CN110917109A

CN110917109A - Anti-aging mask

Info

Publication number: CN110917109A
Application number: CN201811102064.7A
Authority: CN
Inventors: 张伯清; 野口活夫; 贾正虎
Original assignee: TIANJIN BERONI BIOTECHNOLOGY Co Ltd
Current assignee: TIANJIN BERONI BIOTECHNOLOGY Co Ltd
Priority date: 2018-09-20
Filing date: 2018-09-20
Publication date: 2020-03-27

Abstract

An anti-aging mask comprises the following components: butylene glycol, glycerol, 1, 2-pentanediol, placenta active substances, lycopene fermentation extract, grape seed essential oil, ascorbyl tetraisopalmitate, hydrolyzed hyaluronic acid, acetylated sodium hyaluronate, polyquaternary ammonium salt, dipotassium glycyrrhizinate, tocopherol acetate, hydrogenated lecithin, sorbitol, carbomer and the balance of sterile distilled water. The invention provides an anti-aging mask, which utilizes animal placenta active substances and a lycopene fermentation extract as main components, contains rich yeast nutrition active substances such as small molecular peptides, free amino acids, vitamins, nucleotides and the like, and has the nutrition performance of yeast degradation products and the anti-oxidation performance of lycopene; has effects in stimulating skin cell growth, promoting metabolism, stimulating skin cell proliferation, resisting oxidation, and resisting aging.

Description

Anti-aging mask

Technical Field

The invention relates to the field of cosmetics, in particular to an anti-aging mask.

Background

With the aging, the natural anti-free radical and anti-oxidation capability of the human body is continuously reduced, the human cells are aged, the problems of pigmentation, rough skin and the like are also generated on the human appearance, and the tissues and organs of the human body are also aged rapidly. Free radicals are important factors causing skin aging, and air pollution, stress, drugs, etc. all cause the body to generate free radicals. Free radicals have a tendency to pair with molecules or parts of molecules that contain one or more unpaired electrons. Most radicals are therefore very reactive and have a high degree of chemical activity. Under normal conditions, free radicals in the human body are in a dynamic equilibrium with constant production and elimination. However, the free radicals are excessively generated or slowly eliminated, and can cause various damages to the body by attacking vital macromolecular substances and various cells, accelerate the aging process of the body, and show gradual aging changes, such as senile pigmentation, skin wrinkling and the like. At present, the anti-aging effect of the common anti-aging facial masks sold on the market is not obvious, some common anti-aging facial masks are also added with irritant chemical substances, and improper use of the common anti-aging facial masks is easy to accelerate the appearance of wrinkles and the appearance of skin relaxation, so that skin diseases are caused.

Lycopene (Lycopene), also called psi-carotene, belongs to an isoprene compound and is a carotenoid, so that Lycopene is firstly separated from tomatoes, in the past, people have thought that only carotenoids which have β -ionone ring and can be converted into vitamin A, such as α -carotene, β -carotene and the like, are related to human nutrition and health, and Lycopene lacks the structure and does not have the physiological activity of vitamin A, so that the research on the carotenoids is few, however, Lycopene has excellent physiological functions, not only has the effects of resisting and inhibiting cancer, but also has important significance for preventing various adult diseases such as cardiovascular diseases and arteriosclerosis, enhancing the human immune system, delaying aging and the like, and is a novel functional natural pigment with good development prospect, but the Lycopene has poor water solubility and stability and is difficult to be directly applied to cosmetic formulations.

The animal placenta contains rich nutrients, and the amnion and the foliated chorion of the placenta contain great amount of immunoglobulin, amino acids, lecithin, cephalin, lipopolysaccharide, vitamins and trace elements, and can improve the ageing of skin cells.

Therefore, the preparation of a skin care mask for stimulating the proliferation of skin cells, supplementing nutrition, resisting oxidation and resisting aging by using animal placenta active substances and a lycopene fermentation extract as main components is a problem to be solved by the technical personnel in the field.

