CN110720550A - Snack capable of reducing blood fat of pets and preparation method of snack - Google Patents
Snack capable of reducing blood fat of pets and preparation method of snack Download PDFInfo
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- CN110720550A CN110720550A CN201811608384.XA CN201811608384A CN110720550A CN 110720550 A CN110720550 A CN 110720550A CN 201811608384 A CN201811608384 A CN 201811608384A CN 110720550 A CN110720550 A CN 110720550A
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- 210000004369 blood Anatomy 0.000 title claims abstract description 53
- 239000008280 blood Substances 0.000 title claims abstract description 53
- 235000011888 snacks Nutrition 0.000 title claims abstract description 49
- 230000001603 reducing effect Effects 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title abstract description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 20
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 20
- 241000193749 Bacillus coagulans Species 0.000 claims description 16
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 16
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 16
- 229940054340 bacillus coagulans Drugs 0.000 claims description 16
- 229910052804 chromium Inorganic materials 0.000 claims description 16
- 239000011651 chromium Substances 0.000 claims description 16
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 16
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 15
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 15
- 229960001681 croscarmellose sodium Drugs 0.000 claims description 15
- 239000009429 Ginkgo biloba extract Substances 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 13
- 229920002261 Corn starch Polymers 0.000 claims description 12
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 12
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- 239000008120 corn starch Substances 0.000 claims description 12
- 239000000796 flavoring agent Substances 0.000 claims description 12
- 235000019634 flavors Nutrition 0.000 claims description 12
- 229940068052 ginkgo biloba extract Drugs 0.000 claims description 12
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- 229930003944 flavone Natural products 0.000 claims 1
- 150000002212 flavone derivatives Chemical class 0.000 claims 1
- 235000011949 flavones Nutrition 0.000 claims 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract description 8
- 235000019629 palatability Nutrition 0.000 abstract description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 35
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- 150000002632 lipids Chemical class 0.000 description 11
- 241000700159 Rattus Species 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
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- 108010028554 LDL Cholesterol Proteins 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- FPFSGDXIBUDDKZ-UHFFFAOYSA-N 3-decyl-2-hydroxycyclopent-2-en-1-one Chemical compound CCCCCCCCCCC1=C(O)C(=O)CC1 FPFSGDXIBUDDKZ-UHFFFAOYSA-N 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 241000282326 Felis catus Species 0.000 description 2
- 235000011201 Ginkgo Nutrition 0.000 description 2
- 241000218628 Ginkgo Species 0.000 description 2
- 235000008100 Ginkgo biloba Nutrition 0.000 description 2
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
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- 239000012086 standard solution Substances 0.000 description 2
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- 208000004930 Fatty Liver Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 206010060820 Joint injury Diseases 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 206010033307 Overweight Diseases 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
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- 239000000284 extract Substances 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 description 1
- -1 flavonol glycosides Chemical class 0.000 description 1
- 235000011957 flavonols Nutrition 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 230000000055 hyoplipidemic effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
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- 229940125396 insulin Drugs 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
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- 238000009630 liquid culture Methods 0.000 description 1
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- 235000020824 obesity Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
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- 210000005259 peripheral blood Anatomy 0.000 description 1
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- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Botany (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
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Abstract
The invention discloses a snack for reducing blood fat of pets and a preparation method thereof. The snack capable of reducing the blood fat of the pet, which is prepared by the invention, has good palatability and can prevent and improve the problem of the hyperlipidemia of the pet.
Description
Technical Field
The invention relates to snacks for reducing blood fat of pets, in particular to tablets for reducing blood fat of pets and a preparation method thereof.
Background
Pets are friends of humans, and their status in the home is increasing day by day. In recent years, the number of obese pets is increasing, and obesity of pets is the most common factor causing hyperlipidemia of pets.
