CN110694036A

CN110694036A - Sanfu plaster with slow release function and preparation method thereof

Info

Publication number: CN110694036A
Application number: CN201910771431.0A
Authority: CN
Inventors: 黄培冬; 邰先桃; 应力; 袁恺; 张粲; 廖映烨; 马永刚
Original assignee: Yunnan University of Traditional Chinese Medicine TCM
Current assignee: Yunnan University of Traditional Chinese Medicine TCM
Priority date: 2019-08-21
Filing date: 2019-08-21
Publication date: 2020-01-17

Abstract

The invention discloses a Sanfu patch with a slow release function and a preparation method thereof, wherein the Sanfu patch comprises a patch and an ointment, the ointment comprises traditional Chinese medicine active substances, an ointment matrix and a medicine slow release agent, and the traditional Chinese medicine active substances are prepared from the following raw materials in parts by weight: stir-fried mustard seed, vinegar-processed rhizoma corydalis, asarum, euphorbia kansui, herba epimedii, dried ginger, cinnamon, clove and ginger juice. The invention utilizes the compatibility and adds the drug sustained release agent, so that the active ingredients of the traditional Chinese medicine can be continuously released in a longer time to achieve the long-acting effect. The slow-release medicine preparation has the advantages of small irritation, lasting curative effect and safety. Frequent administration is not needed, the times can be reduced, the blood concentration is stable, the peak valley phenomenon is avoided, and the toxic and side effects of the medicine are favorably reduced. Meanwhile, the total dosage of the medicine can be reduced, and the maximum effect can be achieved by using the minimum dosage. Vaseline is used as ointment matrix, active substances carrying traditional Chinese medicines can enter blood circulation through skin, the release speed is stable, and the ointment has a continuous and powerful treatment effect on users.

Description

Sanfu plaster with slow release function and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to summer health-preserving Sanfu paste and a preparation method thereof.

Background

The therapy of 'treating winter diseases in summer' is a characteristic therapy in the traditional Chinese medicine therapy in China, and is based on the principle of 'nourishing yang in spring and summer' in Suzhou, four-qi theory of tranquilization, combined with the heaven moxibustion therapy, the medicine is applied on the acupuncture points of the human body to inspire vital qi and increase the disease resistance, thereby achieving the purpose of preventing and treating diseases. When the three lying days come, yang qi in the body rises, meridians and collaterals are smooth, qi and blood are abundant, and the best time for warming yang qi and dispelling endogenous cold is provided. The opportunity is utilized to treat some cold diseases, the yang qi of the human body can be fully assisted by the Tianyang, the sinking disease can be removed to the maximum extent, the yin-yang balance of the human body can be adjusted, and the disease condition is relieved, and the disease is rarely developed or even not developed. The sanfu patch can dredge channels and collaterals, regulate qi and blood, relieve chest stuffiness and descend qi, strengthen the spleen and stomach, inspire yang qi, regulate the functions of the lung and the spleen of a human body, and continuously enhance the immune function of an organism, thereby achieving the effects of exciting yang qi, promoting blood circulation, dispelling cold evil and enhancing disease resistance. The Sanfu patch can effectively help to relieve children diseases, and has good therapeutic effect on chronic bronchitis, chronic pharyngitis, chronic rhinitis, repeated cold, bronchial asthma, chronic diarrhea, chronic gastritis, cold limbs, aversion to cold, enuresis, and other symptoms or diseases. The three-volt day is the hottest, most yang-qi and highest temperature stage in one year. At the moment, the three-V patch can help loosen the striae of the human body and promote qi and blood circulation of the channels and collaterals, and is an effective method for health preservation and disease prevention.

The current-stage three-volt patch and the use method thereof are as follows: grinding the compatible traditional Chinese medicines into powder of 100-plus-120 meshes, mixing with ginger juice and honey to prepare an ointment with the size of a capillary coin, and then pasting with a medical adhesive plaster or a wound-dampness ointment. The ointment can slide off when the three-folding patch is used, meanwhile, the ointment can cause discomfort of skin and cause skin diseases, and moreover, the ointment is stuck on the body, so that the drug effect release is too concentrated, and the absorption of the drug effect is not facilitated.

