 part of sodium hyaluronate, 3-6 parts of glycerol, auxiliary materials and capsule wall materials.
In order to further realize the invention, the dosage form of the dressing comprises repair and maintenance ice liquid microcapsule powder, repair and maintenance ice dew microcapsule powder, repair and maintenance ice milk microcapsule powder, repair and maintenance gel microcapsule powder and repair and maintenance cream microcapsule powder.
In order to further realize the invention, the capsule wall material consists of 20-30 parts of chitosan and 10-20 parts of sodium alginate.
In order to further realize the invention, the auxiliary materials comprise 150 parts of deionized water 100-150 parts, vitamin E1-3 parts, 1-3 parts of amino acid, 1-5 parts of hydrolyzed collagen, 1-3 parts of nicotinamide and 1-5 parts of deoxyarbutin.
In order to further realize the invention, the auxiliary materials for repairing and maintaining the ice cream microcapsule powder also comprise the following raw materials in parts by weight: 6-9 parts of lecithin and 3-6 parts of xanthan gum.
In order to further realize the invention, the auxiliary materials of the repairing and nourishing gel microcapsule powder also comprise the following raw materials in parts by weight: 9-12 parts of lecithin and 6-10 parts of xanthan gum.
In order to further realize the invention, the auxiliary materials of the repairing and nourishing cream microcapsule powder also comprise the following raw materials in parts by weight: 10-15 parts of lecithin and 9-12 parts of xanthan gum.
A preparation method of a Chinese medicine-containing microcapsule powder whitening medical biological repair dressing is characterized by comprising the following steps:
(1) preparing pearl powder, white muscardine silkworm, gentian, mulberry leaf, common perilla, szechuan lovage rhizome, dahurian angelica root and raw liquoric root into a nano traditional Chinese medicine powder mixing material by adopting a nano traditional Chinese medicine powder preparation process;
(2) mixing the nanometer Chinese medicinal powder mixture obtained in step (1) with 10-25L deionized water by static boiling method, decocting for 45-100min, and cooling to 40-60 deg.C to obtain Chinese medicinal mixed concentrated solution;
(3) heating deionized water to 80-85 deg.C, adding sodium hyaluronate and glycerol, homogenizing, and keeping the temperature for 5-10min to obtain sodium hyaluronate mixture;
(4) cooling the sodium hyaluronate mixture obtained in the step (3) to 40-50 ℃, adding different amounts of the traditional Chinese medicine mixed concentrated solution obtained in the step (2) according to dosage forms, adding different auxiliary materials according to dosage forms, homogenizing, cooling to 38 ℃, and standing until the solution is completely swelled;
(5) and (4) uniformly mixing the transparent solution obtained in the step (4) as a core material with a capsule wall material, and preparing the mixture into microcapsule powder by spray drying equipment to obtain the traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressing.
In order to further realize the invention, the Chinese medicinal mixed concentrated solution with different dosage is added according to the dosage form in the step (4):
adding 20-40% of the Chinese medicinal concentrated solution into the repairing and nourishing gel microcapsule powder;
adding 60-80% of the Chinese medicinal concentrated solution into the repairing and maintaining ice liquid microcapsule powder;
respectively adding 80-100% of the Chinese medicinal concentrated solution into the repairing and maintaining ice dew microcapsule powder and the repairing and maintaining ice milk microcapsule powder;
the repairing and nourishing cream microcapsule powder is added with 100 percent of traditional Chinese medicine mixed concentrated solution.
Compared with the prior art, the invention has the beneficial effects that:
the main components of the microcapsule powder whitening medical biological repair dressing containing the traditional Chinese medicine provided by the invention not only contain nicotinamide, deoxyarbutin and sodium hyaluronate with whitening efficacy, but also contain a traditional Chinese medicine formula which has skin repairing and whitening efficacies and is formed by compatibility of pearl powder, white muscardine silkworm, gentian, mulberry leaf, common perilla, ligusticum wallichii, radix angelicae and raw liquorice, and no chemical preparation which is easy to cause skin reaction, such as hormone, antibiotic, heavy metal, alcohol, essence, pigment fluorescent agent, preservative and the like is added, so that the dressing is safe when being used by special people with poor skin resistance and the like due to hormone.
Pearl powder: has bitter, cold and salty taste, and has effects of invigorating heart and liver channel, removing pox, treating toxic materials, improving immunity, delaying aging, removing speckle, whitening skin, and supplementing calcium. Is compatible with raw licorice, and has the effects of whitening, moisturizing, tonifying qi and enriching blood.
White muscardine silkworm: salty, pungent and mild in nature and flavor, enters liver and lung meridians, and has the effects of removing chloasma, eliminating senile plaque and sunburn. The product is compatible with folium Mori, and has effects of repairing skin, resolving macula and whitening skin.
Gentian: is bitter and cold in nature, enters liver, gallbladder and stomach channels, and has the effects of clearing heat, eliminating dampness, purging excessive fire of liver and gallbladder, inhibiting tyrosinase active ingredients, and destroying melanin formation environment. It is combined with radix Angelicae Dahuricae to regulate skin metabolism and inhibit melanin formation.
Mulberry leaf: has bitter, sweet and cold property, enters liver and lung channels, has good skin beautifying effect, and particularly has better curative effect on acne and brown spots on the face. The product is combined with radix Angelicae Dahuricae to repair skin and increase skin elasticity.
White perilla: is bitter in nature, sweet and warm in taste, and has the effects of tonifying qi and spleen, eliminating dampness and promoting diuresis, moistening skin and the like, and spleen and stomach meridians entered. The product is combined with rhizoma Ligustici Chuanxiong, and has effects of moistening skin, and replenishing water.
Ligusticum wallichii: has pungent and warm nature and flavor, enters liver, gallbladder and pericardium channels, and has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind, relieving pain, moistening skin, relieving itching and improving facial nutrition. It is combined with radix Glycyrrhizae to achieve the effects of replenishing water and keeping moisture.
