CN111000887A - Method for improving drug effect of Mongolian traditional Chinese medicine by using fermentation technology - Google Patents

Method for improving drug effect of Mongolian traditional Chinese medicine by using fermentation technology Download PDF

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Publication number
CN111000887A
CN111000887A CN202010027918.0A CN202010027918A CN111000887A CN 111000887 A CN111000887 A CN 111000887A CN 202010027918 A CN202010027918 A CN 202010027918A CN 111000887 A CN111000887 A CN 111000887A
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mongolian
traditional chinese
chinese medicine
fermentation
drug effect
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李芝发
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Individual
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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Abstract

A method for improving the drug effect of Mongolian traditional Chinese medicine by utilizing a fermentation technology belongs to the technical field of Mongolian traditional Chinese medicine treatment. The invention aims to fully exert the drug effect of Mongolian traditional Chinese medicine, and the method specifically comprises the following steps: cleaning 100kg Mongolian Chinese medicinal materials, removing water, cutting into 2mm pieces, mixing with 3kg biological bacteria culture solution, 5kg oligosaccharide, and 200kg purified water, and fermenting in fermentation tank. The Mongolian traditional Chinese medicine component is fermented and converted by probiotics, and macromolecules are changed into micromolecules, 100 percent of the micromolecules are absorbed and utilized by animals, the onset of action is fast, and the efficacy of the medicine is long. The curative effect is accelerated, the blood is absorbed in 30 minutes, and the medicine is circulated in the whole body within one hour. The drug effect is improved, the curative effect of the fermented Mongolian traditional Chinese medicine is improved by 4-28 times compared with that of the traditional Mongolian traditional Chinese medicine, the drug effect is completely released, the integral dosage is saved, and the drug cost is further saved. Decomposing toxicity during fermentation process, and has no adverse side effects. The taste of Mongolian traditional Chinese medicine is improved, so that the good medicine no longer bitter is changed into beverage, and the Mongolian traditional Chinese medicine powder improves the taste of feed and increases the feed intake.

