CN110812439A - Chewable tablet for clearing and nourishing throat and preparation method thereof - Google Patents

Chewable tablet for clearing and nourishing throat and preparation method thereof Download PDF

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CN110812439A
CN110812439A CN201810889868.XA CN201810889868A CN110812439A CN 110812439 A CN110812439 A CN 110812439A CN 201810889868 A CN201810889868 A CN 201810889868A CN 110812439 A CN110812439 A CN 110812439A
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parts
clearing
throat
moistening
raw materials
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李素琼
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells
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    • A61K36/534—Mentha (mint)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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Abstract

The invention provides a throat-clearing and moistening chewable tablet and a preparation method thereof, and relates to the technical field of chewable tablets. The chewable tablet for clearing and nourishing the throat comprises the following raw materials in parts by weight: 10-30 parts of bulbus fritillariae cirrhosae, 5-25 parts of liquorice, 12-32 parts of lily, 8-28 parts of honeysuckle, 5-25 parts of radix ophiopogonis, 1-20 parts of mint, 1-10 parts of microcrystalline cellulose and 1-10 parts of mannitol, and the preparation method comprises the following steps: (1) decocting and extracting; (2) pulverizing and sieving; (3) preparing materials, stirring and granulating; (4) drying; (5) mixing, tabletting and packaging. The throat-clearing and moistening chewable tablet provided by the invention takes the bulbus fritilariae, the liquorice, the lily, the honeysuckle and the radix ophiopogonis as the main raw materials, so that the curative effects of clearing and moistening the throat are greatly improved, the yin is nourished, the body fluid is generated, and the lung is moisturized to stop cough.

Description

Chewable tablet for clearing and nourishing throat and preparation method thereof
Technical Field
The invention relates to the technical field of chewable tablets, and particularly relates to a throat-clearing and moistening chewable tablet and a preparation method thereof.
Background
Sore throat is the most common disease, which is often caused by cold, tonsillitis, sinusitis, pertussis, pharyngolaryngitis, viral infection and even myocardial infarction in cold seasons of the year.
As the atmospheric pollution on the earth becomes more and more serious, the number of patients suffering from pharyngeal diseases is also increasing. There are many good methods for treating throat diseases, such as taking medicine, containing medicine, oral medicine, etc. However, the methods for preventing and treating throat diseases by adopting health-care foods are not frequent, because few health-care foods which are beneficial to throat in the current market and the throat-moistening health-care effect of the original throat-moistening candy is not good. Therefore, from the current requirements of throat patients, a health food which has good curative effect and is easy to eat is very needed. In addition, careers who use the throat, such as singers, teachers, announcers and the like, need to take precautions and have throat-moistening health care products with good treatment effects.
Disclosure of Invention
The invention provides a throat-clearing and moistening chewable tablet and a preparation method thereof, which aim to solve the problems.
In order to solve the problems, the technical scheme adopted by the invention is as follows:
a chewable tablet for clearing and moistening throat is characterized in that: the composite material comprises the following raw materials in parts by weight: 10-30 parts of bulbus fritillariae cirrhosae, 5-25 parts of liquorice, 12-32 parts of lily, 8-28 parts of honeysuckle, 5-25 parts of radix ophiopogonis, 1-20 parts of mint, 1-10 parts of microcrystalline cellulose and 1-10 parts of mannitol.
Bulbus Fritillariae Cirrhosae is a common Chinese medicine with the traditional effects of moistening lung, relieving cough, and eliminating phlegm, and its underground bulb is used only from ancient times to present. Bulbus Fritillariae Cirrhosae has effects of moistening lung, relieving cough, clearing heat, and eliminating phlegm, and can be used for treating cough due to heat syndrome, such as cough due to wind-heat, cough due to dryness-heat, and cough due to lung-fire. Bulbus Fritillariae Cirrhosae has antitussive, expectorant, blood pressure lowering, and antibacterial effects.