Disclosure of Invention

The invention aims to overcome the defects of the tri-volt patch and provide a brand new tri-volt patch with a slow release function. A kind of three-volt paste with slow release function, characterized by that: comprises a medicine patch (1) and an ointment (2), wherein the ointment (2) comprises traditional Chinese medicine active substances, an ointment matrix and a medicine slow-release agent. The traditional Chinese medicine active substance is prepared from the following raw materials in parts by weight: 20-40 parts of fried mustard seed, 20-40 parts of vinegar rhizoma corydalis, 10-15 parts of asarum, 10-15 parts of euphorbia kansui, 15-25 parts of epimedium, 20-30 parts of dried ginger, 10-15 parts of cinnamon, 10-15 parts of clove and 60-70 parts of ginger juice.

The ointment matrix is vaseline.

The medicament sustained release agent is povidone, can slowly release the medicament and maintain the concentration of the medicament to be at an effective concentration for a long period of time.

Each 1000 parts by weight of the ointment contains 175-265 parts by weight of traditional Chinese medicine active ingredients, 732-824 parts by weight of ointment matrix and 1-3 parts by weight of drug sustained-release agent.

The preparation method of the ginger juice comprises the steps of cleaning fresh ginger, slicing and juicing to obtain the ginger juice.

The structure of medicine subsides (1) comprises thin subsides (3), the solid fixed ring of ointment (4), protection subsides (5), thin subsides (3) one side has viscidity, the solid fixed ring of ointment (4) are located thin subsides (3) middle part that has the viscidity face, and protection subsides (5) are connected with thin subsides (3) that have the viscidity face, and it is sealed to cover whole thin subsides (3) and the solid fixed ring of ointment (4) all.

The invention also aims to provide a preparation method of the tri-volt patch with the slow release function, which is characterized by comprising the following steps:

1. taking the raw materials of stir-fried mustard seed, vinegar-processed corydalis tuber, asarum, euphorbia kansui, epimedium, dried ginger, cinnamon, clove and ginger juice as well as a drug sustained-release agent and an ointment substrate according to the weight parts;

2. pulverizing parched semen Brassicae Junceae, rhizoma corydalis processed with vinegar, herba asari, radix kansui, herba Epimedii, Zingiberis rhizoma, cortex Cinnamomi, and flos Caryophylli with ball mill;

3. blending the ginger juice prepared in the step 1 with the raw material powder prepared in the step 2 for 3-5 minutes, and drying by using a dryer for later use;

4. mixing the traditional Chinese medicine active ingredients prepared in the step 3 with the medicine sustained-release agent and the ointment matrix prepared in the step 1, fully stirring and uniformly mixing, and then loading into a tube;

5. and (4) boxing the completely covered and sealed medicine patch (1) and the prepared ointment (2) in the step (4) to obtain the finished product of the sanfu patch.

In the invention, the mustard seeds are fried, the clean mustard seeds are taken and fried to be dark yellow with spicy flavor by a frying method, and the fried mustard seeds are prepared. Warm in nature, thick in taste and sharp in smell. Enter lung and stomach meridians. Has effects in activating qi-flowing, eliminating phlegm, warming spleen and stomach, dispelling cold, dredging collaterals, and relieving pain. Treating phlegm retention, cough, asthma, fullness and pain in chest and hypochondrium, regurgitation, emesis, apoplexy, numbness of limbs, loempe, carbuncle of yin, toxic swelling, and swelling and pain due to traumatic injury. It is contraindicated in chronic cough due to lung deficiency and fire hyperactivity due to yin deficiency.

Asarum herb, a name of traditional Chinese medicine, belongs to the order of aristolochiales, and belongs to the family of aristolochiaceae; the rootstock is upright or transverse, and has a plurality of fibrous roots; 2 leaves are usually in heart shape or egg shape, and the flower is purple black; the flower stalk is 2-100 px long; the flower is split into triangular ovoid pieces, and the fruit is approximately spherical, about 37.5px in diameter, and brownish yellow. The flowering period is 4-5 months. Has the functions of expelling wind, dispelling cold, promoting diuresis, inducing resuscitation, etc. It is commonly used for wind-cold headache, nasosinusitis, toothache, phlegm-fluid cough, wind-damp arthralgia, etc. The asarum can not only externally disperse wind-cold but also internally dispel yin-cold, and has better effects of relieving pain and cough.

