CN103071078A

CN103071078A - Traditional Chinese medicinal composition for treating viral myocarditis

Info

Publication number: CN103071078A
Application number: CN2012105907213A
Authority: CN
Inventors: 袁中顺
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-12-19
Filing date: 2012-12-19
Publication date: 2013-05-01
Anticipated expiration: 2032-12-19
Also published as: CN103071078B

Abstract

The invention discloses a traditional Chinese medicinal composition for treating viral myocarditis. The traditional Chinese medicine believes that the basic pathogenesis of the viral myocarditis is that weakened defensive Qi, heart invasion by pathogenic toxin, deficiency of healthy Qi and impairment of both Qi and Yin. Therefore, the traditional Chinese medicines comprising rubiaceae randia depauperata, eragrostis minor host, common andrographis herb, indigo naturalis, scrophulariae, coix seed, corydalis tuber, longan, finelydivided phtheirospermum, tuber fleeceflower stem, polygonatum kingianum and Chinese yam are prepared into decoction. According to the clinical test, the cure rate and the total effective rate of the treatment group are 76.1 percent and 97.9 percent respectively and are obviously higher than those of the control group; in particular, the electrocardiogram premature beat curative effect of the treatment group is obviously higher than that of the control group, so the traditional Chinese medicinal composition for treating viral myocarditis is worthy of popularization and application.

Description

A kind of Chinese medicine composition for the treatment of viral myocarditis

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of viral myocarditis.

Background technology

Viral myocarditis is a kind of teenager that is apt to occur in, and is to cause myocardial damage, cardiac dysfunction by multiple virus, or ARR disease.Its sickness rate rises year by year in China, the lighter can find in health check-up once in a while without obvious subjective symptoms, or slight malaise symptoms arranged, as weak, hyperhidrosis, cardiopalmus, dizzy, uncomfortable in chest, breathe hard or breathe etc., the visible premature beat of Electrocardioscopy, ST-T change etc., anxious than the severe one onset, can have obviously weak, cardiopalmus, breathe hard, pareordia discomfort or pain, feel sick, vomiting, diarrhoea etc., visible heart slightly enlarges during inspection, arrhythmia and the performance of other cardiac insufficiency, utmost point severe one then can be broken out in morbidity a few hours to 1～2 day, heart failure or severe arrhythmia appear, heart is the expansion of carrying out property, can develop into DCM (dilated cardiomyopathy), finally cause death.At present, the western medical treatment of viral myocarditis mainly is the Supporting Therapy of suiting the medicine to the illness in the situation that emphasize fully to have a rest, and with cardiac nutrition, it is main improving symptom, there is no specific short.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of viral myocarditis.The traditional Chinese medical science is thought the basic pathogenesis of viral myocarditis, is that weakened defensive QI, evil poison are invaded the heart, healthy energy virtual loss, impairment of both QI and YIN.

The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment viral myocarditis is made by the Chinese medicine of following weight portion: Cortex berberidis dasystachyae 15-20 part, Herba Eragrostidis Poaeoidis 12-14 part, punching connect 6-8 part, Indigo Naturalis 8-10 part, Radix Scrophulariae 13-15 part, Semen Coicis 18-20 part, Rhizoma Corydalis 10-12 part, Arillus Longan 15-25 part, Phtheirospermum tenuisectum Bur.et Franch. 11-13 part, Caulis Polygoni Multiflori 6-8 part, Rhizoma Polygonati 12-15 part, Rhizoma Dioscoreae 15-25 part.

Preferably, 18 parts of Cortex berberidis dasystachyaes, 13 parts of Herba Eragrostidis Poaeoidis, punching connect 7 parts, 9 parts of Indigo Naturaliss, 14 parts of Radix Scrophulariaes, 19 parts of Semen Coiciss, 11 parts of Rhizoma Corydalis, 20 parts of Arillus Longan, 12 parts of Phtheirospermum tenuisectum Bur.et Franch.s, 7 parts of Caulis Polygoni Multiflori, 13 parts of Rhizoma Polygonatis, 20 parts of Rhizoma Dioscoreaes.

Preparation method is made decoction with above-mentioned Chinese medicine by traditional method.

