CN112999288B - Traditional Chinese medicine tablet for treating viral influenza and preparation method thereof - Google Patents
Traditional Chinese medicine tablet for treating viral influenza and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines, and particularly relates to a vitamin C Yinqiao tablet and a preparation method and application thereof. The vitamin C Yinqiao tablet provided by the invention is prepared from traditional Chinese medicine extract particles and auxiliary materials, wherein the traditional Chinese medicine extract particles are prepared from lonicera confusa, fructus forsythiae, herba schizonepetae, burdock, platycodon grandiflorum, liquorice, radix isatidis, herba houttuyniae, herba violae, cape jasmine and semiaquilegia. The vitamin C Yinqiao tablet provided by the invention can cope with viral influenza, the vitamin C in the formula has good stability, the vitamin C cannot be degraded in the preparation process, the vitamin C is well mixed with other components, the prepared tablet has high hardness, and the tablet is easy to coat. In addition, the preparation method of the vitamin C Yinqiao tablets provided by the invention is simple, controllable in conditions, short in production period and beneficial to realizing industrial production.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine tablet for treating viral influenza and a preparation method thereof.
Background
The cold is the most common disease in our daily life, and the vitamin C Yinqiao tablet is a common Chinese patent medicine for treating the cold, can dispel wind, relieve exterior syndrome, clear heat and disinfect, is clinically used for treating the influenza caused by wind heat, and has the symptoms of fever, headache, cough, dry mouth and throat pain. The traditional vitamin C Yinqiao tablet is prepared from lonicera confusa, fructus forsythiae, mint, herba schizonepetae, fermented soybean, great burdock achene, platycodon grandiflorum, lophatherum gracile, liquorice and the like. However, vitamin C in the components of the traditional vitamin C Yinqiao tablets is unstable and is easily degraded after being wetted and heated in granulation, so that the vitamin C needs to be coated firstly, if the vitamin C is not coated, the vitamin C is degraded in the production process, and the final finished product does not meet the quality requirement, however, the whole production period is prolonged by adding the coating treatment process, the process is complex, the coated vitamin C cannot be crushed and damaged, so that the uniformity in ingredient mixing is poor, and the prepared granules have poor viscosity, and are easy to crack, have low hardness, are difficult to coat and other technical problems.
Meanwhile, the pathogenic microorganisms causing cold and disease treatment are various in shape and color, and influenza viruses often have various variant forms, so that the existing vitamin C Yinqiao tablets are often not good in treatment when dealing with complicated and variable pathogenic microorganisms, and therefore a new anti-cold and antiviral traditional Chinese medicine preparation with wide application is required to be developed.
Patent publication No. CN110841011A discloses a vitamin C Yinqiao tablet for treating cold and a preparation method thereof, the components of the tablet comprise flos lonicerae, fructus forsythiae, herba schizonepetae, fermented soybean, lophatherum gracile, rhizoma phragmitis, platycodon grandiflorum, liquorice, fructus arctii, acetaminophen, chlorphenamine maleate, peppermint oil, vitamin C and the like, and the preparation process comprises the process steps of traditional Chinese medicine water extraction, extraction concentration, drying and crushing, mixing granulation, tabletting and the like. The vitamin C Yinqiao tablet prepared by the formula can effectively relieve cold symptoms, and the high-efficiency tablet press can press a plurality of tablet cores once, and can treat powder on the surfaces of the tablet cores before the tablet cores are collected, so that the tablet cores can be directly coated without surface treatment again, but the vitamin C Yinqiao tablet produced by the method does not treat vitamin C, and has poor stability.
Patent publication No. CN101249224A discloses a method for improving the stability of vitamin C Yinqiao tablets, which comprises the processes of traditional Chinese medicine extraction, drying and crushing, mixing and granulating, coating vitamin C, tabletting and the like, wherein the coating vitamin C is obtained by mixing gelatin slurry and vitamin powder, rubbing coarse powder after drying, sieving, continuously coating fine powder with a film, and repeating for 4-6 layers. The vitamin C in the vitamin C Yinqiao tablets prepared by the method is effectively coated, and the vitamin C is prevented from being degraded in the production process, but the method has longer production period, complex process and difficult control of coating thickness.
In conclusion, the prior art generally has the technical problems of poor stability, complex coating process, poor vitamin C uniformity, poor antiviral property and the like.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide a traditional Chinese medicine tablet for treating viral influenza and a preparation method and application thereof. The traditional Chinese medicine tablet for treating viral influenza provided by the invention can cope with viral influenza, the vitamin C in the formula is good in stability, the vitamin C is not degraded in the preparation process, the mixing uniformity of the vitamin C and other components is good, the prepared tablet is high in hardness, and the tablet is easy to coat. In addition, the preparation method of the traditional Chinese medicine tablet for treating viral influenza is simple, controllable in conditions, short in production period and beneficial to realization of industrial production.
