CN105853847A - Traditional Chinese medicine composition for treating triple-vessel disease of coronary heart disease and application thereof - Google Patents
Traditional Chinese medicine composition for treating triple-vessel disease of coronary heart disease and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition which is prepared from, by weight, 29-31 parts of milkvetch roots, 11-13 parts of the rhizome of chuanxiong, 14-16 parts of peach seeds, 14-16 parts of crude Pollen Typhae, 11-13 parts of Chinese Polyphaga, 15 parts of rhizoma sparganii, 12 parts of cassia twigs, 12 parts of fructus aurantii, 9 parts of deer horn tablets, 20 parts of prepared rhizome of rehmannia, 20 parts of herba epimedii, 15 parts of trichosanthes kirilowii Maxim, 15 parts of allium macrostemon, 9 parts of Pinellia ternate, 40 parts of raw concha ostreae and 12 parts of selfheal. The invention further provides application of the traditional Chinese medicine composition. The medicine starts from the disease mechanism, can significantly relieve stenocardia symptoms and syndromes of traditional Chinese medicine of a patient suffering from severe coronary heart disease qi deficiency and blood stasis, significantly improve the living quality of the patient and reduce the dosage of nitroglycerin/ musk heart pills, and has an obvious effect after being taken by the patient for 3 moths.
Description
[technical field]
The present invention relates to the purposes of a kind of Chinese medicine composition, specifically, be that one treats coronary heart disease triple vessel disease
Chinese medicine composition and application.
[background technology]
Along with the high speed development of China's economic, national life mode there occurs violent change.Aging and urbanization are entered
The acceleration of journey, makes the population ratio being exposed to Chronic Non-Communicable Diseases hazards be substantially increased, causes including cardiovascular and cerebrovascular
Disease continues to increase with death toll at interior number of the infected.Wherein, the incidence and mortality of coronary heart disease also meets this change
Trend, family and economic situation to patient bring white elephant.
For the treatment of severe coronary artery disease patient (being not suitable for calcification score and surgery Coronary Artery Bypass), recent domestic is studied
It is focused mainly on gene therapy, growth factor protein treatment and stem-cell therapy.
Although gene therapy, stem-cell therapy and the growth of severe coronary artery disease (being not suitable for PCI and surgery Coronary Artery Bypass)
Factor in treatment has been achieved with greater advance in experimental study, but only has limited benefit in clinical practice subsequently.Therefore, exist
Before being entirely applied to clinic, still there are many problems not yet to solve, the most still stay in the experimental study stage.
Shanghai Chinese Medicine Hospital Cardiological Research Team sums up through constantly improving, special according to the severe coronary artery disease complexity interpretation of the cause, onset and process of an illness
Put and combine classical Chinese medicine theoretical, it is proposed that the method for activating qi and collateral side's treatment obstruction of qi in the chest syndrome of blood stasis due to qi deficiency.This research is intended to observe
Activating qi and collateral side's clinical efficacy to severe coronary artery disease Patients with Qi-deficiency Causing Blood, to evaluating this prescription to angina pectoris disease
Shape, traditional Chinese medical science qi deficiency to blood stasis syndrome and the impact of life quality, for the Chinese medicine study of this type of coronary heart disease, clinical treatment later
Optimization lays the first stone.
Various places use application Chinese medical discrimination in recent years, or give tradition classical prescription plus-minus, or from intending specially side's treatment, or traditional Chinese and western medicine knot
Close treatment, and have developed various novel form such as: electuary, oral liquid, parenteral solution, capsule etc..Such as Chinese patent literature
CN200810194977.6, publication date on June 9th, 2010, discloses one and treats anginal medicine, described medicine be by under
The raw material of row percentage by weight is made: Snakegourd Fruit 10-20%, red sage root 5-20%, profound Hu 5-20%, santal 5-15%, dalbergia wood 5-
15%, Radix Angelicae Sinensis 5-15%, tuber of pinellia 5-15%, and this medicine does not provide clear and definite efficacy experiment, result for the treatment of is imprecise;China
Patent document CN 200910074160.X, on May 11 2011 day for announcing, discloses one and treats anginal Chinese medicine preparation,
Described Chinese medicine preparation is mainly made up of the bulk drug of following weight proportioning: Samson St Johswort 30-80 part, root of kudzu vine 30-80 part, the five tastes
Sub-20-70 part, red sage root 30-80 part, Radix Codonopsis 20-90 part, seed of cowherb 20-70 part, excrementum pteropi 20-70 part, 20-70 part tuber of dwarf lilyturf,
Drop smell good 20-70 part and Snakegourd Fruit 20-80 part, but this effect of drugs is inconspicuous.And the above-mentioned two class drug therapy coronary heart disease hearts
Angina qi deficiency to blood stasis specific aim is the strongest.Therefore, need a kind of preparation technology badly and simply and treat coronary heart disease triple vessel disease effect
Substantially, medicine with strong points, have not been reported about this kind of medicine at present.
[summary of the invention]
It is an object of the invention to for deficiency of the prior art, it is provided that a kind of Chinese medicine composition.
Another purpose of the present invention is to provide a kind of Chinese medicine composition application.
For achieving the above object, the present invention adopts the technical scheme that:
A kind of Chinese medicine composition, described Chinese medicine composition is made up of the bulk drug of following weight portion: Radix Astragali 29-31
Part, Ligusticum wallichii 11-13 part, peach kernel 14-16 part, Pollen Typhae 14-16 part, ground beetle 11-13 part, Rhizoma Sparganii 15 parts, cassia twig 12 parts, Fructus Aurantii
12 parts, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer withered
Grass 12 parts.
Described Chinese medicine composition is made up of the bulk drug of following weight portion: the Radix Astragali 30 parts, Ligusticum wallichii 12 parts, peach kernel 15
Part, Pollen Typhae 15 parts, ground beetle 12 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, Fructus Aurantii 12 parts, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort
20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, selfheal 12 parts.
For realizing above-mentioned second purpose, the present invention adopts the technical scheme that:
The application in preparation treatment treatment coronary heart disease triple vessel disease medicine of a kind of Chinese medicine composition, described Chinese medicine
Composition is made up of the bulk drug of following weight portion: Radix Astragali 29-31 part, Ligusticum wallichii 11-13 part, peach kernel 14-16 part, Pollen Typhae
14-16 part, ground beetle 11-13 part, Rhizoma Sparganii 15 parts, cassia twig 12 parts, Fructus Aurantii 12 parts, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20
Part, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, selfheal 12 parts.
Described Chinese medicine composition is made up of the bulk drug of following weight portion: the Radix Astragali 30 parts, Ligusticum wallichii 12 parts, peach kernel 15
Part, Pollen Typhae 15 parts, ground beetle 12 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, Fructus Aurantii 12 parts, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort
20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, selfheal 12 parts.