Disclosure of Invention

In view of the above, the invention provides an anti-aging mask, which utilizes animal placenta active substances and a lycopene fermentation extract as main components, and lycopene is directly applied to a mask product, contains abundant yeast nutritional active substances such as small molecular peptides, free amino acids, vitamins, nucleotides and the like, and has the nutritional performance of yeast degradation products and the antioxidant performance of lycopene; meanwhile, other components of the facial mask are matched according to a specific proportion, the technical obstacle that lycopene cannot be applied to skin care products due to solubility is solved, multiple functional components are mutually blended and cooperated, and can well penetrate through the surface layer of skin to be absorbed, so that the moisture content of the skin can be improved, the nutrition of the skin can be supplemented, and the effects of stimulating the growth of skin cells, accelerating metabolism, stimulating the proliferation of skin cells, resisting oxidation and resisting aging are further achieved.

In order to achieve the purpose, the invention adopts the following technical scheme:

an anti-aging mask comprises the following components: 1-4% of butanediol, 1-8% of glycerol, 1-4% of 1, 2-pentanediol, 2-5% of placenta active substances, 6-10% of lycopene fermentation extract, 1-4% of grape seed essential oil, 0.05-0.1% of ascorbyl tetraisopalmitate, 0.01-0.05% of hydrolyzed hyaluronic acid, 0.01-0.05% of sodium acetylated hyaluronate, 0.02-0.05% of polyquaternium, 0.01-0.1% of dipotassium glycyrrhizinate, 0.02-0.05% of tocopherol acetate, 0.01-0.06% of hydrogenated lecithin, 0.04-0.08% of sorbitol, 0.5-1% of carbomer and the balance of sterile distilled water.

Further, the composition comprises the following components: 2-4% of butanediol, 5-8% of glycerol, 2-4% of 1, 2-pentanediol, 3-5% of placenta active matter, 6-8% of lycopene fermentation extract, 2-4% of grape seed essential oil, 0.05-0.08% of ascorbyl tetraisopalmitate, 0.01-0.03% of hydrolyzed hyaluronic acid, 0.02-0.05% of sodium hyaluronate, 0.02-0.04% of polyquaternary ammonium salt, 0.05-0.1% of dipotassium glycyrrhizinate, 0.02-0.04% of tocopherol acetate, 0.03-0.06% of hydrogenated lecithin, 0.05-0.08% of sorbitol, 0.8-1% of carbomer, and the balance of sterile distilled water.

The placenta active substance has a large amount of immunoglobulin, rich amino acid, rich lecithin, cephalin, lipopolysaccharide, multiple vitamins and trace elements, and can inhibit peroxidation of organisms, eliminate free radicals, enhance the immune function of cells and inhibit mutagenic action.

The lycopene fermentation extract contains abundant yeast nutritional active substances such as small molecular peptides, free amino acids, vitamins, nucleotides and the like, has the nutritional properties of yeast degradation products and the antioxidant property of lycopene, has the effects of reducing the moisture loss of the epidermis, improving the skin elasticity and the like, and has good use feeling and excellent anti-aging effect.

The grape seed essential oil mainly contains linoleic acid and procyanidin, contains various unsaturated fatty acids, vitamin F, minerals, proteins, linoleic acid, chlorophyll and the like, is beneficial to keeping skin moisture and nourishing skin, can remove dirt in pores, can enable the skin to be glossy, fine and elastic, eliminates wrinkles and color spots or lightens the color spots, and slows down skin aging.

According to the anti-aging mask provided by the invention, the active substances of the animal placenta and the lycopene fermentation extract are used as main components, and the grape seed essential oil, the hydrogenated lecithin and other components are matched according to a specific proportion, so that various functional components are mutually blended and cooperated, the effects of effectively reducing the transepidermal water loss, improving the skin elasticity and the like can be realized, and the anti-aging mask has good use feeling and excellent anti-aging effect.

Further, the lycopene fermentation extract is obtained by fermenting raw tomato juice to obtain fermentation liquor and carrying out enzymolysis on the fermentation liquor by using pectinase and cellulase.

The specific preparation method of the lycopene fermentation extract comprises the following steps:

pulping fructus Lycopersici Esculenti with juice machine, sealing for 5-10 days at 25-30 deg.C; then sealing and fermenting for 12-16 days at 16-20 ℃ to obtain fermentation liquor. Filtering the fermentation liquor to remove residues such as epidermis, seeds, fibers and the like, adding alkali to adjust the pH value to 7.5-8.0, heating and stirring at 50 ℃ for 5 hours, and adjusting the pH value to 4.0. Standing the carotenoid coagulation precipitate, and removing upper turbid liquid to obtain lycopene precipitate.