Radix angelicae: has pungent and warm nature and flavor, enters lung and stomach meridians, and has effects of improving microcirculation, promoting skin metabolism, and delaying skin aging.
Raw licorice root: has sweet and mild nature and taste, and has effects of invigorating spleen, invigorating qi, whitening skin, and keeping moisture.
Deionized water: can better control the microorganisms and impurities of the product.
Sodium hyaluronate: can form a layer of air-permeable film on the surface of skin to make the skin smooth and moist, promote proliferation and differentiation of epidermal cells, remove oxygen free radicals, and promote regeneration of the skin at the injured part.
Vitamin E: can provide the skin with the functions of keeping the skin elasticity, supplementing water and improving and enhancing the elasticity of new cells.
Amino acids: has effects of activating cells, improving metabolism and blood circulation, and reviving skin.
Hydrolyzing collagen: has effects in supplementing collagen, restoring skin elasticity, restoring firmness, reducing sagging phenomenon, and smoothing fine lines and wrinkles.
Nicotinamide: has the effects of accelerating the metabolism of the skin and the dissolution of melanin at the bottom layer of the skin, thereby achieving the whitening effect of the skin.
And (3) deoxyarbutin: has the effect of reducing melanin synthesis by inhibiting the activity of tyrosinase.
Lecithin: the emulsifier, also known as lecithin, has the effect of providing sufficient nutrients such as water and oxygen to the skin to make the skin smooth and soft.
Xanthan gum: has effects in moisturizing skin and delaying skin aging, and can be used as viscosity regulator.
Glycerol: is a moisturizing factor indispensable to cells, has excellent capacity of regulating skin metabolism, promotes the activity of skin aquaporins, and assists in promoting skin metabolism and purification.
Chitosan and sodium alginate: the capsule wall material commonly used for preparing the microcapsule powder.
The traditional Chinese medicine formula and the additive fully consider six compatibility relations of mutual reinforcement, mutual induction, mutual incompatibility, mutual killing, mutual inhibition and reverse between the traditional Chinese medicine formula and the additive and effect differences generated under different dosage proportions of the traditional Chinese medicines and the additive according to the mechanisms of the traditional Chinese medicine science, the traditional Chinese medicine prescriptions and the traditional Chinese medicine pharmacology, optimize dosage and accurately prepare the traditional Chinese medicine formula and the additive, and carry out combination reaction on effective bioactive components dissolved out of the traditional Chinese medicines by using a static boiling method and mixing and decocting the traditional Chinese medicines by using distilled water to form a more complex combination with specific effects, generate huge synergistic effect and greatly enhance the treatment effect, wherein the specific action mechanism is as follows:
the silkworm, the gentian, the mulberry leaf and the angelica dahurica are used as main medicines, and can remove freckles, regulate skin metabolism and delay skin aging; the pearl powder, the common perilla, the szechuan lovage rhizome and the raw liquorice are used as the assistant drugs, and have the effects of tonifying qi and blood, repairing skin, whitening and moisturizing, moistening skin and relieving itching and the like; the main drug property is bitter, salty, pungent and cold, the auxiliary drug property is sweet and mild, and the main drug property and the auxiliary drug property are mutually incompatible, so that the product is mild and has no stimulation; silkworm, gentian and mulberry leaf are mutually matched to enhance the freckle removing effect; radix Gentianae and radix Angelicae Dahuricae are mutually reinforced, and can regulate skin metabolism and inhibit melanin formation; the pearl powder and the angelica dahurica are matched, so that the skin can be repaired, and the effects of moisturizing and wrinkle resisting are achieved; the ligusticum wallichii and the raw liquorice are mutually matched, so that the effects of supplementing water and preserving moisture can be enhanced; the efficacies of replenishing qi and blood and repairing skin of the traditional Chinese medicine formula are in mutual reinforcement with the moisturizing efficacy of additives such as sodium hyaluronate and the like, and the efficacies of repairing skin and increasing skin elasticity can be enhanced; the traditional Chinese medicine formula has the effects of removing freckles, whitening, moisturizing, resisting wrinkles and inhibiting melanin, is matched with the whitening effect of additives such as nicotinamide, deoxyarbutin and the like, and can strengthen the effects of expelling toxin, removing freckles and whitening.
The traditional Chinese medicine formula adopted by the traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressing is prepared according to the traditional Chinese medicine science, the traditional Chinese medicine prescriptions and the traditional Chinese medicine pharmacology mechanism, is simple and effective, has definite component efficacy and action mechanism, strong pertinence and speciality and high safety, has the effects of improving human immunity, delaying senility, removing freckles, whitening, tonifying qi, enriching blood, repairing skin, clearing heat, drying dampness, purging liver and gallbladder excess fire, inhibiting the active ingredients of tyrosinase, destroying the melanin formation environment, regulating skin metabolism, inhibiting melanin formation, treating acne, increasing skin elasticity, tonifying qi, strengthening spleen, eliminating dampness, promoting diuresis, moistening skin, relieving itching, improving facial nutrition, moisturizing, improving microcirculation, whitening, moisturizing and the like, and is cooperated with the additives with the whitening effect such as nicotinamide, deoxyarbutin, sodium hyaluronate and the like, the skin care product also has multiple effects of being mild and non-irritant, relieving the skin, discharging toxin, removing melanin, opening the inherent luster of the skin, repairing damaged skin epidermal cells, deeply nourishing the skin, enhancing the elasticity of the skin, effectively relieving allergy, improving the dry state of the skin, supplementing the moisture of the skin, moisturizing the skin and the like. The microcapsule powder whitening medical biological repair dressing containing the traditional Chinese medicines is matched with various products, and fills the blank that the current market has three effects of professional biological whitening, skin repair and moisturizing, and a professional medical microcapsule powder whitening medical biological repair dressing product.