The traditional Chinese medicine liquorice is dry roots and rhizomes of liquorice, swollen liquorice or glabrous liquorice of leguminous plants, is distributed in northeast, northeast China, northern China, Shanxi, Gansu, Qinghai, Xinjiang, Shandong and other places, and has the effects of tonifying spleen and qi, clearing heat and detoxicating, eliminating phlegm and stopping cough, relieving spasm and pain, and harmonizing the medicines. Licorice root, radix Glycyrrhizae is commonly used for weakness of spleen and stomach, lassitude, hypodynamia, palpitation, shortness of breath, cough, profuse sputum, spasm and pain of the abdomen and limbs, carbuncle, swelling, sore and toxicity, and for alleviating toxicity and strong nature of drugs.
The traditional Chinese medicine Bulbus Lilii is dried fleshy scaly leaf of Liliaceae plant herba Centellae, Bulbus Lilii or Bulbus Lilii Microphylli. Lily has the effects of nourishing yin, moistening lung, clearing heart fire and tranquilizing mind, and is commonly used for treating dry cough due to yin deficiency, overstrain cough, hemoptysis, dysphoria, insomnia, dreaminess and absentmindedness.
The Chinese medicinal material flos Lonicerae is flower bud of Lonicera Japonica flos, Lonicera Zizaniae Caduciflora, and Lonicera fulvidraco of Lonicera of Caprifoliaceae. The honeysuckle is mostly distributed in east China, south China, southwest China, Hebei, Shanxi, Liaoning, Shaanxi, Gansu and other places; lonicera confusa is mostly distributed in Guangdong, Guangxi and Hainan; the lonicera aegypti is distributed in Zhejiang, Anhui, Fujian, Jiangxi, Hubei, Hunan, Guangdong, Guangxi, Sichuan, Guizhou, Yunnan, Taiwan and the like; lonicera fulvidraco is distributed in Guangxi, Guizhou and Yunnan provinces. The honeysuckle has the efficacy of clearing away heat and toxic materials, and is mainly used for treating exogenous wind-heat or epidemic febrile disease fever, heatstroke, heat toxin and bloody dysentery, carbuncle swelling and furuncle, pharyngitis and various infectious diseases.
The radix Ophiopogonis is dried root tuber of Ophiopogon japonicus of Liliaceae. The main functional indications of radix ophiopogonis are as follows: nourishing yin, promoting production of body fluid, moistening lung, and relieving cough; can be used for treating deficiency of body fluid, thirst, dry cough, and hemoptysis due to yin deficiency of lung and stomach; palpitation due to heart yin deficiency and fluid impairment due to heat in the late stage of fever. Mai Dong, Sha Shen and Chuan Bei mu are indicated for dry cough due to lung yin deficiency.
The mint, named as traditional Chinese medicine and named as 'Yindancao' in soil, is a labiate plant, namely other dry whole herbs in the same genus, mostly grows beside a mountain wetland river, and roots and stems transversely grow underground, and is an aromatic crop with special economic value. It is a sweating and antipyretic, and can be used for treating influenza, headache, conjunctival congestion, fever, sore throat, and gum swelling. The mint picked in the bright greenhouse is also a fresh vegetable on a dining table in spring festival, and is fresh, cool and delicious. Herba Menthae is usually used instead of tea for clearing away heart-fire and improving eyesight.
Microcrystalline cellulose is a purified, partially depolymerized cellulose, white, odorless, tasteless, crystalline powder composed of porous microparticles. Microcrystalline cellulose is widely used in pharmaceutical, cosmetic, food and other industries, and different particle sizes and water contents have different characteristics and application ranges. In the pharmaceutical industry, microcrystalline cellulose is commonly used as an adsorbent, suspending agent, diluent, disintegrant. Microcrystalline cellulose is widely used in pharmaceutical formulations, mainly as diluent and binder in oral tablets and capsules, not only for wet granulation but also for dry direct compression. Also has certain lubricating and disintegrating effects, and is very useful in the preparation of tablets.
Mannitol is a homologue of sorbitolIn a isomer, the hydroxyl groups on the second carbon atoms of the two alcohols are oriented differently, and the molecular formula is C6H14O6And the molecular weight is 182.17. Mannitol is readily soluble in water, is a white, transparent solid, and has a sweet taste similar to sucrose. Mannitol as excipient for tablet has no hygroscopicity, quick drying, good chemical stability, good taste, good granulation property, and can be used for most of tablet of anticancer drug, antibacterial drug, antihistamine, and vitamins. In addition, mannitol is also used in chewable tablets such as sobering drugs, mouth coolants, and the like.