As the living standard of people is improved, the investment of pet owners on cats and dogs is larger, and the pet owners hope to give the best pet to the pets. Many pet owners do not have reasonable control over pet diets, and are always concerned about the concern that a pet will eat too much if it is not full, and often "improve their diet" to administer high calorie foods. In addition, most of the current pets are locked at home and lack of movement seriously, which causes the common problem of fat dogs and cats. The diet of the pet is not reasonably controlled, and the pet lacks exercise, so that the weight is overweight, hyperlipidemia is caused, and the occurrence proportion of the hyperlipidemia of the pet is increased year by year.
Hyperlipidemia alone does not have serious consequences, but it can cause a number of serious complications such as pancreatitis, diabetes, fatty liver, cardiovascular disease, atopic dermatitis, joint injury degeneration, etc. Hyperlipidemia does not have initial symptoms, so that many owners can easily ignore the symptoms, and become chronic diseases in treatment after complications of hyperlipidemia occur, which is not only a nuisance to pets, but also a great burden to owners.
Therefore, it is necessary to control the weight and the blood lipid level of the obese pet in time and prevent and treat the hyperlipidemia of the pet in advance.
The invention reduces cholesterol and triglyceride in the blood of the pet by compounding the bacillus coagulans, the chromium yeast and the ginkgo biloba extract so as to achieve the purpose of controlling and reducing the blood fat of the pet. In addition, the beef flavor is added to improve palatability, so that the beef flavor is convenient to eat.
Disclosure of Invention
In order to solve the problems, the invention discloses a snack for reducing the blood fat of pets and a preparation method thereof.
The ginkgo flavone-glycoside component has strong oxidation resistance and free radical scavenging capacity, improves peripheral blood circulation and reduces serum cholesterol by adding the ginkgo leaf extract. By adding yeast chromium, the activity of insulin is activated, the blood sugar is regulated, and the conversion of sugar into fat is inhibited. By adding bacillus coagulans, intestinal balance is adjusted, and cholesterol is promoted to be discharged out of the body.
The technical scheme adopted by the invention for solving the problems is to provide a snack for reducing the blood fat of pets, which is characterized by mainly comprising bacillus coagulans, chromium yeast, a ginkgo extract, beef flavor, microcrystalline cellulose, polyvinylpyrrolidone, croscarmellose sodium, silicon dioxide, magnesium stearate, corn starch and lactose.
The number of bacillus coagulans is more than or equal to 1X1010CFU/g。
The chromium content of the yeast raw material is more than or equal to 2000 ppm.
The content of the total flavonol glycosides of the raw material ginkgo leaf extract is more than or equal to 24 percent.
The water content of the raw materials of corn starch and lactose is less than or equal to 5 percent.
The invention relates to a snack capable of reducing blood fat of pets, which is characterized by comprising the following raw materials in parts by weight: 0.5-3 parts of bacillus coagulans, 0.5-3 parts of chromium yeast, 5-15 parts of ginkgo biloba extract, 0.5-4 parts of beef flavor, 10-25 parts of microcrystalline cellulose, 0.1-4 parts of croscarmellose sodium, 15-50 parts of water, 25-40 parts of corn starch, 25-40 parts of lactose, 3-10 parts of polyvinylpyrrolidone, 0.1-1 part of silicon dioxide and 0.5-2 parts of magnesium stearate.
The preparation method of the snack capable of reducing the blood fat of the pet is characterized by comprising the following specific steps of (1) uniformly mixing 0.5-3 parts of bacillus coagulans, 0.5-3 parts of yeast chromium, 5-15 parts of ginkgo biloba extract, 0.5-4 parts of beef flavor, 10-25 parts of microcrystalline cellulose, 0.1-4 parts of cross-linked sodium carboxymethyl cellulose, 25-40 parts of corn starch and 25-40 parts of lactose; (2) dissolving 3-10 parts of polyvinylpyrrolidone in 15-50 parts of water, wetting the mixture, granulating by using a granulator with a 24-mesh screen, and drying at 60 ℃; (3) sieving with 20 mesh sieve, mixing with silicon dioxide 0.1-1 parts, croscarmellose sodium 0.3-2 parts, and magnesium stearate 0.5-2 parts; (4) tabletting by using a tabletting machine, wherein the diameter of the tablets is controlled to be 8-12mm, and the tablet weight is controlled to be 0.3-0.6g, so that the snack for reducing the blood fat of the pets can be obtained.