Adding 0.2-0.5% of pectinase and cellulase mixture into the lycopene precipitate, wherein the mass ratio of the pectinase to the cellulase is 1:1, treating at 50 ℃ for 3h to remove 90% of non-pigment substances such as pectin and cellulose, centrifuging at 10000r/min for 5-10min, washing the precipitate with 96% of ethanol, filtering, extracting with ethanol and vegetable oil again, and separating an oil phase product to obtain the lycopene fermentation extract.

Further, the placenta used by the placenta active substance is healthy placenta of a full-term mammal, and the taking parts are amnion and chorion of the placenta, wherein the weight ratio of the amnion to the chorion is 1: 5-10.

The extraction method of the placenta active substance comprises the following steps: cutting animal placenta tissue into tissue blocks with diameter less than 0.5mm under aseptic condition, ultrasonic crushing for 1-5min, adding trypsin collagenase I0.1% and collagenase II 0.1%, continuously shaking and hydrolyzing at 37 deg.C for 2 hr, centrifuging at 4 deg.C and 5000-00 rpm for 15min, removing precipitate to obtain placenta crude extract, separating by Sephadex G-100 gel chromatography column, BSA (66kDa),Carbonicandrhydrase (29kDa) and aprotinin (6.5kDa) as molecular weight markers, dextran blue (200kDa) as column pore volume marker, and NaH (0.2M) at pH7.6 as eluent₂PO4--NaHPO₄Buffer solution, controlling the elution speed at 0.2-0.5 ml/min, monitoring the protein outflow condition by using a spectrophotometer, collecting the outflow components with 10-66Kda in sections, and dialyzing by using distilled water to remove salt to obtain the placenta active substance.

The preparation method of the anti-aging mask disclosed by the invention comprises the following steps:

(1) mixing glycerol, butanediol, carbomer, hydrolyzed hyaluronic acid, dipotassium glycyrrhizinate, acetylated sodium hyaluronate, sorbitol and sterile distilled water, adding into a stirring pot, heating to 70-85 deg.C, stirring and dissolving completely to obtain phase A;

(2) adding ascorbyl tetraisopalmitate, tocopherol acetate and hydrogenated lecithin into a stirring pot, and heating to 70-85 ℃ to obtain a phase B;

(3) adding phase B into phase A, emulsifying and homogenizing for 10min, cooling to 35-40 deg.C, adding polyquaternium, stirring, adding placenta active substance, lycopene fermentation extract, grape seed essential oil and 1, 2-pentanediol, stirring, and discharging.

According to the technical scheme, compared with the prior art, the anti-aging mask provided by the invention has the following technical advantages:

the invention uses animal placenta active substance and lycopene fermentation extract as main components, applies the lycopene fermentation extract in the facial mask product, contains rich yeast nutrition active substances such as small molecular peptide, free amino acid, vitamin, nucleotide and the like, and has the nutrition performance of yeast degradation products and the oxidation resistance of lycopene; meanwhile, other components of the facial mask are matched according to a specific proportion, the technical obstacle that lycopene cannot be applied to skin care products due to solubility is solved, multiple functional components are mutually blended and cooperated, and can well penetrate through the surface layer of skin to be absorbed, so that the moisture content of the skin can be improved, the nutrition of the skin can be supplemented, and the effects of stimulating the growth of skin cells, accelerating metabolism, stimulating the proliferation of skin cells, resisting oxidation and resisting aging are further achieved.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.

