CN110693949A - Antibacterial and anti-inflammatory veterinary medicine composition and preparation method thereof - Google Patents
Antibacterial and anti-inflammatory veterinary medicine composition and preparation method thereof Download PDFInfo
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Classifications
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention relates to the field of veterinary medicine preparation, in particular to an antibacterial and anti-inflammatory veterinary medicine composition and a preparation method thereof, wherein the composition is prepared from the following raw materials in parts by weight: 15-22 parts of apramycin sulfate, 8-12 parts of opium and derivatives thereof, 6-9 parts of lincomycin hydrochloride and 20-35 parts of traditional Chinese medicine extract. The compound preparation is compounded with a plurality of bactericidal drugs and traditional Chinese medicines with antibacterial and anti-inflammatory effects, has good antibacterial and anti-inflammatory effects and few side effects, inhibits harmful bacteria in animal bodies by interfering the synthesis of prokaryotic ribose proteins through apramycin sulfate, treats animal diseases caused by escherichia coli and salmonella, enables animals to normally develop, improves gastrointestinal tension and inhibits intestinal movement through opiates and derivative preparations thereof, can inhibit the synthesis of bacterial cell proteins through lincomycin hydrochloride, is used for various bacterial infections, and is completely absorbed when being orally taken.
Description
Technical Field
The invention relates to the field of veterinary medicine preparation, and in particular relates to an antibacterial and anti-inflammatory veterinary medicine composition and a preparation method thereof.
Background
In poultry breeding, diseases are one of the causes of economic losses of breeding masters all the time, after infectious cases appear in a breeding farm, if the infectious cases are not controlled and treated in time, large-area infection is easily caused, so that serious economic losses are caused, in the bacterial infection of poultry, the ideal effect cannot be achieved by singly using a certain specific antibiotic, the reason is that the receptor generates drug resistance due to the single antibiotic for a long time, the situation of cross infection is easy to appear after the poultry is ill, and the treatment effect of the poultry is greatly reduced by adopting a single drug in the prior art.
Disclosure of Invention
The invention provides an antibacterial and anti-inflammatory veterinary drug composition and a preparation method thereof, the composition is compounded with a plurality of bactericidal drugs and traditional Chinese medicines with antibacterial and anti-inflammatory effects, the antibacterial and anti-inflammatory effects are good, the side effects are few, harmful bacteria in animal bodies are inhibited by interfering the synthesis of prokaryotic ribose proteins with apramycin sulfate, animal diseases caused by escherichia coli and salmonella are treated, animals can normally develop, gastrointestinal tension is improved and intestinal tract movement is inhibited by preparations of opium and derivatives thereof, the synthesis of bacterial cell proteins can be inhibited by lincomycin hydrochloride, the composition is used for various bacterial infections, and the composition is completely absorbed when being orally taken.
In order to achieve the purpose, the invention adopts the following technical scheme:
an antibacterial and anti-inflammatory veterinary medicine composition is prepared from the following raw materials in parts by weight: 15-22 parts of apramycin sulfate, 8-12 parts of opium and derivatives thereof, 6-9 parts of lincomycin hydrochloride and 20-35 parts of traditional Chinese medicine extract.
Preferably, the antibacterial and anti-inflammatory veterinary medicine composition is prepared from the following raw materials in parts by weight: 17 parts of apramycin sulfate, 9 parts of opium and derivatives thereof, 7 parts of lincomycin hydrochloride and 28 parts of traditional Chinese medicine extracting solution.
Preferably, the opium and the derivative thereof are one of loperamide hydrochloride, diphenoxylate and compound camphor tincture; the apramycin sulfate, the opium and the derivatives thereof and the lincomycin hydrochloride are all the existing products sold in the market.
Preferably, the traditional Chinese medicine extracting solution is prepared from the following raw materials in parts by weight: 10-15 parts of isatis root, 8-12 parts of corydalis bungeana, 6-9 parts of scutellaria baicalensis, 8-15 parts of quassia and 6-10 parts of andrographis paniculata.