As the atmospheric pollution on the earth becomes more and more serious, the number of patients suffering from pharyngeal diseases is also increasing. There are many good methods for treating throat diseases, such as taking medicine, containing medicine, oral medicine, etc. However, the methods for preventing and treating throat diseases by adopting health-care foods are not frequent, because few health-care foods which are beneficial to throat in the current market and the throat-moistening health-care effect of the original throat-moistening candy is not good. Therefore, from the current requirements of throat patients, a health food which has good curative effect and is easy to eat is very needed. In addition, careers who use the throat, such as singers, teachers, announcers and the like, need to take precautions and have throat-moistening health care products with good treatment effects.
In order to solve the problems, the invention innovatively discovers that the bulbus fritilariae and the liquorice are used together to moisten lung, relieve cough, reduce phlegm and relieve asthma; bulbus Fritillariae Cirrhosae, in combination with radix Ophiopogonis, has effects in nourishing yin, moistening lung, eliminating phlegm, and relieving cough; the compatibility of liquorice and honeysuckle is mainly used for treating carbuncle, furuncle, throat impediment, erysipelas, heat toxin and bloody dysentery, wind-heat type common cold, epidemic febrile disease, fever, carbuncle, cellulitis and the initial stage of back development; the honeysuckle and the dwarf lilyturf tuber are used together, the honeysuckle clears away heat and toxic materials, the dwarf lilyturf tuber nourishes yin and promotes the production of body fluid, and the matching effects of the honeysuckle and the dwarf lilyturf tuber are mutually assisted, so that the honeysuckle and the dwarf lilyturf tuber have good effects of nourishing yin, moistening, clearing; the honeysuckle, the dwarf lilyturf tuber and the liquorice are used together, so that the medicine has good curative effect on hoarseness and sore throat; the lily and the dwarf lilyturf tuber are used together, both can moisten lung, promote fluid production and clear heat, and the lily can relieve cough, has the effects of clearing heat, promoting fluid production, moistening lung and relieving cough and is used for treating dry cough caused by lung injury due to fever and the like.
Therefore, the throat clearing and moistening chewable tablet provided by the invention takes the bulbus fritilariae, the liquorice, the lily, the honeysuckle and the radix ophiopogonis as the main raw materials, so that the curative effects of clearing and moistening the throat are greatly improved, the yin is nourished, the body fluid is generated, and the lung is moisturized to stop cough.
Meanwhile, the shutdown throat clearing and moistening chewable tablets are flavored with mint, are fresh and durable, and greatly improve the acceptability of people at different age stages to the throat clearing and moistening chewable tablets.
In addition, the chewable tablet can be taken in the oral cavity, is convenient to swallow and fast to absorb and takes effect.
In order to achieve the purpose, the invention also provides a preparation method of the throat-clearing and moistening chewable tablet, which comprises the following steps:
(1) decocting and extracting: cleaning Bulbus Fritillariae Cirrhosae, Glycyrrhrizae radix, Bulbus Lilii, flos Lonicerae, radix Ophiopogonis and herba Menthae, respectively adding 8 times of water, boiling under normal pressure for two hours to obtain respective decoction residues and decoctions, respectively, decocting the obtained decoction residues for use, performing secondary decoction extraction, mixing the decoction obtained after the secondary decoction extraction with the decoction obtained by the primary decoction extraction, and concentrating to obtain concentrated slurry of various raw materials;
(2) crushing and sieving: pulverizing microcrystalline cellulose and mannitol, and sieving to obtain corresponding adjuvant powder;
(3) material proportioning, stirring and granulating: reasonably proportioning the concentrated slurry of various raw materials obtained in the step (1) according to a proportion, weighing the auxiliary material powder obtained in the step (2) one by one, pouring the weighed auxiliary material powder into a stirring machine, then pouring the concentrated slurry of various raw materials in sequence, mixing and stirring for 30 minutes until the mixture is uniform, adding a proper amount of purified water, stirring until the mixture is held to be a mass and a soft material which is scattered when the mixture is contacted, and transferring the prepared soft material into a swing type granulator to prepare uniform and consistent particles;
(4) drying: sending the prepared particles into a dryer for drying, and naturally cooling to obtain a semi-finished product;
(5) total mixing, tabletting and packaging: and (3) totally mixing the cooled semi-finished products, feeding the mixture into a tabletting machine for tabletting after total mixing, and packaging tablets obtained after tabletting to obtain the throat-clearing and moistening chewable tablets.