According to the experimental results of the embodiment, the treatment effects of the microcapsule powder whitening medical biological repair dressing containing the traditional Chinese medicines are as follows: 1. compared with the common whitening skin care product which does not contain traditional Chinese medicines in the existing product, the microcapsule powder whitening medical biological repair dressing has the function of whitening treatment; 2. compared with the common whitening skin care product which does not contain traditional Chinese medicines in the existing product, the microcapsule powder whitening medical biological repair dressing containing traditional Chinese medicines has the advantage that the treatment effect of skin repair is increased; 3. compared with the common whitening skin care product which does not contain traditional Chinese medicines in the existing product, the microcapsule powder whitening medical biological repair dressing containing traditional Chinese medicines enhances the moisturizing and moisturizing treatment effects of the skin; 4. compared with two kinds of traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressings which are prepared by adjusting the dosage of the mixed concentrated solution of the traditional Chinese medicine formula, the traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressing prepared according to the traditional Chinese medicine formula provided by the invention has the best treatment effects of whitening, repairing skin and moisturizing; 5. compared with the common whitening skin care product containing other traditional Chinese medicines in the existing product, the microcapsule powder whitening medical biological repair dressing containing the traditional Chinese medicines prepared according to the traditional Chinese medicine formula provided by the invention has the best treatment effects of whitening, repairing skin and moisturizing.
The invention also provides a preparation method of the Chinese medicinal microcapsule powder whitening medical biological repair dressing, and the microcapsule technology adopted by the method has the following effects: 1. medical dressing components which are difficult to process and store are solidified, so that the solubility and the storage stability of the medical dressing components are improved; 2. the volatility is reduced, the volatilization of the odor components of the traditional Chinese medicine is prevented, and the loss of the drug effect is reduced; 3, possible stimulation to the skin can be reduced by controlling the release speed, so that the directional release effect is achieved; 4. the stability of the medical dressing is improved, the medical dressing is prevented from being oxidized, the influence of ultraviolet rays, temperature, humidity and the like is avoided or reduced, the medical components and the nutritional components are not lost, and the treatment effect is not lost; 5. can uniformly mix incompatible components and release the incompatible components in order; 6. isolating the active ingredient and maintaining the activity of the medicinal ingredient in the medical dressing; 7. controlling the time and quantity of the release and action of the medical dressing medicinal components; 8. greatly improves the absorption efficiency of the skin to the medical components of the medical dressing, and further quickly and obviously enhances the treatment effect of the medical dressing.
The traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressing provided by the invention has three effects of professional biological whitening, skin repair and moisturizing, is simple and effective in formula, clear in component effect and action mechanism, strong in pertinence and specificity and high in safety, and fills the blank of a professional medical microcapsule powder whitening medical biological repair dressing product.
Detailed Description
The present invention will be further described with reference to the following embodiments.
Example 1:
(1) preparing 10g of pearl powder, 1.5g of white muscardine silkworm, 6g of gentian, 5-10g of mulberry leaf, 10g of common perilla, 10g of szechuan lovage rhizome, 10g of angelica root and 10g of raw liquorice into a nano traditional Chinese medicine powder mixing material by adopting a nano traditional Chinese medicine powder preparation process;
(2) mixing the nanometer Chinese medicinal powder mixture obtained in step (1) with 25L distilled water by static boiling method, decocting for 100min, and cooling to 60 deg.C to obtain Chinese medicinal mixed concentrated solution;
(3) heating 150g of deionized water to 85 ℃, adding 0.5g of sodium hyaluronate and 6g of glycerol, homogenizing uniformly, and keeping the temperature for 10min to obtain a sodium hyaluronate mixture;
(4) cooling the sodium hyaluronate mixture obtained in the step (3) to 50 ℃, and adding different amounts of the traditional Chinese medicine mixed concentrated solution obtained in the step (2) according to dosage forms, wherein:
respectively adding 40% of traditional Chinese medicine mixed concentrated solution into the repairing quick-cleaning water gel micro-capsule powder and the repairing moistening gel micro-capsule powder;
adding 80% of the traditional Chinese medicine mixed concentrated solution into the repairing and maintaining ice liquid microcapsule powder;
respectively adding the repairing and maintaining ice dew microcapsule powder and the repairing and maintaining ice milk microcapsule powder into 100% of traditional Chinese medicine mixed concentrated solution;
adding 100% of the traditional Chinese medicine mixed concentrated solution into the repairing and nourishing cream microcapsule powder;
then adding different auxiliary materials according to the dosage form, wherein:
adding vitamin E3g, amino acid 3g, hydrolyzed collagen 5g, sodium laureth sulfate 10g, nicotinamide 3g, deoxyarbutin 5g, lecithin 8g and xanthan gum 5g into the repairing quick-cleaning water gel microcapsule powder;
adding vitamin E3g, amino acid 3g, hydrolyzed collagen 5g, nicotinamide 3g and deoxyarbutin 5g into the repairing and maintaining ice liquid microcapsule powder;
adding vitamin E3g, amino acid 3g, hydrolyzed collagen 5g, nicotinamide 3g and deoxyarbutin 5g into the repairing and maintaining ice dew microcapsule powder;
adding vitamin E3g, amino acid 3g, hydrolyzed collagen 5g, nicotinamide 3g, deoxyarbutin 5g, lecithin 9g and xanthan gum 6g into the repairing and maintaining ice cream microcapsule powder;
adding vitamin E3g, amino acid 3g, hydrolyzed collagen 5g, nicotinamide 3g, deoxyarbutin 5g, lecithin 12g and xanthan gum 10g into the repairing and nourishing gel microcapsule powder;
adding vitamin E3g, amino acid 3g, hydrolyzed collagen 5g, nicotinamide 3g, deoxyarbutin 5g, lecithin 15g and xanthan gum 12g into the repairing and nourishing cream microcapsule powder;
homogenizing, cooling to 38 deg.C, standing until the solution is completely swelled;
(5) and (3) uniformly mixing the transparent solution obtained in the step (4) as a core material with 30g of chitosan and 20g of sodium alginate serving as capsule wall materials, and preparing the mixture into microcapsule powder by using spray drying equipment to obtain the traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressing.
