CN101239175A - Lung comforting plaster and preparation thereof - Google Patents
Lung comforting plaster and preparation thereof Download PDFInfo
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- CN101239175A CN101239175A CNA2008100493323A CN200810049332A CN101239175A CN 101239175 A CN101239175 A CN 101239175A CN A2008100493323 A CNA2008100493323 A CN A2008100493323A CN 200810049332 A CN200810049332 A CN 200810049332A CN 101239175 A CN101239175 A CN 101239175A
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Abstract
The present invention relates to a shufei plaster and a method for preparing the same. The patch can resolve the treating problems of asthmatic, shortness of breath, cough, expectoration caused by chronic bronchitis and chronic obstructive pulmonary disease. The technical solutionis that the shufei plaster is prepared from medicines as follows including 5-15g white mustard, 5-15g daphne, 3-7g rhizoma corydalis, 3-7g dried ginger, 3-7g asarum, 7-13g jiaomu, 2-4g cassia, 3-4g hydrogel matrix, 0.5-1ml glycerol, 1-1.5g polyethylene glycol and water; the preparing method includes steps: firstly, preparating hydrogel matrix, secondly, grinding the cassia and preparing volatile oil with asarum, jiaomu and dried ginger, preparing extractum with white mustard, rhizoma corydalis and daphne, finally, grinding the cassia powder added with glycerol; then preparing plaster added with extractum, hydrogel matrix and volatile oil; adding the molten polyethylene glycol and mixing. The shufei plaster has effects of warm activing lung qi, removing expectoration and activing blood, relieving cough and asthma. The shufei plaster has merits of better treating effect, low cost, non-pain, convenient in use and carry.
Description
One, technical field
The present invention relates to field of medicaments, particularly a kind of treat that chronic bronchitis and chronic obstructive pulmonary disease cause pant, breathe hard, the lung comforting plaster of cough, expectoration etc. and preparation method thereof.
Two, background technology
Chronic bronchitis is meant the chronic nonspecific inflammation of trachea, bronchial mucosa and surrounding tissue thereof.Clinically with cough, expectoration or with panting and the chronic process of outbreak repeatedly is a feature.If the state of an illness is slow progress, Chang Bingfa obstructive emphysema, even pulmonary hypertension, pulmonary heart disease.Chronic obstructive pulmonary disease (COPD) is a common clinical, and its sickness rate, disability rate, mortality rate are higher, has a strong impact on patient's quality of life.At present, treatment chronic bronchitis and chronic obstructive pulmonary disease cause pants, breathe hard, the Chinese medicine of cough, expectoration etc. is a lot, and existing oral formulations also has externally applied plaster and aerosol.As: antitussive and antiasthmatic syrup (Pharmacopoeia of the People's Republic of China 2005 version one one 578 pages), externally applied plaster for strengthening healthy energy to stop cough and relieve asthma (Sun Enyi, the patent No.: CN1733014, on February 15th, 2006), the henbane aerosol (Cao Chunlin, Shi Shunqing chief editor. Chinese medicine preparation is explained, Shanghai science tech publishing house, in February, 1993 front page, 373 pages).These medicines are from different theory of Chinese medical science angles, different dosage form and the route of administration of employing, treatment abundant expectoration, cough with asthma.Different medicines, property of medicine difference, curative effect are also different.Clinically, abundant expectoration, cough with asthma belong to multiple disease, refractory disease, and the influence that is subjected to patient's body constitution, environmental factors, climatic factor etc. easily repeatedly.Present medication effect is unsatisfactory.
