CN110755280A - Moisturizing and repairing hand mask - Google Patents
Moisturizing and repairing hand mask Download PDFInfo
- Publication number
- CN110755280A CN110755280A CN201911062738.XA CN201911062738A CN110755280A CN 110755280 A CN110755280 A CN 110755280A CN 201911062738 A CN201911062738 A CN 201911062738A CN 110755280 A CN110755280 A CN 110755280A
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- moisturizing
- skin
- hand
- repairing
- extract
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000001052 yellow pigment Substances 0.000 description 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/88—Polyamides
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- Cosmetics (AREA)
Abstract
The invention discloses a moisturizing and repairing hand mask which comprises urea, panthenol, maritime pine bark extract, Italian chrysanthemum extract, Taikui agave leaf extract and other components, and can repair skin corium layer, basement membrane and skin cutin barrier in a triple mode, so that the moisturizing and repairing hand mask has good effects of improving skin moisture content and reducing skin moisture loss. Experiments show that the moisturizing composition provided by the invention can improve the moisture content of the skin by more than 73% within 30min, and can keep the moisture content of the skin to be increased by more than 54% after 2 h.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to a moisturizing and repairing hand mask.
Background
The hands are exposed and often contacted with various substances, such as dryness, friction and trauma, and are easily subjected to lipid dissolving action of acid, alkali and organic solvents. In life and labor, the skin is easily chapped by local action.
The moisture content in the horny layer is insufficient to cause the skin to be dry, and the moisturizing agent can increase the moisture content of the epidermis and restore the barrier function of the skin, so that the moisturizing agent is one of the necessary components in the cosmetics. At present, the commonly used cosmetic moisturizing agents comprise glycerin, propylene glycol, butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium lactate, urea and the like, although the types of the cosmetic moisturizing agents are many, the moisturizing effect is limited, and the ideal moisturizing effect cannot be achieved.
Urea is a good moisturizing ingredient, and human skin contains a large amount of urea which is mainly present in the horny layer of the skin and is a main ingredient of Natural Moisturizing Factors (NMF) of the skin. The urea has excellent skin care effect, is added into a plurality of skin care products, and is widely applied in the field of medicines.
However, most of the cosmetics on the market use water as a matrix, and urea is not easy to exist stably in water and is easy to decompose into carbon dioxide and ammonia, so that a product system is unstable, the pH value is increased, skin irritation is caused, the appearance is yellowed, and pungent ammonia odor is generated, and the use of the cosmetics is finally influenced.
At present, aiming at the problem that urea is easy to decompose, the problem is not solved fundamentally because the color change phenomenon of the cosmetics sold in the market is only covered by adding yellow pigment and the bad smell is covered by adding essence.
Disclosure of Invention
The technical problem to be solved by the invention is to provide the urea-containing hand mask which is not easy to discolor after being stored for a long time and has good moisturizing and repairing effects.
The specific technical scheme of the invention is as follows:
the moisturizing and repairing hand mask comprises the following components in percentage by mass: 1-10% of urea and 0.2-2% of triethyl citrate.
In one embodiment, the moisturizing hand repairing film comprises the following components in percentage by mass: 5% of urea and 1% of triethyl citrate.
The moisturizing hand repairing film also can comprise a thickening agent, wherein the thickening agent can be composed of acrylic acid (ester)/isodecyl vinyl ester cross-linked polymer, polyacrylate cross-linked polymer-6 and hydroxyethyl cellulose; the addition amount of the acrylic acid (ester)/vinyl isodecanoate crosslinked polymer in the moisturizing and repairing hand membrane can be 0.1-0.3wt%, the addition amount of the polyacrylate crosslinked polymer-6 can be 0.2-0.4wt%, and the addition amount of the hydroxyethyl cellulose can be 0.05-0.3 wt%.
The moisturizing hand repairing film also comprises a humectant which can be composed of glycerin, allantoin, sodium hyaluronate, polyglutamic acid and PEG/PPG-17/6 copolymer; the addition amount of glycerol in the moisturizing and repairing hand membrane can be 5-8%, the addition amount of allantoin can be 0.1-0.3%, the addition amount of sodium hyaluronate can be 0.01-0.1%, the addition amount of polyglutamic acid can be 0.01-0.1%, and the addition amount of PEG/PPG-17/6 copolymer can be 0.1-1.5%.
The moisturizing and repairing hand mask can also comprise repairing active ingredients, wherein the repairing active ingredients comprise an extract of bark of Pinus maritima (Pinus PINASTER), an extract of Parthenia italica (Helichrysum italicium), and an extract of leaves of Agave TEQUILANA (Agave TEQUILANA); the moisture keeping hand repairing hand mask may contain 0.1-1% of Pinus maritima (Pinus PINASTER) bark extract, 0.1-0.5% of Parthenium ITALICUM (Helichrysum ITALICUM) extract, and 0.1-1% of Agave TEQUILANA (Agave TEQUILANA) leaf extract.
