CN110730780A - 用作ROR-γ调节剂的2，3-二氢异吲哚-1-甲酰胺 - Google Patents

用作ROR-γ调节剂的2，3-二氢异吲哚-1-甲酰胺 Download PDF

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Publication number
CN110730780A
CN110730780A CN201880038447.4A CN201880038447A CN110730780A CN 110730780 A CN110730780 A CN 110730780A CN 201880038447 A CN201880038447 A CN 201880038447A CN 110730780 A CN110730780 A CN 110730780A
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CN
China
Prior art keywords
phenyl
dihydro
methylsulfonyl
isoindole
carboxamide
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Pending
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CN201880038447.4A
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English (en)
Chinese (zh)
Inventor
S.莱弗
F.纳耶斯
R.I.奥尔松
S.冯贝里
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AstraZeneca AB
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AstraZeneca AB
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Publication of CN110730780A publication Critical patent/CN110730780A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201880038447.4A 2017-06-14 2018-06-13 用作ROR-γ调节剂的2，3-二氢异吲哚-1-甲酰胺 Pending CN110730780A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762519263P 2017-06-14 2017-06-14
US62/519263 2017-06-14
PCT/EP2018/065712 WO2018229155A1 (en) 2017-06-14 2018-06-13 2,3-dihydroisoindole-1-carboxamides useful as ror-gamma modulators

Publications (1)

Publication Number Publication Date
CN110730780A true CN110730780A (zh) 2020-01-24

Family

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Family Applications (1)

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CN201880038447.4A Pending CN110730780A (zh) 2017-06-14 2018-06-13 用作ROR-γ调节剂的2，3-二氢异吲哚-1-甲酰胺

Country Status (5)

Country Link
US (2) US11034654B2 (enExample)
EP (1) EP3638661A1 (enExample)
JP (1) JP2020524660A (enExample)
CN (1) CN110730780A (enExample)
WO (1) WO2018229155A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021228217A1 (zh) * 2020-05-15 2021-11-18 上海辉启生物医药科技有限公司 可用作RORγ调节剂的苯胺类化合物
CN113717090A (zh) * 2021-08-31 2021-11-30 南京林业大学 一种含三氟甲基全碳季碳中心吲哚乙腈化合物及其制备方法和应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020035557A1 (en) * 2018-08-17 2020-02-20 Leo Pharma A/S Novel heteroaromatic modulators of the retinoid-related orphan receptor gamma
WO2020035556A1 (en) * 2018-08-17 2020-02-20 Leo Pharma A/S Novel heteroaromatic modulators of the retinoid-related orphan receptor gamma

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021228217A1 (zh) * 2020-05-15 2021-11-18 上海辉启生物医药科技有限公司 可用作RORγ调节剂的苯胺类化合物
CN113773251A (zh) * 2020-05-15 2021-12-10 上海辉启生物医药科技有限公司 可用作RORγ调节剂的苯胺类化合物
CN113773251B (zh) * 2020-05-15 2024-06-11 励缔(杭州)医药科技有限公司 可用作RORγ调节剂的苯胺类化合物
CN113717090A (zh) * 2021-08-31 2021-11-30 南京林业大学 一种含三氟甲基全碳季碳中心吲哚乙腈化合物及其制备方法和应用
CN113717090B (zh) * 2021-08-31 2022-04-05 南京林业大学 一种含三氟甲基全碳季碳中心吲哚乙腈化合物及其制备方法和应用

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WO2018229155A1 (en) 2018-12-20
US20210380533A1 (en) 2021-12-09
US11034654B2 (en) 2021-06-15
US20200115338A1 (en) 2020-04-16
JP2020524660A (ja) 2020-08-20
EP3638661A1 (en) 2020-04-22

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Application publication date: 20200124