FIG. 1 is a graph showing the change of hyaluronic acid content in human primary dermal fibroblasts according to the present invention;

FIG. 2 is a graph showing the change of collagen content in human primary dermal fibroblasts according to the present invention;

FIG. 3 is a test chart of skin moisture test results provided by the present invention;

fig. 4 is a diagram illustrating the results of the skin elasticity test provided by the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

An anti-aging mask comprises the following components: 2% of butanediol, 5% of glycerol, 2% of 1, 2-pentanediol, 3% of placenta active substances, 8% of lycopene fermentation extract, 2% of grape seed essential oil, 0.08% of ascorbyl tetraisopalmitate, 0.03% of hydrolyzed hyaluronic acid, 0.02% of sodium hyaluronate acetylated, 0.04% of polyquaternary ammonium salt, 0.05% of dipotassium glycyrrhizinate, 0.04% of tocopherol acetate, 0.03% of hydrogenated lecithin, 0.05% of sorbitol, 0.8% of carbomer and the balance of sterile distilled water.

Wherein the tomato is pulped and crushed by a juice machine, and sealed for 8 days at the temperature of 30 ℃; then fermenting for 15 days at 20 ℃ in a sealing way to obtain fermentation liquor. Filtering the fermentation liquid to remove residues such as epidermis, seeds and fiber, adjusting pH to 7.5 with alkali, heating at 50 deg.C, stirring for 5 hr, and adjusting pH to 4.0. Standing the carotenoid coagulation precipitate, and removing upper turbid liquid to obtain lycopene fermentation extract precipitate.

Adding 0.2% of pectinase and cellulase mixture into lycopene precipitate, wherein the mass ratio of pectinase to cellulase is 1:1, treating at 50 deg.C for 3h to remove 90% of non-pigment substances such as pectin and cellulose, centrifuging at 10000r/min for 10min, washing precipitate with 96% ethanol, filtering, extracting with ethanol and vegetable oil again, and separating oil phase product to obtain lycopene fermented extract.

Meanwhile, the placenta used by the placenta active substance is a healthy placenta of the term goat, and the selected parts are an amnion and a chorion of the placenta, wherein the weight ratio of the amnion to the chorion is 1: 5.

the extraction method of the placenta active substance comprises the following steps: cutting goat placenta tissue into tissue blocks smaller than 0.5mm by using a tissue shear under the aseptic condition, wherein the weight ratio of the amnion to the chorion is 1: 5, ultrasonic crushing for 1-5min, adding 0.1% of trypsin collagenase I and 0.1% of collagenase II, continuously shaking and hydrolyzing for 2 hours at 37 ℃, centrifuging for 15min at 4 ℃ and 10000rpm, removing precipitates to obtain a placenta crude extract, separating the placenta crude extract by a Sephadex G-100 gel chromatographic column, taking BSA (66kDa), carbonic anhydrase (29kDa) and aprotinin (6.5kDa) as molecular weight markers, taking dextran blue (200kDa) as a chromatographic column pore volume marker, and taking NaH (sodium hydroxide) with pH of 7.6 and 0.2M as an eluent₂PO₄--NaHPO₄Buffer solution, controlling elution speed at 0.5ml/min, monitoring protein outflow condition with spectrophotometer, collecting outflow components with 10-66Kda by stages, dialyzing with distilled water to remove salt, and obtaining placenta active substance.

Wherein, glycerol, butanediol, carbomer, hydrolyzed hyaluronic acid, dipotassium glycyrrhizinate, acetylated sodium hyaluronate, sorbitol and sterile distilled water are mixed and added into a stirring pot, heated to 80 ℃, and stirred to be completely dissolved to prepare phase A; simultaneously adding ascorbyl tetraisopalmitate, tocopherol acetate and hydrogenated lecithin into a stirring pot, and heating to 80 ℃ to obtain a phase B; and finally, adding the phase B into the phase A, emulsifying and homogenizing for 10min, cooling to 37 ℃, adding polyquaternium, uniformly stirring, adding the placenta active substance, the lycopene fermentation extract, the grape seed essential oil and 1, 2-pentanediol, fully and uniformly stirring, and discharging to obtain the anti-aging mask.

Example 2

An anti-aging mask comprises the following components: 4% of butanediol, 1% of glycerol, 1, 2-pentanediol, 1% of placenta active substance, 10% of lycopene fermentation extract, 1% of grape seed essential oil, 0.1% of ascorbyl tetraisopalmitate, 0.05% of hydrolyzed hyaluronic acid, 0.01% of sodium hyaluronate acetylated, 0.05% of polyquaternary ammonium salt, 0.01% of dipotassium glycyrrhizinate, 0.05% of tocopherol acetate, 0.01% of hydrogenated lecithin, 0.04% of sorbitol, 1% of carbomer, and the balance of sterile distilled water.