The moisturizing hand repairing film can also comprise a preservative. The preservative may be Euxyl PE9010, and the addition amount thereof may be 0.5-1 wt%. The Euxyl PE9010 is a liquid preservative in Shumei in Germany, and comprises phenoxyethanol and ethylhexyl glycerol.
The moisturizing and repairing hand mask disclosed by the invention also can comprise 0.01-0.05wt% of EDTA disodium, 0.01-0.2wt% of sodium hydroxide, 0.01-0.1wt% of essence, 0.1-0.4wt% of panthenol and 0.3-0.8wt% of p-hydroxyacetophenone.
The technical scheme provided by the embodiment of the invention has the following beneficial effects:
(1) according to the invention, the triethyl citrate is selected to stabilize the urea, so that the problems of easy color change and ammonia odor after the urea is added into the formula of the hand mask are solved;
(2) the invention selects panthenol, PINUS maritima (Pinus PINASTER) bark extract, flos chrysanthemi italicum (Helichrysumitaccum) extract and AGAVE TEQUILANA (Agave TEQUILANA) leaf extract as repairing active ingredients, and repairs the dermis layer, the basement membrane and the cutin barrier of the skin in a triple way, thereby having good effects of improving the moisture content of the skin and reducing the moisture loss of the skin. Experiments prove that the prepared hand mask can effectively reduce transepidermal water loss (TWEL) and effectively repair damaged skin barriers.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in further detail below, but the embodiments of the present invention are not limited thereto, and process parameters or conditions not particularly noted may be performed with reference to conventional techniques.
The Pinus maritima is a plant of Pinus of Pinaceae, and is naturally distributed in mediterranean coast and native place. The Mediterranean pine is a strong and resistant plant and grows in drought, insolation and salt-rich areas. This harsh environment is where other plants cannot grow. The bark extract of Pinus maritima contains procyanidin, and has strong antioxidant and free radical scavenging effects. Suitable maritime pine (Pinus PINASTER) bark extracts may include Pantrofina Skin 360 (from Res Pharma Industriale, USA).
The Italian parietes, which is related to the present invention, generally grows in the wind of sand dunes at seaside and has unique and strong fragrance, and is also called "permanent flowers", "immortal herbs", "Helichrysum ITALICUM", "Curry herbs", etc. Italian parietes extracts are rich in flavonoid and other ingredients, and can promote the release of β -endorphin to achieve a soothing effect and reduce the skin inflammatory response.
The extract of leaves of AGAVE tequilensis (AGAVE TEQUILANA) of the present invention has the effects of balancing the skin microbiome, reestablishing the microbial barrier protection, and protecting against the damaging effects of preservatives. The suitable extract of leaves of tequila (agave et equinulana) may comprise octopein (from seting, france) or blue silk (from setic, france).
D-panthenol, also called vitamin B5, is converted into pantothenic acid after being absorbed by skin after long-term use, and the synthesized coenzyme A by tissues can be present in the tissues and is necessary for metabolism of cell substances, so that the long-term use of vitamin B can improve the cell vitality, repair damaged skin and enhance the barrier function of the skin, thereby obviously reducing TEWL. As a moisturizer, it can improve stratum corneum hydration, reduce TEWL, reduce skin roughness and soothe irritated skin. In addition, the wound healing agent can activate fibroblast proliferation and accelerate epithelial cell regeneration, so that the wound can be healed.
Examples 1 to 3, comparative examples 1 to 6
The hand mask comprises the following components in percentage by mass:
wherein the preservative is Euxyl PE 9010; the aromatic is essence.
The preparation method of the hand mask comprises the following steps:
1. accurately weighing glycerol, acrylic acid (ester)/vinyl isodecanoate crosslinked polymer, allantoin, polyacrylate crosslinked polymer-6, hydroxyethyl cellulose, sodium hyaluronate, polyglutamic acid, EDTA-2NA, p-hydroxyacetophenone and deionized water, adding into an emulsifying pot, heating to 90 ℃, homogenizing for 3-5 minutes, dispersing uniformly, and cooling;
2. adding sodium hydroxide into an emulsifying pot, and neutralizing and stirring uniformly;
3. dissolving urea with appropriate amount of water, adding triethyl citrate into the urea water solution, stirring to be transparent, adding the triethyl citrate when the temperature of the emulsifying pot is reduced to 45 ℃, and stirring to be uniform;
4. adding panthenol, PEG/PPG-17/6 copolymer, antiseptic, maritime pine extract, Italian flos Chrysanthemi extract, TAIKUIYANLANYE extract, and aromatic into emulsifying pot, stirring, discharging, and cooling to room temperature to obtain cosmetic.
