CN110709091A - 使用长效格拉替雷和脂肪源性干细胞治疗多发性硬化症 - Google Patents

使用长效格拉替雷和脂肪源性干细胞治疗多发性硬化症 Download PDF

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Publication number
CN110709091A
CN110709091A CN201780091620.2A CN201780091620A CN110709091A CN 110709091 A CN110709091 A CN 110709091A CN 201780091620 A CN201780091620 A CN 201780091620A CN 110709091 A CN110709091 A CN 110709091A
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CN
China
Prior art keywords
glatiramer acetate
hadscs
pharmaceutical composition
administration
administered
Prior art date
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Pending
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CN201780091620.2A
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English (en)
Chinese (zh)
Inventor
埃胡德·马罗姆
纳达夫·布莱希·基梅尔曼
弗里达·格里恩斯潘
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Stem Cell Medicine Ltd
Mapi Pharma Ltd
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Stem Cell Medicine Ltd
Mapi Pharma Ltd
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Publication of CN110709091A publication Critical patent/CN110709091A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201780091620.2A 2017-05-15 2017-05-15 使用长效格拉替雷和脂肪源性干细胞治疗多发性硬化症 Pending CN110709091A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IL2017/050535 WO2018211486A1 (en) 2017-05-15 2017-05-15 Treatment of multiple sclerosis with long acting glatiramer and adipose-derived stem cells

Publications (1)

Publication Number Publication Date
CN110709091A true CN110709091A (zh) 2020-01-17

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CN201780091620.2A Pending CN110709091A (zh) 2017-05-15 2017-05-15 使用长效格拉替雷和脂肪源性干细胞治疗多发性硬化症

Country Status (8)

Country Link
US (1) US11413311B2 (https=)
EP (1) EP3624815A4 (https=)
JP (1) JP7000458B2 (https=)
CN (1) CN110709091A (https=)
AU (1) AU2017414803B2 (https=)
CA (1) CA3062964C (https=)
IL (1) IL270355B2 (https=)
WO (1) WO2018211486A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
HUE071047T2 (hu) 2016-08-31 2025-07-28 Mapi Pharma Ltd Glatiramer-acetátot tartalmazó depórendszerek
CN110382052A (zh) 2017-03-26 2019-10-25 Mapi医药公司 用于治疗进展型形式的多发性硬化症的格拉替雷储库系统

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US20120164229A1 (en) * 2010-01-04 2012-06-28 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
CN102686235A (zh) * 2010-01-04 2012-09-19 Mapi医药公司 包含格拉默或其药用盐的储药系统
CN103403150A (zh) * 2010-12-17 2013-11-20 人类起源公司 利用羊膜来源贴壁细胞治疗与免疫相关的疾病和紊乱
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CN103403150A (zh) * 2010-12-17 2013-11-20 人类起源公司 利用羊膜来源贴壁细胞治疗与免疫相关的疾病和紊乱

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Publication number Publication date
JP2020519658A (ja) 2020-07-02
EP3624815A1 (en) 2020-03-25
US11413311B2 (en) 2022-08-16
JP7000458B2 (ja) 2022-02-10
IL270355A (https=) 2019-12-31
IL270355B1 (https=) 2023-02-01
US20200147141A1 (en) 2020-05-14
EP3624815A4 (en) 2021-01-20
CA3062964A1 (en) 2018-11-22
IL270355B2 (en) 2023-06-01
CA3062964C (en) 2024-11-12
AU2017414803A1 (en) 2019-12-05
WO2018211486A1 (en) 2018-11-22
AU2017414803B2 (en) 2025-02-13

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