In order to achieve the purpose, the technical scheme of the invention is as follows:
a Chinese medicinal tablet for treating viral influenza comprises Chinese medicinal extract granule and adjuvant.
Furthermore, the traditional Chinese medicine extract particles and the auxiliary materials in the traditional Chinese medicine tablet for treating viral influenza are 7-9:4 in mass ratio.
Further, the traditional Chinese medicine extract particles in the traditional Chinese medicine tablet for treating viral influenza are prepared from the following traditional Chinese medicines in parts by weight: 25-30 parts of lonicera confusa, 15-20 parts of fructus forsythiae, 6-12 parts of schizonepeta, 5-9 parts of burdock, 11-15 parts of platycodon grandiflorum, 7-13 parts of liquorice, 6-15 parts of isatis root, 13-17 parts of houttuynia cordata, 8-14 parts of bunge corydalis herb, 3-5 parts of cape jasmine and 9-16 parts of semiaquilegia adoxoides.
Furthermore, the auxiliary materials in the traditional Chinese medicine tablet for treating viral influenza comprise the following components in parts by weight: vitamin C10-15 parts, silicon dioxide 8-16 parts and magnesium stearate 11-14 parts.
Further, the preparation method of the traditional Chinese medicine extract granules in the traditional Chinese medicine tablet for treating viral influenza comprises the following steps:
s1, respectively adding flos Lonicerae, fructus forsythiae and herba Schizonepetae into a volatile oil extractor, adding water, and extracting by steam distillation for 5-7h to obtain volatile oil and residue;
s2, decocting the residues obtained in the step S1, platycodon grandiflorum, liquorice, isatis root, houttuynia cordata, bunge corydalis herb, cape jasmine fruit and semiaquilegia root in water for 3-5 times, 2-3h each time, filtering and combining the filtrates to obtain a first liquid medicine;
s3, adding the burdock and the ethanol solution into a hot reflux extraction concentrator, carrying out heating reflux extraction for 3-5 times, each time for 2-3h, filtering, combining filtrate, recovering ethanol, dissolving paraffin in the filtrate at 56-60 ℃, cooling until the paraffin floats on the liquid surface after the paraffin is completely dissolved, and removing the paraffin to obtain a second liquid medicine;
s4, mixing the first liquid medicine obtained in the step S2 and the second liquid medicine obtained in the step S3, concentrating under reduced pressure to obtain a thick paste with the density of 0.9-1.0, adding magnesium stearate, uniformly mixing, and drying to obtain a dry extract;
s5, crushing the dry extract prepared in the step S4 into fine particles with the particle size of 0.5-1.5mm, and thus obtaining the dry extract.
Furthermore, the mass percentage of the ethanol solution in the step S3 of the preparation method of the traditional Chinese medicine extract particles in the traditional Chinese medicine tablet for treating viral influenza is 60-70%; the adding mass ratio of the burdock and the ethanol solution is 1: 5-8.
Furthermore, the Chinese medicinal extract granule in the Chinese medicinal tablet for treating viral influenza is prepared by concentrating under reduced pressure at 50-55 deg.C under-0.10-0.12 Mpa in step S4.
The invention also provides a preparation method of the traditional Chinese medicine tablet for treating viral influenza, which comprises the following steps:
(1) taking the traditional Chinese medicine extract particles with the formula amount and the volatile oil obtained in the preparation process thereof for later use;
(2) mixing vitamin C and additives, stirring thoroughly, adding the volatile oil in step (1), preparing into fine particles with particle size of 0.5-1.5mm, mixing with the Chinese medicinal extract particles in step (1), tabletting with a tabletting machine to obtain tablet cores, and coating the tablet cores to obtain the final product.
Furthermore, the traditional Chinese medicine tablet for treating viral influenza, which is prepared by the preparation method of the traditional Chinese medicine tablet for treating viral influenza, is applied to the preparation of medicines for treating wind-cold type common cold and viral influenza.
