CN106074643B - Application of acanthopanax giraldii harms leaf and extract thereof in preparing anti-fatigue medicine or health food - Google Patents
Application of acanthopanax giraldii harms leaf and extract thereof in preparing anti-fatigue medicine or health food Download PDFInfo
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- CN106074643B CN106074643B CN201610640352.2A CN201610640352A CN106074643B CN 106074643 B CN106074643 B CN 106074643B CN 201610640352 A CN201610640352 A CN 201610640352A CN 106074643 B CN106074643 B CN 106074643B
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- 241000092717 Eleutherococcus giraldii Species 0.000 title claims abstract description 62
- 239000000284 extract Substances 0.000 title claims abstract description 56
- 239000003814 drug Substances 0.000 title claims abstract description 13
- 230000002929 anti-fatigue Effects 0.000 title claims abstract description 10
- 235000013402 health food Nutrition 0.000 title claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 69
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 34
- 238000001556 precipitation Methods 0.000 claims description 21
- 238000003809 water extraction Methods 0.000 claims description 16
- 238000001914 filtration Methods 0.000 claims description 13
- 239000007787 solid Substances 0.000 claims description 13
- 239000012530 fluid Substances 0.000 claims description 8
- 238000010438 heat treatment Methods 0.000 claims description 8
- 230000001376 precipitating effect Effects 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 241000208340 Araliaceae Species 0.000 claims description 3
- 229940079593 drug Drugs 0.000 abstract description 5
- 235000013305 food Nutrition 0.000 abstract description 5
- 206010016256 fatigue Diseases 0.000 description 12
- 238000012869 ethanol precipitation Methods 0.000 description 10
- 239000007788 liquid Substances 0.000 description 10
- 230000009182 swimming Effects 0.000 description 9
- 241000699666 Mus <mouse, genus> Species 0.000 description 8
- 230000000694 effects Effects 0.000 description 7
- 238000000605 extraction Methods 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 5
- 244000042430 Rhodiola rosea Species 0.000 description 4
- 235000003713 Rhodiola rosea Nutrition 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000006286 aqueous extract Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 description 2
- HUAUNKAZQWMVFY-UHFFFAOYSA-M sodium;oxocalcium;hydroxide Chemical compound [OH-].[Na+].[Ca]=O HUAUNKAZQWMVFY-UHFFFAOYSA-M 0.000 description 2
- MEAPRSDUXBHXGD-UHFFFAOYSA-N 3-chloro-n-(4-propan-2-ylphenyl)propanamide Chemical compound CC(C)C1=CC=C(NC(=O)CCCl)C=C1 MEAPRSDUXBHXGD-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003777 experimental drug Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229960004604 propranolol hydrochloride Drugs 0.000 description 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol hydrochloride Natural products C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 1
- 210000002363 skeletal muscle cell Anatomy 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
The invention discloses application of acanthopanax giraldii harms leaves and an extract thereof in preparing anti-fatigue medicines or health-care foods. The invention also provides a new extract of acanthopanax giraldii harms leaves. The acanthopanax giraldii harms leaf and the extract thereof can effectively resist fatigue, and provide a new choice for clinic.
Description
Technical Field
The invention relates to application of acanthopanax giraldii harms leaves and an extract thereof in preparing anti-fatigue medicines or health-care foods.
Background
Fatigue is a complex physiological and biochemical change process of an organism, and refers to a normal physiological phenomenon which is necessarily caused when mental or physical strength reaches a certain stage. It marks a temporary decline in the body's original working capacity and may be a precursor to the body's development of a disease state. The fifth international biochemical conference on exercise in 1982 unifies the concept of fatigue, in which physiological processes of the body do not continue its function at a specific level or the organs do not maintain a predetermined exercise intensity. Fatigue can be caused by any change in the metabolism of the substance from the central nervous system to skeletal muscle cells to the inside of the cells, in any intermediate stage or in a combination of stages. According to WHO investigation, more than 35% of people in the world are in fatigue state, and the fatigue state of middle-aged male population reaches 60%. Fatigue can cause reduced exercise capacity, reduced work efficiency, increased error accidents, and reduced combat effectiveness. If the fatigue can not be recovered in time after the occurrence of fatigue, the fatigue can be gradually accumulated to cause ' overstrain ', Chronic Fatigue Syndrome (CFS), overtraining syndrome ' and the like, so that endocrine disturbance and immunity decline of the organism occur, even organic diseases occur, and the health of human beings is threatened.
