CN110914440A - 多转入基因重组腺病毒 - Google Patents

多转入基因重组腺病毒 Download PDF

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Publication number
CN110914440A
CN110914440A CN201880038592.2A CN201880038592A CN110914440A CN 110914440 A CN110914440 A CN 110914440A CN 201880038592 A CN201880038592 A CN 201880038592A CN 110914440 A CN110914440 A CN 110914440A
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recombinant adenovirus
deletion
nucleotides
site
seq
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Chinese (zh)
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托尼·R·雷德
克里斯托弗·拉森
布莱恩·T·奥兰斯基
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Epicentrx Inc
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Epicentrx Inc
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CN201880038592.2A 2017-04-12 2018-04-12 多转入基因重组腺病毒 Pending CN110914440A (zh)

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US201762484841P 2017-04-12 2017-04-12
US62/484,841 2017-04-12
PCT/US2018/027375 WO2018191545A1 (en) 2017-04-12 2018-04-12 Multiple transgene recombinant adenovirus

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CN110914440A true CN110914440A (zh) 2020-03-24

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US (1) US12036247B2 (enExample)
EP (1) EP3610025A4 (enExample)
JP (1) JP7301748B2 (enExample)
KR (1) KR20200006058A (enExample)
CN (1) CN110914440A (enExample)
EA (1) EA201990822A1 (enExample)
WO (1) WO2018191545A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022007800A1 (zh) * 2020-07-06 2022-01-13 嘉兴安宇生物科技有限公司 一种非洲猪瘟的重组腺病毒疫苗及其构建方法
CN116535491A (zh) * 2022-05-06 2023-08-04 珠海丽凡达生物技术有限公司 治疗性核酸分子、混合物、药物及在治疗实体瘤中的应用

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2903582C (en) 2013-03-14 2021-06-08 Salk Institute For Biological Studies Oncolytic adenovirus compositions
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
JP7015551B2 (ja) 2016-02-23 2022-02-15 ソーク インスティテュート フォー バイオロジカル スタディーズ ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現
CA3045892A1 (en) 2016-12-12 2018-06-21 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
AU2019251356B2 (en) 2018-04-09 2025-06-12 Salk Institute For Biological Studies Oncolytic adenovirus compositions with enhanced replication properties
WO2024015876A1 (en) 2022-07-13 2024-01-18 Epicentrx, Inc. Adenoviral vectors encapsulated in cationic liposomes, and preparation and use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050136035A1 (en) * 2003-06-03 2005-06-23 Derek Ko Cell specific replication-competent viral vectors comprising a self processing peptide cleavage site
US7498024B2 (en) * 2003-06-03 2009-03-03 Cell Genesys, Inc. Compositions and methods for enhanced expression of immunoglobulins from a single vector using a peptide cleavage site
US9073980B2 (en) * 2009-03-02 2015-07-07 The Regents Of The University Of California Tumor selective E1a and E1b mutants
CN105307671A (zh) * 2013-04-18 2016-02-03 蒂尔坦生物制药有限公司 增强过继细胞疗法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670488A (en) * 1992-12-03 1997-09-23 Genzyme Corporation Adenovirus vector for gene therapy
AUPN477695A0 (en) 1995-08-14 1995-09-07 Commonwealth Scientific And Industrial Research Organisation Gene therapy
GB9626029D0 (en) 1996-12-14 1997-01-29 Univ Leeds EVH-1 vectors
US20040234505A1 (en) 1998-09-23 2004-11-25 Stuart Naylor Polynucleotide constructs and uses thereof
CN1183250C (zh) 2000-12-01 2005-01-05 卫健生物科技有限公司 高效表达肿瘤血管生成抑制因子的肿瘤细胞内特异性增殖的病毒及其构建方法
CA2445969A1 (en) 2001-04-30 2002-11-07 Cell Genesys, Inc. Viral-mediated delivery and in vivo expression of polynucleotides encoding anti-angiogenic proteins
US7473418B2 (en) 2004-03-25 2009-01-06 Cell Genesys, Inc. Pan cancer oncolytic vectors and methods of use thereof
EP1831382B1 (en) 2004-12-31 2023-01-18 Per Sonne Holm Method for reversing multiple resistance in animal cells
KR100911624B1 (ko) * 2007-05-14 2009-08-12 연세대학교 산학협력단 Ｉｌ－１２ 및 ｉｌ－２３의 효율적인 공동발현 방법
KR100896483B1 (ko) 2007-07-13 2009-05-08 연세대학교 산학협력단 Ｉｌ-12 및 4-1ｂｂｌ을 발현하는 종양 선택적 살상 재조합아데노바이러스 및 수지상 세포를 유효성분으로 포함하는항종양용 약제학적 조성물
TWI688395B (zh) 2010-03-23 2020-03-21 英翠克頌公司 條件性表現治療性蛋白質之載體、包含該載體之宿主細胞及彼等之用途
KR101253276B1 (ko) 2010-07-27 2013-04-10 윤채옥 복합 유전자 치료용 항종양 조성물
WO2012038606A1 (en) 2010-09-24 2012-03-29 Oncos Therapeutics Oy Oncolytic adenoviral vectors coding for monoclonal anti - ctla - 4 antibodies
AU2013214776B2 (en) 2012-02-02 2017-11-09 Board Of Regents, The University Of Texas System Adenoviruses expressing heterologous tumor-associated antigens
CN103614416B (zh) 2013-09-30 2016-09-07 中国人民解放军第二军医大学东方肝胆外科医院 一种携带人穿膜肽p53与GM-CSF基因的重组溶瘤腺病毒及其用途
JP6566214B2 (ja) 2014-05-28 2019-08-28 国立大学法人 岡山大学 Ｒｅｉｃ遺伝子を発現する制限増殖型アデノウイルス
KR102608590B1 (ko) 2014-09-24 2023-12-01 솔크 인스티튜트 포 바이올로지칼 스터디즈 종양 살상 바이러스 및 이의 사용방법
WO2018083259A1 (en) * 2016-11-03 2018-05-11 Psioxus Therapeutics Limited Oncolytic adenovirus encoding transgenes
US10232053B2 (en) 2016-12-30 2019-03-19 Trieza Therapeutics, Inc. Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer
KR20190128634A (ko) 2017-01-30 2019-11-18 에피센트알엑스, 인코포레이티드 다중 트랜스진 재조합 아데노바이러스
WO2018218083A1 (en) 2017-05-24 2018-11-29 Epicentrx, Inc. Anti-angiogenic adenovirus

