CN103432457B

CN103432457B - Chinese medicine preparation for treating viral myocarditis

Info

Publication number: CN103432457B
Application number: CN201310377406.7A
Authority: CN
Inventors: 马世爱; 王世芬; 王金凤
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-08-19
Filing date: 2013-08-19
Publication date: 2014-10-22
Anticipated expiration: 2033-08-19
Also published as: CN103432457A

Abstract

The invention discloses a Chinese medicine preparation for treating viral myocarditis. The viral myocarditis disease belongs to the domains such as wind-warm syndrome, cardiopalmus, palpitation, thoracic obstruction and the like in traditional Chinese medicine. The traditional Chinese medicines including artemisia capillaries, tartarian buckwheat root and rhizome, petasites japonicas, longpeduncle kadsura root, longcalyx chonemorpha stem, honey-fried licorice root, light wheat, wild groundnut seed, astragalus membranaceus, white atractylodes rhizome, ophiopogon latifolius and tuber fleeceflower stem, having the functions of clearing away heat and toxic materials, strengthening the body resistance to eliminate pathogenic factors, promoting blood circulation to remove blood stasis, warming and vibrating heart-yang, and nourishing heart and strengthening the foundation of power, are selected. The Chinese medicine preparation is prepared into a decoction by the department of pharmaceutical preparation in a hospital; the total effective rate can be up to 94.9% by a clinical test, and is demonstrably superior to that of a control group by a clinical test.

Description

A kind of Chinese medicine preparation for the treatment of viral myocarditis

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of viral myocarditis.

Background technology

Viral myocarditis is one of common heart disease, refer to by Coxsackie virus, dust can (ECHO), poliomyelitis, adenovirus 40,41, the myocardium limitation that influenza infection causes or diffuse acute or chronic inflammatory disease pathological changes, belong to infectious cardiomyopathy.Its sickness rate is and increases year by year trend in recent years, is transworld commonly encountered diseases and frequently-occurring disease.Patient's age, sex, the factors such as type, reactivity of organism and extent of disease of infection virus are depended in the clinical manifestation of primary disease, and weight is widely different, and not special, easily causes mistaken diagnosis or fails to pinpoint a disease in diagnosis.The lighter is several asymptomatic and be subclinical process, or symptom is slight; Can there are cardiac dilatation, cardiac insufficiency, severe arrhythmia, shock etc. in severe one, even sudden death.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of viral myocarditis.According to the main clinical syndrome of viral myocarditis, show that primary disease belongs to the categories such as Chinese medicine pathogenic wind-warm, cardiopalmus, palpitation with a distress feeling, the thoracic obstruction.Sick just evil drug-pedlar's heart person, controls with heat-clearing and toxic substances removing; The damp and hot person that invades the heart, controls with Qinghua damp and hot; Deficiency of qi and yin person, controls with Qi-benefiting and heart-nourishing; Deficiency of heart-YANG and kidney-YANG person, controls with temperature compensation heart kidney; The stagnant person of the heart arteries and veins stasis of blood, controls and take the blood circulation promoting and blood stasis dispelling traditional Chinese medical science and think that this sick principle for the treatment of is heat-clearing and toxic substances removing, strengthening vital QI to eliminate pathogenic factors, and blood circulation promoting and blood stasis dispelling, the temperature heart-yang that shakes, nourishes heart and consolidates.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment viral myocarditis is made by the Chinese medicine of following weight portion: Herba Artemisiae Scopariae 15-20 part, Rhizoma Fagopyri Cymosi 20-50 part, Petasites japonicus 15-25 part, Radix Kadsurae longipedunculatae 16-22 part, Caulis Chonemorphae Megacalycis 15-25 part, Radix Glycyrrhizae Preparata 2-9 part, Fructus Tritici Levis 15-30 part, Semen glycines sojae 15-25 part, Radix Astragali 20-30 part, Rhizoma Atractylodis Macrocephalae 10-15 part.Radix Ophiopogonis Dracaenoidis 10-16 part, Caulis Polygoni Multiflori 15-20 part.