The traditional Chinese medicine tablet for treating viral influenza provided by the invention reserves components of lonicera confusa, fructus forsythiae, schizonepeta, burdock, platycodon grandiflorum, liquorice and the like in the traditional vitamin C Yinqiao tablet, and is added with other traditional Chinese medicine components to form the formula of the traditional Chinese medicine tablet for treating viral influenza. Wherein, the isatis root has the efficacies of clearing away heat and toxic material, relieving sore throat and reducing swelling, and also has the efficacies of resisting virus, preventing virus, resisting bacteria and diminishing inflammation and improving immunity. The herba Houttuyniae can be used for regulating infection caused by various viruses and bacteria, such as influenza, wind-heat type common cold, etc., and relieving inflammation such as pneumonia, pharyngitis, etc., and can be used as Chinese medicinal component to avoid side effect caused by antibiotic administration. Herba Violae has effects of clearing heat and detoxicating, sterilizing, diminishing inflammation, and relieving swelling and pain, and herba Semiaquilegiae has effects of clearing heat and detoxicating, relieving swelling and resolving hard mass, inducing diuresis and promoting diuresis. The components of radix isatidis, houttuynia cordata, bunge corydalis herb, semiaquilegia root and the like are used together with the components of the traditional vitamin C Yinqiao tablet, so that the effects of dispelling wind, relieving exterior syndrome, clearing heat and removing toxicity of the vitamin C Yinqiao tablet can be effectively enhanced, viruses can be effectively resisted, and viral influenza can be relieved. The research of the invention finds that the antiviral efficacy is the greatest when the components of the isatis root, the houttuynia cordata, the bunge corydalis herb and the semiaquilegia root are used within the dosage range provided by the invention.
The silicon dioxide is often used in foods such as egg powder, milk powder, cocoa powder and the like, is used as an anticaking agent and has an anticaking effect. According to the invention, the vitamin C is adsorbed and wrapped by the silicon dioxide by mixing the silicon dioxide with large specific surface area, high porosity and strong adsorbability with the vitamin C, so that the vitamin C is prevented from being degraded in the preparation process to influence the drug effect. In addition, the silicon dioxide in the traditional Chinese medicine tablet for treating the viral influenza can also absorb moisture around the tablet, prevent the drug from denaturation and influence the drug effect.
Compared with the prior art, the traditional Chinese medicine tablet for treating viral influenza and the preparation method thereof provided by the invention have the following advantages:
(1) the traditional Chinese medicine tablet for treating viral influenza provided by the invention has the effects of dispelling wind, relieving exterior syndrome, clearing heat and removing toxicity, and can be used for treating viral influenza;
(2) the vitamin C in the formula of the traditional Chinese medicine tablet for treating viral influenza provided by the invention has good stability, can not be degraded in the preparation process, and has good mixing uniformity with other components;
(3) the traditional Chinese medicine tablet for treating viral influenza provided by the invention has the advantages of simple preparation method, controllable conditions and short production period, and is beneficial to realizing industrial production.
Detailed Description
The present invention will be further described below by way of specific embodiments, but the present invention is not limited to only the following examples. Various modifications can be made by those skilled in the art based on the basic idea of the invention, but it is within the scope of the invention as long as it does not depart from the basic idea of the invention.
The traditional Chinese medicine tablet for treating viral influenza in the embodiment comprises traditional Chinese medicine extract particles and auxiliary materials.
Example 1A Chinese medicinal tablet for treating viral influenza, and its preparation method
The traditional Chinese medicine extract particles and the auxiliary materials in the traditional Chinese medicine tablet for treating the viral influenza are 7:4 in mass ratio.
The important extract particles in the traditional Chinese medicine tablet for treating viral influenza are prepared from the following traditional Chinese medicines in parts by weight: 25 parts of lonicera confusa, 15 parts of forsythia, 6 parts of schizonepeta, 5 parts of burdock, 11 parts of platycodon grandiflorum, 7 parts of liquorice, 6 parts of isatis root, 13 parts of houttuynia cordata, 8 parts of bunge corydalis herb, 3 parts of gardenia and 9 parts of semiaquilegia root.
The auxiliary materials in the traditional Chinese medicine tablet for treating viral influenza comprise the following components in parts by weight: 15 parts of vitamin C, 16 parts of silicon dioxide and 14 parts of magnesium stearate.