Preferably, the traditional Chinese medicine extracting solution is prepared from the following raw materials in parts by weight: 12 parts of isatis root, 10 parts of corydalis bungeana, 7 parts of scutellaria baicalensis, 10 parts of quassia, and 8 parts of common andrographis herb.
Preferably, the preparation method of the traditional Chinese medicine extracting solution comprises the following steps: cleaning and crushing the raw materials, mixing the crushed raw materials with 10-20 times of water, sending the mixture into an extraction tank, heating the mixture to 75-85 ℃, stirring the mixture at the rotating speed of 500-700r/m, keeping the mixture for 30-50min, filtering residues, adding 8-15 times of water again for secondary extraction, raising the extraction temperature to 85-100 ℃, keeping the rotating speed and the time unchanged, filtering the residues for the second time, combining the two extracting solutions, and concentrating the extracting solution to 1/20-1/30 of the original volume to obtain the traditional Chinese medicine extracting solution.
Preferably, the preparation method of the traditional Chinese medicine extracting solution comprises the following steps: cleaning and crushing the raw materials, adding 15 times of water, feeding the mixture into an extraction tank, heating the mixture to 80 ℃, setting the stirring speed to 600r/m, keeping the temperature for 40min, filtering residues, adding 10 times of water again for secondary extraction, raising the extraction temperature to 95 ℃, keeping the rotation speed and the time unchanged, filtering the residues for the second time, combining the two extracting solutions, and concentrating the extracting solution to 1/25 of the original volume to obtain the traditional Chinese medicine extracting solution.
A preparation method of an antibacterial and anti-inflammatory veterinary medicine composition comprises the following steps: mixing apramycin sulfate, opium and derivatives thereof, and lincomycin hydrochloride into the traditional Chinese medicine extract, uniformly stirring, then sending into a freeze dryer, precooling for 0.5-2h at minus 20-30 ℃, vacuumizing to 10-30pa after precooling is finished, reducing the temperature to minus 30-40 ℃, stopping drying until the water content of the material is lower than 3%, taking out the material, and pulverizing by using a wall-broken superfine powder technology to obtain the finished product.
A preparation method of an antibacterial and anti-inflammatory veterinary medicine composition comprises the following steps: mixing apramycin sulfate, opium and derivatives thereof and lincomycin hydrochloride into the traditional Chinese medicine extracting solution, uniformly stirring, then sending into a freeze dryer, precooling for 1.5h at the temperature of minus 25 ℃, vacuumizing to 15pa after precooling is finished, reducing the temperature to minus 35 ℃, stopping drying until the water content of the material is lower than 3%, taking out the material, and pulverizing by using a wall-breaking superfine powder technology to obtain the finished product.
The properties and pharmacology of the raw materials of the invention are as follows:
the apramycin sulfate has an action mechanism of interfering the synthesis of prokaryotic ribose protein to inhibit harmful bacteria in an animal body, and treating animal diseases caused by escherichia coli and salmonella so that the animal can normally develop, thereby increasing the weight and improving the feed reward. Is mainly used for preventing and treating dysentery, diarrhea, dysplasia and other diseases of livestock and poultry such as pigs, chickens, cattle and the like caused by escherichia coli and salmonella. Can also be used for treating enteritis of fish and shrimp in aquatic products.
The opiates and derivatives thereof have the effect of stopping diarrhea mainly by improving gastrointestinal tension, inhibiting intestinal movement and stopping propulsive contraction.
The lincomycin hydrochloride is mainly used for resisting gram-positive bacteria and anaerobic bacteria infection, inhibiting the synthesis of bacterial cell protein and treating various bacterial infections in livestock and poultry breeding. The oral preparation is completely absorbed when being taken orally, directly acts on tissues and body fluids such as lung and the like, has high bioavailability, can quickly reach blood concentration, has long half life, has no toxic or side effect on organisms, and is safe to use. Has moderate inhibitory effect on various gram-negative bacilli, such as Escherichia coli, Salmonella, Shigella, Proteus, etc. Sensitive to streptococci, pneumococci, staphylococcus epidermidis and certain mycoplasmas.
