CN110787270A

CN110787270A - Tianshu Huoluo oil and preparation method thereof

Info

Publication number: CN110787270A
Application number: CN201911018957.8A
Authority: CN
Inventors: 修永林
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-10-24
Filing date: 2019-10-24
Publication date: 2020-02-14

Abstract

The embodiment of the invention discloses a Tianshu Huoluo oil and a preparation method thereof, belonging to the technical field of traditional Chinese medicines, wherein the Tianshu Huoluo oil is prepared from the following raw materials in parts by weight: 32-38 parts of gastrodia elata, 28-32 parts of radix angelicae pubescentis, 28-32 parts of notopterygium root, 22-28 parts of divaricate saposhnikovia root, 16-22 parts of ligusticum wallichii, 22-27 parts of angelica sinensis, 16-24 parts of prepared monkshood, 16-22 parts of turmeric, 18-23 parts of gentiana macrophylla, 18-22 parts of cassia bark and 8-12 parts of borneol. The Tianshu Huoluo oil provided by the embodiment of the invention has the effects of dispelling wind-damp, relieving arthralgia, tonifying liver and kidney and tonifying qi and blood, and has a good curative effect on rheumatic arthropathy, rheumatism, rheumatoid diseases, scapulohumeral periarthritis, lumbar muscle strain, synovitis, gout and the like. The Tianshu Huoluo oil has no irritation to skin, high safety, no obvious toxic or side effect on organisms and wide application prospect.

Description

Tianshu Huoluo oil and preparation method thereof

Technical Field

The embodiment of the invention relates to the technical field of traditional Chinese medicines, and particularly relates to a Tianshu Huoluo oil and a preparation method thereof.

Background

In the modern society with increasingly accelerated life pace and multiplied working pressure, people do not exercise frequently, and the symptoms of neck and shoulder discomfort, headache, dizziness, numbness and weakness of limbs, waist and back pain, knee joint pain and the like are caused by long-term bending over of a desk, so that the normal life and work of people are seriously influenced.

At present, when the above symptoms occur, the treatment methods adopted include medication, traction massage physiotherapy, and surgical therapy. The western medicine mainly adopts symptomatic medicines for treatment, but has obvious side effects, patients are unwilling to take the medicines for a long time, and part of the medicines are expensive and difficult to bear, so that the western medicine has great limitations. The traction massage physiotherapy effect is unstable and easy to recur. The operation therapy causes great damage to human body, and has long treatment course and slow recovery.

The traditional Chinese medicine considers that the meridian obstruction and unsmooth qi and blood circulation are caused by wind-cold invasion, so that pain and numbness of limb skin, muscles, bones and joints and the like are caused by the obstruction of the meridian.

The traditional Chinese medicine with the effects of relaxing tendons, activating collaterals, dispelling wind and removing stasis on the market has an unsatisfactory curative effect due to poor compatibility of the components.

Therefore, the research of a medicine for relaxing channels, activating collaterals and easing pain with obvious curative effect, safety and no side effect is needed.

Disclosure of Invention

Therefore, the embodiment of the invention provides the Tianshu Huoluo oil and the preparation method thereof, and the components have good cooperativity, obvious curative effect, safety and no side effect, so as to solve the problems in the prior art.

In order to achieve the above object, the embodiments of the present invention provide the following technical solutions:

according to a first aspect of the embodiments of the present invention, an embodiment of the present invention provides a suoshu collateral-activating oil, which is prepared from the following raw materials in parts by weight: 32-38 parts of gastrodia elata, 28-32 parts of radix angelicae pubescentis, 28-32 parts of notopterygium root, 22-28 parts of divaricate saposhnikovia root, 16-22 parts of ligusticum wallichii, 22-27 parts of angelica sinensis, 16-24 parts of prepared monkshood, 16-22 parts of turmeric, 18-23 parts of gentiana macrophylla, 18-22 parts of cassia bark and 8-12 parts of borneol.