Example 2:
(1) preparing 6g of pearl powder, 1.2g of white muscardine silkworm, 5g of gentian, 8g of mulberry leaf, 6g of common perilla, 6g of szechuan lovage rhizome, 6g of angelica root and 6g of raw liquorice into a nano traditional Chinese medicine powder mixing material by adopting a nano traditional Chinese medicine powder preparation process;
(2) mixing the nanometer Chinese medicinal powder mixture obtained in step (1) with 18L distilled water by static boiling method, decocting for 60min, and cooling to 45 deg.C to obtain Chinese medicinal mixed concentrated solution;
(3) heating 120g of deionized water to 82 ℃, adding 0.3g of sodium hyaluronate and 5g of glycerol, homogenizing uniformly, and keeping the temperature for 8min to obtain a sodium hyaluronate mixture;
(4) cooling the sodium hyaluronate mixture obtained in the step (3) to 45 ℃, and adding different amounts of the traditional Chinese medicine mixed concentrated solution obtained in the step (2) according to dosage forms, wherein:
respectively adding 30% of traditional Chinese medicine mixed concentrated solution into the repairing quick-cleaning water gel micro-capsule powder and the repairing moistening gel micro-capsule powder;
adding 70% of the traditional Chinese medicine mixed concentrated solution into the repairing and maintaining ice liquid microcapsule powder;
respectively adding 90% of the traditional Chinese medicine mixed concentrated solution into the repairing and maintaining ice dew micro-capsule powder and the repairing and maintaining ice milk micro-capsule powder;
adding 100% of the traditional Chinese medicine mixed concentrated solution into the repairing and nourishing cream microcapsule powder;
then adding different auxiliary materials according to the dosage form, wherein:
adding vitamin E2g, amino acid 2g, hydrolyzed collagen 3g, sodium laureth sulfate 8g, nicotinamide 2g, deoxyarbutin 3g, lecithin 6g and xanthan gum 4g into the repairing quick-cleaning water gel microcapsule powder;
adding vitamin E2g, amino acid 2g, hydrolyzed collagen 3g, nicotinamide 2g and deoxyarbutin 3g into the repairing and maintaining ice liquid microcapsule powder;
adding vitamin E2g, amino acid 2g, hydrolyzed collagen 3g, nicotinamide 2g and deoxyarbutin 3g into the repairing and maintaining ice dew microcapsule powder;
adding vitamin E2g, amino acid 2g, hydrolyzed collagen 3g, nicotinamide 2g, deoxyarbutin 3g, lecithin 7g and xanthan gum 4g into the repairing and maintaining ice cream microcapsule powder;
adding vitamin E2g, amino acid 2g, hydrolyzed collagen 3g, nicotinamide 2g, deoxyarbutin 3g, lecithin 10g and xanthan gum 8g into the repairing and nourishing gel microcapsule powder;
vitamin E2g, 2g of amino acid, 3g of hydrolyzed collagen, 2g of nicotinamide, 3g of deoxyarbutin, 12g of lecithin and 10g of xanthan gum are added into the repairing and nourishing cream microcapsule powder;
homogenizing, cooling to 38 deg.C, standing until the solution is completely swelled;
(5) and (4) uniformly mixing the transparent solution obtained in the step (4) as a core material with 25g of chitosan serving as a capsule wall material and 15g of sodium alginate, and preparing the mixture into microcapsule powder by using spray drying equipment to obtain the traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressing.
Example 3:
(1) preparing 3g of pearl powder, 1g of white muscardine silkworm, 3g of gentian, 5g of mulberry leaf, 3g of common perilla, 3g of szechuan lovage rhizome, 3g of angelica root and 2g of raw liquorice into a nano traditional Chinese medicine powder mixing material by adopting a nano traditional Chinese medicine powder preparation process;
(2) mixing the nanometer Chinese medicinal powder mixture obtained in step (1) with 10L distilled water by static boiling method, decocting for 45min, and cooling to 40 deg.C to obtain Chinese medicinal mixed concentrated solution;
(3) heating 100g of deionized water to 80 ℃, adding 0.1g of sodium hyaluronate and 3g of glycerol, homogenizing uniformly, and keeping the temperature for 5min to obtain a sodium hyaluronate mixture;
(4) cooling the sodium hyaluronate mixture obtained in the step (3) to 40 ℃, and adding different amounts of the traditional Chinese medicine mixed concentrated solution obtained in the step (2) according to dosage forms, wherein:
respectively adding 20% of traditional Chinese medicine mixed concentrated solution into the repairing quick-cleaning water gel micro-capsule powder and the repairing moistening gel micro-capsule powder;
adding 60% of the traditional Chinese medicine mixed concentrated solution into the repairing and maintaining ice liquid microcapsule powder;
respectively adding 80% of the Chinese medicinal concentrated solution into the repairing and maintaining ice dew microcapsule powder and the repairing and maintaining ice milk microcapsule powder;
adding 100% of the traditional Chinese medicine mixed concentrated solution into the repairing and nourishing cream microcapsule powder;
then adding different auxiliary materials according to the dosage form, wherein:
adding vitamin E1g, amino acid 1g, hydrolyzed collagen 1g, sodium laureth sulfate 6g, nicotinamide 1g, deoxyarbutin 1g, lecithin 3g and xanthan gum 3g into the repairing quick-cleaning water gel microcapsule powder;
adding vitamin E1g, amino acid 1g, hydrolyzed collagen 1g, nicotinamide 1g and deoxyarbutin 1g into the repairing and maintaining ice liquid microcapsule powder;
adding vitamin E1g, amino acid 1g, hydrolyzed collagen 1g, nicotinamide 1g and deoxyarbutin 1g into the repairing and maintaining ice dew microcapsule powder;
vitamin E1g, amino acid 1g, hydrolyzed collagen 1g, nicotinamide 1g, deoxyarbutin 1g, lecithin 6g and xanthan gum 3g are added into the repairing and maintaining ice cream microcapsule powder;
adding vitamin E1g, amino acid 1g, hydrolyzed collagen 1g, nicotinamide 1g, deoxyarbutin 1g, lecithin 9g and xanthan gum 6g into the repairing and nourishing gel microcapsule powder;
vitamin E1g, amino acid 1g, hydrolyzed collagen 1g, nicotinamide 1g, deoxyarbutin 1g, lecithin 10g and xanthan gum 9g are added into the repairing and nourishing cream microcapsule powder;
homogenizing, cooling to 38 deg.C, standing until the solution is completely swelled;
(5) and (4) uniformly mixing the transparent solution obtained in the step (4) as a core material with 20g of chitosan and 10g of sodium alginate serving as capsule wall materials, and preparing the mixture into microcapsule powder by using spray drying equipment to obtain the traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressing.