The invention has the advantages that:
1, the medicine of the present invention is to start with from severe coronary artery disease complexity pathogenic characteristic, and the medicine of the present invention can significantly improve
The angina pectoris symptom of severe coronary artery disease Patients with Qi-deficiency Causing Blood, tcm syndrome, life quality, reduce monobel/Moschus and protect the heart
Ball drug dose, and treatment 3 months after curative effect become apparent from.
2, the medicine of the present invention is made up of pure Chinese medicine, has no side effect, it is easy to be accepted by patients.
3, the abundant raw materials of the present invention is easy to get, low price, and preparation technology is simple, is suitable for promoting the use of.
[accompanying drawing explanation]
Fig. 1 attack times integral contrast profile diagram
Fig. 2 duration integral contrast profile diagram
Fig. 3 pain degree integral contrast profile diagram
Fig. 4 angina pectoris symptom total mark comparative silhouette figure
Fig. 5 drug dose comparative silhouette figure
Fig. 6 pectoralgia integral contrast profile diagram
Fig. 7 integral contrast uncomfortable in chest profile diagram
Fig. 8 breathes hard integral contrast profile diagram
Fig. 9 palpitaition integral contrast profile diagram
Figure 10 spiritlessness and weakness integral contrast profile diagram
Figure 11 tcm syndrome total score integral contrast profile diagram
Figure 12 CCSGS comparative silhouette figure
Figure 13 body limitation of activity degree standard integral comparative silhouette figure
Figure 14 angina pectoris stable state standard integral comparative silhouette figure
Figure 15 angina pectoris attacks situation standard integral comparative silhouette figure
Figure 16 treats satisfaction standard integral comparative silhouette figure
Figure 17 disease cognitive degree standard integral comparative silhouette figure
Figure 18 total score standard integral comparative silhouette figure
[detailed description of the invention]
The detailed description of the invention provided the present invention below elaborates.
The preparation (one) of embodiment 1 Chinese medicine composition one
The Radix Astragali 30 parts, Ligusticum wallichii 12 parts, 15 parts of peach kernel, Pollen Typhae 15 parts, ground beetle 12 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, trifoliate orange
12 parts of shell, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer
Withered grass 12 parts.Conventional method decocts.
The preparation (two) of embodiment 2 Chinese medicine composition two
The Radix Astragali 29 parts, Ligusticum wallichii 11 parts, 14 parts of peach kernel, Pollen Typhae 14 parts, ground beetle 11 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, trifoliate orange
12 parts of shell, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer
Withered grass 12 parts.Conventional method decocts.
The preparation (three) of embodiment 3 Chinese medicine composition three
The Radix Astragali 31 parts, Ligusticum wallichii 13 parts, 16 parts of peach kernel, Pollen Typhae 16 parts, ground beetle 13 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, trifoliate orange
12 parts of shell, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer
Withered grass 12 parts.Conventional method decocts.
The preparation (four) of embodiment 4 Chinese medicine composition four
The Radix Astragali 30 parts, Ligusticum wallichii 13 parts, 15 parts of peach kernel, Pollen Typhae 14 parts, ground beetle 13 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, trifoliate orange
12 parts of shell, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer
Withered grass 12 parts.Conventional method decocts.
The preparation (five) of embodiment 5 traditional Chinese medicine particle
The Radix Astragali 30 parts, Ligusticum wallichii 12 parts, 15 parts of peach kernel, Pollen Typhae 15 parts, ground beetle 12 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, trifoliate orange
12 parts of shell, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer
Withered grass 12 parts.Add 8-10 times amount water, decoct 3 hours, leach concoction.Add 10 times amount water again, decoct 2-3 hour, leach concoction, close
And secondary decocting liquid, stand, leaching supernatant, concentrate, let cool, with concentrate 2 times amount alcohol, stir precipitates overnight.Take supernatant,
It is concentrated into thick medicinal extract;Add suitable pharmaceutical aids, pelletize, be dried, whole grain, obtain 20g particle, dispense 10g/ bag.
The preparation (six) of embodiment 6 traditional Chinese medicine particle
The Radix Astragali 29 parts, Ligusticum wallichii 11 parts, 14 parts of peach kernel, Pollen Typhae 14 parts, ground beetle 11 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, trifoliate orange
12 parts of shell, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer
Withered grass 12 parts.Add 8-10 times amount water, decoct 3 hours, leach concoction.Add 10 times amount water again, decoct 2-3 hour, leach concoction, close
And secondary decocting liquid, stand, leaching supernatant, concentrate, let cool, with concentrate 2 times amount alcohol, stir precipitates overnight.Take supernatant,
It is concentrated into thick medicinal extract;Add suitable pharmaceutical aids, pelletize, be dried, whole grain, obtain 20g particle, dispense 10g/ bag.
The preparation (seven) of embodiment 7 traditional Chinese medicine particle
The Radix Astragali 31 parts, Ligusticum wallichii 13 parts, 16 parts of peach kernel, Pollen Typhae 16 parts, ground beetle 13 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, trifoliate orange
12 parts of shell, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer
Withered grass 12 parts.Add 8-10 times amount water, decoct 3 hours, leach concoction.Add 10 times amount water again, decoct 2-3 hour, leach concoction, close
And secondary decocting liquid, stand, leaching supernatant, concentrate, let cool, with concentrate 2 times amount alcohol, stir precipitates overnight.Take supernatant,
It is concentrated into thick medicinal extract;Add suitable pharmaceutical aids, pelletize, be dried, whole grain, obtain 20g particle, dispense 10g/ bag.
The preparation (eight) of embodiment 8 traditional Chinese medicine particle
The Radix Astragali 30 parts, Ligusticum wallichii 13 parts, 15 parts of peach kernel, Pollen Typhae 14 parts, ground beetle 13 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, trifoliate orange
12 parts of shell, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer
Withered grass 12 parts.Add 8-10 times amount water, decoct 3 hours, leach concoction.Add 10 times amount water again, decoct 2-3 hour, leach concoction, close
And secondary decocting liquid, stand, leaching supernatant, concentrate, let cool, with concentrate 2 times amount alcohol, stir precipitates overnight.Take supernatant,
It is concentrated into thick medicinal extract;Add suitable pharmaceutical aids, pelletize, be dried, whole grain, obtain 20g particle, dispense 10g/ bag.
The preparation (9) of embodiment 9 Chinese medicine composition
The Radix Astragali 29 parts, Ligusticum wallichii 13 parts, 14 parts of peach kernel, Pollen Typhae 16 parts, ground beetle 11 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, trifoliate orange
12 parts of shell, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer
Withered grass 12 parts.Conventional method decocts.
The preparation (ten) of embodiment 10 Chinese medicine composition
The Radix Astragali 31 parts, Ligusticum wallichii 11 parts, 16 parts of peach kernel, Pollen Typhae 14 parts, ground beetle 13 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, trifoliate orange
12 parts of shell, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer
Withered grass 12 parts.Conventional method decocts.