Three, summary of the invention
At above-mentioned situation, the present invention's purpose just provide a kind of treat that chronic bronchitis and chronic obstructive pulmonary disease cause pant, breathe hard, the lung comforting plaster of cough, expectoration etc. and preparation method thereof, utilize the modern pharmaceutical technology to become acupoint adhesive plaster with materials processing, can solve effectively that chronic bronchitis and chronic obstructive pulmonary disease cause pant, breathe hard, the treatment problem of cough, expectoration etc., the technical scheme of its solution is:
Lung comforting plaster of the present invention is by following thing medicine: Semen Sinapis Albae 5-15g, Flos Genkwa 5-15g, Rhizoma Corydalis 3-7g, Rhizoma Zingiberis 3-7g, Herba Asari 3-7g, Semen zanthoxyli 7-13g, Cortex Cinnamomi 2-4g, hydrogel matrix 3-4g, glycerol 0.5-1ml, Polyethylene Glycol 1-1.5g and water are made;
Its preparation method is realized by following steps:
(1) preparation of hydrogel matrix
Carbopol 940 1g, polyoxyethylene sorbitan monoleate 0.2g, distilled water 30ml are mixed, add ethyl hydroxybenzoate 0.05g, azone 3.6ml again, stir, promptly;
(2) preparation of medicine
2-4g is ground into fine powder with Cortex Cinnamomi, becomes Cortex Cinnamomi powder, crosses 200 mesh sieves, and is standby;
With Herba Asari 3-7g, Semen zanthoxyli 7-13g, Rhizoma Zingiberis 3-7g three herbal medicines, add the water of 8 times of amounts, extract volatile oil with extractor, extraction time is about 8 hours, and it is standby to collect volatile oil;
Is 70% alcohol reflux three times with Semen Sinapis Albae 5-15g, Flos Genkwa 5-15g, Rhizoma Corydalis 3-7g with 10 times of amount mass concentrations of weight meter, each 1.5 hours, filters, merging filtrate, decompression and solvent recovery becomes extractum to the thick paste shape of relative density 1.3-1.4 (60 ℃ of mensuration), and is standby;
(3) patch preparation
Get Cortex Cinnamomi powder 2-4g earlier, glycerol adding 0.5-1ml grinds; Add extractum, hydrogel matrix 3-4g that above-mentioned Semen Sinapis Albae, Flos Genkwa, Rhizoma Corydalis are made again, volatile oil 0.5-1ml grinds well into ointment; Taking polyethylene glycol 1-1.5g in addition then, fusion adds in the above-mentioned ointment, mixing, encapsulation, promptly.
The present invention have temperature shake lung qi, by expectorant invigorate blood circulation, the effect of relieving cough and asthma, cure mainly that chronic bronchitis and chronic obstructive pulmonary disease cause pant, breathe hard, cough, expectoration etc., it is evident in efficacy that the present invention has, production cost is low, patient's no pain carries and advantage easy to use.
Four, the specific embodiment
Below in conjunction with embodiment the specific embodiment of the present invention is elaborated.
The present invention is in concrete enforcement, and lung comforting plaster of the present invention is by following thing medicine: Semen Sinapis Albae 10g, Flos Genkwa 10g, Rhizoma Corydalis 5g, Rhizoma Zingiberis 5g, Herba Asari 5g, Semen zanthoxyli 10g, Cortex Cinnamomi 3g, hydrogel matrix 3.3g, glycerol 0.7ml, Polyethylene Glycol 1.3g and water are made;
Its preparation method is realized by following concrete steps:
At first carbopol 940 1g, polyoxyethylene sorbitan monoleate 0.2g, distilled water 30ml are mixed, add ethyl hydroxybenzoate 0.05g, azone 3.6ml again, stir, make hydrogel matrix, standby;
Again Cortex Cinnamomi 3g is ground into fine powder, becomes Cortex Cinnamomi powder, cross 200 mesh sieves, standby;
Afterwards, with Herba Asari 5g, Semen zanthoxyli 10g, Rhizoma Zingiberis 5g three herbal medicines, add the water of 8 times of amounts, extract volatile oil with extractor, extraction time is about 8 hours, and it is standby to collect volatile oil;
Is 70% ethanol (mass concentration that is 250ml is 70% ethanol) reflux, extract, three times with Semen Sinapis Albae 10g, Flos Genkwa 10g, Rhizoma Corydalis 5g with 10 times of amount mass concentrations of weight meter, each 1.5 hours, filter, merging filtrate, decompression and solvent recovery is to the thick paste shape of relative density 1.25 (60 ℃ of mensuration), make extractum, standby;
Get Cortex Cinnamomi powder 3g at last, glycerol adding 0.7ml grinds; Add the extractum, the hydrogel matrix 3.3g that are made by Semen Sinapis Albae, Flos Genkwa, Rhizoma Corydalis again, volatile oil 0.7ml grinds well into ointment; Taking polyethylene glycol 1.3g in addition then, fusion adds in the above-mentioned ointment, mixing, encapsulation, promptly.