The invention has the beneficial effects that:
the invention adopts bacillus coagulans, chromium yeast and ginkgo biloba extract as main raw materials, can regulate the metabolism of pet organisms and improve the blood lipid condition of pets.
The blood fat reducing snack for pets is easy in raw material obtaining, simple in preparation process, good in palatability and convenient for feeding pets.
Detailed Description
The present invention will be further described with reference to the following examples, but the embodiments of the present invention are not limited thereto, and the experimental methods used in the following examples are all conventional methods unless otherwise specified.
Example 1
Uniformly mixing 0.5g of bacillus coagulans, 3g of yeast chromium, 15g of ginkgo biloba extract, 0.5g of beef flavor, 10g of microcrystalline cellulose, 0.5g of croscarmellose sodium, 25g of corn starch and 40g of lactose;
dissolving 3g of polyvinylpyrrolidone in 15g of water, wetting the mixture, granulating by using a granulator with a 24-mesh screen, and drying at 60 ℃;
granulating with 20 mesh sieve, and mixing with 1g of silicon dioxide, 1g of croscarmellose sodium, and 0.5g of magnesium stearate; tabletting by using a tabletting machine, wherein the diameter of each tablet is 8mm, and the weight of each tablet is 0.3 +/-0.015 g, so that 250 snack foods for reducing the blood fat of the pets can be obtained.
Example 2:
uniformly mixing 1g of bacillus coagulans, 2g of yeast chromium, 10g of ginkgo biloba extract, 2g of beef flavor, 20g of microcrystalline cellulose, 1g of croscarmellose sodium, 30g of corn starch and 25g of lactose;
dissolving 7g of polyvinylpyrrolidone in 35g of water, wetting the mixture, granulating by using a granulator with a 24-mesh screen, and drying at 60 ℃;
granulating with 20 mesh sieve, and mixing with 0.6g of silicon dioxide, 0.8g of croscarmellose sodium, and 0.6g of magnesium stearate; tabletting by using a tabletting machine, wherein the diameter of each tablet is 10mm, and the tablet weight is 0.36 +/-0.018 g, so that 200 snack pieces for reducing the blood fat of the pets can be obtained
Example 3
Uniformly mixing 3g of bacillus coagulans, 0.5g of yeast chromium, 5g of ginkgo biloba extract, 2g of beef flavor, 25g of microcrystalline cellulose, 0.05g of croscarmellose sodium, 25g of corn starch and 27.3g of lactose;
dissolving 10g of polyvinylpyrrolidone in 50g of water, wetting the mixture, granulating by using a granulator with a 24-mesh screen, and drying at 60 ℃;
granulating with 20 mesh sieve, and mixing with 0.1g of silicon dioxide, 0.05g of croscarmellose sodium, and 2g of magnesium stearate; tabletting by using a tabletting machine, wherein the diameter of each tablet is 8mm, and the weight of each tablet is 0.3 +/-0.015 g, so that 250 snack foods for reducing the blood fat of the pets can be obtained.
Example 4
Uniformly mixing 2g of bacillus coagulans, 2g of yeast chromium, 10g of ginkgo biloba extract, 4g of beef flavor, 25g of microcrystalline cellulose, 2g of croscarmellose sodium, 25g of corn starch and 22g of lactose;
dissolving 3g of polyvinylpyrrolidone in 20g of water, wetting the mixture, granulating by using a granulator with a 24-mesh screen, and drying at 60 ℃;
granulating with a 20-mesh sieve, and mixing with 1g of silicon dioxide, 2g of croscarmellose sodium and 2g of magnesium stearate; tabletting by using a tabletting machine, wherein the diameter of each tablet is 8mm, and the weight of each tablet is 0.3 +/-0.015 g, so that 250 snack foods for reducing the blood fat of the pets can be obtained.