Further, the crushing and sieving in the step (2) specifically comprises: respectively pulverizing microcrystalline cellulose and mannitol, sieving with 80 mesh sieve, and respectively filling the sieved fine powder into clean containers.
Further, the granulating in the step (3) specifically comprises: the granules were sized using a 14-mesh sieve.
Further, the drying in the step (4) specifically includes: and (4) uniformly placing the particles prepared in the step (3) in a drying disc, and sending the particles into a dryer for drying at the drying temperature of 50-60 ℃ until the water content of the particles is less than 5%.
Further, the tabletting in the step (5) specifically comprises: the hardness of the tablet obtained after tabletting is 5-8 kg.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
1. the throat-clearing and moistening chewable tablet provided by the invention takes the bulbus fritilariae, the liquorice, the lily, the honeysuckle and the radix ophiopogonis as the main raw materials, so that the curative effects of clearing and moistening the throat are greatly improved, the yin is nourished, the body fluid is generated, and the lung is moisturized to stop cough.
2. The shutdown throat clearing and moistening chewable tablet is supplemented with mint for seasoning, is fresh and durable, and greatly improves the acceptability of people at different age stages to the throat clearing and moistening chewable tablet.
3. The chewable tablet is adopted, can play a role in the oral cavity, is convenient to swallow and fast to absorb and takes effect.
Detailed Description
All features disclosed in this specification may be combined in any combination, except features and/or steps that are mutually exclusive.
Example 1
A chewable tablet for clearing and moistening throat is characterized in that: the composite material comprises the following raw materials in parts by weight: 10 parts of bulbus fritillariae cirrhosae, 5 parts of liquorice, 12 parts of lily, 8 parts of honeysuckle, 5 parts of radix ophiopogonis, 1 part of mint, 1 part of microcrystalline cellulose and 1-part of mannitol.
The preparation method of the chewable tablet for clearing and moistening throat in the embodiment comprises the following steps:
(1) decocting and extracting: cleaning Bulbus Fritillariae Cirrhosae, Glycyrrhrizae radix, Bulbus Lilii, flos Lonicerae, radix Ophiopogonis and herba Menthae, respectively adding 8 times of water, boiling under normal pressure for two hours to obtain respective decoction residues and decoctions, respectively, decocting the obtained decoction residues for use, performing secondary decoction extraction, mixing the decoction obtained after the secondary decoction extraction with the decoction obtained by the primary decoction extraction, and concentrating to obtain concentrated slurry of various raw materials;
(2) crushing and sieving: pulverizing microcrystalline cellulose and mannitol, and sieving to obtain corresponding adjuvant powder;
(3) material proportioning, stirring and granulating: reasonably proportioning the concentrated slurry of various raw materials obtained in the step (1) according to a proportion, weighing the auxiliary material powder obtained in the step (2) one by one, pouring the weighed auxiliary material powder into a stirring machine, then pouring the concentrated slurry of various raw materials in sequence, mixing and stirring for 30 minutes until the mixture is uniform, adding a proper amount of purified water, stirring until the mixture is held to be a mass and a soft material which is scattered when the mixture is contacted, and transferring the prepared soft material into a swing type granulator to prepare uniform and consistent particles;
(4) drying: sending the prepared particles into a dryer for drying, and naturally cooling to obtain a semi-finished product;
(5) total mixing, tabletting and packaging: and (3) totally mixing the cooled semi-finished products, feeding the mixture into a tabletting machine for tabletting after total mixing, and packaging tablets obtained after tabletting to obtain the throat-clearing and moistening chewable tablets.
Example 2
A chewable tablet for clearing and moistening throat is characterized in that: the composite material comprises the following raw materials in parts by weight: 30 parts of bulbus fritillariae cirrhosae, 25 parts of liquorice, 32 parts of lily, 28 parts of honeysuckle, 25 parts of radix ophiopogonis, 20 parts of mint, 10 parts of microcrystalline cellulose and 10 parts of mannitol.