During use, drug ointment is put into the intermediary band of material of non-woven fabrics adhesive plaster, fill band of material, make the ointment surface equal, allow medicine aim at the acupuncture point then, fix the non-woven fabrics adhesive plaster, promptly with band of material.
Stable phase: get acupuncture points such as big vertebra, dazhu, Tiantu, Danzhong, fei shu, Pishu, shen shu, region below the heart Yu, Zhongfu, can divide the group selection acupuncture point clinically and alternate application.The turbid heavy person of expectorant that holds concurrently selects to add and gets air door, Dingchuan, ke shu, acupuncture point such as rich and prosperous.
Deficiency in origin and excess in superficiality card: get acupuncture points such as fei shu, ke shu, Pishu, shen shu, Danzhong, rich and prosperous, big vertebra.
The acute exacerbation phase: big vertebra, dazhu, air door, Zhongfu.Breathe heavily weight person, add Dingchuan, Waidingchuan; The abundant expectoration person adds rich and prosperous; The full vexed person of chest and diaphragm, Danzhong, Zhongfu, Tiantu.
The present invention collects hot temperature, stimulates the menstrual flow, invigorates blood circulation, by the medicine and the meridians combined effect of expectorant, eliminate the phlegm and invigorate blood circulation and temperature is shaken lung qi with eliminating evil and set upright.Simultaneously medicine sticks the acupuncture point, and scalable meridian qi and blood and relevant internal organs excite yang-energy, the temperature of gathering altogether shake lung qi, by expectorant invigorate blood circulation, the effect of relieving cough and asthma.The present invention is used for the clinical good efficacy of receiving, relevant clinical data concrete of the present invention is as follows:
One, selects the standard of case
With the treatment chronic obstructive pulmonary disease is example
Chronic obstructive pulmonary disease (COPD) is a common clinical, and its sickness rate, disability rate, mortality rate are higher, has a strong impact on patient's quality of life.Chronic obstructive pulmonary disease (COPD) is a main clinic symptoms with chronic cough, expectoration or with panting clinically.
All COPD of being diagnosed as and be in the patient of stable phase are all as the standard of selecting case.
Two, diagnostic criteria
" new Chinese medicine clinical research guideline " first volume and the State Administration of Traditional Chinese Medicine of Chinese medical discrimination standard reference Ministry of Public Health promulgation in 1993 " tcm clinical practice disease diagnosis criterion of therapeutical effect ".
Western medicine diagnose and grade scale are with reference to " propose in the chronic obstructive pulmonary disease whole world " (version in 2006) " diagnostic criteria.
Three, therapeutic scheme
Primary Care, two groups all according to state of an illness oral western medicine doxofylline sheet, each 0.2g, every day 2 times.The treatment group is point-application lung comforting plaster of the present invention on the basis of Primary Care, and matched group point-application lung comforting plaster placebo of the present invention pastes weekly 2 times, and two groups of acupuncture point exchanges stick.
1. acupoint selection: the 1st group: big vertebra, fei shu, Dingchuan, Pishu, SHENYU acupoint.The 2nd group of acupuncture point: Tiantu, Danzhong, shen shu, region below the heart Yu, Zhongfu.
2. external application lung comforting plaster of the present invention
3. operational approach: during use, lung comforting plaster drug ointment of the present invention is put into the intermediary band of material of non-woven fabrics adhesive plaster, fill band of material, make the ointment surface equal, allow medicine aim at the acupuncture point then, fix the non-woven fabrics adhesive plaster with band of material, get final product, take off behind the general 6-12h, can take off in advance if any burn feeling, no burn feeling can postpone 12h and take off, in various degree redness, blister, the fiber crops phenomenon of itching can appear in the part of pasting medicine, advise patient to be careful sensation, report at any time is with prevention infection.
4. course of treatment: be a course of treatment February.
