CN106074643A - Cortex Acanthopanacis Giraldii leaf and extract purposes in the medicine or health food of preparation resisting fatigue thereof - Google Patents
Cortex Acanthopanacis Giraldii leaf and extract purposes in the medicine or health food of preparation resisting fatigue thereof Download PDFInfo
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- CN106074643A CN106074643A CN201610640352.2A CN201610640352A CN106074643A CN 106074643 A CN106074643 A CN 106074643A CN 201610640352 A CN201610640352 A CN 201610640352A CN 106074643 A CN106074643 A CN 106074643A
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- 239000000284 extract Substances 0.000 title claims abstract description 48
- 239000003814 drug Substances 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 235000013402 health food Nutrition 0.000 title claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 88
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 51
- 239000002244 precipitate Substances 0.000 claims description 35
- 238000002386 leaching Methods 0.000 claims description 25
- 238000001556 precipitation Methods 0.000 claims description 24
- 239000007787 solid Substances 0.000 claims description 17
- 238000009835 boiling Methods 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 11
- 239000012530 fluid Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 6
- 241000208340 Araliaceae Species 0.000 claims description 3
- 241000092717 Eleutherococcus giraldii Species 0.000 claims description 3
- 241000196324 Embryophyta Species 0.000 claims description 3
- 239000012467 final product Substances 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 2
- 239000000469 ethanolic extract Substances 0.000 claims 1
- 238000003809 water extraction Methods 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 description 12
- 206010016256 fatigue Diseases 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
- 229940079593 drug Drugs 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 230000009182 swimming Effects 0.000 description 7
- 239000006286 aqueous extract Substances 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 230000002929 anti-fatigue Effects 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- -1 0.8g/mL) Substances 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N Calcium oxide Chemical compound [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000581650 Ivesia Species 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000000556 factor analysis Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000008558 metabolic pathway by substance Effects 0.000 description 1
- 230000002969 morbid Effects 0.000 description 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses Cortex Acanthopanacis Giraldii leaf and extract thereof the purposes in the medicine or health food of preparation resisting fatigue.Present invention also offers the extract of new Cortex Acanthopanacis Giraldii leaf.Cortex Acanthopanacis Giraldii leaf of the present invention and extract thereof can effective resisting fatigue, provide a kind of new selection for clinic.
Description
Technical field
The present invention relates to Cortex Acanthopanacis Giraldii leaf and extract thereof and prepare medicine or the purposes of health food of resisting fatigue.
Background technology
Fatigue is the physiological acoustic signals process that body is complicated, refers to necessarily occur during mental or physical arrival certain phase
A kind of normal physiological phenomenon.It had both indicated the temporary transient decline of the original ability to work of body, is probably again body and develops into
The tendency of morbid state.The concept of fatigue has been unified in the 5th international movement biochemistry meeting of nineteen eighty-two: organism physiology process can not
Continue its function and can not maintain predetermined exercise intensity at a specified level or each organ.From central nervous system to skeletal muscle thin
Born of the same parents arrive intracellular substance metabolism process, any one link middle or process synthesis change again, all can cause fatigue.According to
WHO investigates, and the whole world has the people of more than 35% to be in fatigue state, and middle-aged male crowd's fatigue state reaches 60%.Tired appearance,
Can cause motor capacity reduction, work efficiency reduces, mistake and accident increases, fighting capacity goes down.If can not get after tired generation
Recover in time, gradually accumulate, also result in " overwork ", " chronic fatigue syndrome (chro nic fatigue sy occurs
Ndrome, CFS) ", " overtraining syndrome " etc., make body generation endocrine regulation, immunity degradation, device matter even occur
Property disease, threaten human health.
Cortex Acanthopanacis Giraldii leaf is being dried of studies on plants of Acanthopanax Miq. in Araliaceae Cortex Acanthopanacis Giraldii Acanthopanax giraldii Harms
Leaf.The existing research about Cortex Acanthopanacis Giraldii leaf is less, has no that it has the relevant report of anti-fatigue effect.