Compared with the prior art, the invention has the beneficial effects that: the compound preparation is used for various bacterial infections, can completely absorb the compound preparation when being orally taken, and has good antibacterial and anti-inflammatory effects and few side effects.
Detailed Description
The technical solutions in the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
An antibacterial and anti-inflammatory veterinary medicine composition is prepared from the following raw materials in parts by weight: 17 parts of apramycin sulfate, 9 parts of opium and derivatives thereof, 7 parts of lincomycin hydrochloride and 28 parts of traditional Chinese medicine extracting solution.
In embodiment 1, the opioid and the derivative thereof are loperamide hydrochloride, and the Chinese medicinal extract is prepared from the following raw materials in parts by weight: 12 parts of isatis root, 10 parts of corydalis bungeana, 7 parts of scutellaria baicalensis, 10 parts of quassia, and 8 parts of common andrographis herb.
In example 1, the method for preparing the Chinese medicinal extract solution comprises the following steps: cleaning and crushing the raw materials, adding 15 times of water, feeding the mixture into an extraction tank, heating the mixture to 80 ℃, setting the stirring speed to 600r/m, keeping the temperature for 40min, filtering residues, adding 10 times of water again for secondary extraction, raising the extraction temperature to 95 ℃, keeping the rotation speed and the time unchanged, filtering the residues for the second time, combining the two extracting solutions, and concentrating the extracting solution to 1/25 of the original volume to obtain the traditional Chinese medicine extracting solution.
A preparation method of an antibacterial and anti-inflammatory veterinary medicine composition comprises the following steps: mixing apramycin sulfate, opium and derivatives thereof and lincomycin hydrochloride into the traditional Chinese medicine extracting solution, uniformly stirring, then sending into a freeze dryer, precooling for 1.5h at the temperature of minus 25 ℃, vacuumizing to 15pa after precooling is finished, reducing the temperature to minus 35 ℃, stopping drying until the water content of the material is lower than 3%, taking out the material, and pulverizing by using a wall-breaking superfine powder technology to obtain the finished product.
Example 2
An antibacterial and anti-inflammatory veterinary medicine composition is prepared from the following raw materials in parts by weight: 20 parts of apramycin sulfate, 8 parts of opium and derivatives thereof, 6 parts of lincomycin hydrochloride and 25 parts of traditional Chinese medicine extracting solution.
In embodiment 2, the opioid and the derivative thereof are diphenoxylate, and the Chinese medicinal extract is prepared from the following raw materials in parts by weight: 10 parts of isatis root, 8 parts of corydalis bungeana, 7 parts of scutellaria baicalensis, 10 parts of quassia, and 10 parts of common andrographis herb.
In example 2, the preparation method of the Chinese medicinal extract comprises the following steps: cleaning and crushing the raw materials, adding 12 times of water, feeding the mixture into an extraction tank, heating the mixture to 85 ℃, setting the stirring speed to be 500r/m, keeping the temperature for 40min, filtering residues, adding 10 times of water again for secondary extraction, raising the extraction temperature to 95 ℃, keeping the rotation speed and the time unchanged, filtering the residues for the second time, combining the two extracting solutions, and concentrating the extracting solution to 1/30 of the original volume to obtain the traditional Chinese medicine extracting solution.
A preparation method of an antibacterial and anti-inflammatory veterinary medicine composition comprises the following steps: mixing apramycin sulfate, opium and derivatives thereof, and lincomycin hydrochloride into the traditional Chinese medicine extracting solution, uniformly stirring, then sending into a freeze dryer, precooling for 1h at the temperature of minus 30 ℃, vacuumizing to 10pa after precooling is finished, reducing the temperature to minus 35 ℃, stopping drying until the water content of the material is lower than 3%, taking out the material, and pulverizing by using a wall-broken superfine powder technology to obtain the finished product.
Example 3
An antibacterial and anti-inflammatory veterinary medicine composition is prepared from the following raw materials in parts by weight: 22 parts of apramycin sulfate, 10 parts of opium and derivatives thereof, 6 parts of lincomycin hydrochloride and 30 parts of traditional Chinese medicine extracting solution.