Four, efficacy assessment standard
According to " clinical disease diagnosis is according to curing the improvement standard " the COPD curative effect is divided into level Four: clinic control, produce effects, effective, invalid.Calculate integration according to symptom, sign grade scale, [(treating preceding-treatment back integration) * 100%/treatment foreset is divided into standard, judgement comprehensive therapeutic effect, cardinal symptom sign curative effect with integration improvement rate.Clinic control: integration improvement rate 〉=80%; Produce effects: 50%≤integration improvement rate＜80%; Effectively: 20%≤integration improvement rate＜50%; Invalid: integration improvement rate 20%.
Five, statistical disposition
By above-mentioned therapeutic scheme, clinically to use through 142 examples, patient's physical resource sees Table 1, table 2, and two groups of patients learn processing there was no significant difference (P＞0.05) aspect sex, age, the course of disease, state of an illness weight and complication and complication by statistics, have comparability.
Table 1 liang group COPD stable phase patient basic document
| Group | n | Sex | Age (year) | The course of disease (year) | Disease degree (pulmonary function classification) | |||
| Man (n) | Woman (n) | Gently | In | Heavy | ||||
| Treatment group matched group sum | 71 71 142 | 54 55 109 | 17 16 33 | 63.66±4.75 62.63±6.96 62.16±5.89 | 18.38±1.05 19.41±6.61 18.90±3.90 | 13 13 26 | 41 43 84 | 19 13 32 |
Annotate: the conditions of patients classification is with reference to CSRD and GOLD standard.
Table 2COPD stable phase patient's complication and complication situation are relatively
| Complication | Treatment group (n) | Matched group (n) |
| The chronic pulmonary heart disease coronary heart disease of hypertension | 31 14 10 | 31 11 8 |
General curative effect sees Table 3, table 4.Treatment is organized in 71 examples, clinic control, produce effects, effective, invalid 16 examples, 34 examples, 19 examples, 2 examples of being respectively, clinic control, produce effects, effective, invalid 13 examples, 17 examples, 32 examples, 9 examples of being respectively in matched group 71 examples.Two groups of curative effects have significant difference (P＜0.01).
Two groups of clinical efficacies of table 3COPD patient relatively
| Group | n | Clinic control (%) | Produce effects (%) | Effectively (%) | Invalid (%) |
| Treatment group matched group | 71 71 | 16(22.5) 13(18.3) | 34(47.9) 17(23.9) | 19(26.8) 32(45.1) | 2(2.8) 9(12.7) |
Annotate: two groups of curative effects compare:
*P＜0.01
The primary symptom score changes relatively before and after the table 4 liang group patient treatment
| Primary symptom | Treatment group (71) | Matched group (71) | |||||||
| 0 | 1 | 2 | 3 | 0 | 1 | 2 | 3 | ||
| Cough and expectoration asthma sensation of oppression over the chest with shortness of breath | Treat before treating treat before the back is treated treat before the back is treated treat before the back is treated treat before the back is treated after | 0 42 0 53 2 27 0 23 0 10 | 18 24 31 16 16 42 18 37 11 47 | 23 2 19 0 18 2 19 11 25 11 | 30 3 **▲▲ 21 2 **▲▲ 35 0 **▲ 34 0 **▲ 36 3 **▲ | 2 24 2 32 0 20 0 20 0 18 | 7 30 15 20 20 29 17 25 17 34 | 30 5 32 12 15 12 19 17 20 14 | 32 12 ** 22 7 ** 36 10 * 35 9 * 34 5 ** |
Annotate: relatively preceding with treatment: * P＜0.05, * * P＜0.01; With after the treatment of control group relatively: ▲ P＜0.05, ▲ ▲ P＜0.01
Treatment group clinic control 16 examples account for 22.5%; Produce effects example 34 accounts for 47.9%; Effective 19 examples account for 26.8%; Invalid example 2 accounts for 2.8%.Matched group: clinic control 13 examples account for 18.3%; Produce effects 17 examples account for 23.9%; Effective 32 examples account for 45.1%; Invalid 9 examples account for 12.7%.