Description

Method for improving drug effect of Mongolian traditional Chinese medicine by using fermentation technology
Technical Field
The invention belongs to the technical field of Mongolian traditional Chinese medicine treatment, and particularly relates to a method for improving the drug effect of Mongolian traditional Chinese medicine by using a fermentation technology.
Background
The traditional Chinese medicinal materials are treasury of traditional Chinese medicine, make great contribution to the health of human beings and animals, and people gradually realize that the Mongolian traditional Chinese medicine can not decompose compact fibers even after being ground, fine powder or processed, the potency of the Mongolian traditional Chinese medicine is not exerted to 50% at most, under the background, a technology for fermenting the Mongolian traditional Chinese medicine by utilizing bioengineering is generated, and the realization and application fill the blank in the new technical field of Mongolian traditional Chinese medicine preparation in China.
Disclosure of Invention
The invention aims to give full play to the drug effect of Mongolian traditional Chinese medicine, provides a method for improving the drug effect of Mongolian traditional Chinese medicine by using a fermentation technology, and the method is used for treating Mongolian traditional Chinese medicine additive for animals, so that the cure level of the Mongolian traditional Chinese medicine additive for animals can be improved, and the effects of small dosage, quick effect and long drug effect are achieved.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
a method for improving the drug effect of Mongolian traditional Chinese medicine by utilizing a fermentation technology comprises the following steps: cleaning 100kg Mongolian Chinese medicinal materials, removing water, cutting into 2mm pieces, mixing with 3kg biological bacteria culture solution, 5kg oligosaccharide, and 200kg purified water, and fermenting in fermentation tank.
Compared with the prior art, the invention has the beneficial effects that:
(1) the Mongolian traditional Chinese medicine component is fermented and converted by probiotics, and macromolecules are changed into micromolecules, 100 percent of the micromolecules are absorbed and utilized by animals, the effect is fast, and the efficacy is long.
(2) The curative effect is accelerated, the blood is absorbed in 30 minutes, and the medicine is circulated in the whole body within one hour.
(3) The drug effect is improved, the curative effect of the fermented Mongolian traditional Chinese medicine is improved by 4-28 times compared with that of the traditional Mongolian traditional Chinese medicine, the drug effect is completely released, the integral dosage is saved, and the drug cost is further saved.
(4) Decomposing toxicity during fermentation process, and has no adverse side effects.
(5) The taste of Mongolian traditional Chinese medicine is improved, so that the good medicine no longer bitter is changed into beverage, and the Mongolian traditional Chinese medicine powder improves the taste of feed and increases the feed intake.
(6) The Mongolian traditional Chinese medicine is decomposed, modified and recombined under the action of the cultured probiotics group, so that the efficacy of the Mongolian traditional Chinese medicine is fully exerted, and the curative effect is improved by 10-28 times.
Detailed Description
The technical solutions of the present invention are further described below with reference to the following examples, but the present invention is not limited thereto, and modifications and equivalent substitutions may be made to the technical solutions of the present invention without departing from the spirit of the technical solutions of the present invention, and the technical solutions of the present invention are covered by the protection scope of the present invention.
The first embodiment is as follows: the embodiment describes a method for improving the drug effect of Mongolian traditional Chinese medicine by using a fermentation technology, which specifically comprises the following steps: cleaning 100kg Mongolian Chinese medicinal materials, removing water, cutting into 2mm pieces, mixing with 3kg biological bacteria culture solution, 5kg oligosaccharide (culture medium), and 200kg purified water, and fermenting in fermentation tank.
The second embodiment is as follows: the method for improving the drug effect of Mongolian traditional Chinese medicine by utilizing fermentation technology comprises the following steps of taking 2kg of each strain, adding deionized water, controlling the total volume to be 1 ton, adding 5kg of brown sugar and 3kg of oligosaccharide (the brown sugar and the oligosaccharide are used as strain nutrients), and uniformly mixing to obtain the biological bacteria culture solution. The quality requirements of the biological bacteria culture solution are as follows: the granularity is 200 meshes, the pH value is less than 4, and the bacteria content is 200 hundred million/g.
The third concrete implementation mode: in a specific embodiment, the fermentation tank is a stainless steel tank with a height of 2m, a diameter of 1.5 m and five common tanks, and is provided with a heating device, a stirring facility and an automatic extraction structure.
The fourth concrete implementation mode: in a specific embodiment, the method for improving the drug effect of a Mongolian traditional Chinese medicine by using a fermentation technology specifically comprises the following steps: and (3) heating the fermentation tank to 42 ℃, wherein the heating rate is required to be increased to 42 ℃ within one day, then cooling to 28-30 ℃, keeping the temperature (electrically controlled) until the fermentation is finished, and controlling the total fermentation time to be 168 hours. The lowest temperature is not lower than 28 ℃ within seven days, and the fermentation is kept to the end point.
When the temperature in the tank reaches 42 ℃, escherichia coli and salmonella are all inactivated, then the temperature is reduced to 28-30 ℃, probiotics are greatly proliferated in a proliferation mode in the fermentation process, compact fibers in Mongolian traditional Chinese medicines are rapidly decomposed, macromolecules are changed into small molecules, long-chain fiber structures are changed into short-chain molecular structures, and after seven days, active ingredients of the medicines are all released, so that fermentation is completed. Taking out the fermented raw materials, evaporating water, and oven drying at constant temperature to obtain Mongolian medicinal fermented raw material; the small peptide preparation is prepared into various Chinese patent medicine additives according to the regulations of national formulary, and then the small peptide preparation is made into animal feed additives with different needs for animals according to the functional needs for market application.
The fifth concrete implementation mode: the method for improving the drug effect of the Mongolian traditional Chinese medicine by utilizing the fermentation technology is applied to the treatment of Mongolian traditional Chinese medicine additives in animal feed. Optionally adding into veterinary drug, or used as raw material of Chinese patent medicine.
The sixth specific implementation mode: the method for improving the drug effect of a Mongolian traditional Chinese medicine by using a fermentation technology comprises the following steps of taking one of food supplements, yield increasing, antibacterial agents, anti-stress agents, antiseptics and anthelmintics, and optionally matching the food supplements, the yield increasing agents, the antibacterial agents, the anti-stress agents, the antiseptics and the anthelmintics; the food supplement is any one of medicated leaven, malt, hawthorn, dried orange peel, green tangerine orange peel, rhizoma atractylodis, mangnolia officinalis or pine branch; the yield increasing product is any one of polygala tenuifolia, platycladi seed, schisandra chinensis, Chinese yam, herba abri, four-leaf ginseng or cowherb seed; the antibacterial agent is any one of honeysuckle, forsythia, dyers woad leaf, dandelion, poria or phellodendron; the anti-stress material is any one of purple radix bupleuri, radix Scutellariae, herba Cayatiae Japonicae, cornu Bubali, Lumbricus, cacumen Tamaricis or radix astragali; the antiseptic is any one of cortex pseudolaricis, cortex Dictamni Radicis, fructus Zanthoxyli or catechol; the anthelmintic is any one of Arecae semen, rhizoma Osmundae, cortex kaffir lily, radix Stemonae, semen Cucurbitae or mume fructus.
Example 1:
selecting an antibacterial Mongolian traditional Chinese medicine: honeysuckle, dyers woad leaf and phellodendron bark, treating the Mongolian traditional Chinese medicine by using the method of the invention, respectively taking 1kg of the obtained fermented products, mixing, and adding 10 times of water for dilution and pouring when in use; diarrhea comparison experiments were carried out on 10 cows in the experimental group and 10 cows in the control group for 60 days from 8 months 1 to 10 months 1 in 2019. During this period, 10 diarrheal cows and 10 non-chewed cows were selected and drenched with 3 days of fermented Mongolian herbal preparation three times a day at 300 g/head, with the results as follows:
TABLE 1 therapeutic effect of fermented Mongolian Chinese medicinal preparation on diarrhea of milk cow
Figure BDA0002363141320000031
The feeding experiment of 60 days shows that 8 cows have diarrhea in the control group, while the experimental group has no diarrhea in one cow, and the feces are dry and well formed and have little odor, so the Mongolian Chinese medicinal fermentation preparation has good effect of preventing the diarrhea of the cows.
The results show that the Mongolian traditional Chinese medicine fermentation preparation has a good treatment effect on the diarrhea of the dairy cows, and the cure rate of one-time drenching reaches 60 percent, and the cure rate of 3-time continuous drenching reaches 90 percent. The Mongolian traditional Chinese medicine fermentation preparation is administrated to the non-chewed dairy cows once, 10 dairy cows begin to drink water and eat grass and feed after a few hours, the rumen of the dairy cows swells, and the health state is completely recovered after the dairy cows are administrated twice. Antibiotic residue detection is carried out on milk produced by the experimental cows in the experimental period, and the detection result shows that no antibiotic residue exists.
The Mongolian traditional Chinese medicine fermentation preparation is added into the daily ration of the dairy cow, so that the diarrhea of the dairy cow can be well prevented, the digestibility of the dairy cow to the feed is promoted, and no antibiotic residue exists in the milk. Has good treatment effect on diarrhea dairy cows by drenching Mongolian traditional Chinese medicine fermentation preparation. 300 g/first time, the cure rate of one time reaches 60 percent, and the cure rate of three times of continuous drenching reaches 100 percent. During the treatment period with Mongolian Chinese medicinal fermented preparation, there is no antibiotic residue in milk. The Mongolian traditional Chinese medicine fermentation preparation has the advantages that the cow forestomach is flaccid (not chewed), 300 g/head of the fermented Mongolian traditional Chinese medicine fermentation preparation is drenched once, the cure rate is 90%, and the cure rate is 100% after two drenched continuously.

