CN104644897A - Traditional Chinese medicine composition for treating prosopalgia and preparation method thereof - Google Patents

Abstract

The invention discloses a method for preparing a traditional Chinese medicine composition for treating prosopalgia. The method comprises the following steps: (a), taking the following materials in parts by weight: horseweed herb, Chinese photinia leaf, harlequin glorybower leaf and twig, serrate rabdosia herb, alangium platanifolium, excrementum pteropi, viola japonica and radix codonopsitis lanceolatae, and preparing into 60-mesh powder; adding 70 percent ethanol according to the material-liquid ratio of 1:8, performing reflux extraction for three times and 2 hours each time, and merging the reflux liquid; concentrating the liquid into extract with the relative density of 1.28-1.32 at the temperature of 35 DEG C; performing vacuum drying, and preparing into 200-mesh powder; and (b), preparing mulberry fruits in parts by weight into 200-mesh powder, and uniformly mixing with the powder in the step (a); and filling capsules with the uniformly mixed powder according to the weight of 0.38g of each granule, wherein 3-4 granules are taken each time and 2-3 times per day. The medicine for treating the prosopalgia has the outstanding effects of eliminating stagnant blood and dredging collaterals, cooling blood and reducing swelling, clearing away heat and toxic materials and activating blood and relieving pain in the treatment of prosopalgia and is safe and reliable.

Description

One treats prosopalgic Chinese medicine composition and preparation method thereof

Technical field

The invention belongs to medical art, be specially one and treat prosopalgic Chinese medicine composition and preparation method thereof.

Background technology

Carbamazepine is the prosopalgic common drug of clinical treatment, has the effect such as convulsion and neuralgia.Acupuncture and moxibustion therapy trigeminal neuralgia is proved actively effectively.Acupuncture point Hegu can effective promoting blood circulation and stopping pain.Too punching is the source points of Liver Channel, can discongest sun bright few positive two not smooth through meridians to women's head-ornaments face disease curative effect better acupuncture Touwei points such as headache, dizziness simultaneously.Pass, ditch, Baihui and Sishengcong four cave in acupuncture, the analgesic efficacy such as can reach refreshment and allay excitement.Cave, ShiShimonoseki is made up of jointly Various Tissues, is wherein distributed with the Sensory nerve fibre of trigeminal ganglion, and this cave of acupuncture can Shufeng Huoluo and tonneau mandibular joint, effectively eases pain.

Treatment by Chinese herbs has bupleurum powder for relieving liver-qi main component to be Pericarpium Citri Reticulatae, Radix Bupleuri, Rhizoma Chuanxiong, Radix Paeoniae and Radix Glycyrrhizae etc., has dispersing the stagnated live-QI to relieve the stagnation of QI, the effects such as promoting the circulation of QI to relieve pain.Decoction for removing blood stasis have invigorate blood circulation, the effect such as blood stasis dispelling and pain relieving, in side, the Radix Paeoniae Alba has effect of suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, and Rhizoma Chuanxiong has effect of blood-activating and qi-promoting and wind-expelling pain-stopping, Scolopendra energy dispersing pathogen accumulation and removing obstruction in the collateral to relieve pain.

Summary of the invention

The object of this invention is to provide one and treat prosopalgic Chinese medicine composition and preparation method thereof.

The prosopalgic Chinese medicine composition for the treatment of of the present invention; Raw material by following parts by weight: Conyza canadensis (L.) Cronq. 6 ~ 8 parts, Folium Photiniae (Folium Photiniae serrulatae) 9 ~ 11 parts, Folium et Ramulus Clerodendri Trichotomi 8 ~ 10 parts, Herba Rabdosiae Lophanthoidis 10 ~ 12 parts, Radix Alangii 22 ~ 26 parts, Oletum Trogopterori 20 ~ 23 parts, Herba Violae japonicae 12 ~ 14 parts, Fructus Mori 13 ~ 15 parts, Radix Codonopsitis Lanceolatae 16 ~ 18 parts.

As optimization, the prosopalgic Chinese medicine composition of this treatment, is made up of the raw material of following parts by weight: Conyza canadensis (L.) Cronq. 7 parts, Folium Photiniae (Folium Photiniae serrulatae) 10 parts, Folium et Ramulus Clerodendri Trichotomi 9 parts, Herba Rabdosiae Lophanthoidis 12 parts, Radix Alangii 23 parts, Oletum Trogopterori 21 parts, Herba Violae japonicae 13 parts, Fructus Mori 15 parts, Radix Codonopsitis Lanceolatae 17 parts.

Prepare the method that the present invention treats trigeminal neuralgia Chinese medicine composition, comprise the following steps:

A, the Conyza canadensis (L.) Cronq. getting described parts by weight, Folium Photiniae (Folium Photiniae serrulatae), Folium et Ramulus Clerodendri Trichotomi, Herba Rabdosiae Lophanthoidis, Radix Alangii, Oletum Trogopterori, Herba Violae japonicae, Radix Codonopsitis Lanceolatae, make 60 object powder; By solid-liquid ratio 1:8, add 70% ethanol, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.28 ~ 1.32 (35 DEG C); Then vacuum drying, makes 200 object powder;

B, the Fructus Mori getting described parts by weight make 200 object powder; Then with the powder mix homogeneously in step a.By the medicated powder of mix homogeneously, in incapsulating according to 0.38 gram every, each serving with 3 ~ 4, every day 2 ~ 3 times.