Wherein, glycerol, butanediol, carbomer, hydrolyzed hyaluronic acid, dipotassium glycyrrhizinate, acetylated sodium hyaluronate, sorbitol and sterile distilled water are mixed and added into a stirring pot, heated to 85 ℃, and stirred to be completely dissolved to prepare phase A; simultaneously adding ascorbyl tetraisopalmitate, tocopherol acetate and hydrogenated lecithin into a stirring pot, and heating to 85 ℃ to obtain a phase B; and finally, adding the phase B into the phase A, emulsifying and homogenizing for 10min, cooling to 35 ℃, adding polyquaternium, uniformly stirring, adding the placenta active substance, the lycopene fermentation extract, the grape seed essential oil and 1, 2-pentanediol, fully and uniformly stirring, and discharging to obtain the anti-aging mask.

Other technical features are the same as those of embodiment 1, and are not described in detail herein.

Example 3

An anti-aging mask comprises the following components: 1% of butanediol, 8% of glycerol, 4% of 1, 2-pentanediol, 2% of placenta active substances, 6% of lycopene fermentation extract, 4% of grape seed essential oil, 0.05% of ascorbyl tetraisopalmitate, 0.01% of hydrolyzed hyaluronic acid, 0.05% of sodium hyaluronate acylate, 0.02% of polyquaternary ammonium salt, 0.1% of dipotassium glycyrrhizinate, 0.02% of tocopherol acetate, 0.06% of hydrogenated lecithin, 0.08% of sorbitol, 0.5% of carbomer, and the balance of sterile distilled water.

Wherein, glycerol, butanediol, carbomer, hydrolyzed hyaluronic acid, dipotassium glycyrrhizinate, acetylated sodium hyaluronate, sorbitol and sterile distilled water are mixed and added into a stirring pot, heated to 70 ℃, and stirred to be completely dissolved to prepare phase A; simultaneously adding ascorbyl tetraisopalmitate, tocopherol acetate and hydrogenated lecithin into a stirring pot, and heating to 70 ℃ to obtain a phase B; and finally, adding the phase B into the phase A, emulsifying and homogenizing for 10min, cooling to 40 ℃, adding polyquaternium, uniformly stirring, adding the placenta active substance, the lycopene fermentation extract, the grape seed essential oil and 1, 2-pentanediol, fully and uniformly stirring, and discharging to obtain the anti-aging mask.

Example 4

In this example, the facial mask composition prepared in example 1 was added to a culture medium at a final weight ratio of 3% to serve as an experimental group, human primary dermal fibroblasts were cultured and cultured until generation P4, and then synthetic content of collagen and hyaluronic acid in the human primary dermal fibroblasts was measured by ELISA as a time-dependent graph and evaluated after 12 hours, 24 hours, 36 hours, and 48 hours of treatment, and the results are shown in fig. 1 and 2; wherein the control group is supplemented with equal amount of common human primary dermal fibroblast cell culture medium. As can be seen from fig. 1 and 2, after the mask composition is added to the culture solution, the generation of type I collagen and hyaluronic acid is gradually increased, indicating that the mask disclosed by the present invention can promote the synthesis of collagen and hyaluronic acid.

Example 5

This example was performed on 20 volunteers using the mask prepared in example 1 and skin moisture was measured. The specific steps are 20 volunteers, female, age 40, and healthy body and skin condition, and 10 people apply facial mask containing 0.8% of the composition to face 2 times after cleaning face every day for 4 weeks, and perform skin moisture test every week. 10 people wash the face daily, which is a control group. The skin humidity results of the experiment are measured by a CUK skin tester and skin humidity change, and the data are counted, the results are shown in fig. 3, in two groups of volunteers, the initial humidity is not obviously different (day 0), in the following weeks, the skin humidity and the initial period of a control group are slightly reduced, but the skin humidity of the face of the volunteer using the composition mask is obviously improved compared with the initial state and is also improved compared with the volunteer of the control group at the corresponding time, so that the mask has the function of keeping the skin moisture.