The leaves of Acanthopanax giraldii Harms are dried leaves of Acanthopanax giraldii Harms belonging to Acanthopanax giraldii of Araliaceae. The existing researches on the leaves of the acanthopanax giraldii harms are few, and no report about the fatigue resistance of the acanthopanax giraldii harms is found.
Disclosure of Invention
The invention provides the application of the leaves of Acanthopanax giraldii harms and the extract thereof in preparing anti-fatigue drugs or health-care foods.
The invention provides application of acanthopanax giraldii harms leaves and an extract thereof in preparing an anti-fatigue medicament or a health-care food.
Wherein the leaves of Acanthopanax giraldii harms are dried leaves of Acanthopanax giraldii harms belonging to Acanthopanax giraldii of Araliaceae.
Wherein the extract of the leaves of the acanthopanax giraldii harms is a water extract or a water extraction and alcohol precipitation extract.
Wherein the water extract of the acanthopanax giraldii harms leaves is prepared according to the following method: decocting folium Acanthopanacis Senticosi with water, and filtering to obtain solution; preferably, the acanthopanax giraldii harms leaves are taken, water with the volume of 6-10 times (ml/g) is added, the heating and decoction are carried out for 15-45 minutes, the liquid extract is concentrated to be fluid extract, ethanol precipitation is carried out by adopting 80% ethanol, and the solid after the ethanol precipitation is filtered out to obtain the extract after water extraction and the ethanol precipitation.
The alcohol extract of the acanthopanax giraldii harms leaves is prepared according to the following method: taking leaves of Acanthopanax giraldii harms, adding water for decoction, concentrating to obtain an extract, precipitating with 75-85% ethanol, filtering to obtain an ethanol precipitated solid, and obtaining an aqueous extraction and ethanol precipitated extract. Preferably, it is prepared as follows: decocting leaves of Acanthopanax giraldii harms in water, concentrating to obtain extract, precipitating with 80% ethanol, filtering to obtain solid, and extracting with water and precipitating with ethanol to obtain extract. Preferably, the acanthopanax giraldii harms leaf is taken, water in an amount which is 6-10 times (ml/g) of the acanthopanax giraldii harms leaf is added, the mixture is heated and decocted for 15-45 minutes, the mixture is concentrated to fluid extract, ethanol precipitation is carried out by adopting 80% ethanol, and the solid obtained by the ethanol precipitation is filtered to obtain the extract which is extracted by water and precipitated by ethanol.
The invention also provides a water extract of the leaves of the acanthopanax giraldii harms, which is prepared by taking the leaves of the acanthopanax giraldii harms, adding water for decoction and filtering the solution. Preferably, the acanthopanax giraldii harms leaves are taken, water with the volume of 6-10 times (ml/g) is added, the heating and decoction are carried out for 15-45 minutes, the liquid extract is concentrated to be fluid extract, ethanol precipitation is carried out by adopting 80% ethanol, and the solid after the ethanol precipitation is filtered out to obtain the extract after water extraction and the ethanol precipitation.
The invention also provides a water extraction and alcohol precipitation extract of the acanthopanax giraldii harms leaves, which is prepared by the following method: taking leaves of Acanthopanax giraldii harms, adding water for decoction, concentrating to obtain an extract, precipitating with 75-85% ethanol, filtering to obtain an ethanol precipitated solid, and obtaining an aqueous extraction and ethanol precipitated extract. Preferably, the preparation method comprises the following steps of taking leaves of Acanthopanax giraldii harms, adding water for decoction, concentrating to obtain an extract, precipitating with 80% ethanol, filtering to obtain an ethanol precipitated solid, and obtaining an aqueous extraction and ethanol precipitated extract. Preferably, the acanthopanax giraldii harms leaf is taken, water in an amount which is 6-10 times (ml/g) of the acanthopanax giraldii harms leaf is added, the mixture is heated and decocted for 15-45 minutes, the mixture is concentrated to fluid extract, ethanol precipitation is carried out by adopting 80% ethanol, and the solid obtained by the ethanol precipitation is filtered to obtain the extract which is extracted by water and precipitated by ethanol.
