CN110914253A - 一类异吲哚酮-酰亚胺环-1,3-二酮-2-烯化合物、其组合物和用途 - Google Patents

一类异吲哚酮-酰亚胺环-1,3-二酮-2-烯化合物、其组合物和用途 Download PDF

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CN110914253A
CN110914253A CN201880033821.1A CN201880033821A CN110914253A CN 110914253 A CN110914253 A CN 110914253A CN 201880033821 A CN201880033821 A CN 201880033821A CN 110914253 A CN110914253 A CN 110914253A
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CN110914253B (zh
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姚志艺
罗成
谢雨礼
乐立艳
万伟
张元元
蒋华良
陈凯先
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Wigen Biomedicine Technology Shanghai Co Ltd
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Abstract

本发明提供了一类异吲哚酮‑酰亚胺环‑1,3‑二酮‑2‑烯化合物及其制备方法、药物组合物和用途，具体地，本发明提供了一类下式(I)的化合物或其药学上可接受的盐，其中，Ar为通式(II)所示的异吲哚酮‑酰亚胺基团，L不存在，或者为二价、三价或四价连接基团；X为通式(III)所示的基团，其他各基团的定义如说明书中所述。所述的式(I)化合物为一类自噬调节剂，特别是哺乳动物ATG8同源物调节剂。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201880033821.1A 2017-05-22 2018-05-17 一类异吲哚酮-酰亚胺环-1,3-二酮-2-烯化合物、其组合物和用途 Active CN110914253B (zh)

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CN201710365494.7A CN108929307A (zh) 2017-05-22 2017-05-22 一类异吲哚酮-酰亚胺环-1,3-二酮-2-烯化合物、其组合物和用途
CN2017103654947 2017-05-22
PCT/CN2018/087241 WO2018214796A1 (zh) 2017-05-22 2018-05-17 一类异吲哚酮-酰亚胺环-1,3-二酮-2-烯化合物、其组合物和用途

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CN201880033821.1A Active CN110914253B (zh) 2017-05-22 2018-05-17 一类异吲哚酮-酰亚胺环-1,3-二酮-2-烯化合物、其组合物和用途

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SI3784663T1 (sl) * 2018-04-23 2023-11-30 Celgene Corporation Spojine substituiranega 4-aminoizoindolin-1,3-diona in njihova uporaba za zdravljenje limfoma
WO2022152821A1 (en) 2021-01-13 2022-07-21 Monte Rosa Therapeutics Ag Isoindolinone compounds
CN115385859B (zh) * 2022-08-22 2024-03-08 西安交通大学 一种可细胞内自组装的蛋白降解剂及其制备方法和应用
CN115403561B (zh) * 2022-08-22 2024-03-08 西安交通大学 一种基于沙利度胺类似物的细胞内自组装蛋白降解剂及其制备方法和应用

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WO2016065980A1 (zh) * 2014-10-30 2016-05-06 康朴生物医药技术（上海）有限公司 异吲哚啉衍生物、其中间体、制备方法、药物组合物及应用
WO2017079267A1 (en) * 2015-11-02 2017-05-11 Yale University Proteolysis targeting chimera compounds and methods of preparing and using same

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UA114856C2 (uk) * 2010-02-11 2017-08-10 Селджин Корпорейшн Способи лікування із застосуванням похідних арилметоксіізоіндоліну
CN103396397A (zh) * 2013-08-14 2013-11-20 中国人民解放军军事医学科学院毒物药物研究所 来那度胺衍生物及其作为药物的用途

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WO2016065980A1 (zh) * 2014-10-30 2016-05-06 康朴生物医药技术（上海）有限公司 异吲哚啉衍生物、其中间体、制备方法、药物组合物及应用
CN105566290A (zh) * 2014-10-30 2016-05-11 康朴生物医药技术（上海）有限公司 异吲哚啉衍生物、其中间体、制备方法、药物组合物及应用
WO2017079267A1 (en) * 2015-11-02 2017-05-11 Yale University Proteolysis targeting chimera compounds and methods of preparing and using same

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CN108929307A (zh) 2018-12-04
US11021457B2 (en) 2021-06-01
US20200071291A1 (en) 2020-03-05
CN110914253B (zh) 2022-12-16
CA3063804A1 (en) 2019-12-09
WO2018214796A1 (zh) 2018-11-29

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