Example 5 Pet blood lipid lowering snack Cholesterol splitting test
1. Experimental materials:
0.1% cholesterol MRS liquid culture medium, 0.005mg/mL, 0.01mg/mL, 0.015mg/mL, 0.02mg/mL, 0.025mg/mL, 0.03mg/mL cholesterol ethanol standard solution, ferric ammonium sulfate color developing agent and colorimetric tube.
2. Experimental samples:
pet blood lipid reducing snack contest 1, pet blood lipid reducing snack contest 2, pet blood lipid reducing snack contest 3, the pet blood lipid reducing snack of embodiment 1 of the invention, the pet blood lipid reducing snack of embodiment 2 of the invention, the pet blood lipid reducing snack of embodiment 3 of the invention, and the pet blood lipid reducing snack of embodiment 4 of the invention
The main component of the 3 pet blood fat reducing snacks is lactobacillus, the main component of the 4 pet blood fat reducing snacks is bacillus coagulans, and the bacteria in the 7 snacks can be cultured by using a cholesterol MRS culture medium to compare the capacity of decomposing cholesterol.
3. The experimental steps are as follows:
(1) drawing a cholesterol color development standard curve: mixing 2mL of 6-concentration cholesterol ethanol standard solution with 2mL of ferric ammonium sulfate color developing agent, cooling, reading an absorbance value at a wavelength of 560nm, and drawing a standard curve by taking the cholesterol concentration as an abscissa and the absorbance value as an ordinate, wherein the result is shown in Table 1.
TABLE 1 results of absorbance values for cholesterol solutions
(2) Decomposition of cholesterol: firstly, 3 pet blood fat reducing snacks are competitive and 4 pet blood fat reducing snacks are ground into powder according to the bacterial content in each snack and according to the bacterial content of 1.5X109CFU/100mL was inoculated into the medium, two for each snack, and incubated at 37 ℃. After incubation for 24h and 42h, respectively, and after 50-fold dilution according to the method described above, absorbance values at 560nm wavelength were measured, and after bringing into a standard curve, the cholesterol concentration and the amount of decomposed cholesterol were calculated, and the results are shown in Table 2:
TABLE 2 results of in vitro cholesterol decomposition
And (4) experimental conclusion:
as can be seen from Table 2, the blood lipid-lowering snacks of the present invention prepared according to example 1, example 2, example 3 and example 4 were cultured in cholesterol MRS medium for 24h and 42h, and their cholesterol decomposition was significantly higher than that of the other 3 pet blood lipid-lowering snacks.
Example 6 lipid-lowering experiment
1. Experimental materials:
the blood fat reducing snack of the embodiment 1 of the invention, the blood fat reducing snack of the embodiment 2 of the invention, the blood fat reducing snack of the embodiment 3 of the invention, the blood fat reducing snack of the embodiment 4 of the invention, high fat feed and common feed.
2. Experimental animals: 120 SD rats.
3. The experimental steps are as follows:
(1) manufacturing a high fat model animal:
120 SD rats with uniform body weight were divided into 6 groups of 20 rats each. Randomly select 4 groups as experimental group, 1 group as model control group and 1 group as blank control group. And (3) feeding common feed all the time in the blank control group, feeding high-fat feed for 14 days in the experimental group and the model control group for molding, and measuring TC, TG and LDL-C, HDL-C in blood collection to judge that molding is successful. The results are shown in Table 1:
TABLE 1 results (mmol/L) of high fat model animals
(2) Blood fat reduction experiment:
the hypolipidemic snacks of the present invention of example 1, example 2, example 3 and example 4 were ground into powder and administered to each of test group 1, test group 2, test group 3 and test group 4 at a dose of 0.1g/kg body weight by continuous gavage for 7 days while simultaneously gavage with physiological saline of the model control group and the blank control group. After 7 days, blood sampling is carried out to determine TC, TG and LDL-C, HDL-C, and the experimental results are shown in a table 2:
TABLE 2 blood lipid lowering results (mmol/L)
And (4) experimental conclusion:
after the pet blood fat reducing snacks of the invention are given to 4 experimental rats, TG, TC and LDL-C of the 4 experimental rats are obviously lower than those of a model control group and tend to be a blank control group, wherein the pet snacks prepared according to the example 2 have the best blood fat reducing effect. The snack for reducing the blood fat of the pet can play a role in reducing the blood fat.