Corydalis tuber, name of Chinese medicine. Nature and taste: pungent taste; bitter; warming; is nontoxic. Meridian tropism: enter liver, stomach and heart meridians. The efficacy and the effect are as follows: promoting blood circulation; promoting circulation of qi; can be used for relieving pain. Used for treating pain due to qi and blood stagnation; it is pungent, dispersing and warm in property, and has strong actions of activating qi stagnation in blood and qi stagnation in middle and middle, so it is indicated for all pains in upper and lower parts of the body and has strong actions of alleviating pain. It is commonly used for chest stuffiness and pain, stomach ache, hypochondriac distention and pain due to stagnation of qi due to depression of the liver, dysmenorrhea, postpartum abdominal pain due to stasis, hernia of cold type, traumatic injury, and rheumatalgia. Vinegar rhizoma corydalis: mixing rhizoma corydalis with vinegar, soaking until the vinegar is absorbed completely, parching with slow fire to slightly dry, taking out, and cooling; or decocting rhizoma corydalis in vinegar in a pot until the vinegar is completely absorbed, oven drying, taking out, and cooling. The vinegar processed product has analgesic effect.

Dried ginger, named as traditional Chinese medicine. Is dried rhizome of Zingiber officinale Roscoe of Zingiberaceae. Collected in winter, and then the fibrous root and silt are removed, and the mixture is dried in the sun or at low temperature. The sliced ginger is called as "dried ginger slice" when it is dried in the sun or at low temperature. Warming the middle energizer to dispel cold, restoring yang to activate collaterals, warming the lung to resolve retained fluid. It can be used for treating abdominal psychroalgia, emesis, diarrhea, cold limbs, slight pulse, cough and asthma due to cold fluid retention.

Cinnamon is the dry bark and branch bark of cinnamon belonging to Lauraceae family, and is mainly used for tonifying primordial yang, warming spleen and stomach, removing cold accumulation and promoting blood circulation. It is indicated for decline of vital gate fire, cold limbs and slight pulse, yang exhaustion and collapse, abdominal pain and diarrhea, cold hernia and dolphin, cold pain in waist and knee, amenorrhea and abdominal mass, deep rooted carbuncle of yin type, fluid abscess, and floating yang deficiency with cold in the upper heat and lower cold.

Clove is also named as Ding Zi Xiang and Ji Yao, it is warm in nature, pungent in flavor and enters stomach, spleen and kidney meridians. According to the traditional Chinese medicine, the clove has the effects of warming the middle-jiao, warming the kidney and lowering the adverse flow of qi. Can be used for treating singultus, abdominal distention, diarrhea, emesis, halitosis caused by dyspepsia, etc. In addition, clove has the function of tonifying kidney yang, and can be used for treating symptoms such as impotence, premature ejaculation, waist cold intolerance and the like caused by kidney yang deficiency. Modern pharmacological research proves that the clove also has the following health-care effects, can inhibit the growth of bacteria and microorganisms, and can be used for dental oral treatment. Flos Caryophylli in appropriate amount can be decocted with water for gargling to treat oral problems such as toothache, oral ulcer, halitosis, etc., so it can be called natural Chinese medicinal chewing gum. The clove has the effects of invigorating stomach, relieving flatulence, promoting exhaust, relieving hiccup, regurgitation and bad breath caused by stomach fermentation, and relieving abdominal pain caused by stomach stretching.

The invention utilizes the compatibility and adds the drug sustained release agent, so that the active ingredients of the traditional Chinese medicine can be continuously released in a longer time to achieve the long-acting effect. The slow-release medicine preparation has the advantages of small irritation, lasting curative effect and safety. Frequent administration is not needed, the times can be reduced, the blood concentration is stable, the peak valley phenomenon is avoided, and the toxic and side effects of the medicine are favorably reduced. Meanwhile, the total dosage of the medicine can be reduced, and the maximum effect can be achieved by using the minimum dosage.

In the formula, the nature of the dried ginger and the cinnamon is not pungent and hot, and the dried ginger and the cinnamon are used as monarch drugs, the ministerial drugs are euphorbia kansui, epimedium, stir-fried mustard seed and vinegar rhizoma corydalis, the adjuvant drugs are asarum and clove, and the conductant drug is ginger juice.