The preparation (11) of embodiment 11 Chinese medicine composition
The Radix Astragali 30 parts, Ligusticum wallichii 13 parts, 14 parts of peach kernel, Pollen Typhae 16 parts, ground beetle 11 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, trifoliate orange
12 parts of shell, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer
Withered grass 12 parts.Conventional method decocts.
The preparation (12) of embodiment 12 Chinese medicine composition
The Radix Astragali 30 parts, Ligusticum wallichii 11 parts, 16 parts of peach kernel, Pollen Typhae 14 parts, ground beetle 13 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, trifoliate orange
12 parts of shell, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer
Withered grass 12 parts.Conventional method decocts.
The preparation (13) of embodiment 13 Chinese medicine composition
The Radix Astragali 31 parts, Ligusticum wallichii 13 parts, 14 parts of peach kernel, Pollen Typhae 16 parts, ground beetle 11 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, trifoliate orange
12 parts of shell, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer
Withered grass 12 parts.Conventional method decocts.
The preparation (14) of embodiment 14 Chinese medicine composition
The Radix Astragali 29 parts, Ligusticum wallichii 11 parts, 15 parts of peach kernel, Pollen Typhae 14 parts, ground beetle 11 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, trifoliate orange
12 parts of shell, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer
Withered grass 12 parts.Conventional method decocts.
The preparation (15) of embodiment 15 Chinese medicine composition
The Radix Astragali 29 parts, Ligusticum wallichii 13 parts, 15 parts of peach kernel, Pollen Typhae 16 parts, ground beetle 13 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, trifoliate orange
12 parts of shell, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer
Withered grass 12 parts.Conventional method decocts.
Embodiment 16 clinical observation on the therapeutic effect (one)
1. data and method
1.1 research object
This research object is to accept for medical treatment in December, 2015 Shanghai Chinese Medicine Hospital inpatient department and Cardiological outpatient service in January, 2015
Severe coronary artery disease (being not suitable for percutaneous transluminal coronary stent implantation and off pump coronary artery bypass) Patients with Qi-deficiency Causing Blood.Include patient 75 example altogether in,
Come off 5 examples.Use SPSS18.0 software to carry out random digit numbering, be divided into treatment group and each 35 examples of control group.
1.2 inclusive criteria
(1) to be diagnosed as severe coronary artery disease (ramus descendens anterior arteriae coronariae sinistrae, left crown dynamic for patient equal underwent coronary CT or radiography
Arteries and veins Circumflex branch and arteria coronaria dextra three branch vessel all have more than moderate narrow, and piece hemadostewnosis degree of at least a part of which is more than
More than 75%), neither it is appropriate to percutaneous transluminal coronary stent implantation through Cardiological, heart surgical department diagnosis, is not suitable for again carrying out coronary artery bypass grafting
The patient of art;Or patient and family members abandon the patient of row percutaneous transluminal coronary stent implantation or off pump coronary artery bypass;
(2) age 40-80 year, male or female;
(3) Chinese medical discrimination is syndrome of blood stasis due to qi deficiency;
(4) patient and family members be ready to accept to treat continuously 3 months and more than, it is possible to periodically accept to follow up a case by regular visits to;
(6) do not participate in other traditional Chinese medicines or doctor trained in Western medicine clinical testing simultaneously.
1.3 exclusion standard
(1) age is below 40 years old or more than 80 years old;
(2) heart function 4 grades or pulmonary edema;
(3) serious hepatic and kidney function obstacle;
(4) Chinese medicine it is not resistant to;
(5) occurred together malignant disease;
(6) several inflammatory disease;
(7) there is hemorrhagic disease;
(8) acute coronary syndrome;
(9) other clinical testing is participated in nearly 1 month;
(10) gestation or women breast-feeding their children.
1.4 reject and the standard that comes off
(1) need to stop the accident (including trial drug is not resistant to) of trial drug treatment;
(2) sb.'s illness took a turn for the worse, it is impossible to again takes investigational agent;
(3) patient refuses to continue to participate in research;
(4) researcher thinks that patient should not continue to participate in test;
(5) research approach (including that compliance is poor) is run counter to.
1.5 severe coronary artery disease doctor trained in Western medicine diagnostic criteria
" China's percutaneous coronary intervention is write according to angiocardiology branch of Chinese Medical Association Interventional cardiology group
Treatment guidelines 2012 " in severe coronary artery disease diagnostic criteria.
Severe coronary artery disease: coronary artery CT or radiography prompting ramus descendens anterior arteriae coronariae sinistrae, rami circumflexus arteriae coronariae sinistrae and the right side
Coronary artery three branch vessel all has more than moderate narrow, and piece hemadostewnosis degree of at least a part of which is more than more than 75%, carefully
The diagnosis of internal medicine, heart surgical department is neither appropriate to percutaneous transluminal coronary stent implantation, is not suitable for again carrying out off pump coronary artery bypass;Or patient and family members
Abandon row percutaneous transluminal coronary stent implantation or off pump coronary artery bypass.
1.6 traditional Chinese medical science qi deficiency to blood stasis syndrome diagnostic criterions
The qi deficiency to blood stasis syndrome diagnostic criterion in " new Chinese medicine guideline of clinical investigations " is write according to Zheng Xiao cornel,
That is: primary symptom: pectoralgia;Secondary disease: uncomfortable in chest, palpitaition, breathe hard, purple dark, the weak pulse of spiritlessness and weakness, words and puckery.There are 1 primary symptom and 2
Secondary disease is the most diagnosable.
1.7 packets and administration
Application SPSS18.0 software random number word generator produces random digit, then random digit is randomly divided into control group
With treatment group.The 70 example patients meeting inclusive criteria are entered group successively in the way of extraction random digit.Treatment group and control group
Drug delivery regimen and follow up time are 3 months, and therapeutic scheme is as follows:
(1) control group: according to patient's different situations, use the standard care that " diagnosis of coronary heart disease and treatment guidelines " is recommended
Scheme, includes but not limited to anti-platelet drug, hypotensive class medicine, nitrate esters medicine, statins etc..
(2) treatment group: treatment group adds the present invention (activating qi and collateral side) (granule, embodiment on the basis of control group
5), every day potion, boiling water brews 300ml, and the most each 150ml warmly takes, side medicine as follows: the Radix Astragali 30 parts, Ligusticum wallichii 12 parts, peach kernel
15 parts, Pollen Typhae 15 parts, ground beetle 12 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, Fructus Aurantii 12 parts, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, excessive sheep
The leaves of pulse plants 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, selfheal 12 parts.
1.8 observation index
(1) basic condition before patient therapy: sex, age, height, body weight, smoking history, the course of disease, medicining condition, merging
Disease.(2) angina pectoris symptom integration: all patients before the treatment, treatment 1 month after, treatment 3 months after, fill in " angina pectoris respectively
Symptom integral table ".