Claims (6)

1. A method for improving the drug effect of Mongolian traditional Chinese medicine by utilizing a fermentation technology is characterized by comprising the following steps: the method specifically comprises the following steps: cleaning 100kg Mongolian Chinese medicinal materials, removing water, cutting into 2mm pieces, mixing with 3kg biological bacteria culture solution, 5kg oligosaccharide, and 200kg purified water, and fermenting in fermentation tank.
2. The method for improving the drug effect of Mongolian medicinal herbs by using fermentation technology as claimed in claim 1, wherein: the biological bacteria culture solution contains strains including lactobacillus, saccharomycetes, bacillus subtilis, photosynthetic bacteria, actinomycetes, coprococcus and bifidobacterium, and is prepared by taking 2kg of each strain, adding deionized water, controlling the total volume to be 1 ton, adding 5kg of brown sugar and 3kg of oligosaccharide, and uniformly mixing to obtain the biological bacteria culture solution.
3. The method for improving the drug effect of Mongolian medicinal herbs by using fermentation technology as claimed in claim 1, wherein: the fermentation tank is a stainless steel tank, is 2 meters high and 1.5 meters in diameter, and is internally provided with a heating device and a stirring facility.
4. The method for improving the drug effect of Mongolian medicinal herbs by using fermentation technology as claimed in claim 1, wherein: the fermentation process specifically comprises the following steps: and (3) heating the fermentation tank to 42 ℃, then cooling to 28-30 ℃, keeping the temperature until the fermentation is finished, and controlling the total fermentation time to be 168 hours.
5. The method for improving the drug effect of Mongolian medicinal herbs by using fermentation technology as claimed in claim 1, wherein: the method is applied to the treatment of Mongolian traditional Chinese medicine additives in animal feed.
6. The method of claim 5, wherein the fermentation technique is used to improve the drug effect of Mongolian medicinal herbs, and comprises: the Mongolian traditional Chinese medicine is any one of food enhancing, yield increasing, antibacterial, anti-stress, antiseptic or anthelmintic; the food supplement is any one of medicated leaven, malt, hawthorn, dried orange peel, green tangerine orange peel, rhizoma atractylodis, mangnolia officinalis or pine branch; the yield increasing product is any one of polygala tenuifolia, platycladi seed, schisandra chinensis, Chinese yam, herba abri, four-leaf ginseng or cowherb seed; the antibacterial agent is any one of honeysuckle, forsythia, dyers woad leaf, dandelion, poria or phellodendron; the anti-stress material is any one of purple radix bupleuri, radix Scutellariae, herba Cayatiae Japonicae, cornu Bubali, Lumbricus, cacumen Tamaricis or radix astragali; the antiseptic is any one of cortex pseudolaricis, cortex Dictamni Radicis, fructus Zanthoxyli or catechol; the anthelmintic is any one of Arecae semen, rhizoma Osmundae, cortex kaffir lily, radix Stemonae, semen Cucurbitae or mume fructus.
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