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050136035A1 (en) * 2003-06-03 2005-06-23 Derek Ko Cell specific replication-competent viral vectors comprising a self processing peptide cleavage site
US7498024B2 (en) * 2003-06-03 2009-03-03 Cell Genesys, Inc. Compositions and methods for enhanced expression of immunoglobulins from a single vector using a peptide cleavage site
US9073980B2 (en) * 2009-03-02 2015-07-07 The Regents Of The University Of California Tumor selective E1a and E1b mutants
CN105307671A (zh) * 2013-04-18 2016-02-03 蒂尔坦生物制药有限公司 增强过继细胞疗法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
SHI-BING WANG ET AL: "Complete Eradication of Xenograft Hepatoma by Oncolytic Adenovirus ZD55 Harboring TRAIL-IETD-Smac Gene with Broad Antitumor Effect", HUMAN GENE THERAPY, no. 23 *
TAKEHIKO TAKAYANAGI ET AL: "Constitutive Stimulation of Vascular Smooth Muscle Cells by Angiotensin II Derived From an Adenovirus Encoding a Furin-Cleavable Fusion Protein", AM J HYPERTENS, vol. 25, no. 03, pages 281 *
XIAOFENG WU ET AL: "Induction of Potent TRAIL-Mediated Tumoricidal Activity by hFLEX/Furin/TRAIL Recombinant DNA Construct", MOLECULAR THERAPY, vol. 09, no. 05 *

Cited By (3)

* Cited by examiner, † Cited by third party
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WO2022007800A1 (zh) * 2020-07-06 2022-01-13 嘉兴安宇生物科技有限公司 一种非洲猪瘟的重组腺病毒疫苗及其构建方法
CN116535491A (zh) * 2022-05-06 2023-08-04 珠海丽凡达生物技术有限公司 治疗性核酸分子、混合物、药物及在治疗实体瘤中的应用
CN116535491B (zh) * 2022-05-06 2024-03-22 珠海丽凡达生物技术有限公司 治疗性核酸分子、混合物、药物及在治疗实体瘤中的应用

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