Six, conclusion
Not only easy economy of applying acupoint application treatment chronic obstructive pulmonary disease stable phase but also practicability and effectiveness.Interior disease external treatment, convenient, safety have no side effect, the present invention is insufficiency of QI of the lung and kidney, turbid phlegm obstructing in the lung according to the main pathogenesis of the stable phase of chronic bronchitis and chronic obstructive pulmonary disease, or double blood-vessel obstructive is, and is wherein depressed with lung qi, the turbid or phlegm and blood stasis of the expectorant of often holding concurrently and to block lung be crucial.Treatment is a rule of treatment when the lung qi that shakes with temperature, by expectorant dissipating fluid-retention, promoting flow of QI and blood.The hot temperature of Semen Sinapis Albae is gone into lung meridian in the side, promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, sharp diaphragm the chest stuffiness relieving and the drink that reduces phlegm is monarch drug.The hot temperature of Flos Genkwa is gone into spleen, lung, kidney channel, and by drink, circulation of qi promoting is promoted blood circulation, and is ministerial drug by expectorant in eliminating the pathogens from the lung.The arduous temperature of Rhizoma Corydalis is returned liver, spleen channel, and promoting flow of QI and blood makes gas capable and water is capable gives birth to exhausted expectorant; Herba Asari cold expelling warming the lung to resolve fluid-retention; Rhizoma Zingiberis, hot, return spleen, lung meridian, warming spleen and stomach for dispelling cold, warming the lung to resolve fluid-retention; Semen zanthoxyli is arduous, goes into spleen, urinary bladder channel, reduces phlegm and exempts from drink, the sending down the abnormal ascending QI of relievining asthma.Above-mentioned Rhizoma Corydalis, Herba Asari, Rhizoma Zingiberis, Semen zanthoxyli compatibility gather the effect that warming the lung for resolving phlegm is invigorated blood circulation altogether, auxilliary Semen Sinapis Albae and Flos Genkwa and be adjuvant drug altogether.The hot temperature of Cortex Cinnamomi is supporing yang, and cold expelling is invigorated blood circulation, and draws the property that makes all medicines and see through skin and infiltrate venation and play a role, and is messenger drug.The present invention collects hot temperature, stimulates the menstrual flow, invigorates blood circulation, by the medicine and the meridians combined effect of expectorant, eliminate the phlegm and invigorate blood circulation and temperature is shaken lung qi with eliminating evil and set upright.Simultaneously medicine sticks the acupuncture point, and scalable meridian qi and blood and relevant internal organs excite yang-energy, the temperature of gathering altogether shake lung qi, by expectorant invigorate blood circulation, the effect of relieving cough and asthma.Select the cave according to symptomatic treatment in acute condition, this principle of relieving the primary symptom in a chronic case is dissected knowledge in conjunction with modern medicine simultaneously, and acupoint selection focuses mostly in the residing position of back shu points sympathetic chain.Clinical proof stimulates certain acupuncture point can alleviate bronchial spasm, and the dermal osmosis that the medicine that sticks can be by application site, discharges medicine and play a role, and reaches the effect of inner disease outer treat.Of the present invention succeeding in developing brought benefit to the mankind, and its economic and social benefit is huge.
Claims (4)
1, a kind of lung comforting plaster, it is characterized in that by following thing medicine: Semen Sinapis Albae 5-15g, Flos Genkwa 5-15g, Rhizoma Corydalis 3-7g, Rhizoma Zingiberis 3-7g, Herba Asari 3-7g, Semen zanthoxyli 7-13g, Cortex Cinnamomi 2-4g, hydrogel matrix 3-4g, glycerol 0.5-1ml, Polyethylene Glycol 1-1.5g and water are made.
2, lung comforting plaster according to claim 1, it is characterized in that this lung comforting plaster is to be made by said Semen Sinapis Albae 10g, Flos Genkwa 10g, Rhizoma Corydalis 5g, Rhizoma Zingiberis 5g, Herba Asari 5g, Semen zanthoxyli 10g, Cortex Cinnamomi 3g, hydrogel matrix 3.3g, glycerol 0.7ml, Polyethylene Glycol 1.3g and water.