The preparation method of the traditional Chinese medicine extract granules in the traditional Chinese medicine tablet for treating viral influenza comprises the following steps:
s1, respectively adding flos Lonicerae, fructus forsythiae and herba Schizonepetae into a volatile oil extractor, adding water, and extracting by steam distillation for 5 hr to obtain volatile oil and residue;
s2, decocting the residues obtained in the step S1, platycodon grandiflorum, liquorice, isatis root, houttuynia cordata, bunge corydalis herb, cape jasmine fruit and semiaquilegia root in water for 3 times, 2 hours each time, filtering and combining the filtrates to obtain a first liquid medicine;
s3, adding the burdock and 60% ethanol solution in a mass ratio of 1:5 into a hot reflux extraction concentrator, carrying out heating reflux extraction for 3 times, 2 hours each time, filtering, combining filtrate, recovering ethanol, dissolving paraffin in the filtrate at 56 ℃, cooling until the paraffin floats on the liquid level after the paraffin is completely dissolved, and removing the paraffin to obtain a second liquid medicine;
s4, mixing the first liquid medicine obtained in the step S2 and the second liquid medicine obtained in the step S3, concentrating under reduced pressure to form thick paste with the density of 0.9, wherein the pressure of the concentration under reduced pressure is-0.10 Mpa, the temperature of the concentration under reduced pressure is 50 ℃, then adding magnesium stearate, mixing uniformly, and drying to obtain dry extract;
s5, crushing the dry extract prepared in the step S4 into fine particles with the particle size of 0.5mm, and thus obtaining the dry extract.
The preparation method of the traditional Chinese medicine tablet for treating viral influenza specifically comprises the following steps:
(1) taking the traditional Chinese medicine extract particles with the formula amount and the volatile oil obtained in the preparation process thereof for later use;
(2) mixing vitamin C and additives, stirring thoroughly, adding the volatile oil in step (1), preparing into fine particles with particle size of 0.5mm, mixing with the Chinese medicinal extract particles in step (1), tabletting with a tabletting machine to obtain tablet cores, and coating the tablet cores to obtain the final product.
Example 2A Chinese medicinal tablet for treating viral influenza, and its preparation method
The traditional Chinese medicine extract particles and the auxiliary materials in the traditional Chinese medicine tablet for treating the viral influenza are 8:4 in mass ratio.
The important extract particles in the traditional Chinese medicine tablet for treating viral influenza are prepared from the following traditional Chinese medicines in parts by weight: 28 parts of lonicera confusa, 17 parts of fructus forsythiae, 9 parts of schizonepeta, 7 parts of burdock, 14 parts of platycodon grandiflorum, 11 parts of liquorice, 10 parts of isatis root, 15 parts of houttuynia cordata, 12 parts of bunge corydalis herb, 4 parts of cape jasmine and 13 parts of semiaquilegia root.
The auxiliary materials in the traditional Chinese medicine tablet for treating viral influenza comprise the following components in parts by weight: 12 parts of vitamin C, 13 parts of silicon dioxide and 12 parts of magnesium stearate.
The preparation method of the traditional Chinese medicine extract granules in the traditional Chinese medicine tablet for treating viral influenza comprises the following steps:
s1, respectively adding flos Lonicerae, fructus forsythiae and herba Schizonepetae into a volatile oil extractor, adding water, and extracting by steam distillation for 6 hr to obtain volatile oil and residue;
s2, decocting the residues obtained in the step S1, platycodon grandiflorum, liquorice, isatis root, houttuynia cordata, bunge corydalis herb, cape jasmine fruit and semiaquilegia root in water for 4 times, 2.5 hours each time, filtering and combining the filtrates to obtain a first liquid medicine;
s3, adding the burdock and 65% ethanol solution in a mass ratio of 1:7 into a hot reflux extraction concentrator, carrying out heating reflux extraction for 4 times, 2.5h each time, filtering, merging filtrate, recovering ethanol, dissolving paraffin in the filtrate at the temperature of 58 ℃, cooling until the paraffin floats on the liquid level after the paraffin is completely dissolved, and removing the paraffin to obtain a second liquid medicine;
s4, mixing the first liquid medicine obtained in the step S2 and the second liquid medicine obtained in the step S3, concentrating under reduced pressure to form thick paste with the density of 0.95, wherein the pressure of the concentration under reduced pressure is-0.11 Mpa, the temperature of the concentration under reduced pressure is 53 ℃, then adding magnesium stearate, mixing uniformly, and drying to obtain dry extract;
s5, crushing the dry extract prepared in the step S4 into fine particles with the particle size of 0.9mm, and thus obtaining the dry extract.
The preparation method of the traditional Chinese medicine tablet for treating viral influenza specifically comprises the following steps:
(1) taking the traditional Chinese medicine extract particles with the formula amount and the volatile oil obtained in the preparation process thereof for later use;
(2) mixing vitamin C and additives, stirring thoroughly, adding the volatile oil in step (1), preparing into fine particles with particle size of 0.9mm, mixing with the Chinese medicinal extract particles in step (1), tabletting with a tabletting machine to obtain tablet cores, and coating the tablet cores to obtain the final product.