Summary of the invention
The technical scheme is that providing Cortex Acanthopanacis Giraldii leaf and extract thereof is preparing medicine or the health care of resisting fatigue
Purposes in food.
The invention provides Cortex Acanthopanacis Giraldii leaf and extract thereof the purposes in preparing anti-fatigue medicament or health food.
Wherein, described Cortex Acanthopanacis Giraldii leaf is studies on plants of Acanthopanax Miq. in Araliaceae Cortex Acanthopanacis Giraldii Acanthopanax giraldii
The dried leaves of Harms.
Wherein, the extract of described Cortex Acanthopanacis Giraldii leaf is water extract or water extract-alcohol precipitation extract.
Wherein, the water extract of described Cortex Acanthopanacis Giraldii leaf is prepared as follows: takes Cortex Acanthopanacis Giraldii leaf, adds decocting
Boil, leaching solution, to obtain final product；Preferably, taking Cortex Acanthopanacis Giraldii leaf, add 6～10 times amount (ml/g) water, heating decocts 15～45 minutes,
Being concentrated into fluid extract, use the ethanol of 80% to carry out precipitate with ethanol, leaching precipitate with ethanol solid obtains water extract-alcohol precipitation extract.
Wherein, the alcohol extraction thing of described Cortex Acanthopanacis Giraldii leaf is prepared as follows: take Cortex Acanthopanacis Giraldii leaf, boiling,
It is concentrated to give extractum, precipitates with the ethanol of 75～85%, leaching precipitate with ethanol solid, obtain water extract-alcohol precipitation extract.Preferably, it be according to
Prepared by following method: take Cortex Acanthopanacis Giraldii leaf, boiling, be concentrated to give extractum, and the ethanol with 80% precipitates, and leaching precipitate with ethanol is solid
Body, obtains water extract-alcohol precipitation extract.It is further preferred that take Cortex Acanthopanacis Giraldii leaf, add 6～10 times amount (ml/g) water, heat decoction 15
～45 minutes, it being concentrated into fluid extract, use the ethanol of 80% to carry out precipitate with ethanol, leaching precipitate with ethanol solid obtains water extract-alcohol precipitation extract.
Present invention also offers a kind of Cortex Acanthopanacis Giraldii leaf water extract, take Cortex Acanthopanacis Giraldii leaf, boiling, leaching solution, i.e.
?.Preferably, taking Cortex Acanthopanacis Giraldii leaf, add 6～10 times amount (ml/g) water, heating decocts 15～45 minutes, is concentrated into fluid extract, adopts
Ethanol with 80% carries out precipitate with ethanol, and leaching precipitate with ethanol solid obtains water extract-alcohol precipitation extract.
Present invention also offers a kind of Cortex Acanthopanacis Giraldii leaf water extract-alcohol precipitation extract, it is prepared as follows: take
Cortex Acanthopanacis Giraldii leaf, boiling, it is concentrated to give extractum, precipitates with the ethanol of 75～85%, leaching precipitate with ethanol solid, obtain water extract-alcohol precipitation and carry
Take thing.Preferably, it be prepared as follows take Cortex Acanthopanacis Giraldii leaf, boiling, be concentrated to give extractum, by the second of 80%
Alcohol precipitates, and leaching precipitate with ethanol solid obtains water extract-alcohol precipitation extract.It is further preferred that take Cortex Acanthopanacis Giraldii leaf, add 6～10 times amount
(ml/g) water, heating decocts 15～45 minutes, is concentrated into fluid extract, uses the ethanol of 80% to carry out precipitate with ethanol, leaching precipitate with ethanol solid
Obtain water extract-alcohol precipitation extract.
Cortex Acanthopanacis Giraldii leaf of the present invention and extract thereof can be with resisting fatigue, and itself avirulence can make medicine or guarantor
In health food, provide a kind of new selection for clinical treatment resisting fatigue.
Obviously, according to the foregoing of the present invention, according to ordinary technical knowledge and the customary means of this area, without departing from
Under the present invention above-mentioned basic fundamental thought premise, it is also possible to make the amendment of other various ways, replace or change.