(3) monobel/HMP consumption: all patients before the treatment, treatment 1 month after, treatment 3 months after,
Fill in " monobel/HMP scale " respectively.
(4) traditional Chinese medical science qi deficiency to blood stasis syndrome integration: all patients before the treatment, after treatment 1 month, after treatment 3 months, respectively
Fill in " traditional Chinese medical science qi deficiency to blood stasis syndrome table of integrals ".
(5) Canadian cardiovascular association classification integration: all patients before the treatment, treatment 1 month after, treatment 3 months after,
Fill in " the Canadian cardiovascular association classification table of integrals " (Canadian Cardiovascular Society Grading respectively
Scale, CCSGS).
(6) Seattle angina pectoris integration: all patients before the treatment, treatment 1 month after, treatment 3 months after, fill in respectively
" western learning introduced into China " SeattleAngina Questionnaire, SAQ
1.9 Data acquisition,s and statistical procedures method
(1) cooperate with Shanghai Univ. of Traditional Chinese Medicine's clinical drug research center, use electronization clinical data management system to build
Vertical database, application SPSS18.0 software carries out statistical analysis.
(2) statistics of measurement data describes and uses mean ± standard deviation to represent, the statistics of enumeration data describes and uses number of cases
(percentage) represents.
(3) two sample measurement datas compare employing wilcoxon rank test (age, height, body weight, smoking history, the course of disease,
Angina pectoris symptom integral, monobel/HMP consumption, traditional Chinese medical science qi deficiency to blood stasis syndrome before medicining condition, complication, treatment
Integration, Canadian cardiovascular association classification integration, western learning introduced into China integration).
(4) two sample enumeration datas compare employing χ2Inspection (sex).
(5) Repeated Measurement Data uses repeated-measures analysis, the person that meets sphericity test, uses sphericity test;Discontented football
Shape proofer, (before and after treatment, the heart protected by angina pectoris symptom integration, monobel/Moschus to use Greenhouse-Geisser to analyze
Ball consumption, traditional Chinese medical science qi deficiency to blood stasis syndrome integration, Canadian cardiovascular association classification integration, western learning introduced into China integration).
(6) (angina pectoris symptom integration before and after treatment, nitric acid are sweet to compare employing wilcoxon rank test in patients before and after intervention group
Oil/HMP consumption, traditional Chinese medical science qi deficiency to blood stasis syndrome integration, Canadian cardiovascular association classification integration, Seattle angina pectoris
Scale integration).
(7) all results all use two-sided test, think statistically significant with P≤0.05.
(8) reject and the patient data that comes off does not carries out statistical analysis.
2. result
2.1 physical data analyses
Patient 75 example is included in this research altogether in, and come off 5 examples.Case source is in January, 2015 in the December, 2015 of Shanghai City
Doctor's hospital's worry section outpatient service and inpatient department, and it is randomly divided into treatment group and control group.Treatment group patient is 35 examples, the wherein male sex 19
Example, women 16 example, 67.23 ± 8.58 years old mean age, average height 163.74 ± 7.63 centimetres, average weight 68.69 ±
7.77 kilograms, smoking history 16.86 ± 11.83 years, the course of disease 5.37 ± 1.11 years, use aspirin 33 example, use clopidogrel 3
Example, uses beta-blocker 5 example, uses angiotensin converting enzyme inhibitor 16 example, uses angiotensin-ii receptor antagonism
Agent 21 example, uses calcium ion antagonist 20 example, uses diuretics 6 example, uses Statins 8 example, uses nitrate esters 14 example, merges
There are hypertension 35 example, hyperlipidemia 8 example, cardiac insufficiency 15 example, diabetes 4 example.Control group patient is 35 examples, the wherein male sex 14
Example, women 21 example, 67.94 ± 8.43 years old mean age, average height 163.29 ± 8.00 centimetres, average weight 70.60 ±
8.28 kilograms, smoking history 14.00 ± 11.68 years, the course of disease 5.63 ± 0.81 years, use aspirin 31 example, use clopidogrel 5
Example, uses beta-blocker 7 example, uses angiotensin converting enzyme inhibitor 17 example, uses angiotensin-ii receptor antagonism
Agent 20 example, uses calcium ion antagonist 20 example, uses diuretics 7 example, uses Statins 10 example, uses nitrate esters 15 example, closes
And have hypertension 35 example, hyperlipidemia 10 example, cardiac insufficiency 16 example, diabetes 7 example.(being shown in Table 1)
Table 1 ordinary circumstance [N (%),]
Use χ2Inspection, Wilcoxon rank test.
By above-mentioned analysis result, treatment group and control group sex, the age, height, body weight, smoking history, the course of disease,
Medicining condition, complication distribution on, no statistical difference difference (P >=0.193), there is clinical comparativity.
Compare between group before 2.2 treatments
2.2.1 compare between angina pectoris symptom integral group before treatment
The every integration of angina pectoris symptom and total score to treatment group and control group are treated and are compared between front group, and result shows
Show, group difference equal not statistically significant (P before attack times integration, duration integration, pain degree integration and total score treatment
≥0.307).(being shown in Table 2)
Compare between group before the treatment of table 2 angina pectoris symptom integration
Use Wilcoxon rank test.
2.2.2 compare between monobel/HMP consumption group before treatment
Treating the monobel/HMP consumption for the treatment of group and control group and compare between front group, result shows,
Group difference not statistically significant (Z=-0.527, P=0.598) before treatment.(being shown in Table 3)
Compare between group before table 3 monobels/HMP consumption treatment
Use Wilcoxon rank test.
2.2.3 compare between Chinese medicine syndrome integral group before treatment
The every integration of tcm syndrome and total score to treatment group and control group are treated and are compared between front group, and result shows,
Before pectoralgia integration, integration uncomfortable in chest, integration of breathing hard, palpitaition integration, spiritlessness and weakness integration and total score treatment, group difference is all without statistics
Learn meaning (P >=0.074).(being shown in Table 4)
Compare between group before the treatment of table 4 Chinese medicine syndrome integral
Use Wilcoxon rank test.
2.2.4 compare between CCSGS group before treatment
Treating the CCSGS for the treatment of group and control group and compare between front group, result shows, before treatment, group difference is without system
Meaning (Z=-0.193, P=0.847) learned by meter.(being shown in Table 5)
Compare between group before table 5CCSGS treatment
Use Wilcoxon rank test.
2.2.5 compare between the packet of SAQ canonical product before treatment
SAQ all standard integration and total score to treatment group and control group are treated and are compared between front group, and result shows, removes
Group difference statistically significant (Z=-2.126, P=0.033) before the treatment of angina pectoris stable state integration, remaining each individual event
The equal not statistically significant of group difference (P >=0.281) before integration and total score treatment.(being shown in Table 6)
Compare between group before the treatment of table 6SAQ standard integral
Use Wilcoxon rank test.
