CN110799217A - 季铵化烟酰胺腺嘌呤二核苷酸补救途径抑制剂缀合物 - Google Patents

季铵化烟酰胺腺嘌呤二核苷酸补救途径抑制剂缀合物 Download PDF

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CN110799217A
CN110799217A CN201880042426.XA CN201880042426A CN110799217A CN 110799217 A CN110799217 A CN 110799217A CN 201880042426 A CN201880042426 A CN 201880042426A CN 110799217 A CN110799217 A CN 110799217A
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C·S·诺伊曼
K·奥利瓦
R·里昂
K·P·王
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Seagen Inc
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Seattle Genetics Inc
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
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CN201880042426.XA 2017-04-27 2018-04-27 季铵化烟酰胺腺嘌呤二核苷酸补救途径抑制剂缀合物 Pending CN110799217A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762490733P 2017-04-27 2017-04-27
US62/490,733 2017-04-27
US201762573987P 2017-10-18 2017-10-18
US62/573,987 2017-10-18
PCT/US2018/030018 WO2018201087A1 (en) 2017-04-27 2018-04-27 Quaternized nicotinamide adenine dinucleotide salvage pathway inhibitor conjugates

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CN110799217A true CN110799217A (zh) 2020-02-14

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US (2) US11931414B2 (https=)
EP (1) EP3615081A1 (https=)
JP (2) JP7425606B2 (https=)
KR (1) KR20190141181A (https=)
CN (1) CN110799217A (https=)
AU (2) AU2018258687C1 (https=)
BR (1) BR112019022445A2 (https=)
CA (1) CA3060206A1 (https=)
IL (1) IL269794A (https=)
MA (1) MA51189A (https=)
MX (2) MX2019012194A (https=)
SG (1) SG11201909563VA (https=)
TW (1) TW201904613A (https=)
WO (1) WO2018201087A1 (https=)

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CN111454327A (zh) * 2020-04-02 2020-07-28 中国人民解放军第二军医大学 一种nampt蛋白降解靶向嵌合体及其制备方法和应用
CN116092586A (zh) * 2023-03-10 2023-05-09 西北工业大学 一种基于生物电子等排体搜索平台的数据处理方法
CN119219604A (zh) * 2024-09-25 2024-12-31 大连理工大学 一种吡啶季铵盐类fk866前药、其制备方法及应用
WO2025162305A1 (zh) * 2024-02-01 2025-08-07 浙江养生堂天然药物研究所有限公司 含季铵盐的抗体偶联药物及其医药用途

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MX2019001302A (es) 2016-08-09 2019-06-12 Seattle Genetics Inc Conjugados de farmaco con enlazadores autoestabilizantes que tienen propiedades fisioquimicas mejoradas.
TWI835714B (zh) 2016-10-18 2024-03-21 美商思進公司 菸鹼醯胺腺嘌呤二核苷酸補救合成(salvage pathway)抑制劑之靶向投遞
WO2018201087A1 (en) 2017-04-27 2018-11-01 Seattle Genetics, Inc. Quaternized nicotinamide adenine dinucleotide salvage pathway inhibitor conjugates
CN110339181A (zh) * 2019-07-02 2019-10-18 中国药科大学 一种基于点击反应的pH响应型纳米制剂及其制法和应用
WO2021207701A1 (en) * 2020-04-10 2021-10-14 Seagen Inc. Charge variant linkers
JP2025530213A (ja) 2022-09-09 2025-09-11 ミリックス ファーマ リミテッド Ｎｍｔ阻害剤を含む抗体薬物コンジュゲート及びその使用

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