Compared with the prior art that the ointment is blended with honey and then applied to a user, the ointment has the advantages of small viscosity, stable property, stable release speed and continuous and powerful treatment effect on the user, and the vaseline carrying traditional Chinese medicine active substances can enter blood circulation through skin.

Drawings

FIG. 1 is a schematic structural view of the present invention;

fig. 2 is a side view of the present invention.

1 is a medicinal patch, 2 is an ointment, 3 is a thin patch, 4 is an ointment fixing ring, and 5 is a protective patch.

Detailed Description

Example 1

The invention aims to overcome the defects of the tri-volt patch, and provides a brand new tri-volt patch with a slow release function, which is characterized in that: comprises a medicine patch 1 and an ointment 2, wherein the ointment 2 comprises traditional Chinese medicine active substances, ointment matrix vaseline and medicine sustained-release agent povidone. The traditional Chinese medicine active substance is prepared from the following raw materials in parts by weight: every 1000 weight parts of the ointment comprise 20 parts of stir-fried mustard seed, 20 parts of vinegar rhizoma corydalis, 10 parts of asarum, 10 parts of kansui root, 15 parts of epimedium, 20 parts of dried ginger, 10 parts of cinnamon, 10 parts of clove and 60 parts of ginger juice.

Comprises 824 parts by weight of ointment matrix and 1 part of drug sustained-release agent.

The patch 1 is structurally composed of a thin patch 3, an ointment fixing ring 4 and a protective patch 5, wherein one side of the thin patch 3 is provided with viscosity, the ointment fixing ring 4 is positioned in the middle of the thin patch 3 with a viscous surface, the protective patch 5 is connected with the thin patch 3 with the viscous surface, and the whole thin patch 3 and the ointment fixing ring 4 are completely covered and sealed.

1. taking the raw materials of stir-fried mustard seed, vinegar rhizoma corydalis, asarum, euphorbia kansui, epimedium, dried ginger, cinnamon, clove, ginger juice, vaseline and povidone according to the weight parts;

3. blending the ginger juice prepared in the step 1 with the raw material powder prepared in the step 2, and drying the mixture for later use by using a dryer after blending for 5 minutes;

Example 2

A kind of three-volt paste with slow release function, characterized by that: comprises a plaster 1 and an ointment 2, wherein the ointment 2 comprises traditional Chinese medicine active substances, ointment matrix vaseline and drug sustained release agent povidone. The traditional Chinese medicine active substance is prepared from the following raw materials in parts by weight: 40 parts of fried mustard seed, 40 parts of vinegar rhizoma corydalis, 15 parts of asarum, 15 parts of euphorbia kansui, 25 parts of epimedium, 30 parts of dried ginger, 15 parts of cinnamon, 15 parts of clove and 70 parts of ginger juice.

Each 1000 parts by weight of the ointment contains 732 parts by weight of ointment matrix and 3 parts by weight of drug sustained-release agent.

3. blending the ginger juice prepared in the step 1 with the raw material powder prepared in the step 2, and drying the mixture for later use by using a dryer after blending for 3 minutes;

5. and (4) packaging the completely covered and sealed patch 1 and the prepared ointment 2 in the box in step (4) to obtain the finished product Sanfu patch.

Example 3

A kind of three-volt paste with slow release function, characterized by that: comprises a plaster 1 and an ointment 2, wherein the ointment 2 comprises traditional Chinese medicine active substances, ointment matrix vaseline and drug sustained release agent povidone. The traditional Chinese medicine active substance is prepared from the following raw materials in parts by weight: 30 parts of fried mustard seed, 28 parts of vinegar rhizoma corydalis, 13 parts of asarum, 13 parts of kansui root, 20 parts of epimedium, 22 parts of dried ginger, 13 parts of cinnamon, 11 parts of clove and 62 parts of ginger juice.

Each 1000 parts by weight of ointment contains 786 parts by weight of ointment matrix and 2 parts of drug sustained-release agent.