Further, the feed is prepared from the following raw materials in parts by weight: 35 parts of gastrodia elata, 30 parts of radix angelicae pubescentis, 30 parts of notopterygium root, 25 parts of divaricate saposhnikovia root, 20 parts of ligusticum wallichii, 25 parts of angelica sinensis, 20 parts of prepared monkshood, 20 parts of turmeric, 20 parts of gentiana macrophylla, 20 parts of cassia bark and 10 parts of borneol.

According to a second aspect of the embodiments of the present invention, the embodiments of the present invention provide a preparation method of the above-mentioned Tianshu Huoluo oil, including the following steps:

1) weighing the raw materials according to the formula, and respectively crushing the raw materials into fine powder for later use;

2) extracting rhizoma Gastrodiae and Borneolum Syntheticum with ethanol, separating, and concentrating the obtained extractive solution to obtain extract A; frying radix Angelicae Pubescentis, Notopterygii rhizoma, radix Saposhnikoviae, rhizoma Ligustici Chuanxiong, radix Angelicae sinensis, radix Aconiti lateralis Preparata, Curcuma rhizome, radix Gentianae Marcrophyllae and cortex Cinnamomi with oleum Sesami, and separating to obtain solution B;

3) and combining the extract A and the solution B.

Further, in the step 1, the particle size of the fine powder is 100-150 meshes.

Further, in the step 2, the gastrodia elata and the borneol are placed in a glass container, 55-65-degree white spirit is added, the liquid level is 2-3 cm higher than the medicine level, sealing is conducted, and the medicine is placed in a cool and dry place for 15-20 days.

Further, in the step 2, the frying temperature is 90-110 ℃, and the frying time is 35-50 minutes.

Gastrodia elata: dried tubers of Gastrodia elata (Gastrodia elata) Bl., belonging to Shen nong's herbal Jing, are traditional and precious Chinese medicinal materials in China. Has effects of calming endogenous wind, relieving spasm, suppressing liver yang, dispelling pathogenic wind, and dredging collaterals, and is suitable for treating headache, giddiness, limbs anesthesia, infantile convulsion, etc. The rhizoma Gastrodiae mainly contains gastrodine and its aglycone, rhizoma Gastrodiae polysaccharide, alkaloid, organic acid, and vanillyl alcohol, etc., and the main active component of rhizoma Gastrodiae is gastrodine. The research shows that gastrodin has the functions of resisting convulsion, protecting nerves and the like.

Radix angelicae pubescentis: is dried root of Angelica gigas nakai of Umbelliferae, Angelica pubescens Maxim.f. biserrata Shannet Yuan, has mild warm nature, pungent and bitter taste, and has effects of dispelling pathogenic wind, removing dampness, and relieving arthralgia. Modern pharmacological research shows that the dihydrocarveol in the radix angelicae pubescentis has the effects of resisting inflammation, repairing ultraviolet-damaged keratinocytes and the like; isoimperatorin has analgesic effect, and can significantly reduce body twisting frequency of mice caused by acetic acid; the volatile oil has anti-inflammatory and analgesic effects, and is closely related to pharmacological effects of radix Angelicae Pubescentis in relieving arthralgia and pain.

Notopterygium root: is dried root and rhizome of Notopterygium incisum or Notopterygium forbesii of Umbelliferae, pungent, bitter and warm in nature, and enters bladder and kidney meridians. The main effects are relieving exterior syndrome, dispelling cold, dispelling wind, removing dampness and relieving pain. Modern pharmacological research shows that the notopterygium root has the effects of relieving pain, resisting inflammation, resisting bacteria, resisting allergy, resisting blood coagulation, relieving fever, resisting thrombosis, resisting myocardial ischemia, resisting arrhythmia, enhancing the immunologic function of a human body and the like. Clinically, Qiang Huo is usually indicated for wind-cold, fever, headache and body pain due to exogenous pathogens.

Wind prevention: is dried root of Saposhnikovia Divaricata (Turcz.) Schischk of Umbelliferae, and mainly contains chromone, coumarin, volatile oil, and polysaccharides. Wind-proof property is slightly warm, taste is pungent and sweet, and the wind-proof property enters bladder, liver and spleen channels, and has the efficacies of dispelling wind and relieving exterior syndrome, eliminating dampness and relieving pain, relieving spasm and the like.