Example 3A Chinese medicinal tablet for treating viral influenza, and its preparation method
The traditional Chinese medicine extract particles and the auxiliary materials in the traditional Chinese medicine tablet for treating the viral influenza are 9:4 in mass ratio.
The important extract particles in the traditional Chinese medicine tablet for treating viral influenza are prepared from the following traditional Chinese medicines in parts by weight: 30 parts of lonicera confusa, 20 parts of forsythia, 12 parts of schizonepeta, 9 parts of burdock, 15 parts of platycodon grandiflorum, 13 parts of liquorice, 15 parts of isatis root, 17 parts of houttuynia cordata, 14 parts of bunge corydalis herb, 5 parts of gardenia and 16 parts of semiaquilegia root.
The auxiliary materials in the traditional Chinese medicine tablet for treating viral influenza comprise the following components in parts by weight: 10 parts of vitamin C, 8 parts of silicon dioxide and 11 parts of magnesium stearate.
The preparation method of the traditional Chinese medicine extract granules in the traditional Chinese medicine tablet for treating viral influenza comprises the following steps:
s1, respectively adding flos Lonicerae, fructus forsythiae and herba Schizonepetae into a volatile oil extractor, adding water, and extracting by steam distillation for 7 hr to obtain volatile oil and residue;
s2, decocting the residues obtained in the step S1, platycodon grandiflorum, liquorice, isatis root, houttuynia cordata, bunge corydalis herb, cape jasmine fruit and semiaquilegia root in water for 5 times, 3 hours each time, filtering and combining the filtrates to obtain a first liquid medicine;
s3, adding the burdock and 70% ethanol solution in a mass ratio of 1:8 into a hot reflux extraction concentrator, carrying out heating reflux extraction for 5 times, 3 hours each time, filtering, combining filtrate, recovering ethanol, dissolving paraffin in the filtrate at the temperature of 60 ℃, cooling until the paraffin floats on the liquid level after the paraffin is completely dissolved, and removing the paraffin to obtain a second liquid medicine;
s4, mixing the first liquid medicine obtained in the step S2 and the second liquid medicine obtained in the step S3, concentrating under reduced pressure to obtain a concentrated paste with the density of 1.0, wherein the pressure of the concentration under reduced pressure is-0.12 Mpa, the temperature of the concentration under reduced pressure is 55 ℃, then adding magnesium stearate, mixing uniformly, and drying to obtain a dry extract;
s5, crushing the dry extract prepared in the step S4 into fine particles with the particle size of 1.5mm, and thus obtaining the dry extract.
The preparation method of the traditional Chinese medicine tablet for treating viral influenza specifically comprises the following steps:
(1) taking the traditional Chinese medicine extract particles with the formula amount and the volatile oil obtained in the preparation process thereof for later use;
(2) mixing vitamin C and additives, stirring thoroughly, adding the volatile oil in step (1), preparing into fine particles with particle size of 1.5mm, mixing with the Chinese medicinal extract particles in step (1), tabletting with a tabletting machine to obtain tablet cores, and coating the tablet cores to obtain the final product.
Comparative example 1, a Chinese medicinal tablet for treating viral influenza and a preparation method thereof
The traditional Chinese medicine extract particles and the auxiliary materials in the traditional Chinese medicine tablet for treating the viral influenza are 8:4 in mass ratio.
The important extract particles in the traditional Chinese medicine tablet for treating viral influenza are prepared from the following traditional Chinese medicines in parts by weight: 28 parts of lonicera confusa, 17 parts of fructus forsythiae, 9 parts of schizonepeta, 7 parts of burdock, 14 parts of platycodon grandiflorum, 11 parts of liquorice, 10 parts of isatis root, 15 parts of houttuynia cordata, 12 parts of bunge corydalis herb, 4 parts of cape jasmine and 13 parts of semiaquilegia root.
The auxiliary materials in the traditional Chinese medicine tablet for treating viral influenza comprise the following components in parts by weight: 12 parts of vitamin C and 12 parts of magnesium stearate.
The preparation method of the traditional Chinese medicine extract granules in the traditional Chinese medicine tablet for treating viral influenza is similar to that in example 2.
The preparation method of the traditional Chinese medicine tablet for treating viral influenza is similar to that of the example 2.
The comparative example differs from example 2 in that: no silica was added in this comparative example.
Comparative example 2, a Chinese medicinal tablet for treating viral influenza and a preparation method thereof
The traditional Chinese medicine extract particles and the auxiliary materials in the traditional Chinese medicine tablet for treating the viral influenza are 8:4 in mass ratio.