In example 3, the opium and the derivative thereof are compound camphor tincture, and the traditional Chinese medicine extracting solution is prepared from the following raw materials in parts by weight: 15 parts of isatis root, 8 parts of corydalis bungeana, 8 parts of scutellaria baicalensis, 12 parts of quassia, and 8 parts of common andrographis herb.
The preparation method of the traditional Chinese medicine extracting solution comprises the following steps: cleaning and crushing the raw materials, mixing the crushed raw materials with 12 times of water, feeding the mixture into an extraction tank, heating the mixture to 85 ℃, setting the stirring speed to 700r/m, keeping the temperature for 35min, filtering residues, adding 8 times of water again for secondary extraction, raising the extraction temperature to 90 ℃, keeping the rotation speed and the time unchanged, filtering the residues for the second time, combining the two extracting solutions, and concentrating the extracting solution to 1/30 of the original volume to obtain the traditional Chinese medicine extracting solution.
A preparation method of an antibacterial and anti-inflammatory veterinary medicine composition comprises the following steps: mixing apramycin sulfate, opium and derivatives thereof, and lincomycin hydrochloride into the traditional Chinese medicine extracting solution, uniformly stirring, then sending into a freeze dryer, precooling for 2h at the temperature of minus 30 ℃, vacuumizing to 30pa after precooling is finished, reducing the temperature to minus 35 ℃, stopping drying until the water content of the material is lower than 3%, taking out the material, and pulverizing by using a wall-broken superfine powder technology to obtain the finished product.
Test example 1
Introduction of the test: 40 broilers of 60 days old are randomly divided into four groups, unified feed is adopted for feeding, wherein three groups are added with the antibacterial and anti-inflammatory veterinary drug composition prepared in the embodiments 1-3 of the invention to serve as an embodiment, the rest group is added with a similar product with antibacterial and anti-inflammatory functions sold in the market to serve as a comparative example, the feeding mode is free foraging and free drinking, the medicine adding mode is that 100 g of water is added into the feed according to the invention, the broilers are uniformly inoculated with salmonella in the test according to the recommended dosage of the commercial product, the death condition and the recovery condition are recorded after five days, the recovery standard in the test is that the broilers inoculated with the salmonella do not have abnormal expression after five days, the spirit, the appetite, the body temperature and the like are recovered to be recovered, and the detailed test data are shown in the.
| Number of deaths | Mortality rate | Number of recovery | Rate of recovery | |
| Example 1 | 0 | 0 | 10 | 100％ |
| Example 2 | 1 | 10％ | 9 | 90％ |
| Example 3 | 0 | 0 | 10 | 100％ |
| Comparative example | 2 | 20％ | 8 | 80％ |
TABLE 1
Test example 2
Introduction of the test: 40 golden ducks of 60 days old are randomly divided into four groups and are fed by unified feed, wherein the three groups are added with the antibacterial and anti-inflammatory veterinary drug composition prepared in the embodiments 1-3 of the invention as the embodiments, the other group is added with a certain brand of similar products with antibacterial and anti-inflammatory functions as the comparative examples, the feeding mode is free foraging and free drinking, the dosing mode is that 100 g of water is added into the feed according to the invention, the commercial products are uniformly inoculated with escherichia coli according to the recommended dosage, the death condition and the recovery condition are recorded after five days, the recovery standard in the test is that the golden ducks inoculated with the escherichia coli have no abnormal expression after five days, the spirit, appetite, body temperature and the like are recovered to be normal and are recovered, and the detailed test data are shown in the table 2.
| Number of deaths | Mortality rate | Number of recovery | Rate of recovery | |
| Example 1 | 0 | 0 | 10 | 100％ |
| Example 2 | 0 | 0 | 10 | 100％ |
| Example 3 | 0 | 0 | 10 | 100％ |
| Comparative example | 1 | 10％ | 9 | 90％ |
TABLE 2
As can be seen from the data in tables 1 and 2, the antibacterial and anti-inflammatory veterinary drug composition prepared by the invention has the advantages that the cure rate of salmonella is over 90 percent, the cure rate of escherichia coli is basically 100 percent, and the effect is better than that of the comparative example.