From the foregoing, except the statistically significant (Z of group difference before the treatment of SAQ angina pectoris stable state individual event integration
=-2.126, P=0.033), two groups of patients are at age, height, body weight, medicining condition, complication and the every integration of each scale
On, the equal not statistically significant of group difference (P >=0.074) before treatment, it is therefore contemplated that two groups of patients have comparativity, can
Under carrying out
One step research.
Comparitive study before and after 2.3 treatments
2.3.1 angina pectoris symptom integral contrast
Repeated measurement is analyzed, and result shows:
(1) not considering time factor, treatment group and control group are at attack times integration, duration integration, pain degree
Integration, the equal not statistically significant of total score group difference (P >=0.063 is shown in Table 7).
(2) packet factor is not considered, the attack times integration between different time points, duration integration, pain degree
Integration, total score difference the most statistically significant (P≤0.05 is shown in Table 7*).
(3) in addition to the duration (F=2.391, P=0.110 are shown in Table 7#), the packet of other every integrations and time point
Between there is reciprocation (P≤0.010 is shown in Table 7#), i.e. attack times before and after treatment group and treatment of control group, pain degree,
The passage that total score is put over time, its amplitude of variation is different.
(4) treatment group and control group attack times integration, duration integration, pain degree integration, the front base of total score treatment
Line is consistent (being shown in Table 2), amasss through wilcoxon rank test, treatment group and control group attack times integration, duration meanwhile
Point, the passage put over time of pain degree integration, total score, difference statistically significant (P≤0.05 is shown in Table 7& ,@).
(5) prompting treatment group attack times integration, duration integration, pain degree integration, total score amplitude of variation excellent
In control group.
(6) the score difference of each time point between further analysis group, result shows, treatment group and control group are in attack times
In integration, duration integration, pain degree integration, total score, after treating 3 months group difference statistically significant (P≤
0.011, it is shown in Table 7$).
(7) in sum, from the point of view of angina pectoris symptom integration, treatment group curative effect is better than control group, and pushing away over time
The curative effect moving treatment group becomes apparent from.
Compare before and after the treatment of table 7 angina pectoris symptom integration
Note: repeated-measures analysis: $, * main effect, # interaction, compares between $ group, P≤0.05;Wilcoxon sum of ranks is examined
Test: with this group before treatment, P≤0.05 ,@compares & with the treatment of this group for 1 month, P≤0.05.
Fig. 1 finds, treatment group attack times integration fall relatively control group is bigger, treats and becomes apparent from for 3 months.Prompting is controlled
Treatment group curative effect is better than control group, and treatment becomes apparent from after 3 months.Finding from Fig. 2, treatment group duration integration fall is relatively
Control group is bigger, treats and becomes apparent from for 3 months.Prompting treatment group curative effect is better than control group, and treatment becomes apparent from for 3 months.Send out from Fig. 3
Existing, treatment group pain degree integration fall relatively control group is bigger, treats and becomes apparent from for 3 months.Prompting treatment group curative effect is better than
Control group, and treatment within 3 months, become apparent from.As can be seen from Figure 4, treatment group angina pectoris symptom total mark fall relatively control group is more
Greatly, treatment becomes apparent from for 3 months.Prompting treatment group curative effect is better than control group, and treatment becomes apparent from for 3 months.
2.3.2 monobel/HMP amount ratio is relatively
Repeated measurement is analyzed, and result shows:
(1) do not consider time factor, treatment group and control group on monobel/HMP consumption, group difference
Not statistically significant (F=1.056, P=0.308 are shown in Table 8 $).
(2) not considering packet factor, the monobel between different time points/HMP usage variance has statistics
Meaning (F=56.609, P=0.000 are shown in Table 8*).
(3) there is reciprocation (F=15.538, P=0.000 are shown in Table 8#) between packet and time point, i.e. treatment group and
The passage that before and after treatment of control group, monobel/HMP consumption is put over time, its amplitude of variation is different.
(4) treatment group and baseline consistent (being shown in Table 3) before control group monobel/HMP consumption treatment, meanwhile, warp
The passage that wilcoxon rank test, treatment group and control group monobel/HMP consumption are put over time, difference has
Statistical significance (P≤0.05 is shown in Table 8& ,@).
(5) amplitude of variation of prompting treatment group monobel/HMP consumption is better than control group.
(6) the score difference of each time point between further analysis group, result shows, treatment group and control group are sweet at nitric acid
On oil/HMP consumption, after treating 3 months, statistically significant (F=8.594, P=0.005 are shown in Table 8 to group difference
$).
(7) in sum, from the point of view of monobel/HMP consumption, treatment group curative effect is better than control group, and along with
The curative effect of the passage treatment group of time becomes apparent from.
Compare before and after table 8 monobels/HMP consumption treatment
Note: repeated-measures analysis: $, * main effect, # interaction, compares between $ group, P≤0.05;Wilcoxon sum of ranks is examined
Test: with this group before treatment, P≤0.05 ,@compares & with the treatment of this group for 1 month, P≤0.05.
As can be seen from Figure 5, treatment group drug dose fall relatively control group is bigger, treats and becomes apparent from for 3 months.Prompting treatment
Group curative effect is better than control group, and treatment becomes apparent from for 3 months.
2.3.3 Chinese medicine syndrome integral compares
Repeated measurement is analyzed, and result shows:
(1) not considering time factor, treatment group is amassed in pectoralgia integration, integration uncomfortable in chest, integration of breathing hard, palpitaition with control group
Point, spiritlessness and weakness integration, total score group difference the most statistically significant (P≤0.019 is shown in Table 9).
(2) not considering packet factor, the pectoralgia integration between different time points, integration uncomfortable in chest, integration of breathing hard, palpitaition are long-pending
Point, spiritlessness and weakness integration, total score difference the most statistically significant (P=0.000 is shown in Table 9*).
(3) there is reciprocation (P≤0.032 is shown in Table 9#), i.e. treatment group and treatment of control group between packet and time point
The passage that front and back pectoralgia integration, integration uncomfortable in chest, integration of breathing hard, palpitaition integration, spiritlessness and weakness integration, total score are put over time, its
Amplitude of variation is different.
(4) the pectoralgia integration for the treatment of group and control group, integration uncomfortable in chest, integration of breathing hard, palpitaition integration, spiritlessness and weakness integration,
Baseline consistent (being shown in Table 4) before total score treatment, meanwhile, through wilcoxon rank test, treatment group and control group pectoralgia integration, uncomfortable in chest
The passage that integration, integration of breathing hard, palpitaition integration, spiritlessness and weakness integration, total score are put over time, difference statistically significant (P≤
0.05, it is shown in Table 9& ,@).