The important extract particles in the traditional Chinese medicine tablet for treating viral influenza are prepared from the following traditional Chinese medicines in parts by weight: 28 parts of lonicera confusa, 17 parts of fructus forsythiae, 9 parts of schizonepeta, 7 parts of burdock, 14 parts of platycodon grandiflorum, 11 parts of liquorice, 15 parts of houttuynia cordata, 12 parts of bunge corydalis herb, 4 parts of gardenia and 13 parts of semiaquilegia.
The auxiliary materials in the traditional Chinese medicine tablet for treating viral influenza comprise the following components in parts by weight: 12 parts of vitamin C, 13 parts of silicon dioxide and 12 parts of magnesium stearate.
The preparation method of the traditional Chinese medicine extract granules in the traditional Chinese medicine tablet for treating viral influenza is similar to that in example 2.
The preparation method of the traditional Chinese medicine tablet for treating viral influenza is similar to that of the example 2.
The comparative example differs from example 2 in that: in this comparative example, no isatis root was added.
Comparative example 3, traditional Chinese medicine tablet for treating viral influenza and preparation method thereof
The traditional Chinese medicine extract particles and the auxiliary materials in the traditional Chinese medicine tablet for treating the viral influenza are 8:4 in mass ratio.
The important extract particles in the traditional Chinese medicine tablet for treating viral influenza are prepared from the following traditional Chinese medicines in parts by weight: 28 parts of lonicera confusa, 17 parts of fructus forsythiae, 9 parts of schizonepeta, 7 parts of burdock, 14 parts of platycodon grandiflorum, 11 parts of liquorice, 10 parts of isatis root, 12 parts of bunge corydalis herb, 4 parts of gardenia and 13 parts of semiaquilegia adoxoides.
The auxiliary materials in the traditional Chinese medicine tablet for treating viral influenza comprise the following components in parts by weight: 12 parts of vitamin C, 13 parts of silicon dioxide and 12 parts of magnesium stearate.
The preparation method of the traditional Chinese medicine extract granules in the traditional Chinese medicine tablet for treating viral influenza is similar to that in example 2.
The preparation method of the traditional Chinese medicine tablet for treating viral influenza is similar to that of the example 2.
The comparative example differs from example 2 in that: no houttuynia cordata was added to this comparative example.
Comparative example 4, a Chinese medicinal tablet for treating viral influenza and a method for preparing the same
The traditional Chinese medicine extract particles and the auxiliary materials in the traditional Chinese medicine tablet for treating the viral influenza are 8:4 in mass ratio.
The important extract particles in the traditional Chinese medicine tablet for treating viral influenza are prepared from the following traditional Chinese medicines in parts by weight: 28 parts of lonicera confusa, 17 parts of forsythia, 9 parts of schizonepeta, 7 parts of burdock, 14 parts of platycodon grandiflorum, 11 parts of liquorice, 10 parts of isatis root, 15 parts of houttuynia cordata, 12 parts of bunge corydalis herb and 4 parts of gardenia.
The auxiliary materials in the traditional Chinese medicine tablet for treating viral influenza comprise the following components in parts by weight: 12 parts of vitamin C, 13 parts of silicon dioxide and 12 parts of magnesium stearate.
The preparation method of the traditional Chinese medicine extract granules in the traditional Chinese medicine tablet for treating viral influenza is similar to that in example 2.
The preparation method of the traditional Chinese medicine tablet for treating viral influenza is similar to that of the example 2.
The comparative example differs from example 2 in that: no semiaquilegia was added to this comparative example.
Comparative example 5, a Chinese medicinal tablet for treating viral influenza and a preparation method thereof
The traditional Chinese medicine extract particles and the auxiliary materials in the traditional Chinese medicine tablet for treating the viral influenza are 1:1 in mass ratio.
The important extract particles in the traditional Chinese medicine tablet for treating viral influenza are prepared from the following traditional Chinese medicines in parts by weight: 28 parts of lonicera confusa, 17 parts of fructus forsythiae, 9 parts of schizonepeta, 7 parts of burdock, 14 parts of platycodon grandiflorum, 11 parts of liquorice, 10 parts of isatis root, 15 parts of houttuynia cordata, 12 parts of bunge corydalis herb, 4 parts of cape jasmine and 13 parts of semiaquilegia root.
The auxiliary materials in the traditional Chinese medicine tablet for treating viral influenza comprise the following components in parts by weight: 12 parts of vitamin C, 13 parts of silicon dioxide and 12 parts of magnesium stearate.
The preparation method of the traditional Chinese medicine extract granules in the traditional Chinese medicine tablet for treating viral influenza is similar to that in example 2.