The patch 1 is composed of a thin patch 3, an ointment fixing ring 4 and a protective patch 5, wherein one surface of the thin patch 3 has viscosity, the ointment fixing ring 4 is positioned in the middle of the thin patch 3 with a viscosity surface, the protective patch 5 is connected with the thin patch 3 with a viscosity surface, and the whole thin patch 3 and the ointment fixing ring 4 are completely covered and sealed.

1. taking the raw materials of stir-fried mustard seed, vinegar rhizoma corydalis, asarum, dried ginger, cinnamon, clove and ginger juice as well as a drug sustained-release agent and an ointment matrix according to the requirements of the weight parts;

5. and (4) packing the completely covered and sealed medicine patch 1 and the prepared ointment 2 in the step (4) to obtain the finished product of the sanfu patch.

Application method

The invention combines the ointment and the medicinal plaster for use together, firstly, the ointment and the medicinal plaster in the three-volt plaster which is packed in a box are taken out, and then the ointment which is arranged in a tube is smeared on the acupuncture points uniformly; finally, the protective plaster is uncovered, the plaster fixing ring 4 is placed at the position where the plaster is applied, the application area is fixed, and the thin plaster 3 is fixed on the skin of the user.

Matters of use

1. The application is prohibited for patients allergic to the effective components

2. The use of pregnant and lactating women is prohibited

3. The application of the additive to patients with allergy is prohibited

Claims

1. A kind of three-volt paste with slow release function, characterized by that: the Sanfu plaster can be an ointment (2) and a medicinal plaster (1), wherein the Sanfu plaster (2) consists of traditional Chinese medicine active substances, an ointment matrix and a medicine slow-release agent, and the traditional Chinese medicine active substances are prepared from the following raw materials in parts by weight: 20-40 parts of fried mustard seed, 20-40 parts of vinegar rhizoma corydalis, 10-15 parts of asarum, 10-15 parts of euphorbia kansui, 15-25 parts of epimedium, 20-30 parts of dried ginger, 10-15 parts of cinnamon, 10-15 parts of clove and 60-70 parts of ginger juice.

2. The patch according to claim 1, wherein the patch has a slow release function, and is characterized in that: the ointment matrix is vaseline.

3. The patch according to claim 1, wherein the patch has a slow release function, and is characterized in that: the drug sustained release agent is povidone.

4. The patch according to claim 1, wherein the patch has a slow release function, and is characterized in that: each 1000 parts by weight of the ointment contains 150-225 parts by weight of traditional Chinese medicine active substances, 772-849 parts by weight of ointment matrix and 1-3 parts by weight of drug sustained-release agent.

5. A kind of three-volt paste with slow release function, characterized by that: three lie prostrate subsides medicine (1) structure by thin subsides (3), the solid fixed ring of ointment (4), protection subsides (5) constitute according to the preface, wherein thin subsides (3) one side has viscidity, the solid fixed ring of ointment (4) are located thin subsides (3) middle part that has the viscidity face, and protection subsides (5) are connected with thin subsides (3) that have the viscidity face, and protection subsides (5) are all covered sealed whole thin subsides (3) and the solid fixed ring of ointment (4).

6. A preparation method of a patch with a slow release function is characterized by comprising the following steps:

(1) taking the raw materials of stir-fried mustard seed, vinegar rhizoma corydalis, asarum, dried ginger, cinnamon, clove and ginger juice as well as a drug sustained-release agent and an ointment matrix according to the requirements of the parts by weight;

(2) pulverizing parched semen Brassicae Junceae, rhizoma corydalis processed with vinegar, herba asari, radix kansui, herba Epimedii, Zingiberis rhizoma, cortex Cinnamomi, and flos Caryophylli with ball mill;

(3) blending the ginger juice prepared in the step (1) with the raw material powder prepared in the step (2) for 3-5 minutes, and drying by using a dryer for later use;

(4) mixing the traditional Chinese medicine active ingredients prepared in the step (3) with the medicine sustained-release agent and the ointment matrix prepared in the step (1), fully stirring and uniformly mixing to obtain an ointment (2), and filling the ointment (2) into a tube;

(5) and (4) boxing the completely covered and sealed medicine patch (1) and the prepared ointment (2) in the step (4) to obtain the finished product of the sanfu patch.

7. The patch according to claim 1, wherein the patch has a slow release function, and is characterized in that: the ginger juice is prepared by cleaning fresh ginger, slicing and squeezing.