(5) prompting treatment group pectoralgia integration, integration uncomfortable in chest, integration of breathing hard, palpitaition integration, spiritlessness and weakness integration, total score
Amplitude of variation is better than control group.
(6) the score difference of each time point between further analysis group, result shows, treatment group and control group amass in pectoralgia
Point, in integration uncomfortable in chest, integration of breathing hard, palpitaition integration, spiritlessness and weakness integration, total score, treat 1 month, treat 3 months after poor between group
Different statistically significant (P≤0.043 is shown in Table 9$).
(7) in sum, from the point of view of tcm syndrome, treatment group curative effect is better than control group, and As time goes on treats
The curative effect of group becomes apparent from.
Compare before and after the treatment of table 9 Chinese medicine syndrome integral
Note: repeated-measures analysis: $, * main effect, # interaction, compares between $ group, P≤0.05;Wilcoxon sum of ranks is examined
Test: with this group before treatment, P≤0.05 ,@compares & with the treatment of this group for 1 month, P≤0.05.
As can be seen from Figure 6, treatment group pectoralgia integration fall relatively control group is bigger, treats latter 3 months and becomes apparent from.Prompting is controlled
Treatment group curative effect is better than control group, and treatment becomes apparent from for 3 months.As can be seen from Figure 7, treatment group integration fall uncomfortable in chest relatively control group
Bigger, treat latter 3 months and become apparent from.Prompting treatment group curative effect is better than control group, and treatment becomes apparent from for 3 months.As can be seen from Figure 8,
Treatment group integration fall relatively control group of breathing hard is bigger, treats latter 3 months and becomes apparent from.Prompting treatment group curative effect is better than comparison
Group, and treatment within 3 months, become apparent from.As can be seen from Figure 9, treatment group palpitaition integration fall relatively control group is bigger, treats latter 3 months
Become apparent from.Prompting treatment group curative effect is better than control group, and treatment becomes apparent from for 3 months.As can be seen from Figure 10, treatment group spiritlessness and weakness amasss
Divide fall relatively control group bigger, treat latter 3 months and become apparent from.Prompting treatment group curative effect is better than control group, and treats 3 months
Become apparent from.As can be seen from Figure 11, treatment group tcm syndrome total score integration fall relatively control group is bigger, treat latter 3 months brighter
Aobvious.Prompting treatment group curative effect is better than control group, and treatment becomes apparent from for 3 months.
2.3.4CCSGS compare
(1) do not consider time factor, treatment group and control group in CCSGS score, group difference not statistically significant (F
=3.837, P=0.054, be shown in Table 10 $).
(2) packet factor is not considered, the CCSGS statistically significant (F=of score difference between different time points
57.047, P=0.000, it is shown in Table 10*).
(3) there is reciprocation (F=25.466, P=0.000 are shown in Table 10#), i.e. treatment group between packet and time point
The passage put over time with CCSGS score before and after treatment of control group, its amplitude of variation is different.
(4) treatment group and baseline consistent (being shown in Table 5) before the treatment of control group CCSGS score, examine through wilcoxon sum of ranks meanwhile
Testing, the passage that treatment group and control group CCSGS score are put over time, difference is statistically significant, and (P≤0.05 is shown in Table
10&、@)。
(5) amplitude of variation of prompting treatment group CCSGS score is better than control group.
(6) the score difference of each time point between further analysis group, result shows, treatment group and control group obtain at CCSGS
On Fen, group difference statistically significant (F=24.990, P=0.000 are shown in Table 10$) after treating 3 months.
(7) in sum, from the point of view of CCSGS score, treatment group curative effect is better than control group, and As time goes on treats
The curative effect of group becomes apparent from.
Compare before and after table 10CCSGS treatment
Note: repeated-measures analysis: $, * main effect, # interaction, compares between $ group, P≤0.05;Wilcoxon sum of ranks is examined
Test:
With this group before treatment, P≤0.05 ,@compares & with the treatment of this group for 1 month, P≤0.05.
As can be seen from Figure 12, treatment group CCSGS fall relatively control group is bigger, treats latter 3 months and becomes apparent from.Prompting treatment
Group curative effect is better than control group, and treatment becomes apparent from for 3 months.
2.3.5SAQ standard integral compares
Repeated measurement is analyzed, and result shows:
(1) time factor is not considered, treatment group and control group (F=0.768, P in addition to angina pectoris attacks situation project
=0.384, it is shown in Table 11 $), it is satisfied with journey in body limitation of activity degree standard integral, angina pectoris stable state standard integral, treatment
On scale quasi-integral, disease cognitive degree standard integral, total score standard integral, group difference the most statistically significant (P≤
0.023, it is shown in Table 11 $).
(2) not considering packet factor, the body limitation of activity degree standard integral between different time points, angina pectoris are stable
Status criteria integration, angina pectoris attacks situation standard integral, treatment satisfaction standard integral, disease cognitive degree canonical product
Point, total score standard integral difference statistically significant (P≤0.001 is shown in Table 11*).
(3) there is reciprocation (P≤0.009 is shown in Table 11#) between packet and time point, i.e. treatment group and control group are controlled
Body limitation of activity degree standard integral before and after treatment, angina pectoris stable state standard integral, angina pectoris attacks situation standard integral,
The passage that treatment satisfaction standard integral, disease cognitive degree standard integral, total score standard integral are put over time, its change
Amplitude is different.
(4) except angina pectoris stable state standard integral (Z=-2.126, P=0.033 are shown in Table 6), treatment group and comparison
The body limitation of activity degree standard integral of group, angina pectoris attacks situation standard integral, treatment satisfaction standard integral, disease
Before the treatment of awareness standard integral, total score standard integral, baseline is consistent (being shown in Table 6), through wilcoxon rank test, controls meanwhile
The treatment satisfaction standard integral for the treatment of group, disease cognitive degree standard integral, treatment group and the body limitation of activity of control group
Degree standard integral, angina pectoris stable state standard integral, angina pectoris attacks situation standard integral, total score standard integral along with time
Between point passage, difference statistically significant (P≤0.05 is shown in Table 11& ,@).
(5) prompting treatment group body limitation of activity degree standard integral, angina pectoris stable state standard integral, angina pectoris are sent out
Make situation standard integral, treatment satisfaction standard integral, disease cognitive degree standard integral, the change width of total score standard integral
Degree is better than control group.
(6) the score difference of each time point between further analysis group, result shows, treatment group and control group are movable at body
In limited degree, angina pectoris stable state, treatment satisfaction, disease cognitive degree, total score score, treat 1 month, treatment 3
Group difference statistically significant (P≤0.014 is shown in Table 11$) after individual month;Treatment group and control group are in angina pectoris attacks situation
In score, group difference statistically significant (P≤0.012 is shown in Table 11$) after treating 3 months.
(7) in sum, from the point of view of SAQ standard integral, treatment group curative effect is better than control group, and As time goes on controls
The curative effect for the treatment of group becomes apparent from.