The acanthopanax giraldii harms leaf and the extract thereof can resist fatigue, have no toxicity, can be prepared into medicines or health-care foods, and provide a new choice for clinical treatment and fatigue resistance.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Detailed Description
Example 1 preparation of an aqueous extract of Acanthopanax giraldii harms leaf of the present invention
Taking leaves of Acanthopanax giraldii harms, adding 6 times (ml/g) of water, heating and decocting for 15 minutes, and filtering to obtain a solution.
Example 2 preparation of an aqueous extract of Acanthopanax giraldii harms leaf of the present invention
Taking leaves of Acanthopanax giraldii harms, adding 6 times (ml/g) of water, heating and decocting for 15 minutes, concentrating to obtain a fluid extract, carrying out alcohol precipitation by using 75% ethanol, and filtering to obtain an alcohol precipitated solid.
Example 3 preparation of aqueous extract of Acanthopanax giraldii harms leaf of the present invention
Taking leaves of Acanthopanax giraldii harms, adding 6 times (ml/g) of water, heating and decocting for 15 minutes, concentrating to obtain a fluid extract, carrying out alcohol precipitation by adopting 85% ethanol, and filtering to obtain an alcohol precipitation solid.
The beneficial effects of the invention are illustrated by way of experimental examples below:
experimental example 1 anti-fatigue efficacy of Acanthopanax giraldii harms leaves
1 Material
1.1 medicaments
The acanthopanax giraldii harms leaf extract is provided by a classic investigator of national academy of medicine university of Chengdu, wherein the acanthopanax giraldii harms leaf extract is brown liquid (0.8 g/mL), the water extraction and alcohol precipitation liquid is brown liquid (0.8 g/mL), and the rhodiola rosea extract is red brown liquid (1.33 g/mL); propranolol hydrochloride tablets, Shanxi Yunpeng pharmaceutical Co., Ltd (approval document: national standard character H14020768, product batch No. A130502).
The preparation method of the acanthopanax giraldii harms leaf water extract comprises the following steps: taking leaves of Acanthopanax giraldii harms, adding 10 times (mL/g) of water, heating and decocting for 45 minutes, filtering to obtain a solution, and concentrating the solution until the concentration is 0.8 g/mL.
The preparation method of the water extraction and alcohol precipitation solution comprises the following steps: taking leaves of Acanthopanax giraldii harms, adding 10 times (mL/g) of water, heating and decocting for 45 minutes, concentrating to obtain a fluid extract, carrying out alcohol precipitation by adopting 80% ethanol, filtering to obtain an alcohol precipitation solid, adding water for dissolution, and concentrating to the concentration of 1.33 g/mL.
1.2 animals
SPF-grade KM mice, half male and female, 120 mice, weight 20 + -2 g, provided by WUDUDUDOU Biotech, Inc., certification number: SCXK 2013-24.
1.3 reagents and instruments
Electronic scale (T100 type, double Jie test instruments factory, Normal mature city); analytical balance (FA1104 type, shanghai liangping instruments ltd); 1ml disposable sterile syringe (Jiangsu Kangjin medical devices Co., Ltd.); a stopwatch; a mouse gastric lavage needle; soda lime, Beijing Delli soda lime plant (batch number: 20070105)
2 experiment site
The license number SYXK (Chuan) 2009-124 is observed by experimental animals in the laboratory of the college of medicine of Chengdu traditional Chinese medicine university. The indoor illumination, humidity and temperature are suitable (the room temperature of the air conditioner is controlled to be about 22 ℃, the relative humidity is 40-50%), the ventilation condition is good, and the environment is relatively quiet.
The experiment is carried out in Chinese medicine pharmacology laboratory (third-level scientific research laboratory of State administration of traditional Chinese medicine, No. TCM-2009-315) of Chengdu Chinese medicine university.