The preparation method of the traditional Chinese medicine tablet for treating viral influenza is similar to that of the example 2.
The comparative example differs from example 2 in that: in the comparative example, the traditional Chinese medicine extract particles and the auxiliary materials are mixed according to the mass ratio of 1: 1.
Test example one, antiviral test
Test samples: the Chinese medicinal tablets for treating viral influenza prepared in examples 1 to 3 and comparative examples 1 to 4;
the test method comprises the following steps: 110 Kunming mice with the weight of 18-22g are selected, the male and female parts of the Kunming mice are provided by the research institute of laboratory animals of Chinese academy of medical sciences, the Kunming mice are raised and adapted to the indoor environment for 3 days before the experiment, the room temperature is 18-25 ℃, and the relative humidity is 45-65%. The mice were randomly divided into 11 groups of 10 mice each, namely, examples 1-3, comparative examples 1-4, a positive control group, a virus control group and a normal control group.
In this test, a mouse pneumonia model infected with influenza A virus subtype (FM1 strain) (H1N1) was used to examine the inhibitory effect of test samples on influenza A virus subtype (FM1 strain) (H1N1), and anti-influenza virus duffy was used as a positive control. The test sample is crushed and then administered by intragastric administration 24 hours after virus infection, the intragastric administration amount is 0.9g/kg, the death number and average life day (day) of the mouse after intragastric administration are observed, and the virus titer of the lung tissue of the mouse is detected.
And (3) test results: the test results are shown in tables 1 and 2.
TABLE 1 Effect of Chinese medicinal tablets for treating viral influenza on mice infected with influenza virus FM1
Note: the test data are all as follows
. + -. SD, Chi-square method for% survival%<0.05、**p<0.001vs virus control group; the Kaplan-Meier method compares average life days,#p<0.05，##p<0.001vs control group of viruses
TABLE 2 Effect of Chinese medicinal tablets for treating influenza on Lung tissue of mice infected with influenza virus
Note: the test data are all as follows
. + -. SD denotes p<0.05、**p<0.001vs control group of viruses
As can be seen from tables 1 and 2, the traditional Chinese medicine tablets for treating viral influenza provided by the invention can significantly reduce the viral titer of the lung tissue of a mouse, and have very significant statistical difference compared with a virus control group, and the positive control duffy can significantly reduce the viral titer of the lung tissue of the mouse, and have very significant statistical difference compared with the virus control group. The results show that compared with the virus control group, the mouse is administrated by gastric gavage 24 hours after infection, and the tested drug has definite improvement effect on the survival rate, the average life day, the lung tissue virus titer and other observation indexes, namely the anti-influenza virus effect. Therefore, the traditional Chinese medicine tablet for treating viral influenza, which is obtained in the embodiment of the invention, has a definite anti-influenza virus effect on infected mice. The traditional Chinese medicine tablet for treating viral influenza prepared in example 2 has the optimal effect on indexes such as survival rate, average life day and lung tissue virus titer, and is the best embodiment of the invention.
Compared with the example 2, the comparative examples 2 to 4 do not add radix isatidis, houttuynia cordata and semiaquilegia adoxoides respectively, but the antiviral effect of the prepared traditional Chinese medicine tablet for treating viral influenza is poor, which shows that the components of radix isatidis, houttuynia cordata and semiaquilegia adoxoides in the formula of the invention play a role of synergistic antiviral; the comparative example 5 changes the weight ratio of the traditional Chinese medicine composition granules to the auxiliary materials, but the antiviral effect of the prepared traditional Chinese medicine tablet for treating the viral influenza is poor, which shows that the weight ratio of the traditional Chinese medicine composition granules to the auxiliary materials in the formula of the invention is optimized.
Test example two, stability test
Test samples: the Chinese medicinal tablets for treating viral influenza prepared in examples 1 to 3 and comparative example 1;
the test method comprises the following steps: the test sample is packaged in a 35mL oral solid medicinal high-density polyethylene bottle, a paper box (namely the market selling packaging condition) is externally arranged, the bottle is placed for 12 months under the conditions that the temperature is 25 +/-2 ℃ and the relative humidity is 60 +/-10%, the sample is taken every 3 months, the detection is respectively carried out on the sample with 0 month, 3 months, 6 months, 9 months and 12 months according to the key stability investigation items, and the sample is respectively taken for 18 months and 24 months after 12 months for detection. Vitamin C content inspection was performed according to the national drug Standard WS 3-B-4000-98-2003.
And (3) test results: the test results are shown in Table 3.