Ligusticum wallichii: is a dried rhizome of Ligusticum chuanxiong Hort (Ligusticum chuanxiong Hort.) belonging to the family Umbelliferae, is a commonly used blood-activating and qi-moving medicine, has the effects of activating blood and moving qi, dispelling wind and relieving pain, and is widely used for treating amenorrhea dysmenorrhea, headache, rheumatalgia and the like. The phenolic acid component is a main characteristic component of the ligusticum wallichii playing a medicinal effect and has the effects of resisting platelet aggregation, removing oxygen free radicals, expanding blood vessels and the like.

Chinese angelica: is the dried root of Angelica sinensis (Oliv.) Diels of Umbelliferae, has sweet and pungent taste, warm nature, and effects of tonifying blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel, and relieving constipation, and can be used for treating blood deficiency, sallow complexion, giddiness, cardiopalmus, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, rheumatalgia, traumatic injury, superficial infection, pyocutaneous disease, and constipation. The chemical components contained in angelica are complex and mainly include phthalides, organic acids, polysaccharides and the like. The ferulic acid in radix Angelicae sinensis has effects of resisting platelet aggregation, resisting thrombosis, and protecting myocardium, and the phthalide has effects of resisting tumor activity, relieving pain, relieving spasm, lowering blood pressure, and resisting inflammation.

Monkshood: is processed product of seed root of Aconitum carmichaelii Debx of Ranunculaceae. Has the effects of restoring yang, relieving collapse, invigorating fire, supporting yang, dispelling cold, and relieving pain. Aconitum alkaloids belong to the effective components of radix Aconiti lateralis, but are also toxic components. In order to ensure the clinical efficacy and safe application, it is processed and used. The invention adopts a processing method: putting a proper amount of sand into a pot, heating the pot, putting the cleaned aconite slices into the pot, and stir-frying the mixture; when the auxiliary piece is bulged and slightly discolored, the auxiliary piece is taken out; sieving to remove sand, and cooling to obtain radix Aconiti lateralis Preparata.

Turmeric: is a perennial herb of curcuma of zingiberaceae, has the effects of breaking blood and promoting qi circulation, and stimulating menstrual flow and relieving pain, and is clinically used for treating chest stuffiness and pains, dysmenorrheal amenorrhea, traumatic injury and swelling pain and the like. The main component of the turmeric is curcumin compound, including curcumin, demethoxycurcumin and bisdemethoxycurcumin, and has anticancer, antiinflammatory, antioxidant, antiatherosclerotic and central nervous system protecting effects.

Large-leaved gentian: is one of the important traditional Chinese medicines in China, has the functions of dispelling wind-damp, clearing damp-heat, relieving arthralgia and relieving deficiency heat, and is listed as a Chinese product from Shen nong Ben Cao Jing. Modern researches show that the gentiana macrophylla contains chemical components such as iridoid glycosides, lignans, flavonoids and triterpenes, and has pharmacological effects of resisting inflammation, easing pain, protecting liver, suppressing immunity, reducing blood pressure, protecting brain tissue, resisting influenza virus, resisting tumor and the like.

A cassia core: it is one of cinnamon, generally speaking, cinnamon is the bark of cinnamon tree, and is barrel-shaped after being dried, called as "Guitong", and the "Guixin" is the cinnamon without outer layer of thick bark, also written as "Guitong". It has effects of tonifying fire, supporting yang, inducing fire to return to original place, dispelling cold and relieving pain, and can be used for treating rheumatism, abdominal pain, dysphagia, abdominal distention, abdominal psychroalgia, and nine kinds of heartache.

Borneol: is one of the commonly used rare Chinese medicinal materials, is pungent and bitter in taste, slightly cold in nature and enters heart, spleen and lung meridians. Has effects of inducing resuscitation, refreshing mind, clearing heat and relieving pain. Can be used for treating fever unconsciousness, convulsion syncope, apoplexy with phlegm syncope, qi stagnation and sudden syncope, coma, conjunctival congestion, aphtha, sore throat, and purulence in ear canal. Modern researches show that the borneol has pharmacological effects of protecting cerebral ischemia, promoting blood brain barrier opening, relieving pain, resisting inflammation and the like.