Preferably, 18 parts of Herba Artemisiae Scopariae, 25 parts of Rhizoma Fagopyri Cymosi, 20 parts of Petasites japonicus, 19 parts of Radix Kadsurae longipedunculataes, 18 parts of Caulis Chonemorphae Megacalyciss, 5 parts of Radix Glycyrrhizae Preparatas, 25 parts of Fructus Tritici Levis, 20 parts of Semen glycines sojaes, 25 parts of the Radixs Astragali, 13 parts of the Rhizoma Atractylodis Macrocephalaes, 14 parts of Radix Ophiopogonis Dracaenoidiss, 17 parts of Caulis Polygoni Multiflori.

Preparation method is made decoction by above-mentioned Chinese medicine decocting.

In side: Herba Artemisiae Scopariae, Rhizoma Fagopyri Cymosi heat-clearing and toxic substances removing, expelling wind and removing dampness; Petasites japonicus reducing swelling and alleviating pain, detoxification and removing stasis; Radix Kadsurae longipedunculatae, Caulis Chonemorphae Megacalycis, Caulis Polygoni Multiflori promoting blood circulation by removing wind, eliminating stasis to stop pain; Dredging collateral; Radix Glycyrrhizae Preparata, Fructus Tritici Levis are nourished heart and consolidate, Yiqi and vein recovery; Semen glycines sojae liver and kidney tonifying, the removing toxic substances of dispeling the wind; The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Ophiopogonis Dracaenoidis benefiting QI for strengthening the superficies, and in nourish heart, feel at ease to repose.

Clinical data

1, this group of physical data patient 78 examples, are out-patient, by table of random number, case are divided into treatment group and each 39 examples of matched group at random.Treatment group man 19 examples, female's 20 examples; 20～50 years old age, average 35.5 years old, the course of disease 2 months～1 year.Matched group man 18 examples, female's 21 examples; Age is 21～55 years old, average 36 years old, and the course of disease 3 months～1.5 years.Two groups of patient's comparisons aspect sex, age, the course of disease, no significant difference (P>0.05), has comparability.

2, diagnostic criteria is got rid of known various cardiovascular disease as rheumatic heart disease, the myocarditis that hypertension, atherosclerosis and other causes of disease cause etc.There is the symptom of upper respiratory tract or enterovirus infection in premorbid 1-3 week, adds cardiac symptom and the sign of recent appearance, as uncomfortable in chest, cardiopalmus etc., particularly various, variable abnormal electrocardiographic pattern.

3, Therapeutic Method treatment group is taken Chinese medicine preparation of the present invention, takes 15 parts of Herba Artemisiae Scopariae, Rhizoma Fagopyri Cymosi 25g, Petasites japonicus 20g, Radix Kadsurae longipedunculatae 19g, Caulis Chonemorphae Megacalycis 18g, Radix Glycyrrhizae Preparata 5g, Fructus Tritici Levis 25g, Semen glycines sojae 20g, Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 13g, Radix Ophiopogonis Dracaenoidis 14g, Caulis Polygoni Multiflori 17g.Decocting becomes decoction, and potion, divided and sooner or later took for 2 times every day; Matched group gives adenosine triphosphate 10～20mg, intramuscular injection, every day 2～3 times.Two groups equal 2 weeks is a course for the treatment of.

4, criterion of therapeutical effect clinical cure: clinical symptoms, sign disappear, the every inspection of laboratory recovers normal.Effective: clinical symptoms, sign disappear, and electrocardiogram, sero-enzyme recover normally substantially, and other have clear improvement.Effective: clinical symptoms, sign make moderate progress, the every inspection of laboratory has certain improvement.Invalid: clinical symptoms, sign and lab testing are all without improving.

5, curative effect comparison after the course for the treatment of of two groups of therapeutic outcomes treatment, treatment group 39 examples, wherein cure 26 examples (66.7%), effective 7 examples (17.9%), effective 4 examples (10.3%), invalid 2 examples (5.1%), total effective rate 94.9%; Matched group 39 examples, wherein cure 17 examples (43.6%), effective 8 examples (20.5%), effective 6 examples (15.4%), invalid 8 examples (20.5%), total effective rate 79.5%.Two groups of comparisons, treatment group cure rate, total effective rate are obviously better than matched group, have comparability.P<0.05。