Table 3 stability test results
As can be seen from Table 3, the vitamin C in the traditional Chinese medicine tablet for treating viral influenza provided by the invention is stable for a long time, and the detection results after 24 months of the test all accord with the relevant national regulations. Comparative example 1 compared with example 2, the additive silicon dioxide is reduced in the formula, but the stability of vitamin C in the prepared traditional Chinese medicine tablet for treating viral influenza is greatly reduced, which shows that the silicon dioxide can adsorb and wrap the vitamin C, so that the vitamin C is prevented from being degraded.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Those skilled in the art will recognize that changes may be made to the embodiments described above without departing from the spirit and scope of the invention. Therefore, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the technical spirit of the present invention are covered by the claims of the present invention.
Claims (6)
1. A traditional Chinese medicine tablet for treating viral influenza is characterized by comprising traditional Chinese medicine extract particles and auxiliary materials according to the mass ratio of 7-9: 4;
the traditional Chinese medicine extract particles are prepared from the following traditional Chinese medicines in parts by weight: 25-30 parts of lonicera confusa, 15-20 parts of fructus forsythiae, 6-12 parts of schizonepeta, 5-9 parts of burdock, 11-15 parts of platycodon grandiflorum, 7-13 parts of liquorice, 6-15 parts of isatis root, 13-17 parts of houttuynia cordata, 8-14 parts of bunge corydalis herb, 3-5 parts of cape jasmine and 9-16 parts of semiaquilegia; the auxiliary materials comprise the following components in parts by weight: vitamin C10-15 parts, silicon dioxide 8-16 parts and magnesium stearate 11-14 parts.
2. The traditional Chinese medicine tablet for treating viral influenza according to claim 1, wherein the preparation method of the traditional Chinese medicine extract particles comprises the following steps:
s1, respectively adding flos Lonicerae, fructus forsythiae and herba Schizonepetae into a volatile oil extractor, adding water, and extracting by steam distillation for 5-7h to obtain volatile oil and residue;
s2, decocting the residues obtained in the step S1, platycodon grandiflorum, liquorice, isatis root, houttuynia cordata, bunge corydalis herb, cape jasmine fruit and semiaquilegia root in water for 3-5 times, 2-3h each time, filtering and combining the filtrates to obtain a first liquid medicine;
s3, adding the burdock and the ethanol solution into a hot reflux extraction concentrator, carrying out heating reflux extraction for 3-5 times, each time for 2-3h, filtering, combining filtrate, recovering ethanol, dissolving paraffin in the filtrate at 56-60 ℃, cooling until the paraffin floats on the liquid surface after the paraffin is completely dissolved, and removing the paraffin to obtain a second liquid medicine;
s4, mixing the first liquid medicine obtained in the step S2 and the second liquid medicine obtained in the step S3, concentrating under reduced pressure to obtain a thick paste with the density of 0.9-1.0, adding magnesium stearate, uniformly mixing, and drying to obtain a dry extract;
s5, crushing the dry extract prepared in the step S4 into fine particles with the particle size of 0.5-1.5mm, and thus obtaining the dry extract.
3. The traditional Chinese medicine tablet for treating viral influenza according to claim 2, wherein the ethanol solution in step S3 of the preparation method of the traditional Chinese medicine extract particles is 60-70% by mass; the adding mass ratio of the burdock and the ethanol solution is 1: 5-8.
4. The Chinese medicinal tablet for treating viral influenza according to claim 2, wherein the pressure of the concentration under reduced pressure in step S4 is-0.10 to 0.12MPa, and the temperature of the concentration under reduced pressure is 50 to 55 ℃.
5. A method for preparing a Chinese medicinal tablet for treating viral influenza according to any one of claims 2 to 4, comprising the steps of:
(1) taking the traditional Chinese medicine extract particles with the formula amount and the volatile oil obtained in the preparation process thereof for later use;
(2) mixing vitamin C and silicon dioxide, stirring thoroughly, adding the volatile oil in step (1), preparing into fine particles with particle size of 0.5-1.5mm, mixing with the Chinese medicinal extract particles in step (1), tabletting with a tabletting machine to obtain tablet core, and coating the tablet core.
6. The use of the Chinese medicinal tablet for treating viral influenza, which is prepared by the preparation method of the Chinese medicinal tablet for treating viral influenza according to claim 5, in the preparation of a medicament for treating viral influenza.
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| CN110841011A (en) * | 2019-12-13 | 2020-02-28 | 广东恒诚制药股份有限公司 | Vitamin C honeysuckle and forsythia tablet for cold and preparation method thereof |
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