The detailed description of the invention of form by the following examples, remakes the most specifically the foregoing of the present invention
Bright.But this should not being interpreted as, the scope of the above-mentioned theme of the present invention is only limitted to Examples below.All based on foregoing of the present invention
The technology realized belongs to the scope of the present invention.
Detailed description of the invention
Detailed description of the invention
The preparation of embodiment 1 Cortex Acanthopanacis Giraldii of the present invention leaf water extract
Taking Cortex Acanthopanacis Giraldii leaf, add 6 times amount (ml/g) water, heating decocts 15 minutes, leaching solution,.
The preparation of embodiment 2 Cortex Acanthopanacis Giraldii of the present invention leaf water extract
Taking Cortex Acanthopanacis Giraldii leaf, add 6 times amount (ml/g) water, heating decocts 15 minutes, is concentrated into fluid extract, uses the second of 75%
Alcohol carries out precipitate with ethanol, leaching precipitate with ethanol solid,.
The preparation of embodiment 3 Cortex Acanthopanacis Giraldii of the present invention leaf water extract
Taking Cortex Acanthopanacis Giraldii leaf, add 6 times amount (ml/g) water, heating decocts 15 minutes, is concentrated into fluid extract, uses the second of 85%
Alcohol carries out precipitate with ethanol, leaching precipitate with ethanol solid,.
Below by way of the mode of experimental example beneficial effects of the present invention is described:
The anti-fatigue effect of experimental example 1 Cortex Acanthopanacis Giraldii leaf
1 material
1.1 medicine
Cortex Acanthopanacis Giraldii leaf Aqueous extracts (brown liquid, 0.8g/mL), water extract-alcohol precipitation liquid (brown liquid, 0.8g/mL), red scape
It extracting solution (rufous liquid, 1.33g/mL), is provided by ethnic drug institute of Chengdu University of Traditional Chinese Medicine Gu Rui assistant researcher；Hydrochloric acid
Propranolol sheet, Shanxi Yun Peng pharmaceutical Co. Ltd (authentication code: traditional Chinese medicines quasi-word H14020768, batch number A130502).
The preparation method of Cortex Acanthopanacis Giraldii leaf Aqueous extracts is: take Cortex Acanthopanacis Giraldii leaf, adds 10 times amount (ml/g) water, heats decoction 45
Minute, leaching solution, being concentrated into concentration is 0.8g/mL.
The preparation method of water extract-alcohol precipitation liquid is: take Cortex Acanthopanacis Giraldii leaf, adds 10 times amount (ml/g) water, and heating decocts 45 minutes,
Being concentrated into fluid extract, use the ethanol of 80% to carry out precipitate with ethanol, leaching precipitate with ethanol solid, be dissolved in water, being concentrated into concentration is 1.33g/
mL。
1.2 animal
SPF level KM kind mice, male and female half and half, totally 120, body weight 20 ± 2g, by Da Shuo bio tech ltd, Chengdu
There is provided, the quality certification number: SCXK (river) 2013-24.
1.3 reagent and instrument
Electronic scale (T100 type, Shuan Jie test instrunment factory of Changshu City)；Analytical balance (FA1104 type, upper current chart level device instrument
Table company limited)；1ml disposable sterilized injector (Jiangsu Kangjin Medical Instrument Co., Ltd.)；Stopwatch；Mouse stomach pin；Sodium
Calx, Beijing Dare Li Nashihuichang (lot number: 20070105)
2 experimental sites
Laboratory animal observation ward of pharmaceutical college of Chengdu University of Traditional Chinese Medicine, laboratory animal observes credit number SYXK (river) 2009-
124.Indoor illumination, humidity, proper temperature (airconditioning control room temperature is about 22 DEG C, and relative humidity is 40～50%), air duct slats
Part is good, and environment is the quietest.
Test Chengdu University of Traditional Chinese Medicine's pharmacology of Chinese materia medica laboratory (three grades of R&D units of State Administration of Traditional Chinese Medicine,
№ .TCM-2009-315) in carry out.