3, the preparation method of the described lung comforting plaster of claim 1 is characterized in that, is realized by following steps:
(1) preparation of hydrogel matrix
Carbopol 940 1g, polyoxyethylene sorbitan monoleate 0.2g, distilled water 30ml are mixed, add ethyl hydroxybenzoate 0.05g, azone 3.6ml again, stir, promptly;
(2) preparation of medicine
2-4g is ground into fine powder with Cortex Cinnamomi, becomes Cortex Cinnamomi powder, crosses 200 mesh sieves, and is standby;
With Herba Asari 3-7g, Semen zanthoxyli 7-13g, Rhizoma Zingiberis 3-7g three herbal medicines, add the water of 8 times of amounts, extract volatile oil with extractor, extraction time is about 8 hours, and it is standby to collect volatile oil;
Is 70% alcohol reflux three times with Semen Sinapis Albae 5-15g, Flos Genkwa 5-15g, Rhizoma Corydalis 3-7g with 10 times of amount mass concentrations of weight meter, each 1.5 hours, filters, merging filtrate, decompression and solvent recovery, 60 ℃ of surveys, relative density is the extractum of 1.3-1.4, and is standby;
(3) patch preparation
Get Cortex Cinnamomi powder 2-4g earlier, glycerol adding 0.5-1ml grinds; Add extractum, hydrogel matrix 3-4g that above-mentioned Semen Sinapis Albae, Flos Genkwa, Rhizoma Corydalis are made again, volatile oil 0.5-1ml grinds well into ointment; Taking polyethylene glycol 1-1.5g in addition then, fusion adds in the above-mentioned ointment, mixing, encapsulation, promptly.
4, the preparation method of lung comforting plaster according to claim 3 is characterized in that, also can be realized by following steps:
At first carbopol 940 1g, polyoxyethylene sorbitan monoleate 0.2g, distilled water 30ml are mixed, add ethyl hydroxybenzoate 0.05g, azone 3.6ml again, stir, make hydrogel matrix, standby;
Again Cortex Cinnamomi 3g is ground into fine powder, becomes Cortex Cinnamomi powder, cross 200 mesh sieves, standby;
Afterwards, with Herba Asari 5g, Semen zanthoxyli 10g, Rhizoma Zingiberis 5g three herbal medicines, add the water of 8 times of amounts, extract volatile oil with extractor, extraction time is about 8 hours, and it is standby to collect volatile oil;
Is 70% alcohol reflux three times with Semen Sinapis Albae 10g, Flos Genkwa 10g, Rhizoma Corydalis 5g with 10 times of amount mass concentrations of weight meter, each 1.5 hours, filter, and merging filtrate, decompression and solvent recovery, 60 ℃ of surveys, relative density is 1.25 extractum, and is standby;
Get Cortex Cinnamomi powder 3g at last, glycerol adding 0.7ml grinds; Add the extractum, the hydrogel matrix 3.3g that are made by Semen Sinapis Albae, Flos Genkwa, Rhizoma Corydalis again, volatile oil 0.7ml grinds well into ointment; Taking polyethylene glycol 1.3g in addition then, fusion adds in the above-mentioned ointment, mixing, encapsulation, promptly.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107441474A (en) * | 2017-08-17 | 2017-12-08 | 河南中医药大学 | A kind of Chinese medicine compound prescription situ-gel for treating cough and asthma and preparation method thereof |
| CN107625934A (en) * | 2016-07-18 | 2018-01-26 | 北京中医药大学东方医院 | A kind of Chinese medicine composition for treating cough and asthma and its application |
| CN110694036A (en) * | 2019-08-21 | 2020-01-17 | 云南中医药大学 | Sanfu plaster with slow release function and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1733014A (en) * | 2005-08-27 | 2006-02-15 | 孙恩义 | Externally applied plaster for strengthening healthy energy to stop cough and relieve asthma |
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2008
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107625934A (en) * | 2016-07-18 | 2018-01-26 | 北京中医药大学东方医院 | A kind of Chinese medicine composition for treating cough and asthma and its application |
| CN107625934B (en) * | 2016-07-18 | 2020-08-21 | 北京中医药大学东方医院 | Traditional Chinese medicine composition for treating cough and asthma and application thereof |
| CN107441474A (en) * | 2017-08-17 | 2017-12-08 | 河南中医药大学 | A kind of Chinese medicine compound prescription situ-gel for treating cough and asthma and preparation method thereof |
| CN110694036A (en) * | 2019-08-21 | 2020-01-17 | 云南中医药大学 | Sanfu plaster with slow release function and preparation method thereof |
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