Experimental example 1:
(1) comparative experiment for scald repair of white rat: taking 25 white rats with the weight of about 110g, carrying out back unhairing treatment by using 6.5% sodium sulfide solution, wherein the unhairing area is 2.5cm multiplied by 2.0cm, and normally feeding the white rats for 12h after being washed clean by deionized water. The wounds were cut along the depilated site with a laser beam after anaesthesia with ether at a cutting rate of 0.5m/min, resulting in post-operative wounds which were then randomly divided into five groups of 5 per group. Then, the maintenance ice liquid micro-capsule powder (essence), the maintenance gel micro-capsule powder (maintenance milk) and the maintenance nourishing cream micro-capsule powder (face cream) prepared by the formula and the preparation method of the embodiment 1 are coated in the coating sequence, and are replaced once every 2 hours for 10 times at most, scabbing is taken as a healing judgment condition, scabbing time is taken as a comparison index, and the experimental result is shown in table 1.
(2) Comparative experiment of face whitening and moisturizing treatment: 25 female volunteers aged 35-40 years and weighed 45-55kg, had no other facial skin diseases, similar skin color brightness values and skin moisture contents, and were randomly divided into five groups of 5 persons each. Then, the skin-care ice cream microcapsule powder (essence), the repair and nourishing gel microcapsule powder (repair cream) and the repair and nourishing cream microcapsule powder (face cream) prepared by the formulation and the preparation method of example 1 were coated in the order of coating, changed 2 times per day for a total of 5 days, and the moisture index contained in the facial skin and the index (L value in L a b) reflecting the skin brightness before and after the experiment were detected and recorded by a skin detector, and the average value on the day calculated for each group was used as a comparative index. The tested volunteers were cleaned after applying for 1h every day, and the facial muscles were relaxed for 30min at room temperature of 22-25 deg.C and relative humidity of 55 + -5%. An Ina high-precision skin detector is used for detecting the moisture index of the facial skin, the probe repeatedly measures for 3 times in the same measured area during measurement, and an average value is obtained. The results are shown in tables 2-3. Skin brightness index was measured using a multifunctional skin tester MPA9, Courage Khazaka electronics, germany.
TABLE 1 comparative experiment results for scald repair
Figure BDA0002225893370000101
Figure BDA0002225893370000111
Table 2 results of the comparative experiment for whitening the face
Test object Before the experiment Day 1 Day 2 Day 3 Day 4 Day 5
Volunteer 1 64.38 66.18 67.77 69.40 71.06 73.48
Volunteer 2 65.06 66.56 68.09 69.65 71.95 73.61
Volunteer 3 64.81 66.43 68.76 70.47 72.24 74.76
Volunteer 4 64.32 65.67 67.05 68.86 70.58 72.06
Volunteer 5 65.65 67.29 68.97 70.70 72.47 74.28
Average L value 64.84 66.43 68.13 69.82 71.66 73.64
Cumulative increment 0.00 1.58 3.28 4.97 6.82 8.79
TABLE 3 comparison of the results of the Water supplement treatment
Test object Before the experiment Day 1 Day 2 Day 3 Day 4 Day 5
Volunteer 1 36.24 37.11 37.78 38.34 39.11 39.89
Volunteer 2 35.57 36.14 37.11 37.63 38.31 38.89
Volunteer 3 36.42 37.04 37.63 38.53 39.23 40.17
Volunteer 4 36.05 36.70 37.32 38.29 38.83 39.37
Volunteer 5 35.93 36.46 37.12 37.64 38.20 38.66
Average water content 36.04 36.69 37.39 38.09 38.74 39.40
Cumulative increment 0.00 0.65 1.35 2.05 2.70 3.36
Experimental example 2:
(1) comparative experiment for scald repair of white rat: taking 25 white rats with the weight of about 110g, carrying out back unhairing treatment by using 6.5% sodium sulfide solution, wherein the unhairing area is 2.5cm multiplied by 2.0cm, and normally feeding the white rats for 12h after being washed clean by deionized water. The wounds were cut along the depilated site with a laser beam after anaesthesia with ether at a cutting rate of 0.5m/min, resulting in post-operative wounds which were then randomly divided into five groups of 5 per group. Then, the maintenance ice liquid micro-capsule powder (essence), the maintenance gel micro-capsule powder (maintenance milk) and the maintenance nourishing cream micro-capsule powder (face cream) prepared by the formula and the preparation method of the embodiment 1 are coated in the coating sequence, and are replaced once every 2 hours for 10 times at most, scabbing is taken as a healing judgment condition, scabbing time is taken as a comparison index, and the experimental result is shown in table 4.
(2) Comparative experiment of face whitening and moisturizing treatment: 25 female volunteers aged 35-40 years and weighed 45-55kg, had no other facial skin diseases, similar skin color brightness values and skin moisture contents, and were randomly divided into five groups of 5 persons each. Then, the skin-care ice cream microcapsule powder (essence), the repair and nourishing gel microcapsule powder (repair cream) and the repair and nourishing cream microcapsule powder (face cream) prepared by the formulation and the preparation method of example 1 were coated in the order of coating, changed 2 times per day for a total of 5 days, and the moisture index contained in the facial skin and the index (L value in L a b) reflecting the skin brightness before and after the experiment were detected and recorded by a skin detector, and the average value on the day calculated for each group was used as a comparative index. The tested volunteers were cleaned after applying for 1h every day, and the facial muscles were relaxed for 30min at room temperature of 22-25 deg.C and relative humidity of 55 + -5%. An Ina high-precision skin detector is used for detecting the moisture index of the facial skin, the probe repeatedly measures for 3 times in the same measured area during measurement, and an average value is obtained. The results are shown in tables 5-6. Skin brightness index was measured using a multifunctional skin tester MPA9, Courage Khazaka electronics, germany.