Example 6

This example was conducted on 20 volunteers using the mask prepared in example 1, and skin elasticity was measured. The specific steps are 20 volunteers, female, age 40, healthy body and skin, and 10 people apply facial mask containing 0.8% of the composition to face 2 times after cleaning face every day for 4 weeks, and perform skin elasticity test every week. 10 people wash the face daily, which is a control group. The skin elasticity result of the experiment is detected by a German MPA580 elasticity tester, the change of the skin elasticity after the cosmetics are used is inspected by testing the size of the recovery deformation of the skin, and the anti-aging efficacy index is evaluated to be an elasticity index R2, namely the ratio of the rebound quantity of the skin without negative pressure to the maximum stretching quantity with negative pressure is closer to 1, which indicates that the skin elasticity is better and the anti-aging effect is more obvious, the statistics is carried out by Prism5, the result is shown in figure 4, the initial elasticity index of two groups of volunteers is not obviously different (day 0), the skin elasticity and the initial period of a control group are not obviously changed in the following weeks, and the facial elasticity of the volunteer using the composition mask is obviously improved compared with the initial state and is also improved compared with the volunteer of the control group with the corresponding time.

The invention provides an anti-aging mask, which utilizes animal placenta active substances and a lycopene fermentation extract as main components, directly applies lycopene to a mask product, contains abundant yeast nutritional active substances such as small molecular peptides, free amino acids, vitamins, nucleotides and the like, and has the nutritional property of yeast degradation products and the antioxidant property of lycopene; meanwhile, other components of the facial mask are matched according to a specific proportion, the technical obstacle that lycopene cannot be applied to skin care products due to solubility is solved, multiple functional components are mutually blended and cooperated, and can well penetrate through the surface layer of skin to be absorbed, so that the moisture content of the skin can be improved, the nutrition of the skin can be supplemented, and the effects of stimulating the growth of skin cells, accelerating metabolism, stimulating the proliferation of skin cells, resisting oxidation and resisting aging are further achieved.

The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. The device disclosed by the embodiment corresponds to the method disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the method part for description.

The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. An anti-aging mask is characterized by comprising the following components: 1-4% of butanediol, 1-8% of glycerol, 1-4% of 1, 2-pentanediol, 2-5% of placenta active substances, 6-10% of lycopene fermentation extract, 1-4% of grape seed essential oil, 0.05-0.1% of ascorbyl tetraisopalmitate, 0.01-0.05% of hydrolyzed hyaluronic acid, 0.01-0.05% of sodium acetylated hyaluronate, 0.02-0.05% of polyquaternium, 0.01-0.1% of dipotassium glycyrrhizinate, 0.02-0.05% of tocopherol acetate, 0.01-0.06% of hydrogenated lecithin, 0.04-0.08% of sorbitol, 0.5-1% of carbomer and the balance of sterile distilled water.

2. The anti-aging mask as claimed in claim 1, which comprises the following components: 2-4% of butanediol, 5-8% of glycerol, 2-4% of 1, 2-pentanediol, 3-5% of placenta active matter, 6-8% of lycopene fermentation extract, 2-4% of grape seed essential oil, 0.05-0.08% of ascorbyl tetraisopalmitate, 0.01-0.03% of hydrolyzed hyaluronic acid, 0.02-0.05% of sodium hyaluronate, 0.02-0.04% of polyquaternary ammonium salt, 0.05-0.1% of dipotassium glycyrrhizinate, 0.02-0.04% of tocopherol acetate, 0.03-0.06% of hydrogenated lecithin, 0.05-0.08% of sorbitol, 0.8-1% of carbomer, and the balance of sterile distilled water.

3. The mask according to claim 1 or 2, wherein the lycopene fermentation extract is obtained by fermenting raw tomato juice to obtain a fermentation broth, and performing enzymolysis on the fermentation broth by using pectinase and cellulase.

4. The anti-aging mask according to claim 1 or 2, wherein the placenta used by the placenta active substance is a healthy placenta of a full-term mammal, and the access sites are an amniotic membrane and a chorion of the placenta, wherein the weight ratio of the amniotic membrane to the chorion is 1: 5-10.