3 experimental techniques
3.1 Cortex Acanthopanacis Giraldii leaf the different extracted parts mice room temperature swimming with a load attached to the body experiments
Take mice 60, male and female half and half, be previously placed in 3d in Animal House and adapt to environment, be layered by body weight, be randomly divided into six
Group, i.e. blank group, Radix Rhodiolae extracting solution group (positive drug group), Cortex Acanthopanacis Giraldii leaf Aqueous extracts high and low dose group, red hair five
Add leaf water extract-alcohol precipitation liquid high and low dose group.Giving distilled water with 0.2mL/10g/d gavage respectively, Radix Rhodiolae extracting solution is with corresponding
The drug solution of dosage.Dosage and drug level are shown in Table 1.Gastric infusion 6d continuously, before last is administered, water is can't help in fasting
12h, 30min after last administration, be equivalent to the weight of Mouse Weight 10%, mice put into the depth of water at mouse tail root bundle
20cm, room temperature pond in, record mice starts swimming, and to muscle power, (mouse head submerged 10S can not emersion the exhaustion time
The water surface is that muscle power is exhausted).
Table 1 Experimental agents dosage and concentration table
3.2 statistical method
Data SPSS16.0 statistical software carries out Treatment Analysis, and all indexs all represent with mean ± standard deviation, adopt
Group difference is compared with one factor analysis of variance.
4 experimental results
4.1 Cortex Acanthopanacis Giraldii leaf the different extracted parts mice room temperature swimming with a load attached to the body experiments
Each administration group compares with blank group, and Radix Rhodiolae and Folium Styracis Suberifoliae Folium Acanthopanacis Radicis water extract-alcohol precipitation liquid low dosage can be obviously prolonged
The time (P ＜ 0.05) that mice burden swimming muscle power is exhausted, Folium Styracis Suberifoliae Folium Acanthopanacis Radicis water extract-alcohol precipitation high dose can significantly extend mice and bear
Revisit nectosome power and exhaust the time (P ＜ 0.01).Folium Styracis Suberifoliae Folium Acanthopanacis Radicis Aqueous extracts has prolongation mice burden swimming muscle power to exhaust the time
Trend, but not statistically significant (P ＞ 0.05) (being shown in Table 2).Having a certain amount effect relationship between dosage and effect, high dose group is relatively
Low dose group is effective.
The impact on mice room temperature walking weight load of the table 2 Cortex Acanthopanacis Giraldii leaf the different extracted parts
Note: compare with blank group, * P ＜ 0.05, * * P ＜ 0.01
4.2 discuss and conclusion
The studies above shows, Folium Styracis Suberifoliae Folium Acanthopanacis Radicis skin the different extracted parts can extend the time of mice burden swimming, Qi Zhongshui
Putting forward alcohol deposit fluid high dose effect best, water extract-alcohol precipitation low dosage effect is taken second place, and Aqueous extracts has the trend of prolongation, in certain dosage
Effect relation.
Experimental result illustrates, red skin Folium Acanthopanacis Radicis and water extract-alcohol precipitation liquid thereof have obvious antifatigue effect.
To sum up, Cortex Acanthopanacis Giraldii leaf of the present invention and extract can effectively extend the time of mice burden swimming, have anti-tired
Effect of labor, application prospect is good.
Claims (10)
1. Cortex Acanthopanacis Giraldii leaf and extract purposes in the medicine or health food of preparation resisting fatigue thereof.
Purposes the most according to claim 1, it is characterised in that: described Cortex Acanthopanacis Giraldii leaf is that studies on plants of Acanthopanax Miq. in Araliaceae is red
The dried leaves of hair slender acanthopanax Acanthopanax giraldii Harms.
Purposes the most according to claim 1 and 2, it is characterised in that: the extract of described Cortex Acanthopanacis Giraldii leaf is water extraction
Thing or water extract-alcohol precipitation extract.