TABLE 4 comparative experiment results for scald repair
Test object Scab formation time (h)
White rat 1 8
White rat 2 9
White rat 3 8
White rat 4 7
White rat 5 9
Average 8.2
Table 5 comparative test results for facial whitening
Test object Before the experiment Day 1 Day 2 Day 3 Day 4 Day 5
Volunteer 1 64.65 68.85 70.23 71.63 73.78 75.55
Volunteer 2 65.12 67.99 70.98 74.10 77.06 78.60
Volunteer 3 64.72 67.05 68.39 70.44 71.85 74.01
Volunteer 4 64.05 69.17 74.71 77.70 81.58 83.21
Volunteer 5 65.72 69.01 73.15 74.61 76.47 78.00
Average L value 64.85 68.41 71.49 73.70 76.15 77.88
Cumulative increment 0.00 3.56 6.64 8.84 11.30 13.02
TABLE 6 comparative Experimental results of Water supplement treatment
Test object Before the experiment Day 1 Day 2 Day 3 Day 4 Day 5
Volunteer 1 36.47 37.49 38.43 39.39 40.49 41.50
Volunteer 2 36.85 37.74 38.61 39.57 40.56 41.61
Volunteer 3 36.33 37.23 38.24 39.16 40.25 41.26
Volunteer 4 35.95 36.74 37.65 38.71 39.64 40.71
Volunteer 5 35.85 36.74 37.66 38.60 39.49 40.48
Average water content 36.29 37.19 38.12 39.09 40.09 41.11
Cumulative increaseMeasurement of 0.00 0.90 1.83 2.80 3.80 4.82
Experimental example 3:
(1) comparative experiment for scald repair of white rat: taking 25 white rats with the weight of about 110g, carrying out back unhairing treatment by using 6.5% sodium sulfide solution, wherein the unhairing area is 2.5cm multiplied by 2.0cm, and normally feeding the white rats for 12h after being washed clean by deionized water. The wounds were cut along the depilated site with a laser beam after anaesthesia with ether at a cutting rate of 0.5m/min, resulting in post-operative wounds which were then randomly divided into five groups of 5 per group. Then, the maintenance ice liquid micro-capsule powder (essence), the maintenance gel micro-capsule powder (maintenance milk) and the maintenance nourishing cream micro-capsule powder (face cream) prepared by the formula and the preparation method of the embodiment 1 are coated in the coating sequence, and are replaced once every 2 hours for 10 times at most, scabbing is taken as a healing judgment condition, scabbing time is taken as a comparison index, and the experimental result is shown in table 7.
(2) Comparative experiment of face whitening and moisturizing treatment: 25 female volunteers aged 35-40 years and weighed 45-55kg, had no other facial skin diseases, similar skin color brightness values and skin moisture contents, and were randomly divided into five groups of 5 persons each. Then, the skin-care ice cream microcapsule powder (essence), the repair and nourishing gel microcapsule powder (repair cream) and the repair and nourishing cream microcapsule powder (face cream) prepared by the formulation and the preparation method of example 1 were coated in the order of coating, changed 2 times per day for a total of 5 days, and the moisture index contained in the facial skin and the index (L value in L a b) reflecting the skin brightness before and after the experiment were detected and recorded by a skin detector, and the average value on the day calculated for each group was used as a comparative index. The tested volunteers were cleaned after applying for 1h every day, and the facial muscles were relaxed for 30min at room temperature of 22-25 deg.C and relative humidity of 55 + -5%. An Ina high-precision skin detector is used for detecting the moisture index of the facial skin, the probe repeatedly measures for 3 times in the same measured area during measurement, and an average value is obtained. The results are shown in tables 8-9. Skin brightness index was measured using a multifunctional skin tester MPA9, Courage Khazaka electronics, germany.
Table 7 comparative experiment results for scald repair
Test object Scab formation time (h)
White rat 1 10
White rat 2 10
White rat 3 9
White rat 4 11
White rat 5 12
Average 10.4
Table 8 comparative test results for whitening of face
Test object Before the experiment Day 1 Day 2 Day 3 Day 4 Day 5
Volunteer 1 65.48 67.77 68.38 69.07 69.76 71.85
Volunteer 2 64.26 66.50 67.10 67.77 68.45 69.82
Volunteer 3 65.16 67.44 67.98 69.20 70.24 71.65
Volunteer 4 64.87 68.11 70.16 71.56 72.28 73.00
Volunteer 5 65.36 67.32 68.67 69.35 70.39 71.80
Average L value 65.03 67.43 68.46 69.39 70.22 71.62
Cumulative increment 0.00 2.41 3.43 4.37 5.20 6.60
TABLE 9 comparative Experimental results of Water supplement treatment
Figure BDA0002225893370000131
Figure BDA0002225893370000141
Experimental example 4:
common whitening skin care products which do not contain traditional Chinese medicines and have the same content of sodium hyaluronate are selected and coated according to the coating sequence of essence, skin care milk and face cream, the experimental method is the same as that of examples 1-3, and the experimental results are shown in tables 10-12.