In this medicament composing prescription, Conyza canadensis (L.) Cronq. clearing away heat-damp and promoting diuresis, dissipating blood stasis for subsidence of swelling.Enteritis, dysentery, infectious hepatitis, cholecystitis; Psoriasis is controlled in external, traumatic injury, furuncle toxic swelling, rheumatic ostalgia, traumatic hemorrhage; Fresh leaf is smash juice and is controlled otitis media, eye conjunctivitis.

Folium Photiniae (Folium Photiniae serrulatae) wind-damp dispelling, the meridian dredging.Cure mainly rheumatic arthralgia, aching pain in waist and back, flaccidity of the lower limbs is unable, migraine, and flaccidity of the lower limbs is unable, migraine, rubella pruritus.

Folium et Ramulus Clerodendri Trichotomi wind-damp dispelling, the meridian dredging, suppressing the hyperactive liver and subsiding YANG.Cure mainly rheumatic arthralgia, numb limbs and tense tendons, hemiplegia, excessive rising of liver-YANG, headache, dizzy.

Radix Alangii expelling wind and removing dampness, dissipating blood stasis dredging collateral, analgesia.Cure mainly rheumatic arthralgia, paralysis and numbness, impairment caused by overstrain lumbago, traumatic injury.

Herba Rabdosiae Lophanthoidis is traditional herbal medicine, is commonly called as Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) etc., has effect of clearing away heat-damp and promoting diuresis, jaundice eliminating damp eliminating, cool the blood dissipate blood stasis, is used for the treatment of the diseases such as acute icterohepatitis, acute cholecystitis, dysentery, enteritis, traumatic injury stasis of blood pain.

Oletum Trogopterori promoting blood circulation to remove blood stasis, parch to black stops blooding.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black controls metrostaxis; Traumatic injury is controlled in external, Serpentis, insect bite wound.

Herba Violae japonicae heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.For acute conjunctivitis, pharyngolaryngitis, acute icterohepatitis, mastitis, carbuncle furuncle and phyma poison, suppurative osteomyelitis, venom.

Fructus Mori nourishing YIN and benefiting blood; Promote the production of body fluid; Intestine moistening.Having a dizzy spell of main deficiency of the liver and kindey and blood deficiency damage of essence; Soreness of waist tinnitus; Early whitening of beard and hair; Insomnia and dreamful sleep; Tianjin wound is thirsty; Quench one's thirst; Dryness of the intestine constipation.

Radix Codonopsitis Lanceolatae is the root of Campanulaceae Lac caprae seu ovis, has effect of nourishing YIN and moistening the lung, expectorant evacuation of pus, heat-clearing and toxic substances removing.

The present invention treats prosopalgic medicine, the detumescence of dissipating blood stasis dredging collateral, removing heat from blood, heat-clearing and toxic substances removing, invigorating blood circulation analgesia, and each component synergism is very remarkable, and treatment trigeminal neuralgia is given prominence to, and safe and reliable.

Interrelated data physical data: select the routine affected nerves of patients with trigeminal neuralgia of in March, 2013 ~ 2014 year December 190, be inpatient, wherein man 78 example, female 112 example, 27 ~ 66 years old age, average 43.8 years old, the course of disease 12 days to 4.2 years, average 1.4 years.Be divided into matched group and treatment group, often organize 95 people.

Therapeutic Method: all patients withdraw other analgesic, physical therapys etc. and other treatment medicine, and observe routine blood test and liver function afterwards before the treatment.Check after taking medicine 20 days.Treatment group takes the embodiment of the present invention 1 capsule, each serving with 3, and every day 3 times.It within 10 days, is 1 course for the treatment of.Matched group: carbamazepine 0.1g tid 10 days is a course for the treatment of.Observe the curative effect after three courses for the treatment of.

Criterion of therapeutical effect: " the Chinese medical disease Standardization of diagnosis and curative effect " issued for 1994 according to State Administration of Traditional Chinese Medicine is drafted.1. curative effect judging standard cures: symptom and sign disappear completely, do not recur in half a year; 2. effective: pain disappears substantially or panic attacks number of times reduces more than 50%; 3. effective: pain relief, attack times reduces less than 50%; 4. invalid: pain does not subtract or alleviates not obvious.Efficacy result is in table 1.

Statistical analysis: adopt SPSS 18.0 statistics software processes, measurement data mean ± standard deviation (x ± s) represents, adopts t inspection; The comparison of enumeration data rate adopts x ²inspection.P<0.05 is that difference has statistical significance.