Test 1, stability test
Sensory testing: visually observing the properties of the product to see whether the product is abnormal or not;
and (3) heat resistance test: pouring the content of the hand membrane into a hand membrane material, sealing, putting into an electric heating constant temperature incubator at the temperature of (40 +/-1) DEG C for 24 hours, and observing whether phenomena such as thinning, discoloration, layering, hardness change and the like exist after the temperature is recovered to judge the heat resistance of the sample;
cold resistance test: and (3) pouring the hand film content into the hand film material, sealing, putting into a refrigerator at (-5 to-10) + -1 ℃ for 24h, and observing whether phenomena such as thinning, discoloration, layering, hardness change and the like exist after the room temperature is recovered to judge the cold resistance of the sample.
TABLE 1 stability test results for examples 1-3, comparative examples 1-5
As can be seen from Table 1, comparative example 5, to which no triethyl citrate was added, underwent a change in heat resistance with the problem of ammoniacal odor, while the other test groups were not abnormal. Therefore, the invention selects triethyl citrate to stabilize the urea, and solves the problems of easy color change and ammonia odor of the urea added into the formula of the hand mask.
Test 2 efficacy test
1 test instrument
A multifunctional skin tester, model Cutomer dual MPA 580, from CK, Germany, selects a skin moisture content test probe and a skin moisture loss TEWL test probe for the test.
2 test method
2.1 MMV test method for skin moisture content
2.1.1 experimental principle: the capacitance method is used for measuring the moisture content of the human skin stratum corneum, and is based on the obvious difference of dielectric constants of water and other substances, the capacitance values of the measured skin are different according to the moisture content of the skin stratum corneum, and the parameters can represent the moisture content of the skin.
2.1.2 protocol: 20 volunteers with the same conditions were selected for testing, 10 males and 10 females, with the age of 24-40. The regional basic value of forearm test is between 15 ~ 45 (Corneomter Unit, c.u), and before the examination, the unified clear water of testee cleans both hands forearm inboard, wipes dry with paper towel, at test environment temperature: 20 ℃ to 22 ℃, humidity: standing for 20min in 40-60% environment, distributing the sample and blank control area in the forearm inner area of volunteer according to the random distribution table of the test area, wherein each area has a size of 4.0cm × 5.0cm, and the sample dosage is (2.0 + -0.1) mg/cm2. The moisture content of the skin stratum corneum is tested before the product is used and 30min, 60min, 1h and 2h after the product is used. An uncoated sample (blank) was used as a control.
2.1.3 Experimental data: and (4) data of the change rate of the moisture content of the stratum corneum of the skin, removing the maximum value and the minimum value, and taking an average value. The results are shown in Table 2. Wherein the change rate of the moisture content of the stratum corneum = (test value-0 min test value)/0 min test value = 100%.
Table 2 water content test results of stratum corneum
2.2 percutaneous moisture loss TEWL test method
2.2.1 test principle
The measurement principle of the experimental instrument is derived from Fick's diffusion law: dm/dt = D.A.dp/dx. the moisture content through skin is directly measured by two groups of temperature and humidity sensors to measure the water vapor pressure gradient formed by the loss of moisture from the stratum corneum to different bright points near the epidermis (within about 1 cm). TEWL is an important indicator of the quality of the skin barrier. A lower TEWL value of the skin indicates a better barrier function of the skin and vice versa.
2.2.2 subjects
Selecting 20 healthy women with the age of 18-50 (30.5 +/-5.94); the subject has no serious chronic consumptive diseases (such as asthma, diabetes and the like), and has no skin lesion, inflammation, eczema and the like; the tested part of the subject has no hair, skin damage and other influence measurement factors; subjects were able to complete the experiment and sign informed consent as required. The following were excluded: women currently in pregnancy or lactation; the tested part has diseases such as dermatitis, scar or serious folliculitis and the like and can influence the experimental result; a subject suffering from clinical non-healing inflammatory dermatosis at a test part; those who use antihistamines for nearly one week or immunosuppressants for nearly one month; patients with immunodeficiency or autoimmune disease; constitutions are highly sensitive; the subject's participation in the last month in relevant or other clinical trials or oral hormonal drugs etc. may affect the activity of the test results. During the experiment, the subjects have adverse reactions, missed visits or violations of the study scheme (such as using other cosmetics or drugs which have an influence on the study results) and other special reasons, and are evaluated and confirmed by the clinical responsible person/dermatologist, and if the subjects are considered to be no longer suitable for continuing the experiment, the subjects are required to be quitted.
2.2.3 test methods
D0-D1: on day 0 before the start of the experiment, the subject was rested in a constant temperature and humidity environment (temperature (22. + -.2 ℃ C., relative humidity (50. + -.5)%) for 30min, and a 4 cm. times.5 cm area was marked on the inner side of each forearm. And (3) performing a closed patch test on SLS solution with the mass fraction of 7% in a region defined by the inner sides of the two forearms for 24h to induce erythema.