3 Experimental methods
3.1 Normal temperature load bearing swimming test of mice with different extraction parts of Acanthopanax giraldii harms leaves
Taking 60 mice with half of male and female, placing in an animal house for 3d to adapt to the environment, layering according to body weight, and randomly dividing into six groups, namely a blank control group, a rhodiola rosea extract group (positive drug group), a high and low dose group of acanthopanax giraldii harms leaf water extract, and a high and low dose group of acanthopanax giraldii harms leaf water extract alcohol precipitation solution. Respectively performing intragastric administration with 0.2mL/10g/d of distilled water, rhodiola rosea extract and medicinal solution with corresponding dose. The dose and concentration are shown in Table 1. Continuously performing gastric lavage for 6 days, fasting before the last administration for 12h, and 30min after the last administration, putting the mouse into a water pool with water depth of 20cm and room temperature, and recording the time from the beginning of swimming to the exhaustion of the physical strength of the mouse (the head of the mouse is immersed in water for 10S and cannot float out of the water surface, so that the physical strength is exhausted).
TABLE 1 Experimental drug dosages and concentration tables
3.2 statistical methods
Data were analyzed with SPSS16.0 statistical software, all indices are expressed as mean ± standard deviation, and differences between groups were compared using one-way analysis of variance.
4 results of the experiment
4.1 Normal temperature load bearing swimming test of mice with different extraction parts of Acanthopanax giraldii harms leaves
Compared with the blank control group, the low dose of the rhodiola rosea and acanthopanax giraldii harms leaf water extraction and alcohol precipitation liquid can obviously prolong the time (P is less than 0.05) of the exhaustion of the mouse weight-bearing swimming physical strength, and the high dose of the acanthopanax giraldii harms leaf water extraction and alcohol precipitation can obviously prolong the time (P is less than 0.01) of the exhaustion of the mouse weight-bearing swimming physical strength. The water extract of the acanthopanax giraldii harms leaves has the tendency of prolonging the physical exhaustion time of mice in load swimming, but has no statistical significance (P is more than 0.05) (see table 2). There is a certain dose-effect relationship between dose and effect, and the high dose group has good effect in the lower dose group.
TABLE 2 influence of different parts of Acanthopanax giraldii harms leaves on normal temperature swimming time
Note: p < 0.05, P < 0.01, compared to the blank control group
4.2 discussion and conclusions
The research shows that different extraction parts of the acanthopanax giraldii harms leaf skin can prolong the time of heavy swimming of a mouse, wherein the effect of high dose of the water extraction and alcohol precipitation liquid is the best, the effect of low dose of the water extraction and alcohol precipitation is the second, and the water extraction liquid has a prolonged trend and is in a certain dose effect relationship.
The experimental result shows that the acanthopanax giraldii harms leaves and the water extraction and alcohol precipitation liquid thereof have obvious anti-fatigue effect.
In conclusion, the acanthopanax giraldii harms leaf and the extract can effectively prolong the time of mouse weight swimming, have the anti-fatigue effect and have good application prospect.
Claims (3)
1. Use of Acanthopanax giraldii harms leaf extract in preparing anti-fatigue medicine or health food; the extract of the acanthopanax giraldii harms leaves is an extract obtained by water extraction and alcohol precipitation;
the water extraction and alcohol precipitation extract is prepared according to the following method: decocting leaves of Acanthopanax giraldii harms in water, concentrating to obtain extract, precipitating with 80% ethanol, filtering to obtain solid, and extracting with water and precipitating with ethanol to obtain extract.
2. Use according to claim 1, characterized in that: the water extraction and alcohol precipitation extract is prepared according to the following method: taking leaves of Acanthopanax giraldii harms, adding 6-10 times of ml/g of water, heating and decocting for 15-45 minutes, concentrating to obtain a fluid extract, carrying out alcohol precipitation by adopting 80% ethanol, filtering and taking an alcohol precipitation solid to obtain a water extraction and alcohol precipitation extract.
3. Use according to claim 1, characterized in that: the leaves of Acanthopanax giraldii Harms are dried leaves of Acanthopanax giraldii Harms belonging to Acanthopanax of Araliaceae.
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Non-Patent Citations (3)
| Title |
|---|
| 川产藏药红毛五加不同药用部位中多糖的含量比较;任朝琴等;《华西药学杂志》;20081231;第23卷(第05期);602-603页 * |
| 红毛五加叶水提液对羟自由基清除率的测定;杨鑫嵎等;《安徽农业科学》;20111231;第39卷(第35期);第21653-21656，21659页 * |
| 红毛五加多糖对解除运动后大鼠骨骼肌疲劳作用的组织化学研究;应瑞春等;《西安体育学院学报》;20060331;第23卷(第2期);70-73页 * |
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