Detailed description of the invention

The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; those skilled in the art to nonessential improvement and adjustment more of the present invention, still belong to protection scope of the present invention according to content of the present invention.

Embodiment 1, a, get Conyza canadensis (L.) Cronq. 7 grams, Folium Photiniae (Folium Photiniae serrulatae) 10 grams, Folium et Ramulus Clerodendri Trichotomi 9 grams, Herba Rabdosiae Lophanthoidis 12 grams, Radix Alangii 23 grams, Oletum Trogopterori 21 grams, Herba Violae japonicae 13 grams, Radix Codonopsitis Lanceolatae 17 grams, make 60 object powder; By solid-liquid ratio 1:8, add 70% ethanol, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.28 ~ 1.32 (35 DEG C); Then vacuum drying, makes 200 object powder;

B, get Fructus Mori 15 and restrain into 200 object powder; Then with the powder mix homogeneously in step a.By the medicated powder of mix homogeneously, in incapsulating according to 0.38 gram every, each serving with 3 ~ 4, every day 2 ~ 3 times.

Embodiment 2, a, get Conyza canadensis (L.) Cronq. 6 grams, Folium Photiniae (Folium Photiniae serrulatae) 9 grams, Folium et Ramulus Clerodendri Trichotomi 8 grams, Herba Rabdosiae Lophanthoidis 10 grams, Radix Alangii 22 grams, Oletum Trogopterori 20 grams, Herba Violae japonicae 12 grams, Radix Codonopsitis Lanceolatae 16 grams, make 60 object powder; By solid-liquid ratio 1:8, add 70% ethanol, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.28 ~ 1.32 (35 DEG C); Then vacuum drying, makes 200 object powder;

B, get Fructus Mori 13 and restrain into 200 object powder; Then with the powder mix homogeneously in step a.By the medicated powder of mix homogeneously, in incapsulating according to 0.38 gram every, each serving with 3 ~ 4, every day 2 ~ 3 times.

Embodiment 3, a, get Conyza canadensis (L.) Cronq. 8 grams, Folium Photiniae (Folium Photiniae serrulatae) 11 grams, Folium et Ramulus Clerodendri Trichotomi 10 grams, Herba Rabdosiae Lophanthoidis 12 grams, Radix Alangii 26 grams, Oletum Trogopterori 23 grams, Herba Violae japonicae 14 grams, Radix Codonopsitis Lanceolatae 18 grams, make 60 object powder; By solid-liquid ratio 1:8, add 70% ethanol, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.28 ~ 1.32 (35 DEG C); Then vacuum drying, makes 200 object powder;

B, get Fructus Mori 15 and restrain into 200 object powder; Then with the powder mix homogeneously in step a.By the medicated powder of mix homogeneously, in incapsulating according to 0.38 gram every, each serving with 3 ~ 4, every day 2 ~ 3 times.

Claims (3)

1. the prosopalgic Chinese medicine composition for the treatment of; It is characterized in that by the raw material of following parts by weight: Conyza canadensis (L.) Cronq. 6 ~ 8 parts, Folium Photiniae (Folium Photiniae serrulatae) 9 ~ 11 parts, Folium et Ramulus Clerodendri Trichotomi 8 ~ 10 parts, Herba Rabdosiae Lophanthoidis 10 ~ 12 parts, Radix Alangii 22 ~ 26 parts, Oletum Trogopterori 20 ~ 23 parts, Herba Violae japonicae 12 ~ 14 parts, Fructus Mori 13 ~ 15 parts, Radix Codonopsitis Lanceolatae 16 ~ 18 parts.

2. treat prosopalgic Chinese medicine composition according to claim 1, be made up of the raw material of following heavy number described in it is characterized in that: Conyza canadensis (L.) Cronq. 7 parts, Folium Photiniae (Folium Photiniae serrulatae) 10 parts, Folium et Ramulus Clerodendri Trichotomi 9 parts, Herba Rabdosiae Lophanthoidis 12 parts, Radix Alangii 23 parts, Oletum Trogopterori 21 parts, Herba Violae japonicae 13 parts, Fructus Mori 15 parts, Radix Codonopsitis Lanceolatae 17 parts.

3. prepare a method for the treatment of trigeminal neuralgia Chinese medicine composition described in claim 1, it is characterized in that comprising the following steps:

A, the Conyza canadensis (L.) Cronq. getting described parts by weight, Folium Photiniae (Folium Photiniae serrulatae), Folium et Ramulus Clerodendri Trichotomi, Herba Rabdosiae Lophanthoidis, Radix Alangii, Oletum Trogopterori, Herba Violae japonicae, Radix Codonopsitis Lanceolatae, make 60 object powder; By solid-liquid ratio 1:8, add 70% ethanol, reflux, extract, 3 times, each 2 hours, merge backflow; Be condensed into the extractum that relative density is 1.28 ~ 1.32 (35 DEG C); Then vacuum drying, makes 200 object powder;

B, the Fructus Mori getting described parts by weight make 200 object powder; Then with the powder mix homogeneously in step a.