The preparation method of the chewable tablet for clearing and moistening throat in the embodiment comprises the following steps:
(1) decocting and extracting: cleaning Bulbus Fritillariae Cirrhosae, Glycyrrhrizae radix, Bulbus Lilii, flos Lonicerae, radix Ophiopogonis and herba Menthae, respectively adding 8 times of water, boiling under normal pressure for two hours to obtain respective decoction residues and decoctions, respectively, decocting the obtained decoction residues for use, performing secondary decoction extraction, mixing the decoction obtained after the secondary decoction extraction with the decoction obtained by the primary decoction extraction, and concentrating to obtain concentrated slurry of various raw materials;
(2) crushing and sieving: pulverizing microcrystalline cellulose and mannitol, and sieving to obtain corresponding adjuvant powder;
(3) material proportioning, stirring and granulating: reasonably proportioning the concentrated slurry of various raw materials obtained in the step (1) according to a proportion, weighing the auxiliary material powder obtained in the step (2) one by one, pouring the weighed auxiliary material powder into a stirring machine, then pouring the concentrated slurry of various raw materials in sequence, mixing and stirring for 30 minutes until the mixture is uniform, adding a proper amount of purified water, stirring until the mixture is held to be a mass and a soft material which is scattered when the mixture is contacted, and transferring the prepared soft material into a swing type granulator to prepare uniform and consistent particles;
(4) drying: sending the prepared particles into a dryer for drying, and naturally cooling to obtain a semi-finished product;
(5) total mixing, tabletting and packaging: and (3) totally mixing the cooled semi-finished products, feeding the mixture into a tabletting machine for tabletting after total mixing, and packaging tablets obtained after tabletting to obtain the throat-clearing and moistening chewable tablets.
Example 3
A chewable tablet for clearing and moistening throat is characterized in that: the composite material comprises the following raw materials in parts by weight: 15 parts of bulbus fritillariae cirrhosae, 10 parts of hay, 17 parts of lily, 13 parts of honeysuckle, 10 parts of radix ophiopogonis, 5 parts of mint, 3 parts of microcrystalline cellulose and 3 parts of mannitol.
The preparation method of the chewable tablet for clearing and moistening throat in the embodiment comprises the following steps:
(1) decocting and extracting: cleaning Bulbus Fritillariae Cirrhosae, Glycyrrhrizae radix, Bulbus Lilii, flos Lonicerae, radix Ophiopogonis and herba Menthae, respectively adding 8 times of water, boiling under normal pressure for two hours to obtain respective decoction residues and decoctions, respectively, decocting the obtained decoction residues for use, performing secondary decoction extraction, mixing the decoction obtained after the secondary decoction extraction with the decoction obtained by the primary decoction extraction, and concentrating to obtain concentrated slurry of various raw materials;
(2) crushing and sieving: pulverizing microcrystalline cellulose and mannitol, and sieving to obtain corresponding adjuvant powder;
(3) material proportioning, stirring and granulating: reasonably proportioning the concentrated slurry of various raw materials obtained in the step (1) according to a proportion, weighing the auxiliary material powder obtained in the step (2) one by one, pouring the weighed auxiliary material powder into a stirring machine, then pouring the concentrated slurry of various raw materials in sequence, mixing and stirring for 30 minutes until the mixture is uniform, adding a proper amount of purified water, stirring until the mixture is held to be a mass and a soft material which is scattered when the mixture is contacted, and transferring the prepared soft material into a swing type granulator to prepare uniform and consistent particles;
(4) drying: sending the prepared particles into a dryer for drying, and naturally cooling to obtain a semi-finished product;
(5) total mixing, tabletting and packaging: and (3) totally mixing the cooled semi-finished products, feeding the mixture into a tabletting machine for tabletting after total mixing, and packaging tablets obtained after tabletting to obtain the throat-clearing and moistening chewable tablets.
Example 4
A chewable tablet for clearing and moistening throat is characterized in that: the composite material comprises the following raw materials in parts by weight: 25 parts of bulbus fritillariae cirrhosae, 20 parts of hay, 27 parts of lily, 23 parts of honeysuckle, 20 parts of radix ophiopogonis, 15 parts of mint, 8 parts of microcrystalline cellulose and 8 parts of mannitol.