6, model case Lee, man, 35 years old, professional teacher, in first visit on August 5 in 2012.Patient suffers from respiratory tract infection before more than ten day accidentally, occurs rhinorrhea, heating, pharyngalgia, cough, the symptom such as uncomfortable in chest.After the treatment of local clinic, upper respiratory tract infection symptoms is alleviated, but occurs cardiopalmus, breathes hard, suffocating pain over the chest, and there is ecchymosis on red tongue, limit, pulse condition number.Electrocardioscopy is shown: ST section moves down, and T ripple is low flat, QT interval prolongation.Disease arteries and veins closes ginseng, distinguishes as viral myocarditis.Side's medicine: Herba Artemisiae Scopariae 15g, Rhizoma Fagopyri Cymosi 25g, Petasites japonicus 20g, Radix Kadsurae longipedunculatae 19g, Caulis Chonemorphae Megacalycis 18g, Radix Glycyrrhizae Preparata 5g, Fructus Tritici Levis 25g, Semen glycines sojae 20g, Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 13g, Radix Ophiopogonis Dracaenoidis 14g, Caulis Polygoni Multiflori 17g.Every day, potion, was decocted in water for oral dose 2 times, serve on 1 week.Patient's further consultation of coming after medicine, tells cardiopalmus, breathes hard, uncomfortable in chestly subtracts greatly, and continuous top takes again two weeks, and all diseases are removed, follow up a case by regular visits to so far recurrence.

The specific embodiment

Embodiment mono-: Herba Artemisiae Scopariae 18g, Rhizoma Fagopyri Cymosi 25g, Petasites japonicus 20g, Radix Kadsurae longipedunculatae 19g, Caulis Chonemorphae Megacalycis 20g, Radix Glycyrrhizae Preparata 5g, Fructus Tritici Levis 25g, Semen glycines sojae 20g, Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 13g.Radix Ophiopogonis Dracaenoidis 14g, Caulis Polygoni Multiflori 17g.Above-mentioned Chinese medicine decocting is made to decoction.

Embodiment bis-: Herba Artemisiae Scopariae 20g, Rhizoma Fagopyri Cymosi 50g, Petasites japonicus 15g, Radix Kadsurae longipedunculatae 22g, Caulis Chonemorphae Megacalycis 25g, Radix Glycyrrhizae Preparata 9g, Fructus Tritici Levis 15g, Semen glycines sojae 25g, Radix Astragali 20g, Rhizoma Atractylodis Macrocephalae 15g, Radix Ophiopogonis Dracaenoidis 16g, Caulis Polygoni Multiflori 20g.Above-mentioned Chinese medicine decocting is made to decoction.

Embodiment tri-: Herba Artemisiae Scopariae 15g, Rhizoma Fagopyri Cymosi 20g, Petasites japonicus 25g, Radix Kadsurae longipedunculatae 16g, Caulis Chonemorphae Megacalycis 15g, Radix Glycyrrhizae Preparata 2g, Fructus Tritici Levis 30g, Semen glycines sojae 15g, Radix Astragali 30g, Rhizoma Atractylodis Macrocephalae 10g.Radix Ophiopogonis Dracaenoidis 10g, Caulis Polygoni Multiflori 15.Above-mentioned Chinese medicine decocting is made to decoction.

Claims

1. treat a Chinese medicine preparation for viral myocarditis, it is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: Herba Artemisiae Scopariae 15-20 part, Rhizoma Fagopyri Cymosi 20-50 part, Petasites japonicus 15-25 part, Radix Kadsurae longipedunculatae 16-22 part, Caulis Chonemorphae Megacalycis 15-25 part, Radix Glycyrrhizae Preparata 2-9 part, Fructus Tritici Levis 15-30 part, Semen glycines sojae 15-25 part, Radix Astragali 20-30 part, Rhizoma Atractylodis Macrocephalae 10-15 part, Radix Ophiopogonis Dracaenoidis 10-16 part, Caulis Polygoni Multiflori 15-20 part.

2. a kind of Chinese medicine preparation for the treatment of viral myocarditis according to claim 1, is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: 18 parts of Herba Artemisiae Scopariae, 25 parts of Rhizoma Fagopyri Cymosi, 20 parts of Petasites japonicus, 19 parts of Radix Kadsurae longipedunculataes, 18 parts of Caulis Chonemorphae Megacalyciss, 5 parts of Radix Glycyrrhizae Preparatas, 25 parts of Fructus Tritici Levis, 20 parts of Semen glycines sojaes, 25 parts of the Radixs Astragali, 13 parts of the Rhizoma Atractylodis Macrocephalaes, 14 parts of Radix Ophiopogonis Dracaenoidiss, 17 parts of Caulis Polygoni Multiflori.