CN110753549A - 双磷脂素凝胶制剂及其用途 - Google Patents

双磷脂素凝胶制剂及其用途 Download PDF

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Publication number
CN110753549A
CN110753549A CN201880038759.5A CN201880038759A CN110753549A CN 110753549 A CN110753549 A CN 110753549A CN 201880038759 A CN201880038759 A CN 201880038759A CN 110753549 A CN110753549 A CN 110753549A
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China
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formulation
patient
present disclosure
infection
amount
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CN201880038759.5A
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English (en)
Chinese (zh)
Inventor
S·A·凯茨
K·A·约翰逊
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Lakewood Amedex Inc
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Lakewood Amedex Inc
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Publication of CN110753549A publication Critical patent/CN110753549A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Ophthalmology & Optometry (AREA)
CN201880038759.5A 2017-06-12 2018-06-12 双磷脂素凝胶制剂及其用途 Pending CN110753549A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762518262P 2017-06-12 2017-06-12
US62/518,262 2017-06-12
PCT/US2018/037151 WO2018231863A1 (en) 2017-06-12 2018-06-12 Bisphosphocin gel formulations and uses thereof

Publications (1)

Publication Number Publication Date
CN110753549A true CN110753549A (zh) 2020-02-04

Family

ID=64562861

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880038759.5A Pending CN110753549A (zh) 2017-06-12 2018-06-12 双磷脂素凝胶制剂及其用途

Country Status (14)

Country Link
US (5) US11096954B2 (https=)
EP (2) EP3638251B1 (https=)
JP (2) JP7148994B2 (https=)
KR (3) KR20260035292A (https=)
CN (1) CN110753549A (https=)
AU (3) AU2018282905B2 (https=)
BR (2) BR112019026073B1 (https=)
CA (1) CA3066722A1 (https=)
DK (1) DK3638251T3 (https=)
ES (1) ES2981923T3 (https=)
FI (1) FI3638251T3 (https=)
MX (1) MX2019014772A (https=)
PT (1) PT3638251T (https=)
WO (1) WO2018231863A1 (https=)

Cited By (1)

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CN112839662A (zh) * 2018-10-17 2021-05-25 莱克伍德阿美达克斯股份有限公司 用于治疗口腔粘膜炎的方法和组合物

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CA2604943C (en) 2005-04-15 2013-09-17 Clarus Therapeutics, Inc. Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same
US8492369B2 (en) 2010-04-12 2013-07-23 Clarus Therapeutics Inc Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same
US12030908B2 (en) 2017-03-10 2024-07-09 Lakewood Amedex, Inc. Antimicrobial compounds, compositions, and uses thereof
US11377468B2 (en) 2017-03-10 2022-07-05 Lakewood Amedex, Inc. Antimicrobial compounds, compositions, and uses thereof
US11795192B2 (en) 2017-03-10 2023-10-24 Lakewood Amedex, Inc. Antimicrobial compounds, compositions, and uses thereof
KR102317158B1 (ko) * 2017-03-10 2021-10-25 레이크우드 아메덱스, 인크. 항미생물 화합물, 조성물, 및 그의 용도
KR20260035292A (ko) 2017-06-12 2026-03-12 레이크우드 아메덱스, 인크. 비스포스포신 겔 제제 및 이의 용도
US11564933B2 (en) 2019-04-12 2023-01-31 Tolmar, Inc. Methods of treating testosterone deficiency
JP2024525259A (ja) * 2021-07-22 2024-07-12 レイクウッド アメデックス、インコーポレイテッド ビスホスホシンを調製するための方法
WO2025179296A1 (en) * 2024-02-22 2025-08-28 Lakewood Amedex, Inc. Crystalline forms of nu-3 and uses thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112839662A (zh) * 2018-10-17 2021-05-25 莱克伍德阿美达克斯股份有限公司 用于治疗口腔粘膜炎的方法和组合物

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Publication number Publication date
BR112019026073B1 (pt) 2021-11-03
WO2018231863A1 (en) 2018-12-20
CA3066722A1 (en) 2018-12-20
MX2019014772A (es) 2020-02-07
US11096954B2 (en) 2021-08-24
AU2018282905A1 (en) 2019-12-19
US20210361689A1 (en) 2021-11-25
AU2018282905B2 (en) 2022-06-02
KR20200014904A (ko) 2020-02-11
EP3638251B1 (en) 2024-03-06
EP3638251A4 (en) 2021-03-10
EP3638251A1 (en) 2020-04-22
AU2022224829A1 (en) 2022-09-29
DK3638251T3 (da) 2024-05-13
US20230125677A1 (en) 2023-04-27
JP2022183154A (ja) 2022-12-08
US12156883B2 (en) 2024-12-03
EP4241769A3 (en) 2023-11-08
KR20260035292A (ko) 2026-03-12
FI3638251T3 (fi) 2024-04-29
JP2020523322A (ja) 2020-08-06
US20250262234A1 (en) 2025-08-21
US20200360415A1 (en) 2020-11-19
KR20230031370A (ko) 2023-03-07
EP4241769A2 (en) 2023-09-13
AU2024202211B2 (en) 2025-12-04
JP7470449B2 (ja) 2024-04-18
PT3638251T (pt) 2024-05-22
BR122021011439B1 (pt) 2022-03-29
JP7148994B2 (ja) 2022-10-06
ES2981923T3 (es) 2024-10-11
NZ759577A (en) 2025-10-31
BR112019026073A2 (pt) 2020-06-30
AU2022224829B2 (en) 2024-12-05
US20180353529A1 (en) 2018-12-13
AU2024202211A1 (en) 2024-05-02

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