In the side: Cortex berberidis dasystachyae, Herba Eragrostidis Poaeoidis, punching company, Indigo Naturalis heat-clearing and toxic substances removing, dampness detumescence; Radix Scrophulariae: clearing away heat and cooling blood, YIN nourishing detoxifcation; The Semen Coicis promoting diuresis to eliminate damp pathogen, spleen invigorating eliminating impediment, clearing away heat and discharging pus; Rhizoma Corydalis: blood-activating and qi-promoting pain relieving; Arillus Longan reinforcing the heart spleen, replenishing QI and blood, tranquilizing mind; The Phtheirospermum tenuisectum Bur.et Franch. tranquilizing by nourishing the heart, hemostasis; The Caulis Polygoni Multiflori tranquilizing by nourishing the heart, dispelling wind and removing obstruction in the collateral; Rhizoma Polygonati nourishing kidney lung moistening, invigorating the spleen and replenishing QI; Rhizoma Dioscoreae spleen invigorating dehumidifying, using tonifying Qi reinforcing lungs, the benefit of reinforcing the kidney essence.

Clinical data

1, physical data is originally organized 244 examples and is this Out-patient Department and inpatient, is divided at random treatment group 184 examples, male's 84 examples, women's 100 examples; 14～18 years old age, 80 examples, 19～25 years old 28 example, 26～35 years old 40 example, 36～45 years old 22 example, 46～55 years old 14 example, average (25.83 ± 12.36) year; The course of disease 1 week～5 year, year person 142 examples wherein＜1, average out to (2.64 ± 3.17) month,＞1 year person's 42 example, average out to (2.38 ± 1.04) year.Matched group 60 examples, male's 26 examples, women's 34 examples; 14～18 years old age, 10 examples, 19～25 years old 18 example, 26～35 years old 12 example, 36～45 years old 12 example, 46～55 years old 8 example; The course of disease 8 days～5 years, year person 44 examples wherein＜1, average out to (2.76 ± 2.96) month,＞1 year person's 16 example, average out to (2.76 ± 1.10) year.Treatment group acute stages 110 example, convalescent periods 32 example, lag phase 42 examples; Matched group acute stages 34 example, convalescent periods 10 example, lag phase 16 examples.All cases tcm diagnosis standard reference " new drug (Chinese medicine) clinical guidance principle ".And except the myocarditis that causes of the factor such as hyperthyroidism, rheumatism, poisoning.Two groups of cases basis equalization on age, sex, the course of disease, severe extent distribute, statistical procedures (chi-square criterion) there was no significant difference has comparability.

2, known various cardiovascular disease such as rheumatic heart disease, the myocarditis that hypertension, atherosclerosis and other causes of disease cause etc. are got rid of in diagnostic criteria.There is the symptom of upper respiratory tract or enterovirus infection in premorbid 1-3 week, adds cardiac symptom and the sign of recent appearance, such as uncomfortable in chest, cardiopalmus etc., particularly various, variable abnormal electrocardiographic pattern.The acute myocarditis diagnosis is clear and definite, and clinical symptoms and ECG change etc. show as repeatedly outbreak or protracted course of disease, and the course of disease is person more than 1 year, and diagnosable is the chronic viral myocarditis.

3, the Therapeutic Method treatment group is taken above-described Chinese medicine composition, every day potion, secondary early, late sub-service; The oral coenzyme Q10 20mg of matched group, vitamin C 0.3g, every day 3 times, premature beat is main and sinus tachycardia person adds the aminoacyl 12.5mg that feels at ease, equal 10 days of twice, two group of every day is a course for the treatment of.

4, " guideline of clinical investigations of new Chinese medicine treatment viral myocarditis " relevant curative effect determinate standard is formulated in the criterion of therapeutical effect " the new Chinese medicine guideline of clinical investigations " developed and published with reference to Ministry of Public Health in 1993: 1. clinical cure: clinical symptoms, sign disappear, and the every inspection of laboratory recovers normal; 2. produce effects: clinical symptoms, sign disappear substantially, and electrocardiogram, serum enzyme recover normally substantially, and other have clear improvement; 3. effective: clinical symptoms, sign make moderate progress, and the lab testing indices has certain improvement; 4. invalid: clinical symptoms, sign and lab testing are all without improving.

Premature beat efficacy determination: 1. clinical cure: premature beat in 24 hours is accidental or complete obiteration; 2. produce effects: premature beat reduces more than 80%; 3. effective: premature beat reduces 50%-80%; 4. invalid: premature beat reduces less than 50%.

5, curative effect relatively sees Table 1 after two groups of therapeutic outcomes treatment three courses for the treatment of.

Curative effect relatively after table 1 a liang group was treated three courses for the treatment of

Found out by table 1, the treatment group total effective rate is 97.9%, and the matched group total effective rate is 80.0%, and the clinical cure rate for the treatment of group, total effective rate are significantly higher than matched group, and difference has statistical significance (P＜0.05).

Electrocardiogram Holte premature beat curative effect relatively sees Table 2 after (2) two groups of treatments three courses for the treatment of.