The embodiment of the invention has the following advantages:

the Tianshu Huoluo oil takes rhizoma gastrodiae, radix angelicae pubescentis, notopterygium root, divaricate saposhnikovia root, ligusticum wallichii, Chinese angelica, prepared monkshood, turmeric, large-leaved gentian, cassia bark core and borneol as raw materials, wherein the rhizoma gastrodiae can calm liver yang, dispel wind and dredge collaterals; radix Angelicae Pubescentis, Notopterygii rhizoma, radix Saposhnikoviae and radix Gentianae Marcrophyllae have effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind and removing dampness; the hemlock parsley, the angelica and the turmeric can promote blood circulation and remove blood stasis, and enrich and promote blood circulation; prepared aconite root, cassia bark core and borneol can dispel cold and relieve pain, clear heat and relieve pain. The medicines are combined to relax muscles and tendons, promote blood circulation, remove blood stasis, dredge collaterals, dispel cold, draw out toxin, relieve swelling and pain, and relieve pain. Has effects in dispelling pathogenic wind and dampness, relieving arthralgia, invigorating liver and kidney, and invigorating qi and blood. Has good curative effect on rheumatic arthropathy, rheumatism, rheumatoid diseases, scapulohumeral periarthritis, lumbar muscle strain, synovitis, gout, etc. The Tianshu Huoluo oil has no irritation to skin, high safety, no obvious toxic or side effect on organisms and wide application prospect.

Detailed Description

The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

A TIANSHUOLUO oil comprises: 35 g of tall gastrodia tuber, 30 g of doubleteeth pubescent angelica root, 30 g of incised notopterygium rhizome, 22 g of divaricate saposhnikovia root, 20 g of Szechuan lovage rhizome, 22 g of Chinese angelica, 24 g of prepared common monkshood daughter root, 18 g of turmeric, 18 g of largeleaf gentian root, 18 g of cassia bark and 10 g of borneol.

The preparation method comprises the following steps:

1) weighing the raw materials, and respectively crushing the raw materials into fine powder with the particle size of 120 meshes for later use;

2) placing the gastrodia elata into a glass container, adding 55-degree white spirit to enable the liquid level to be 2-3 cm higher than the medicine level, sealing, placing in a cool and dry place for 18 days, separating, and concentrating the obtained extracting solution under reduced pressure to obtain an extract A; frying radix angelicae pubescentis, notopterygium root, divaricate saposhnikovia root, ligusticum wallichii, angelica sinensis, prepared monkshood, turmeric, gentiana macrophylla and cassia bark core with sesame oil at the temperature of 100 ℃ for 40 minutes, cooling and filtering to obtain a solution B;

3) and combining the extract A and the solution B.

Example 2

A TIANSHUOLUO oil comprises: 32 g of tall gastrodia tuber, 32 g of doubleteeth pubescent angelica root, 28 g of incised notopterygium rhizome, 28 g of divaricate saposhnikovia root, 16 g of Szechuan lovage rhizome, 25 g of Chinese angelica, 20 g of prepared common monkshood daughter root, 22 g of turmeric, 20 g of largeleaf gentian root, 21 g of cassia bark core and 10 g of borneol.

The preparation method comprises the following steps:

1) weighing the raw materials, and respectively crushing the raw materials into fine powder with the particle size of 150 meshes for later use;

2) placing the gastrodia elata into a glass container, adding 65-degree white spirit to enable the liquid level to be 2-3 cm higher than the medicine level, sealing, placing in a cool and dry place for 15 days, separating, and concentrating the obtained extracting solution under reduced pressure to obtain an extract A; frying radix angelicae pubescentis, notopterygium root, divaricate saposhnikovia root, ligusticum wallichii, angelica sinensis, prepared monkshood, turmeric, gentiana macrophylla and cassia bark core with sesame oil at 90 ℃ for 50 minutes, cooling and filtering to obtain a solution B;

3) and combining the extract A and the solution B.