While there have been shown and described what are at present considered to be the principles of the invention, its essential features and advantages, the invention further resides in various modifications and changes that fall within the scope of the invention as claimed.
Claims (7)
1. The snack capable of reducing the blood fat of pets is characterized by consisting of bacillus coagulans, chromium yeast, ginkgo biloba extract, beef flavor, microcrystalline cellulose, polyvinylpyrrolidone, croscarmellose sodium, silicon dioxide, magnesium stearate, water, corn starch and lactose.
2. The snack for reducing the blood fat of the pet according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 0.5-3 parts of bacillus coagulans, 0.5-3 parts of chromium yeast, 5-15 parts of ginkgo biloba extract, 0.5-4 parts of beef flavor, 10-25 parts of microcrystalline cellulose, 0.1-4 parts of croscarmellose sodium, 15-50 parts of water, 25-40 parts of corn starch, 25-40 parts of lactose, 3-10 parts of polyvinylpyrrolidone, 0.1-1 part of silicon dioxide and 0.5-2 parts of magnesium stearate.
3. The pet blood lipid-lowering snack food as claimed in any one of claims 1 or 2, wherein the number of bacillus coagulans is not less than 1X1010CFU/g。
4. The snack food for reducing the blood fat of pets according to any one of claims 1 or 2, characterized in that the chromium content of the raw material yeast chromium is more than or equal to 2000 ppm.
5. The snack food for reducing the blood fat of pets according to any one of claims 1 or 2, wherein the total flavone content of the raw material ginkgo biloba extract is not less than 24%.
6. The pet blood lipid-lowering snack food according to any one of claims 1 or 2, wherein the moisture content of the raw materials corn starch and lactose is less than or equal to 5%.
7. The pet blood lipid-lowering snack according to any one of claims 1 to 6, characterized in that it is prepared by the following steps:
(1) uniformly mixing 0.5-3 parts of bacillus coagulans, 0.5-3 parts of yeast chromium, 5-15 parts of ginkgo biloba extract, 0.5-4 parts of beef flavor, 10-25 parts of microcrystalline cellulose, 0.1-4 parts of croscarmellose sodium, 25-40 parts of corn starch and 25-40 parts of lactose;
(2) dissolving 3-10 parts of polyvinylpyrrolidone in 15-50 parts of water, wetting the mixture, granulating by using a granulator with a 24-mesh screen, and drying at 60 ℃;
(3) sieving with 20 mesh sieve, mixing with silicon dioxide 0.1-1 parts, croscarmellose sodium 0.3-2 parts, and magnesium stearate 0.5-2 parts;
(4) tabletting with tablet machine, wherein the diameter of tablet is controlled at 8-12mm, and the weight of tablet is controlled at 0.3-0.6 g.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024038169A1 (en) * | 2022-08-19 | 2024-02-22 | De Faire Medical Ab | Compositions for use in treating and/or preventing type 2 diabetes, pre-diabetes, and/or a symptom thereof |
Citations (1)
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| CN104739891A (en) * | 2015-02-26 | 2015-07-01 | 江苏农牧科技职业学院 | Pet dog health product with function of adjusting lipid metabolism |
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| CN104739891A (en) * | 2015-02-26 | 2015-07-01 | 江苏农牧科技职业学院 | Pet dog health product with function of adjusting lipid metabolism |
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| 中华预防医学会微生态学分会主办: "《中华预防医学会第十一届全国微生态学学术会议论文汇编》", 30 September 2010, 中华预防医学会微生态学分会 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2024038169A1 (en) * | 2022-08-19 | 2024-02-22 | De Faire Medical Ab | Compositions for use in treating and/or preventing type 2 diabetes, pre-diabetes, and/or a symptom thereof |
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Application publication date: 20200124 |