CN110741003A - 作为gls1抑制剂的化合物 - Google Patents

作为gls1抑制剂的化合物 Download PDF

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Publication number
CN110741003A
CN110741003A CN201880038963.7A CN201880038963A CN110741003A CN 110741003 A CN110741003 A CN 110741003A CN 201880038963 A CN201880038963 A CN 201880038963A CN 110741003 A CN110741003 A CN 110741003A
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China
Prior art keywords
compound
pharmaceutically acceptable
isomer
acceptable salt
group
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CN201880038963.7A
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CN110741003B (zh
Inventor
廖勇刚
刘超男
韦昌青
吴颢
陈曙辉
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NANJING MINGDE NEW DRUG RESEARCH AND DEVELOPMENT Co Ltd
Medshine Discovery Inc
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NANJING MINGDE NEW DRUG RESEARCH AND DEVELOPMENT Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings

Abstract

式(Ⅰ)所示的作为GLS1抑制剂的化合物或其药学上可接受的盐。

Description

PCT国内申请，说明书已公开。

Claims (18)

  1. PCT国内申请，权利要求书已公开。
CN201880038963.7A 2017-06-13 2018-06-13 作为gls1抑制剂的化合物 Active CN110741003B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2017104440396 2017-06-13
CN201710444039 2017-06-13
PCT/CN2018/091083 WO2018228435A1 (zh) 2017-06-13 2018-06-13 作为gls1抑制剂的化合物

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CN110741003A true CN110741003A (zh) 2020-01-31
CN110741003B CN110741003B (zh) 2021-07-23

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CN201880038963.7A Active CN110741003B (zh) 2017-06-13 2018-06-13 作为gls1抑制剂的化合物

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US (1) US11254666B2 (zh)
EP (1) EP3640250B1 (zh)
JP (1) JP7275053B2 (zh)
CN (1) CN110741003B (zh)
ES (1) ES2903182T3 (zh)
WO (1) WO2018228435A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111440199A (zh) * 2020-03-11 2020-07-24 中国药科大学 大环类谷氨酰胺酶gls1抑制剂或其可药用的盐、其制备方法及用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106029659A (zh) * 2014-01-06 2016-10-12 理森制药股份公司 谷氨酰胺酶抑制剂
CN106795150A (zh) * 2014-05-30 2017-05-31 阿斯利康(瑞典)有限公司 1,3,4‑噻二唑化合物及其在治疗癌症中的用途
US20170152255A1 (en) * 2015-11-30 2017-06-01 Astrazeneca Ab 1,3,4-Thiadiazole Compounds and Their Use in Treating Cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2782570B1 (en) 2011-11-21 2019-09-18 Calithera Biosciences Inc. Heterocyclic inhibitors of glutaminase
PT2920168T (pt) 2012-11-16 2021-10-18 Calithera Biosciences Inc Inibidores heterocíclicos de glutaminase
US10245254B2 (en) 2014-10-03 2019-04-02 University of Pittsburgh—of the Commonwealth System of Higher Education Glutaminase inhibitors
US10125128B2 (en) 2015-06-30 2018-11-13 Board Of Regents, The University Of Texas System GLS1 inhibitors for treating disease

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106029659A (zh) * 2014-01-06 2016-10-12 理森制药股份公司 谷氨酰胺酶抑制剂
CN106795150A (zh) * 2014-05-30 2017-05-31 阿斯利康(瑞典)有限公司 1,3,4‑噻二唑化合物及其在治疗癌症中的用途
US20170152255A1 (en) * 2015-11-30 2017-06-01 Astrazeneca Ab 1,3,4-Thiadiazole Compounds and Their Use in Treating Cancer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111440199A (zh) * 2020-03-11 2020-07-24 中国药科大学 大环类谷氨酰胺酶gls1抑制剂或其可药用的盐、其制备方法及用途
CN111440199B (zh) * 2020-03-11 2023-02-24 中国药科大学 大环类谷氨酰胺酶gls1抑制剂或其可药用的盐、其制备方法及用途

Also Published As

Publication number Publication date
US20200216436A1 (en) 2020-07-09
ES2903182T3 (es) 2022-03-31
JP2020523369A (ja) 2020-08-06
WO2018228435A1 (zh) 2018-12-20
JP7275053B2 (ja) 2023-05-17
EP3640250B1 (en) 2021-12-15
EP3640250A4 (en) 2020-04-22
EP3640250A1 (en) 2020-04-22
US11254666B2 (en) 2022-02-22
CN110741003B (zh) 2021-07-23

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