Example 3

A TIANSHUOLUO oil comprises: 35 g of tall gastrodia tuber, 30 g of doubleteeth pubescent angelica root, 30 g of incised notopterygium rhizome, 25 g of divaricate saposhnikovia root, 20 g of Szechuan lovage rhizome, 25 g of Chinese angelica, 20 g of prepared common monkshood daughter root, 20 g of turmeric, 20 g of largeleaf gentian root, 20 g of cassia bark core and 10 g of borneol.

The preparation method comprises the following steps:

1) weighing the raw materials, and respectively crushing the raw materials into fine powder with the particle size of 100 meshes for later use;

2) placing the gastrodia elata into a glass container, adding 60-degree white spirit to enable the liquid level to be 2-3 cm higher than the medicine level, sealing, placing in a cool and dry place for 20 days, separating, and concentrating the obtained extracting solution under reduced pressure to obtain extract A; frying radix angelicae pubescentis, notopterygium root, divaricate saposhnikovia root, ligusticum wallichii, angelica sinensis, prepared monkshood, turmeric, gentiana macrophylla and cassia bark core with sesame oil at 90 ℃ for 45 minutes, cooling and filtering to obtain a solution B;

3) and combining the extract A and the solution B.

Example 4

A TIANSHUOLUO oil comprises: 38 g of tall gastrodia tuber, 32 g of doubleteeth pubescent angelica root, 28 g of incised notopterygium rhizome, 25 g of divaricate saposhnikovia root, 20 g of Szechuan lovage rhizome, 27 g of Chinese angelica, 18 g of prepared common monkshood daughter root, 16 g of turmeric, 22 g of largeleaf gentian root, 20 g of cassia bark and 8 g of borneol.

The preparation method comprises the following steps:

2) placing the gastrodia elata into a glass container, adding 60-degree white spirit to enable the liquid level to be 2-3 cm higher than the medicine level, sealing, placing in a cool and dry place for 20 days, separating, and concentrating the obtained extracting solution under reduced pressure to obtain extract A; frying radix angelicae pubescentis, notopterygium root, divaricate saposhnikovia root, ligusticum wallichii, angelica sinensis, prepared monkshood, turmeric, gentiana macrophylla and cassia bark core with sesame oil at the temperature of 110 ℃ for 35 minutes, cooling and filtering to obtain a solution B;

3) and combining the extract A and the solution B.

Example 5

A TIANSHUOLUO oil comprises: 34 g of tall gastrodia tuber, 28 g of doubleteeth pubescent angelica root, 32 g of incised notopterygium rhizome, 25 g of divaricate saposhnikovia root, 22 g of Szechuan lovage rhizome, 25 g of Chinese angelica, 16 g of prepared common monkshood daughter root, 20 g of turmeric, 23 g of largeleaf gentian root, 22 g of cassia bark core and 12 g of borneol.

The preparation method comprises the following steps:

2) placing the gastrodia elata into a glass container, adding 55-degree white spirit to enable the liquid level to be 2-3 cm higher than the medicine level, sealing, placing in a cool and dry place for 18 days, separating, and concentrating the obtained extracting solution under reduced pressure to obtain an extract A; frying radix angelicae pubescentis, notopterygium root, divaricate saposhnikovia root, ligusticum wallichii, angelica sinensis, prepared monkshood, turmeric, gentiana macrophylla and cassia bark core with sesame oil at the temperature of 100 ℃ for 35 minutes, cooling and filtering to obtain a solution B;

3) and combining the extract A and the solution B.

Test example

1. General data

Selecting 360 pain patients, including rheumatic arthropathy, rheumatism, rheumatoid diseases, scapulohumeral periarthritis, lumbar muscle strain, synovitis, gout, and mechanical strain, randomly dividing all patients into 1-5 groups and control groups, each group comprises 60 patients. The data of the general data such as age, sex, course and the like of each group of patients are not obviously different (P is more than 0.05).

2. Method of treatment

The patients in the treatment groups 1-5 are respectively coated with the Tianshu Huoluo oil prepared in the examples 1-5, and the using method comprises the following steps: the TIANSHUOLUOLUO is applied onto cotton or palm for 1-2 min, or soaked in medicated liquor and applied onto the affected part for 3 times daily, and 7 days is a treatment course for 2 treatment courses.