Purposes the most according to claim 3, it is characterised in that: the water extract of described Cortex Acanthopanacis Giraldii leaf is according to such as lower section
Prepared by method: take Cortex Acanthopanacis Giraldii leaf, boiling, leaching solution, to obtain final product；Preferably, take Cortex Acanthopanacis Giraldii leaf, add 6～10 times amount
(ml/g) water, heating decocts 15～45 minutes, leaching solution,.
Purposes the most according to claim 3, it is characterised in that: the alcohol extraction thing of described Cortex Acanthopanacis Giraldii leaf is as follows
Preparation: take Cortex Acanthopanacis Giraldii leaf, boiling, be concentrated to give extractum, precipitates with the ethanol of 75～85%, leaching precipitate with ethanol solid, obtains water
Carry precipitate with ethanol extract.
Purposes the most according to claim 5, it is characterised in that: it is prepared as follows: take Cortex Acanthopanacis Giraldii leaf,
Boiling, is concentrated to give extractum, and the ethanol with 80% precipitates, and leaching precipitate with ethanol solid obtains water extract-alcohol precipitation extract；Preferably, take
Cortex Acanthopanacis Giraldii leaf, adds 6～10 times amount (ml/g) water, and heating decocts 15～45 minutes, is concentrated into fluid extract, uses the ethanol of 80%
Carrying out precipitate with ethanol, leaching precipitate with ethanol solid obtains water extract-alcohol precipitation extract.
7. a Cortex Acanthopanacis Giraldii leaf water extract, it is characterised in that: take Cortex Acanthopanacis Giraldii leaf, boiling, leaching solution, to obtain final product；Excellent
Selection of land, takes Cortex Acanthopanacis Giraldii leaf, adds 6～10 times amount (ml/g) water, and heating decocts 15～45 minutes, leaching solution,.
8. a Cortex Acanthopanacis Giraldii leaf water extract-alcohol precipitation extract, it is characterised in that: it is prepared as follows: take red hair five
Add leaf, boiling, be concentrated to give extractum, precipitate with the ethanol of 75～85%, leaching precipitate with ethanol solid, obtain water extract-alcohol precipitation extract.
Cortex Acanthopanacis Giraldii alcohol extracts from the leaves the most according to claim 8, it is characterised in that: it is prepared as follows:
Taking Cortex Acanthopanacis Giraldii leaf, boiling, be concentrated to give extractum, the ethanol with 80% precipitates, leaching precipitate with ethanol solid, obtains water extract-alcohol precipitation and extracts
Thing.
Cortex Acanthopanacis Giraldii alcohol extracts from the leaves the most according to claim 9, it is characterised in that: take Cortex Acanthopanacis Giraldii leaf, add 6～10 times
Amount (ml/g) water, heating decocts 15～45 minutes, is concentrated into fluid extract, uses the ethanol of 80% to carry out precipitate with ethanol, and leaching precipitate with ethanol is solid
Body obtains water extract-alcohol precipitation extract.
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|---|---|---|---|
| CN201610640352.2A CN106074643B (en) | 2016-08-05 | 2016-08-05 | Application of acanthopanax giraldii harms leaf and extract thereof in preparing anti-fatigue medicine or health food |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107048384A (en) * | 2017-03-27 | 2017-08-18 | 西南民族大学 | Acanthopanax giraldii Harms leaf and lily resist oxygen lack purposes |
-
2016
- 2016-08-05 CN CN201610640352.2A patent/CN106074643B/en not_active Expired - Fee Related
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| 任朝琴等: "川产藏药红毛五加不同药用部位中多糖的含量比较", 《华西药学杂志》 * |
| 应瑞春等: "红毛五加多糖对解除运动后大鼠骨骼肌疲劳作用的组织化学研究", 《西安体育学院学报》 * |
| 杨鑫嵎等: "红毛五加叶水提液对羟自由基清除率的测定", 《安徽农业科学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107048384A (en) * | 2017-03-27 | 2017-08-18 | 西南民族大学 | Acanthopanax giraldii Harms leaf and lily resist oxygen lack purposes |
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