The preparation method of the chewable tablet for clearing and moistening throat in the embodiment comprises the following steps:
(1) decocting and extracting: cleaning Bulbus Fritillariae Cirrhosae, Glycyrrhrizae radix, Bulbus Lilii, flos Lonicerae, radix Ophiopogonis and herba Menthae, respectively adding 8 times of water, boiling under normal pressure for two hours to obtain respective decoction residues and decoctions, respectively, decocting the obtained decoction residues for use, performing secondary decoction extraction, mixing the decoction obtained after the secondary decoction extraction with the decoction obtained by the primary decoction extraction, and concentrating to obtain concentrated slurry of various raw materials;
(2) crushing and sieving: pulverizing microcrystalline cellulose and mannitol, and sieving to obtain corresponding adjuvant powder;
(3) material proportioning, stirring and granulating: reasonably proportioning the concentrated slurry of various raw materials obtained in the step (1) according to a proportion, weighing the auxiliary material powder obtained in the step (2) one by one, pouring the weighed auxiliary material powder into a stirring machine, then pouring the concentrated slurry of various raw materials in sequence, mixing and stirring for 30 minutes until the mixture is uniform, adding a proper amount of purified water, stirring until the mixture is held to be a mass and a soft material which is scattered when the mixture is contacted, and transferring the prepared soft material into a swing type granulator to prepare uniform and consistent particles;
(4) drying: sending the prepared particles into a dryer for drying, and naturally cooling to obtain a semi-finished product;
(5) total mixing, tabletting and packaging: and (3) totally mixing the cooled semi-finished products, feeding the mixture into a tabletting machine for tabletting after total mixing, and packaging tablets obtained after tabletting to obtain the throat-clearing and moistening chewable tablets.
Example 5
A chewable tablet for clearing and moistening throat is characterized in that: the composite material comprises the following raw materials in parts by weight: 20 parts of bulbus fritillariae cirrhosae, 15 parts of hay, 22 parts of lily, 18 parts of honeysuckle, 15 parts of radix ophiopogonis, 10 parts of mint, 5 parts of microcrystalline cellulose and 5 parts of mannitol.
The preparation method of the chewable tablet for clearing and moistening throat in the embodiment comprises the following steps:
(1) decocting and extracting: cleaning Bulbus Fritillariae Cirrhosae, Glycyrrhrizae radix, Bulbus Lilii, flos Lonicerae, radix Ophiopogonis and herba Menthae, respectively adding 8 times of water, boiling under normal pressure for two hours to obtain respective decoction residues and decoctions, respectively, decocting the obtained decoction residues for use, performing secondary decoction extraction, mixing the decoction obtained after the secondary decoction extraction with the decoction obtained by the primary decoction extraction, and concentrating to obtain concentrated slurry of various raw materials;
(2) crushing and sieving: pulverizing microcrystalline cellulose and mannitol, and sieving to obtain corresponding adjuvant powder;
(3) material proportioning, stirring and granulating: reasonably proportioning the concentrated slurry of various raw materials obtained in the step (1) according to a proportion, weighing the auxiliary material powder obtained in the step (2) one by one, pouring the weighed auxiliary material powder into a stirring machine, then pouring the concentrated slurry of various raw materials in sequence, mixing and stirring for 30 minutes until the mixture is uniform, adding a proper amount of purified water, stirring until the mixture is held to be a mass and a soft material which is scattered when the mixture is contacted, and transferring the prepared soft material into a swing type granulator to prepare uniform and consistent particles;
(4) drying: sending the prepared particles into a dryer for drying, and naturally cooling to obtain a semi-finished product;
(5) total mixing, tabletting and packaging: and (3) totally mixing the cooled semi-finished products, feeding the mixture into a tabletting machine for tabletting after total mixing, and packaging tablets obtained after tabletting to obtain the throat-clearing and moistening chewable tablets.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be able to cover the technical scope of the present invention and the equivalent alternatives or modifications according to the technical solution and the inventive concept of the present invention within the technical scope of the present invention.