Compare before and after the treatment of table 11SAQ standard integral
Note: repeated-measures analysis: $, * main effect, # interaction, compares between $ group, P≤0.05;Wilcoxon sum of ranks is examined
Test: with this group before treatment, P≤0.05 ,@compares & with the treatment of this group for 1 month, P≤0.05.
It is seen from figure 13 that treatment group body limitation of activity degree standard integral ascensional range relatively control group is bigger, after treatment 3
Within individual month, become apparent from.Prompting treatment group curative effect is better than control group, and treatment becomes apparent from for 3 months.As can be seen from Figure 14, treatment group angina pectoris
Stable state standard integral ascensional range relatively control group is bigger, treats latter 3 months and becomes apparent from.Prompting treatment group curative effect is better than comparison
Group, and treatment within 3 months, become apparent from.As can be seen from Figure 15, treatment group angina pectoris attacks situation standard integral ascensional range relatively control group
Bigger, treat latter 3 months and become apparent from.Prompting treatment group curative effect is better than control group, and treatment becomes apparent from for 3 months.As can be seen from Figure 16,
Treatment group treatment satisfaction standard integral ascensional range relatively control group is bigger, treats latter 3 months and becomes apparent from.Prompting treatment group is treated
Effect is better than control group, and treatment becomes apparent from for 3 months.As can be seen from Figure 17, treatment group disease cognitive degree standard integral ascensional range
Relatively control group is bigger, treats latter 3 months and becomes apparent from.Prompting treatment group curative effect is better than control group, and treatment becomes apparent from for 3 months.From
Figure 18 finds out, treatment group total score standard integral ascensional range relatively control group is bigger, treats latter 3 months and becomes apparent from.Prompting treatment group
Curative effect is better than control group, and treatment becomes apparent from for 3 months.
Embodiment 17 clinical observation on the therapeutic effect (two)
1 research data and method
1.1 physical data
1.1 research object
This research object is to accept for medical treatment in December, 2014 Shanghai Chinese Medicine Hospital inpatient department and Cardiological outpatient service in January, 2014
Severe coronary artery disease (being not suitable for percutaneous transluminal coronary stent implantation and off pump coronary artery bypass) Patients with Qi-deficiency Causing Blood.Include patient 240 example altogether in.
Use SPSS18.0 software to carry out random digit numbering, be divided into treatment group 1, treatment group 2, treatment group 3 treatment group 4 and comparison
Group 1, control group 2, control group 3, each 30 examples of control group 4.
1.2 inclusive criteria
See above example 16
1.3 exclusion standard
See above example 16
1.4 reject and the standard that comes off
See above example 16
1.5 severe coronary artery disease doctor trained in Western medicine diagnostic criteria
See above example 16
1.6 traditional Chinese medical science qi deficiency to blood stasis syndrome diagnostic criterions
See above example 16
1.7 packets and administration
Control group 1: according to patient's different situations, use the standard care side that " diagnosis of coronary heart disease and treatment guidelines " is recommended
Case, includes but not limited to anti-platelet drug, hypotensive class medicine, nitrate esters medicine, statins etc..
Control group 2: add (granule) on the basis of control group 1, every day potion, boiling water brews 300ml, the most each the most once
150ml warmly takes, side medicine as follows: Ligusticum wallichii 12 parts, 15 parts of peach kernel, Pollen Typhae 15 parts, ground beetle 12 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts,
Fructus Aurantii 12 parts, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts,
Selfheal 12 parts.Add 8-10 times amount water, decoct 3 hours, leach concoction.Add 10 times amount water again, decoct 2-3 hour, leach concoction,
Merge secondary decocting liquid, stand, leaching supernatant, concentrate, let cool, with concentrate 2 times amount alcohol, stir precipitates overnight.Take supernatant
Liquid, is concentrated into thick medicinal extract;Add suitable pharmaceutical aids, pelletize, be dried, whole grain, obtain 20g particle, dispense 10g/ bag.
Control group 3: add (granule) on the basis of control group 1, every day potion, boiling water brews 300ml, the most each the most once
150ml warmly takes, side medicine as follows: the Radix Astragali 30 parts, Ligusticum wallichii 12 parts, Pollen Typhae 15 parts, ground beetle 12 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts,
Fructus Aurantii 12 parts, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts,
Selfheal 12 parts.Add 8-10 times amount water, decoct 3 hours, leach concoction.Add 10 times amount water again, decoct 2-3 hour, leach concoction,
Merge secondary decocting liquid, stand, leaching supernatant, concentrate, let cool, with concentrate 2 times amount alcohol, stir precipitates overnight.Take supernatant
Liquid, is concentrated into thick medicinal extract;Add suitable pharmaceutical aids, pelletize, be dried, whole grain, obtain 20g particle, dispense 10g/ bag.
Control group 4: add (granule) on the basis of control group 1, every day potion, boiling water brews 300ml, the most each the most once
150ml warmly takes, and side's medicine is as follows: the Radix Astragali 30 parts, scorpio 3 parts, centipede 6 parts, the red sage root 43 parts, Fructus Aurantii 2 parts, 12 parts of peach kernel.Add 8-10
Times amount water, decocts 3 hours, leaches concoction.Add 10 times amount water again, decoct 2-3 hour, leach concoction, merge secondary decocting liquid, quiet
Put, leaching supernatant, concentrate, let cool, with concentrate 2 times amount alcohol, stir precipitates overnight.Take supernatant, be concentrated into thick medicinal extract;
Add suitable pharmaceutical aids, pelletize, be dried, whole grain, obtain 20g particle, dispense 10g/ bag.
Treatment group 1: add on the basis of control group 1 (granule, embodiment 5), every day potion, boiling water brews 300ml, early
Evening each 150ml warmly take, side medicine as follows: the Radix Astragali 30 parts, Ligusticum wallichii 12 parts, 15 parts of peach kernel, Pollen Typhae 15 parts, ground beetle 12 parts,
Rhizoma Sparganii 15 parts, cassia twig 12 parts, Fructus Aurantii 12 parts, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, half
Summer 9 parts, raw oyster 40 parts, selfheal 12 parts.
Treatment group 2: add on the basis of control group 1 (granule, embodiment 6), every day potion, boiling water brews 300ml, early
Evening each 150ml warmly take, side medicine as follows: the Radix Astragali 29 parts, Ligusticum wallichii 11 parts, 14 parts of peach kernel, Pollen Typhae 14 parts, ground beetle 11 parts,
Rhizoma Sparganii 15 parts, cassia twig 12 parts, Fructus Aurantii 12 parts, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, half
Summer 9 parts, raw oyster 40 parts, selfheal 12 parts.