Comparative experiment result for repairing surface 10 scald
Test object Scab formation time (h)
White rat 1 12
White rat 2 12
White rat 3 12
White rat 4 11
White rat 5 13
Average 12
Table 11 comparative results of skin whitening
Test object Before the experiment Day 1 Day 2 Day 3 Day 4 Day 5
Volunteer 1 65.27 65.47 65.79 66.06 66.39 66.65
Volunteer 2 65.20 66.50 66.70 67.10 67.44 67.78
Volunteer 3 65.84 66.04 66.43 66.63 66.97 67.17
Volunteer 4 64.81 65.26 65.59 65.92 66.18 66.31
Volunteer 5 64.35 64.48 64.80 65.13 65.39 65.58
Average L value 65.09 65.55 65.86 66.17 66.47 66.70
Cumulative increment 0.00 0.46 0.77 1.07 1.38 1.60
TABLE 12 comparative Experimental results of Water supplement treatment
Test object Before the experiment Day 1 Day 2 Day 3 Day 4 Day 5
Volunteer 1 35.71 35.85 35.92 36.00 36.10 36.18
Volunteer 2 36.24 36.35 36.46 36.53 36.64 36.70
Volunteer 3 36.40 36.51 36.69 36.80 36.89 37.00
Volunteer 4 36.14 36.21 36.32 36.43 36.54 36.65
Volunteer 5 35.73 35.84 35.94 36.02 36.12 36.16
Average water content 36.04 36.15 36.27 36.36 36.46 36.54
Cumulative increment 0.00 0.11 0.22 0.31 0.42 0.49
Experimental example 5:
selecting common moisturizing skin care products containing other traditional Chinese medicines and the same content of sodium hyaluronate in the existing products, coating according to the coating sequence of essence, skin care milk and face cream, and performing the same experimental method as in examples 1-3, wherein the experimental results are shown in tables 13-15.
Comparative experiment result for repairing surface 13 scald
Test object Scab formation time (h)
White rat 1 11
White rat 2 12
White rat 3 10
White rat 4 12
White rat 5 10
Average 11
Table 14 comparative test results for facial whitening
Test object Before the experiment Day 1 Day 2 Day 3 Day 4 Day 5
Volunteer 1 65.24 65.46 65.62 65.78 65.93 66.09
Volunteer 2 65.42 67.25 69.61 71.55 74.42 76.50
Volunteer 3 65.35 65.66 65.90 66.14 66.39 66.63
Volunteer 4 64.83 65.02 65.22 65.42 65.61 65.81
Volunteer 5 64.57 64.70 65.02 65.35 65.61 65.81
Average L value 65.08 65.62 66.27 66.85 67.59 68.17
Cumulative increment 0.00 0.54 1.19 1.77 2.51 3.09
TABLE 15 comparative Experimental results of Water supplement treatment
Test object Before the experiment Day 1 Day 2 Day 3 Day 4 Day 5
Volunteer 1 35.62 35.85 36.05 36.27 36.44 36.66
Volunteer 2 36.15 36.35 36.60 36.80 36.98 37.21
Volunteer 3 36.20 36.40 36.62 36.84 37.06 37.28
Volunteer 4 36.15 36.35 36.54 36.74 36.98 37.24
Volunteer 5 35.92 36.13 36.33 36.51 36.72 36.98
Average water content 36.01 36.21 36.43 36.63 36.84 37.08
Cumulative increment 0.00 0.21 0.42 0.62 0.83 1.07
Experimental examples 1-5 comprehensive comparative analysis comparison experiments on scald skin repair and comparison experiments on facial whitening and moisturizing treatment, the results are shown in tables 16-18:
TABLE 16 Experimental examples 1-5 comparative experimental results for scald repair
Figure BDA0002225893370000151
Table 17 experimental examples 1 to 5 comparative experimental results for whitening of face
Figure BDA0002225893370000152
Figure BDA0002225893370000161
TABLE 18 Experimental examples 1-5 comparative experimental results of water supplement treatment
Experimental examples 1-5 experimental data comparison results:
(1) the data in table 16 show that the medical biological repair dressing for whitening skin by using the microcapsule powder containing traditional Chinese medicine provided by the invention (example 2) has the best scabbing effect on the scalded part, and the scabbing effect is 8.2 h; when the traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressing (example 1) provided by the invention is used, the scabbing effect of a scald part is the second, and is 9.6 h; when the traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressing (example 3) provided by the invention is used, the scabbing effect of a scald part is the third, and is 10.4 hours; when the existing product is used for a common whitening skin care product containing other traditional Chinese medicines, the scabbing effect of the scalded part is the fourth, namely 11.0 h; when the common whitening skin care product without traditional Chinese medicines in the existing product is used, the scabbing time of the scalded part is the longest and is 12.0 h. Experimental data show that compared with the common whitening skin care product which does not contain traditional Chinese medicines in the existing product, the microcapsule powder whitening medical biological repair dressing containing traditional Chinese medicines has the effect of improving the treatment effect of skin repair.
(2) The data in table 17 show that the whitening effect is the best when the microcapsule powder containing traditional Chinese medicine provided by the invention is used for whitening the medical biological repair dressing (example 2), and the skin brightness index is 77.88; the microcapsule powder containing traditional Chinese medicine provided by the invention is used for whitening medical biological repair dressing (example 1), the whitening effect is the second, and the skin brightness index is 73.64; the microcapsule powder containing traditional Chinese medicine provided by the invention is used for whitening medical biological repair dressing (example 3), the whitening effect is the third, and the skin brightness index is 71.62; the common whitening skin care product containing other traditional Chinese medicines in the existing product is used, the whitening effect is fourth, and the skin brightness index is 68.17; the common whitening skin care product which does not contain traditional Chinese medicines in the existing products is used, the whitening effect is the worst, and the skin brightness index is 66.70. Experimental data show that compared with the common whitening skin care product which does not contain traditional Chinese medicines in the existing product, the microcapsule powder whitening medical biological repair dressing containing traditional Chinese medicines has the effect of whitening treatment.