D06 h: on day 0 before the start of the experiment, the spot tester on the arm was removed 24h after the spot was stuck. Measuring TEWL value of the skin at the double forearm patch position after 6 h.
D1-D8: on days 1-8 of the experiment, subjects used the test product in the morning and evening on the right forearm (4 cm x 5cm area of the arm) and no product on the left forearm (4 cm x 5cm area of the arm).
D1/D3/D5/D7/D9: skin repair (skin TEWL) was measured at the site of left and right forearm patches on days 1, 3, 5, 7 and 9 after application of the test product, respectively.
2.2.4 Experimental data
The skin barrier function was analyzed by measuring the trans-epidermal water loss rate (TEWL) with a skin water loss tester. Measurement conditions were as follows: indoor has no direct sunlight and no wind, room temperature is 22 +/-2 ℃, and relative humidity is 50 +/-5 percent. When in measurement, the probe of the instrument is kept vertical to the surface of the skin, so that the coverage of other objects is avoided. The same part is selected for each measurement, the measurement is carried out for 5 times in total, the maximum value and the minimum value are removed, and the average value of the middle 3 times is taken. The results are shown in Table 3.
TABLE 3 TEWL values for the time periods
As can be seen from the table 3, the hand mask provided by the invention has the advantages that the formula structure is stable, the proportion of the components is scientific, the change rate of the moisture content of the skin is more than 73% in time, and the increase of the change rate of the moisture content of the skin which is more than 54% can be kept for 2 hours. Compared with the comparative examples 1-4, the formula components provided in the examples 1-3 have obviously improved effects of improving the moisture content and inhibiting the moisture loss, and show that the compounding of the components has obvious synergistic effect.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any simple modification, equivalent change and modification made to the above embodiment according to the technical spirit of the present invention will still fall within the scope of the technical solution of the present invention without departing from the content of the technical solution of the present invention.
Claims (8)
1. The moisturizing and repairing hand mask is characterized by comprising the following components in percentage by mass: 1-10% of urea and 0.2-2% of triethyl citrate.
2. The moisture-preserving hand repairing film according to claim 1, which is characterized by comprising the following components in percentage by mass: 5% of urea and 1% of triethyl citrate.
3. The moisturizing hand mask of claim 1, further comprising a thickener consisting of an acrylic/vinyl isodecanoate crosspolymer, polyacrylate crosspolymer-6, hydroxyethyl cellulose; the addition amount of the acrylic acid (ester)/vinyl isodecanoate crosslinked polymer in the moisturizing and repairing hand mask is 0.1-0.3wt%, the addition amount of the polyacrylate crosslinked polymer-6 is 0.2-0.4wt%, and the addition amount of the hydroxyethyl cellulose is 0.05-0.3 wt%.
4. The moisturizing hand repair film of claim 1, further comprising a humectant consisting of glycerin, allantoin, sodium hyaluronate, polyglutamic acid, PEG/PPG-17/6 copolymer; the moisturizing and repairing hand membrane comprises 5-8% of glycerol, 0.1-0.3% of allantoin, 0.01-0.1% of sodium hyaluronate, 0.01-0.1% of polyglutamic acid and 0.1-1.5% of PEG/PPG-17/6 copolymer.
5. The moisture preserving healing hand mask of claim 1, further comprising a healing active ingredient consisting of an extract of the bark of maritime pine (Pinus PINASTER), an extract of Italian chamomile (Helichrysum italicium), and an extract of the leaves of Thymelaeaceae TEQUILANA (Agave TEQUILANA).
6. The moisturizing hand mask of claim 5, wherein the amount of the Pinus maritima (PINUS PINATER) bark extract added is 0.1-1%, the amount of the Helichrysum ITALICUM (Helichrysum ITALICUM) extract added is 0.1-0.5%, and the amount of the Agave TEQUILANA (Agave TEQUILANA) leaf extract added is 0.1-1%.
7. The moisturizing hand repair film of claim 1, further comprising a preservative, wherein the preservative is composed of phenoxyethanol and ethylhexyl glycerol.
8. The moisture-preserving hand repairing film as claimed in claim 1, further comprising 0.01-0.05wt% of disodium EDTA, 0.01-0.2wt% of sodium hydroxide, 0.01-0.1wt% of essence, 0.1-0.4wt% of panthenol and 0.3-0.8wt% of p-hydroxyacetophenone.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113456542A (en) * | 2020-03-30 | 2021-10-01 | 仙婷(广州)科技研发有限公司 | Composition and application thereof |
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| US20120142767A1 (en) * | 2009-06-02 | 2012-06-07 | Action Pin | Pine pco ester cosmetic composition |
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