Treatment group 3: add on the basis of control group 1 (granule, embodiment 7), every day potion, boiling water brews 300ml, early
Evening each 150ml warmly take, side medicine as follows: the Radix Astragali 31 parts, Ligusticum wallichii 13 parts, 16 parts of peach kernel, Pollen Typhae 16 parts, ground beetle 13 parts,
Rhizoma Sparganii 15 parts, cassia twig 12 parts, Fructus Aurantii 12 parts, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, half
Summer 9 parts, raw oyster 40 parts, selfheal 12 parts.
Treatment group 4: add on the basis of control group 1 (granule, embodiment 8), every day potion, boiling water brews 300ml, early
Evening each 150ml warmly take, side medicine as follows: the Radix Astragali 30 parts, Ligusticum wallichii 13 parts, 15 parts of peach kernel, Pollen Typhae 14 parts, ground beetle 13 parts,
Rhizoma Sparganii 15 parts, cassia twig 12 parts, Fructus Aurantii 12 parts, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, half
Summer 9 parts, raw oyster 40 parts, selfheal 12 parts.
1.8 clinical efficacy evaluation criteria
1.8.1 tcm syndrome efficacy assessment standard: according to " clinical research of new Chinese medicine treatment coronary disease and angina pectoris is instructed
Principle " formulate, point effective, effective, invalid, increase the weight of.Mainly judge according to Chinese medicine syndrome integral deduction rate.Tcm symptom score mark
Accurate (with reference to " new Chinese medicine guideline of clinical investigations " 2002 editions formulations).
The most effective: clinical symptoms, sign are obviously improved, Chinese medicine syndrome integral deduction rate >=70%.
The most effective: clinical symptoms, sign all take a favorable turn, 70% Chinese medicine syndrome integral deduction rate >=30%.
The most invalid: clinical symptoms, sign are not improved, 30% Chinese medicine syndrome integral deduction rate >=0%.
4. increase the weight of: clinical symptoms, sign all have and increase the weight of, Chinese medicine syndrome integral deduction rate < 0%.
Total effective rate calculation is: patient/valuable total patient × 100% of (effective+effective)
1.9 statistical method
Use SPSS 15.0 statistics analysis software package.Clinical observation data is with mean ± standard deviationRepresent, each group
Sample average first carries out homogeneity test of variance.Measurement data t checks, and enumeration data is used
χ2Inspection.It is judged to that there is statistical significance with P < 0.05.
2 results
2.1 8 groups of angina pectoris efficacy analysis
2.1.1 heart line pain efficacy analysis
Each group angina pectoris efficacy result is shown in Table 12.Each group result makees significance analysis, through χ2Inspection P 0.05, treatment
Group 1, treatment group 2, treatment group 3 and treatment group 4 and control group 1, control group 2, control group 3, control group 4 is compared all has conspicuousness poor
Different, illustrate that treatment group 1 in terms of allevating angina pectoris, treatment group 2, treatment group 3 and treatment group 4 are significantly better than that control group 1, comparison
Group 2, control group 3, control group 4.
12 5 groups of angina pectoris comparitive study (example %) of table
Group | Number of cases | Effective | Effectively | Invalid | Increase the weight of | Total effective rate |
Treatment group 1 | 30 | 12 | 17 | 1 | 0 | 96.6% |
Treatment group 2 | 30 | 11 | 17 | 2 | 0 | 93.33% |
Treatment group 3 | 30 | 11 | 17 | 2 | 0 | 93.33% |
Treatment group 4 | 30 | 11 | 17 | 2 | 0 | 93.33% |
Control group 4 | 30 | 10 | 16 | 4 | 0 | 86.66% |
Control group 3 | 30 | 11 | 16 | 3 | 0 | 90% |
Control group 2 | 30 | 11 | 16 | 3 | 0 | 90% |
Control group 1 | 30 | 4 | 16 | 10 | 0 | 66.67% |
The present invention is according to severe coronary artery disease complexity pathogenic characteristic and combines classical Chinese medicine theory, from " heart kidney qi blood vessels network phlegm
The stasis of blood " multi-direction, multi-angle treats, and righting reaches heresy, treats both principal and secondary aspect of disease and prescription, therefore prescription medicine is different from other, has
Novelty.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, on the premise of without departing from the inventive method, it is also possible to makes some improvement and supplements, and these improve and supplement and also should be regarded as
Protection scope of the present invention.
Claims (4)
1. the Chinese medicine composition of a kind, it is characterised in that described Chinese medicine composition is made up of the bulk drug of following weight portion:
Radix Astragali 29-31 part, Ligusticum wallichii 11-13 part, peach kernel 14-16 part, Pollen Typhae 14-16 part, ground beetle 11-13 part, Rhizoma Sparganii 15 parts, cassia twig
12 parts, Fructus Aurantii 12 parts, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster
40 parts, selfheal 12 parts.
Chinese medicine composition the most according to claim 1, it is characterised in that described Chinese medicine composition is by following weight portion
Bulk drug make: the Radix Astragali 30 parts, Ligusticum wallichii 12 parts, 15 parts of peach kernel, Pollen Typhae 15 parts, ground beetle 12 parts, Rhizoma Sparganii 15 parts, cassia twig 12
Part, Fructus Aurantii 12 parts, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40
Part, selfheal 12 parts.
3. a Chinese medicine composition treats the application in coronary heart disease triple vessel disease medicine in preparation treatment, it is characterised in that
Described Chinese medicine composition is made up of the bulk drug of following weight portion: Radix Astragali 29-31 part, Ligusticum wallichii 11-13 part, peach kernel 14-16
Part, Pollen Typhae 14-16 part, ground beetle 11-13 part, Rhizoma Sparganii 15 parts, cassia twig 12 parts, Fructus Aurantii 12 parts, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land,
Barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, selfheal 12 parts.
Application the most according to claim 3, it is characterised in that described Chinese medicine composition is by the raw material of following weight portion
Medicine is made: the Radix Astragali 30 parts, Ligusticum wallichii 12 parts, 15 parts of peach kernel, Pollen Typhae 15 parts, ground beetle 12 parts, Rhizoma Sparganii 15 parts, cassia twig 12 parts, trifoliate orange
12 parts of shell, sliced CORNUS CERVI 9 parts, 20 parts of cultivated land, barrenwort 20 parts, Snakegourd Fruit 15 parts, Longstamen Onion Bulb 15 parts, the tuber of pinellia 9 parts, raw oyster 40 parts, summer
Withered grass 12 parts.
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CN1970069A (en) * | 2006-12-26 | 2007-05-30 | 曹国胜 | Chinese medicinal pill for treating coronary heart disease |
CN102078510A (en) * | 2011-01-24 | 2011-06-01 | 孙华清 | Chinese medicinal composition for treating coronary heart disease |
CN102416036A (en) * | 2011-12-09 | 2012-04-18 | 上海市中医医院 | Chinese medicinal compositions for preventing and treating ventricular reconstruction due to coronary heart disease and use thereof |
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