Claims (8)

1. A chewable tablet for clearing and moistening throat is characterized in that: the composite material comprises the following raw materials in parts by weight: 10-30 parts of bulbus fritillariae cirrhosae, 5-25 parts of liquorice, 12-32 parts of lily, 8-28 parts of honeysuckle, 5-25 parts of radix ophiopogonis, 1-20 parts of mint, 1-10 parts of microcrystalline cellulose and 1-10 parts of mannitol.
2. The chewable tablet for clearing and nourishing the throat according to claim 1, which is characterized in that: the composite material comprises the following raw materials in parts by weight: 15-25 parts of bulbus fritillariae cirrhosae, 10-20 parts of hay, 17-27 parts of lily, 13-23 parts of honeysuckle, 10-20 parts of radix ophiopogonis, 5-15 parts of mint, 3-8 parts of microcrystalline cellulose and 3-8 parts of mannitol.
3. The chewable tablet for clearing and nourishing the throat according to claim 1, which is characterized in that: the composite material comprises the following raw materials in parts by weight: 20 parts of bulbus fritillariae cirrhosae, 15 parts of hay, 22 parts of lily, 18 parts of honeysuckle, 15 parts of radix ophiopogonis, 10 parts of mint, 5 parts of microcrystalline cellulose and 5 parts of mannitol.
4. A method for preparing a chewable tablet for clearing and moistening the throat according to claims 1 to 3, which is characterized in that: the method comprises the following steps:
(1) decocting and extracting: cleaning Bulbus Fritillariae Cirrhosae, Glycyrrhrizae radix, Bulbus Lilii, flos Lonicerae, radix Ophiopogonis and herba Menthae, respectively adding 8 times of water, boiling under normal pressure for two hours to obtain respective decoction residues and decoctions, respectively, decocting the obtained decoction residues for use, performing secondary decoction extraction, mixing the decoction obtained after the secondary decoction extraction with the decoction obtained by the primary decoction extraction, and concentrating to obtain concentrated slurry of various raw materials;
(2) crushing and sieving: pulverizing microcrystalline cellulose and mannitol, and sieving to obtain corresponding adjuvant powder;
(3) material proportioning, stirring and granulating: reasonably proportioning the concentrated slurry of various raw materials obtained in the step (1) according to a proportion, weighing the auxiliary material powder obtained in the step (2) one by one, pouring the weighed auxiliary material powder into a stirring machine, then pouring the concentrated slurry of various raw materials in sequence, mixing and stirring for 30 minutes until the mixture is uniform, adding a proper amount of purified water, stirring until the mixture is held to be a mass and a soft material which is scattered when the mixture is contacted, and transferring the prepared soft material into a swing type granulator to prepare uniform and consistent particles;
(4) drying: sending the prepared particles into a dryer for drying, and naturally cooling to obtain a semi-finished product;
(5) total mixing, tabletting and packaging: and (3) totally mixing the cooled semi-finished products, feeding the mixture into a tabletting machine for tabletting after total mixing, and packaging tablets obtained after tabletting to obtain the throat-clearing and moistening chewable tablets.
5. The method for preparing chewable tablets for clearing and nourishing throat according to claim 4, characterized in that: the crushing and sieving in the step (2) are specifically as follows: respectively pulverizing microcrystalline cellulose and mannitol, sieving with 80 mesh sieve, and respectively filling the sieved fine powder into clean containers.
6. The method for preparing chewable tablets for clearing and nourishing throat according to claim 4, characterized in that: the granulation in the step (3) specifically comprises the following steps: the granules were sized using a 14-mesh sieve.
7. The method for preparing chewable tablets for clearing and nourishing throat according to claim 4, characterized in that: the drying in the step (4) specifically comprises the following steps: and (4) uniformly placing the particles prepared in the step (3) in a drying disc, and sending the particles into a dryer for drying at the drying temperature of 50-60 ℃ until the water content of the particles is less than 5%.
8. The method for preparing chewable tablets for clearing and nourishing throat according to claim 4, characterized in that: the tabletting in the step (5) specifically comprises the following steps: the hardness of the tablet obtained after tabletting is 5-8 kg.
CN201810889868.XA 2018-08-07 2018-08-07 Chewable tablet for clearing and nourishing throat and preparation method thereof Pending CN110812439A (en)

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Application publication date: 20200221