CN110914417A - 一种立体选择性的转氨酶在不对称合成手性胺中的应用 - Google Patents

一种立体选择性的转氨酶在不对称合成手性胺中的应用 Download PDF

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CN110914417A
CN110914417A CN201880046478.4A CN201880046478A CN110914417A CN 110914417 A CN110914417 A CN 110914417A CN 201880046478 A CN201880046478 A CN 201880046478A CN 110914417 A CN110914417 A CN 110914417A
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polypeptide
amino acid
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acid sequence
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CN110914417B (zh
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程占冰
张涛
田振华
瞿旭东
丁少南
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Yikelai Biotechnology (Group) Co.,Ltd.
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Abstract

一种立体选择性的转氨酶在不对称合成手性胺中的应用。具体地，提供了一种多肽在生产手性胺或以手性胺为前体的下游产物中的用途。还提供了生产手性胺的方法，所述方法包括培养表达所述多肽的菌株，从而得到式手性胺。还提供了一种手性胺生产菌株，以及所述手性胺生产菌株的构建方法。立体选择性的转氨酶，具有宽广的底物谱，在手性胺的制备方面具有很大的应用潜力。

Description

PCT国内申请，说明书已公开。

Claims (14)

  1. PCT国内申请，权利要求书已公开。
CN201880046478.4A 2017-07-11 2018-07-10 一种立体选择性的转氨酶在不对称合成手性胺中的应用 Active CN110914417B (zh)

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CN109234327A (zh) * 2017-07-11 2019-01-18 上海弈柯莱生物医药科技有限公司 一种立体选择性的转氨酶在不对称合成手性胺中的应用

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CN108586346B (zh) 2018-05-10 2019-10-01 北京富盛嘉华医药科技有限公司 一种生物催化合成西他列汀及其中间体的方法
WO2021077425A1 (zh) * 2019-10-25 2021-04-29 凯莱英医药化学（阜新）技术有限公司 转氨酶突变体及其应用
CN113061594B (zh) 2019-12-31 2023-11-24 弈柯莱生物科技(集团)股份有限公司 转氨酶突变体、固定化转氨酶及用于制备西他列汀的用途
CN110950788B (zh) * 2020-02-26 2020-06-16 凯莱英医药集团（天津）股份有限公司 含氟手性胺类化合物的合成方法
CN111235127B (zh) 2020-04-29 2020-08-14 凯莱英医药集团（天津）股份有限公司 转氨酶突变体及其应用
CN112094856B (zh) * 2020-09-23 2023-06-27 国药集团威奇达药业有限公司 一种转氨酶突变体及其在西格列汀合成中的应用
CN113430184B (zh) * 2021-06-29 2022-04-01 台州酶易生物技术有限公司 转氨酶及其在制备西他列汀中的应用
CN113481254B (zh) * 2021-06-29 2023-05-26 台州酶易生物技术有限公司 西他列汀中间体的制备方法
CN114195664A (zh) * 2021-12-30 2022-03-18 辰欣药业股份有限公司 一种磷酸西格列汀关键中间体的制备方法
WO2024098269A1 (zh) * 2022-11-09 2024-05-16 上海邦林生物科技有限公司 一种转氨酶突变体及其在西他列汀合成中的应用

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CN110914417B (zh) 2020-10-27
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WO2019011236A1 (zh) 2019-01-17
EP3650537A1 (en) 2020-05-13
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US11965193B2 (en) 2024-04-23
US11499172B2 (en) 2022-11-15
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