The patients in the control group adopt the collateral-activating oil (Zhuhai Hongli pharmaceutical Co., Ltd., national Standard Z20023059), and the application method is the same as above.

3. Observation index and evaluation criterion

And observing the clinical symptoms of the patients, and recording the occurrence condition of adverse reactions after the patients take the medicine.

The clinical symptoms and physical signs of two groups of patients are evaluated according to the marking standard of traditional Chinese medicine syndrome integral formulated in the clinical research guiding principle of new traditional Chinese medicine, the treatment effect is judged according to the reduction rate of the syndrome integral, and the treatment effect grades are divided into obvious effect, effective effect and ineffective effect.

The effect is shown: the syndrome score after treatment is reduced by more than or equal to 60 percent compared with that before treatment;

the method has the following advantages: the syndrome score after treatment is reduced by 30-60% compared with that before treatment;

and (4) invalidation: the syndrome score after treatment is reduced by less than 30 percent compared with that before treatment, the obvious effect and the effective effect are counted as total effective, and the total effective rate of treatment is calculated.

4. Statistical method

The results of comparing the clinical efficacy of the treatment group and the control group are shown in Table 1.

TABLE 1

Group of	Number of examples	Show effect	Is effective	Invalidation	Total effective rate
						Treatment 1 group	60	39	18	3	95％
Treatment of 2 groups	60	37	22	1	98.3％
						Treatment of 3 groups	60	45	15	0	100％
Treatment of 4 groups	60	36	20	4	93.3％
						Treatment of 5 groups	60	41	17	2	96.7％
Control group	60	20	26	14	76.7％

As can be seen from Table 1, the total clinical treatment effective rate of the patients in the treatment group is significantly higher than that of the control group, SPSS23.0 statistical software is used for analyzing data, and counting data are expressed in (%) and tested by chi-square; the statistical software analyzes that P is less than 0.05, and the method has statistical significance.

And (3) safety evaluation: the treatment of 1-5 groups of patients showed no abnormality in blood routine, liver function and electrocardiogram during and after the treatment.

Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims

1. The Tianshu Huoluo oil is characterized by being prepared from the following raw materials in parts by weight: 32-38 parts of gastrodia elata, 28-32 parts of radix angelicae pubescentis, 28-32 parts of notopterygium root, 22-28 parts of divaricate saposhnikovia root, 16-22 parts of ligusticum wallichii, 22-27 parts of angelica sinensis, 16-24 parts of prepared monkshood, 16-22 parts of turmeric, 18-23 parts of gentiana macrophylla, 18-22 parts of cassia bark and 8-12 parts of borneol.

2. The Tianshuhuoluo oil as claimed in claim 1, which is prepared from the following raw materials in parts by weight: 35 parts of gastrodia elata, 30 parts of radix angelicae pubescentis, 30 parts of notopterygium root, 25 parts of divaricate saposhnikovia root, 20 parts of ligusticum wallichii, 25 parts of angelica sinensis, 20 parts of prepared monkshood, 20 parts of turmeric, 20 parts of gentiana macrophylla, 20 parts of cassia bark and 10 parts of borneol.

3. A method for preparing the Tianshuhuoluo oil as claimed in claim 1, which comprises the following steps:

3) and combining the extract A and the solution B.

4. The preparation method of Tianshuhuoluo oil as claimed in claim 3, wherein in step 1, the particle size of the fine powder is 100-150 meshes.

5. The preparation method of Tianshuhuoluo oil as claimed in claim 3, wherein in step 2, the gastrodia elata and the borneol are placed in a glass container, the 55-65 ° white spirit is added to make the liquid level 2-3 cm higher than the medicine level, the mixture is sealed, and the mixture is placed in a cool and dry place for 15-20 days.

6. The preparation method of Tianshuhuoluo oil as claimed in claim 3, wherein in the step 2, the frying temperature is 90-110 ℃ and the frying time is 35-50 minutes.