Finally, it should be noted that the above-mentioned preferred embodiments of the present invention are provided merely to help illustrate the present invention. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims (8)
1. An antibacterial and anti-inflammatory veterinary medicine composition is characterized by being prepared from the following raw materials in parts by weight: 15-22 parts of apramycin sulfate, 8-12 parts of opium and derivatives thereof, 6-9 parts of lincomycin hydrochloride and 20-35 parts of traditional Chinese medicine extract.
2. The antibacterial and anti-inflammatory veterinary drug composition according to claim 1, which is prepared from the following raw materials in parts by weight: 17 parts of apramycin sulfate, 9 parts of opium and derivatives thereof, 7 parts of lincomycin hydrochloride and 28 parts of traditional Chinese medicine extracting solution.
3. The veterinary drug composition for antibacterial and anti-inflammatory according to claim 1, wherein the opium and the derivative thereof are one of loperamide hydrochloride, diphenoxylate and compound camphor tincture.
4. The antibacterial and anti-inflammatory veterinary drug composition as claimed in claim 1, wherein the traditional Chinese medicine extracting solution is prepared from the following raw materials in parts by weight: 10-15 parts of isatis root, 8-12 parts of corydalis bungeana, 6-9 parts of scutellaria baicalensis, 8-15 parts of quassia and 6-10 parts of andrographis paniculata.
5. The antibacterial and anti-inflammatory veterinary drug composition as claimed in claim 4, wherein the traditional Chinese medicine extracting solution is prepared from the following raw materials in parts by weight: 12 parts of isatis root, 10 parts of corydalis bungeana, 7 parts of scutellaria baicalensis, 10 parts of quassia, and 8 parts of common andrographis herb.
6. The antibacterial and anti-inflammatory veterinary drug composition according to claim 4, wherein the preparation method of the traditional Chinese medicine extracting solution comprises the following steps: cleaning and crushing the raw materials, mixing the crushed raw materials with 10-20 times of water, sending the mixture into an extraction tank, heating the mixture to 75-85 ℃, stirring the mixture at the rotating speed of 500-700r/m, keeping the mixture for 30-50min, filtering residues, adding 8-15 times of water again for secondary extraction, raising the extraction temperature to 85-100 ℃, keeping the rotating speed and the time unchanged, filtering the residues for the second time, combining the two extracting solutions, and concentrating the extracting solution to 1/20-1/30 of the original volume to obtain the traditional Chinese medicine extracting solution.
7. The antibacterial and anti-inflammatory veterinary drug composition according to claim 6, wherein the preparation method of the traditional Chinese medicine extracting solution comprises the following steps: cleaning and crushing the raw materials, adding 15 times of water, feeding the mixture into an extraction tank, heating the mixture to 80 ℃, setting the stirring speed to 600r/m, keeping the temperature for 40min, filtering residues, adding 10 times of water again for secondary extraction, raising the extraction temperature to 95 ℃, keeping the rotation speed and the time unchanged, filtering the residues for the second time, combining the two extracting solutions, and concentrating the extracting solution to 1/25 of the original volume to obtain the traditional Chinese medicine extracting solution.
8. The preparation method of the antibacterial and anti-inflammatory veterinary medicine composition is characterized by comprising the following steps: mixing apramycin sulfate, opium and derivatives thereof, and lincomycin hydrochloride into the traditional Chinese medicine extract, uniformly stirring, then sending into a freeze dryer, precooling for 0.5-2h at minus 20-30 ℃, vacuumizing to 10-30pa after precooling is finished, reducing the temperature to minus 30-40 ℃, stopping drying until the water content of the material is lower than 3%, taking out the material, and pulverizing by using a wall-broken superfine powder technology to obtain the finished product.
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| Title |
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| 李松龄等: "鸡常见细菌性疾病的防治及注意事项", 《河南畜牧兽医》 * |
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