(3) The data in table 18 show that the medical biological repair dressing for whitening skin by using the microcapsule powder containing traditional Chinese medicines (example 2) provided by the invention has the best moisturizing effect, and the moisture index of the skin is 41.11; when the traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressing (example 1) provided by the invention is used, the moisturizing effect is second, and the moisture index of the skin is 39.40; when the traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressing provided by the invention is used (example 3), the moisturizing effect is the third, and the moisture index of the skin is 38.89; the existing product contains other traditional Chinese medicines, and the common whitening skin care product has the fourth moisturizing effect, and the moisture index of the skin is 37.08; when the common whitening skin care product which does not contain traditional Chinese medicines in the existing product is used, the moisturizing effect is the worst, and the moisture index of the skin is 36.54. Experimental data show that compared with the existing common whitening skin care product which does not contain traditional Chinese medicines, the microcapsule powder whitening medical biological repair dressing containing traditional Chinese medicines enhances the skin moisturizing and moisturizing treatment effects.
(4) The effect rankings in tables 16-18 show that the microcapsule powder whitening medical bioremediation dressing prepared according to the traditional Chinese medicine formula provided by the invention has the best treatment effects of whitening, skin repair and moisturizing compared with the two microcapsule powder whitening medical bioremediation dressings containing traditional Chinese medicines for adjusting the dosage of the mixed concentrated solution of the traditional Chinese medicine formula provided by the invention.
(5) The effect rankings in tables 16-18 show that compared with the existing products containing other traditional Chinese medicines in common whitening skin care products, the microcapsule powder whitening medical biological repair dressing prepared according to the traditional Chinese medicine formula provided by the invention has the best treatment effects of whitening, skin repair and moisturizing.

Claims (9)

1. The traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressing is characterized by comprising the following raw materials in parts by weight: 3-10 parts of pearl powder, 1-1.5 parts of white muscardine silkworm, 3-6 parts of gentian, 5-10 parts of mulberry leaf, 3-10 parts of common perilla, 3-10 parts of szechuan lovage rhizome, 3-10 parts of angelica dahurica, 2-10 parts of raw liquoric root, 0.1-0.5 part of sodium hyaluronate, 3-6 parts of glycerol, auxiliary materials and capsule wall materials.
2. The Chinese medicinal microcapsule powder whitening medical bioremediation dressing as claimed in claim 1, wherein: the preparation formulation of the dressing comprises repair and maintenance ice liquid microcapsule powder, repair and maintenance ice dew microcapsule powder, repair and maintenance ice milk microcapsule powder, repair and maintenance gel microcapsule powder and repair and maintenance cream microcapsule powder.
3. The Chinese medicinal microcapsule powder whitening medical bioremediation dressing as claimed in claim 2, wherein: the capsule wall material consists of 20-30 parts of chitosan and 10-20 parts of sodium alginate.
4. The Chinese medicinal microcapsule powder whitening medical bioremediation dressing as claimed in claim 3, wherein: the auxiliary materials comprise 150 parts of deionized water 100, 1-3 parts of vitamin E, 1-3 parts of amino acid, 1-5 parts of hydrolyzed collagen, 1-3 parts of nicotinamide and 1-5 parts of deoxyarbutin.
5. The Chinese medicinal microcapsule powder whitening medical bioremediation dressing as claimed in claim 4, wherein: the auxiliary materials for repairing and maintaining the ice cream microcapsule powder also comprise the following raw materials in parts by weight: 6-9 parts of lecithin and 3-6 parts of xanthan gum.
6. The Chinese medicinal microcapsule powder whitening medical bioremediation dressing as claimed in claim 4, wherein: the auxiliary materials of the repairing and nourishing gel microcapsule powder also comprise the following raw materials in parts by weight: 9-12 parts of lecithin and 6-10 parts of xanthan gum.
7. The Chinese medicinal microcapsule powder whitening medical bioremediation dressing as claimed in claim 4, wherein: the auxiliary materials of the repairing and nourishing cream microcapsule powder also comprise the following raw materials in parts by weight: 10-15 parts of lecithin and 9-12 parts of xanthan gum.
8. The preparation method of the Chinese medicinal microcapsule powder whitening medical bioremediation dressing as claimed in any one of claims 1-7, which is characterized by comprising the following steps:
(1) preparing pearl powder, white muscardine silkworm, gentian, mulberry leaf, common perilla, szechuan lovage rhizome, dahurian angelica root and raw liquoric root into a nano traditional Chinese medicine powder mixing material by adopting a nano traditional Chinese medicine powder preparation process;
(2) mixing the nanometer Chinese medicinal powder mixture obtained in step (1) with 10-25L deionized water by static boiling method, decocting for 45-100min, and cooling to 40-60 deg.C to obtain Chinese medicinal mixed concentrated solution;
(3) heating deionized water to 80-85 deg.C, adding sodium hyaluronate and glycerol, homogenizing, and keeping the temperature for 5-10min to obtain sodium hyaluronate mixture;
(4) cooling the sodium hyaluronate mixture obtained in the step (3) to 40-50 ℃, adding different amounts of the traditional Chinese medicine mixed concentrated solution obtained in the step (2) according to dosage forms, adding different auxiliary materials according to dosage forms, homogenizing, cooling to 38 ℃, and standing until the solution is completely swelled;
(5) and (4) uniformly mixing the transparent solution obtained in the step (4) as a core material with a capsule wall material, and preparing the mixture into microcapsule powder by spray drying equipment to obtain the traditional Chinese medicine-containing microcapsule powder whitening medical biological repair dressing.
9. The preparation method of the microcapsule powder whitening medical bioremediation dressing containing traditional Chinese medicines according to claim 8, wherein: adding the traditional Chinese medicine mixed concentrated solution with different dosage according to the dosage form in the step (4):
adding 20-40% of the Chinese medicinal concentrated solution into the repairing and nourishing gel microcapsule powder;
adding 60-80% of the Chinese medicinal concentrated solution into the repairing and maintaining ice liquid microcapsule powder;
respectively adding 80-100% of the Chinese medicinal concentrated solution into the repairing and maintaining ice dew microcapsule powder and the repairing and maintaining ice milk microcapsule powder;
the repairing and nourishing cream microcapsule powder is added with 100 percent of traditional Chinese medicine mixed concentrated solution.
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CN106309303A (en) * 2015-07-09 2017-01-11 雷桂丽 Traditional Chinese medicine whitening mask powder and preparation method thereof
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