Table 2 liang group electrocardiogram Holte premature beat curative effect is (example (%)) relatively

Two groups to electrocardiogram premature beat all is improved in varying degrees, the treatment group total effective rate is apparently higher than matched group.

6, untoward reaction and toxic and side effects 184 routine treatment group patients find no untoward reaction and toxic and side effects in whole treatment observation process, and liver, kidney merit check without significant change, show that the Chinese medicine composition for the treatment of viral myocarditis takes safety.

The model case Wang, the woman, 38 years old, married, in first visit on May 8 in 2009.The patient suffers from respiratory tract infection before more than ten day accidentally, rhinorrhea, heating, pharyngalgia, cough, uncomfortable in chest, general malaise etc. occur; After the treatment of local clinic, upper respiratory tract infection symptoms is alleviated, but occur as weak, hyperhidrosis, cardiopalmus, dizziness, uncomfortable in chest, breathe hard or breathe the pulse condition number; Electrocardioscopy is shown: the ST section moves down, and the T ripple is low flat, the QT interval prolongation.The disease arteries and veins closes ginseng, distinguishes to be the healthy energy virtual loss, and impairment of both QI and YIN is invaded in the evil poison.Take Chinese medicine composition of the present invention, 1 dose/d, be decocted in water for oral dose 2 times, serve on for 1 week.Patient's further consultation of coming behind the medicine is told cardiopalmus, is breathed hard, uncomfortable in chestly subtracts greatly, and continuous top takes again two weeks, and all diseases are removed, follow up a case by regular visits to so far recurrence.

The specific embodiment

Embodiment one: take by weighing Cortex berberidis dasystachyae 18g, Herba Eragrostidis Poaeoidis 13g, punching connects 7g, Indigo Naturalis 9g, Radix Scrophulariae 14g, Semen Coicis 19g, Rhizoma Corydalis 11g, Arillus Longan 20g, Phtheirospermum tenuisectum Bur.et Franch. 12g, Caulis Polygoni Multiflori 7g, Rhizoma Polygonati 10g, Rhizoma Dioscoreae 20g; Fry in shallow oil into decoction by traditional method, every day potion, sooner or later sub-service of secondary.

Embodiment two: take by weighing Cortex berberidis dasystachyae 15g, Herba Eragrostidis Poaeoidis 12g, punching connects 6g, Indigo Naturalis 8g, Radix Scrophulariae 13g, Semen Coicis 18g, Rhizoma Corydalis 10g, Arillus Longan 15g, Phtheirospermum tenuisectum Bur.et Franch. 11g, Caulis Polygoni Multiflori 6g, Rhizoma Polygonati 9g, Rhizoma Dioscoreae 25g; Fry in shallow oil into decoction by traditional method, every day potion, secondary early, late sub-service.

Embodiment three: take by weighing Cortex berberidis dasystachyae 20g, Herba Eragrostidis Poaeoidis 14g, punching connects 8g, Indigo Naturalis 10g, Radix Scrophulariae 15g, Semen Coicis 20g, Rhizoma Corydalis 12g, Arillus Longan 25g, Phtheirospermum tenuisectum Bur.et Franch. 13g, Caulis Polygoni Multiflori 8g, Rhizoma Polygonati 11g, Rhizoma Dioscoreae 15g; Fry in shallow oil into decoction by traditional method, every day potion, sooner or later sub-service of secondary.

Claims

1. Chinese medicine composition for the treatment of viral myocarditis, it is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: Cortex berberidis dasystachyae 15-20 part, Herba Eragrostidis Poaeoidis 12-14 part, punching connect 6-8 part, Indigo Naturalis 8-10 part, Radix Scrophulariae 13-15 part, Semen Coicis 18-20 part, Rhizoma Corydalis 10-12 part, Arillus Longan 15-25 part, Phtheirospermum tenuisectum Bur.et Franch. 11-13 part, Caulis Polygoni Multiflori 6-8 part, Rhizoma Polygonati 12-15 part, Rhizoma Dioscoreae 15-25 part.

2. a kind of Chinese medicine composition for the treatment of viral myocarditis according to claim 1 is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: 18 parts of Cortex berberidis dasystachyaes, 13 parts of Herba Eragrostidis Poaeoidis, punching connect 7 parts, 9 parts of Indigo Naturaliss, 14 parts of Radix Scrophulariaes, 19 parts of Semen Coiciss, 11 parts of Rhizoma Corydalis, 20 parts of Arillus Longan, 12 parts of Phtheirospermum tenuisectum Bur.et Franch.s, 7 parts of Caulis Polygoni Multiflori, 13 parts of Rhizoma Polygonatis, 20 parts of Rhizoma Dioscoreaes.